Representative publications

  1. Kaidong Liu # , Yanrui Cui # , Huiming Han # , Erliang Guo, Xingyang Shi, Kai Xiong, Nan Zhang, Songmei Zhai, Shaocong Sang, Mingyue Liu, Bo Chen,  Yunyan Gu * . Fibroblast atlas: shared and specific cell types across tissues.  Science Advances.  2025 Apr 2;11(14):eado0173. doi: 10.1126/sciadv.ado0173.
  2. Qi Dong # , Yingying Guo # , Chen Lv # , Lingxue Ren, Bo Chen, Yan Wang, Yang Liu, Mingyue Liu, Kaidong Liu, Nan Zhang, Linzhu Wang, Shaocong Sang, Xin Lia, Yang Hui * , Haihai Liang * Yunyan Gu * . Unveiling a novel cancer hallmark by evaluation of neural infiltration in cancer.  Briefings In Bioinformatics.  2025 Mar 4;26(2):bbaf082. doi: 10.1093/bib/bbaf082.
  3. Songliu Hu # , Ning Zhan # , Jian Li # , Liqun Wang, Yiyan Liu, Ke Jin, Yixuan Wang, Juxuan Zhang, Yiyang Chen, Yang Bai, Yichong Wang,  Lishuang Qi * , and Shilong Liu * . RBM15 recruits myeloid-derived suppressor cells via the m6A-IGF2BP3/CBR3-AS1/miR-409-3p/CXCL1 axis, facilitating radioresistance in non-small-cell lung cancer.  Journal of translational medicine.  2025 Feb 17;23(1):191. doi: 10.1186/s12967-025-06205-y.
  4. Wenyue Li # , Linzhu Wang # , Wen Tian # , Weihang Ji, Danyang Bing, Yan Wang, Bingqian Xu, Jiayue Feng,  Peng Zhang, Haihai Liang,  Yunyan Gu * , Baofeng Yang * . SNRNP70 regulates the splicing of CD55 to promote osteosarcoma progression.  JCI Insight.  2024 Dec 20;9(24):e185269. doi: 10.1172/jci.insight.185269.
  5. Minghui Cai # , Jiaxing Deng # , Shangjie Wu, Yang Cao, Hong Chen, Hao Tang, Chendan Zou, Hui Zhu * Lishuang Qi * . Alpha-1 antitrypsin targeted neutrophil elastase protects against sepsis-induced inflammation and coagulation in mice via inhibiting neutrophil extracellular trap formation.  Life sciences.  2024 Sep 15:353:122923. doi: 10.1016/j.lfs.2024.122923.
  6. Zhangxiang Zhao # , Yuquan Wang # , Zixin Jin, Huiming Han, Bo Chen, Mingyue Liu, Kaidong Liu, Shuping Zhuang,  Haihai Liang * Yunyan Gu * . Alternative splicing of immune-related genes identifies breast cancer subtypes with differential immune cell infiltration.   Genes & Disease.  2024 Jun 14;12(2):101349. doi: 10.1016/j.gendis.2024.101349.
  7. Kaidong Liu # , Huiming Han # , Kai Xiong # , Songmei Zhai, Xiuqi Yang, Xinmiao Yu, Bo Chen, Mingyue Liu, Qi Dong, Hongxue Meng * Yunyan Gu * . Single-cell landscape of intratumoral heterogeneity and tumor microenvironment remolding in pre-nodal metastases of breast cancer.  Journal of Translational Medicine.  2024 Aug 29;22(1):804. doi: 10.1186/s12967-024-05625-6.
  8. Mingyue Liu # , Zhangxiang Zhao # , Chengyu Wang # , Shaocong Sang, Yanrui Cui, Chen Lv, Xiuqi Yang, Nan Zhang, Kai Xiong, Bo Chen, Qi Dong, Kaidong Liu,  Yunyan Gu * . Harnessing genetic interactions for prediction of immune checkpoint inhibitors response signature in cancer cells. Cancer Letters.  2024 Jul 10:594:216991. doi: 10.1016/j.canlet.2024.216991.
  9. Qi Dong # , Tong Yu # , Bo Chen, Mingyue Liu, Xiang Sun, Huiying Cao, Kaidong Liu, Huanhuan Xu, Yuquan Wang, Shuping Zhuang, Zixin Jin, Haihai Liang, Yang Hui * Yunyan Gu * . Mutant RB1 enhances therapeutic efficacy of PARPis in lung adenocarcinoma by triggering the cGAS/STING pathway. JCI Insight.  2023 Nov 8;8(21):e165268. doi: 10.1172/jci.insight.165268.
