Representative publications

  1. Yingying Guo # , Qianqian Wang # , Yuhan Zhang # , Lingxue Ren # , Yuquan Wang, Yang Liu, Miao Liu, Xiaomu Tian, Qiudi Liu, Yi Chen, Jian Sun, Tongzhu Jin, Xinyue Wang, Yanbo Wang, Tianyu Li, Yuhong Zhou,  Zhixin Li * Yunyan Gu * , Baofeng Yang * , Haihai Liang * . Rbms1 promotes pulmonary fibrosis by stabilising Sumo2 mRNA to facilitate Smad4-SUMOylation and fibroblast activation.  European Respiratory Journal.  2025 Jun 5:2401667. doi: 10.1183/13993003.01667-2024.
  2. Jiayu Guo # , Yan Wang # , Qiudi Liu # , Zhaoyang Luo # , Xiaomu Tian, Yuquan Wang, Yang Liu, Zhiwei Ning, Yingying Guo, Huiying Gao, Xinyue Wang, Jinglong Feng, Mengmeng Liu, Dina Saifullina, Yixin Zhang, Tengfei Pan, Yu Bian, Tao Ban, Tianyu Li,  Yunyan Gu * , Haihai Liang * . Nephronectin (NPNT) is a Crucial Determinant of Idiopathic Pulmonary Fibrosis: Modulating Cellular Senescence via the ITGA3/YAP1 Signaling Axis.  Advanced Science.  2025 May 30:e01956. doi: 10.1002/advs.202501956.
  3. Kaidong Liu # , Yanrui Cui # , Huiming Han # , Erliang Guo, Xingyang Shi, Kai Xiong, Nan Zhang, Songmei Zhai, Shaocong Sang, Mingyue Liu, Bo Chen,  Yunyan Gu * . Fibroblast atlas: shared and specific cell types across tissues.  Science Advances.  2025 Apr 2;11(14):eado0173. doi: 10.1126/sciadv.ado0173.
  4. Qi Dong # , Yingying Guo # , Chen Lv # , Lingxue Ren, Bo Chen, Yan Wang, Yang Liu, Mingyue Liu, Kaidong Liu, Nan Zhang, Linzhu Wang, Shaocong Sang, Xin Li, Yang Hui * , Haihai Liang * Yunyan Gu * . Unveiling a novel cancer hallmark by evaluation of neural infiltration in cancer.  Briefings In Bioinformatics.  2025 Mar 4;26(2):bbaf082. doi: 10.1093/bib/bbaf082.
  5. Songliu Hu # , Ning Zhan # , Jian Li # , Liqun Wang, Yiyan Liu, Ke Jin, Yixuan Wang, Juxuan Zhang, Yiyang Chen, Yang Bai, Yichong Wang,  Lishuang Qi * , and Shilong Liu * . RBM15 recruits myeloid-derived suppressor cells via the m6A-IGF2BP3/CBR3-AS1/miR-409-3p/CXCL1 axis, facilitating radioresistance in non-small-cell lung cancer.  Journal of translational medicine.  2025 Feb 17;23(1):191. doi: 10.1186/s12967-025-06205-y.
  6. Wenyue Li # , Linzhu Wang # , Wen Tian # , Weihang Ji, Danyang Bing, Yan Wang, Bingqian Xu, Jiayue Feng,  Peng Zhang, Haihai Liang,  Yunyan Gu * , Baofeng Yang * . SNRNP70 regulates the splicing of CD55 to promote osteosarcoma progression.  JCI Insight.  2024 Dec 20;9(24):e185269. doi: 10.1172/jci.insight.185269.
  7. Minghui Cai # , Jiaxing Deng # , Shangjie Wu, Yang Cao, Hong Chen, Hao Tang, Chendan Zou, Hui Zhu * Lishuang Qi * . Alpha-1 antitrypsin targeted neutrophil elastase protects against sepsis-induced inflammation and coagulation in mice via inhibiting neutrophil extracellular trap formation.  Life sciences.  2024 Sep 15:353:122923. doi: 10.1016/j.lfs.2024.122923.
  8. Zhangxiang Zhao # , Yuquan Wang # , Zixin Jin, Huiming Han, Bo Chen, Mingyue Liu, Kaidong Liu, Shuping Zhuang,  Haihai Liang * Yunyan Gu * . Alternative splicing of immune-related genes identifies breast cancer subtypes with differential immune cell infiltration.   Genes & Disease.  2024 Jun 14;12(2):101349. doi: 10.1016/j.gendis.2024.101349.
  9. Kaidong Liu # , Huiming Han # , Kai Xiong # , Songmei Zhai, Xiuqi Yang, Xinmiao Yu, Bo Chen, Mingyue Liu, Qi Dong, Hongxue Meng * Yunyan Gu * . Single-cell landscape of intratumoral heterogeneity and tumor microenvironment remolding in pre-nodal metastases of breast cancer.  Journal of Translational Medicine.  2024 Aug 29;22(1):804. doi: 10.1186/s12967-024-05625-6.
  10. Mingyue Liu # , Zhangxiang Zhao # , Chengyu Wang # , Shaocong Sang, Yanrui Cui, Chen Lv, Xiuqi Yang, Nan Zhang, Kai Xiong, Bo Chen, Qi Dong, Kaidong Liu,  Yunyan Gu * . Harnessing genetic interactions for prediction of immune checkpoint inhibitors response signature in cancer cells. Cancer Letters.  2024 Jul 10:594:216991. doi: 10.1016/j.canlet.2024.216991.
  11. Qi Dong # , Tong Yu # , Bo Chen, Mingyue Liu, Xiang Sun, Huiying Cao, Kaidong Liu, Huanhuan Xu, Yuquan Wang, Shuping Zhuang, Zixin Jin, Haihai Liang, Yang Hui * Yunyan Gu * . Mutant RB1 enhances therapeutic efficacy of PARPis in lung adenocarcinoma by triggering the cGAS/STING pathway. JCI Insight.  2023 Nov 8;8(21):e165268. doi: 10.1172/jci.insight.165268.
  12. Mingyue Liu # , Qi Dong # , Bo Chen, Kaidong Liu, Zhangxiang Zhao, Yuquan Wang, Shuping Zhuang, Huiming Han, Xingyang Shi, Zixin Jin, Yang Hui * Yunyan Gu * . Synthetic viability induces resistance to immune checkpoint inhibitors in cancer cells. British Journal of Cancer.  2023 Oct;129(8):1339-1349. doi: 10.1038/s41416