  10. Mingyue Liu # , Qi Dong # , Bo Chen, Kaidong Liu, Zhangxiang Zhao, Yuquan Wang, Shuping Zhuang, Huiming Han, Xingyang Shi, Zixin Jin, Yang Hui * Yunyan Gu * . Synthetic viability induces resistance to immune checkpoint inhibitors in cancer cells. British Journal of Cancer.  2023 Oct;129(8):1339-1349. doi: 10.1038/s41416-023-02404-w.
  11. Shanqi Xu # , Xin Li # , Jianxiong Geng, Yingyue Cao, Yan Yu * Lishuang Qi * . Sec61γ is a vital protein in the endoplasmic reticulum membrane promoting tumor metastasis and invasion in lung adenocarcinoma. British Journal of Cancer.  2023 Apr;128(8):1478-1490. doi: 10.1038/s41416-023-02150-z.
  12. Bo Chen # , Pengfei Li # , Mingyue Liu # , Kaidong Liu, Min Zou, Yiding Geng, Shuping Zhuang, Huanhuan Xu, Linzhu Wang, Tingting Chen, Yawei Li, Zhangxiang Zhao, Lishuang Qi * Yunyan Gu * . A genetic map of the chromatin regulators to drug response in cancer cells. Journal of Translational Medicine.  2022 Sep 30;20(1):438. doi: 10.1186/s12967-022-03651-w.
  13. Tingting Chen # , Tong Yu # , Shuping Zhuang, Yiding Geng, Junwen Xue, Jiayi Wang, Liqiang Ai, Bo Chen, Zhangxiang Zhao, Yawei Li, Jinghao Wang, Haihai Liang, Yan Xu * Yunyan Gu * . Upregulation of CXCL1 and LY9 contributes to BRCAness in ovarian cancer and mediates response to PARPi and immune checkpoint blockade. British Journal of Cancer.  2022 Sep;127(5):916-926. doi: 10.1038/s41416-022-01836-0.
  14. Kaidong Liu # , Yiding Geng # , Linzhu Wang # , Huanhuan Xu, Min Zou, Yawei Li, Zhangxiang Zhao, Tingting Chen, Fengyan Xu, Liang Sun, Shuliang Wu * Yunyan Gu * . Systematic exploration of the underlying mechanism of gemcitabine resistance in pancreatic adenocarcinoma. Molecular Oncology.  2022 Aug;16(16):3034-3051. doi: 10.1002/1878-0261.13279.
  15. Hailong Zheng # , Jiajing Xie # , Kai Song, Jing Yang, Huiting Xiao, Jiashuai Zhang, Keru Li, Rongqiang Yuan, Yuting Zhao,  Yunyan Gu * and Wenyuan Zhao * . StemSC: a cross-dataset human stemness index for single-cell samples. Stem Cell Research & Therapy.  2022 Mar 21;13(1):115. doi: 10.1186/s13287-022-02803-5.
  16. Zhangxiang Zhao # , YingYing Guo # , Yaoyao Liu # , Lichun Sun, Bo Chen, Chengyu Wang, Tingting Chen, Yuquan Wang, Yawei Li, Qi Dong, Liqiang Ai, Ran Wang,  Yunyan Gu * , Xia Li * . Individualized lncRNA differential expression profile reveals heterogeneity of breast cancer.  Oncogene.  2021 Jul;40(27):4604-4614. doi: 10.1038/s41388-021-01883-6.
  17. Tingting Chen # , Yingying Guo # , Jiayi Wang # , Liqiang Ai, Lu Ma, Wenxin He, Zhixin Li, Xiaojiang Yu, Jinrui Li, Xingxing Fan,  Yunyan Gu * , Haihai Liang * . LncRNA CTD-2528L19.6 prevents the progression of IPF by alleviating fibroblast activation.  Cell Death & Disease.  2021 Jun 10;12(6):600. doi: 10.1038/s41419-021-03884-5.
  18. Haihai Liang # , Mengxue Yu # , Rui Yang # , Lu Zhang , Lijia Zhang, Di Zhu, Hongwei Luo, Yaozhen Hong, Tong Yu, Jian Sun, Hongli Shan * Yunyan Gu * . A PTAL-miR-101-FN1 axis promotes EMT and invasion-metastasis in serous ovarian cancer. Molecular Therapy–Oncolytics.  2019 Dec 11:16:53-62. doi: 10.1016/j.omto.2019.12.002.
  19. Chengyu Wang # , Fan Yang # , Tingting Chen, Qi Dong, Zhangxiang Zhao, Yaoyao Liu, Bo Chen, Haihai Liang, Huike Yang * Yunyan Gu * . RHPCG: a database of the Regulation of the Hippo Pathway in Cancer Genome. Database (Oxford).  2019 Jan 1:2019:baz135. doi: 10.1093/database/baz135.
  20. Ruiping Wang # , Yue Han # , Zhangxiang Zhao, Fan Yang, Ya Han, Tingting Chen, Xianlong Wang, Lishuang Qi, Wenyuan Zhao, Zheng Guo * Yunyan Gu * . Link synthetic lethality to drug sensitivity of cancer cells. Briefings in Bioinformatics.  2019 Sep 6:17:688-700. doi: 10.1016/j.omtn.2019.07.003.
  21. Yunyan Gu # , Ruiping Wang # , Yue Han, Wenbin Zhou, Zhangxiang Zhao, Tingting Chen, Yuanyuan Zhang, Fuduan Peng, Haihai Liang, Lishuang Qi, Wenyuan Zhao, Da Yang * , Zheng Guo * . A landscape of synthetic viable interactions in cancer. Briefings in Bioinformatics.  2018 Jul 20;19(4):644-655. doi: 10.1093/bib/bbw142.
  22. Wenbin Zhou # , Zhangxiang Zhao # , Ruiping Wang, Yue Han, Chengyu Wang, Fan Yang, Ya Han, Haihai Liang, Lishuang Qi, Chenguang Wang, Zheng Guo * Yunyan Gu* * . Identification of driver copy number alterations in diverse cancer types and application in drug repositioning. Molecular oncology.  2017 Oct;11(10):1459-1474. doi: 10.1002/1878-0261.12112.
  23. Fuduan Peng # , Ruiping Wang # , Yuanyuan Zhang # , Zhangxiang Zhao, Wenbin Zhou, Zhiqiang Chang, Haihai Liang, Wenyuan Zhao, Lishuang Qi, Zheng Guo * Yunyan Gu * . Differential expression analysis at the individual level reveals a lncRNA prognostic signature for lung adenocarcinoma. Molecular Cancer.  2017 Jun 6;16(1):98. doi: 10.1186/s12943-017-0666-z.
  24. Zhangxiang Zhao # , Wenbin Zhou # , Yue Han, Fuduan Peng, Ruiping Wang, Ruihan Yu, Chengyu Wang, Haihai Liang, Zheng Guo * Yunyan Gu * . EMT-Regulome: a database for EMT-related regulatory interactions, motifs and network. Cell Death & Disease.  2017 Jun 15;8(6):e2872. doi: 10.1038/cddis.2017.267.
  25. Fuduan Peng, Yuanyuan Zhang, Ruiping Wang, Wenbin Zhou, Zhangxiang Zhao, Haihai Liang, Lishuang Qi, Wenyuan Zhao, Hongwei Wang, Chenguang Wang, Zheng Guo * Yunyan Gu * . Identification of differentially expressed miRNAs in individual breast cancer patient and application in personalized medicine. Oncogenesis.  2016 Feb 15;5(2):e194. doi: 10.1038/oncsis.2016.4.
  26. Haihai Liang # Yunyan Gu # , Tianyu Li, Ying Zhang, Longtao Huangfu, Meiyu Hu, Dandan Zhao, Yang Chen, Shanshan Liu, Yuechao Dong, Li Xuelian, Lu Yanjie, Yang Baofeng*,Shan Hongli * . Integrated analyses identify the involvement of microRNA-26a in epithelial-mesenchymal transition during idiopathic pulmonary fibrosis. Cell Death & Disease.  2014 May 22;5(5):e1238. doi: 10.1038/cddis.2014.207.
  27. Yunyan Gu # , Da Yang # , Jinfeng Zou, Wencai Ma, Ruihong Wu, Wenyuan Zhao, Yuannv Zhang, Hui Xiao, Xue Gong, Min Zhang, Zhu Jing, Zheng Guo * . Systematic interpretation of comutated genes in large-scale cancer mutation profiles. Molecular Cancer Therapeutics.  2010 Aug;9(8):2186-95. doi: 10.1158/1535-7163.MCT-10-0022.
(*(co-)corresponding author, #(co-)first author)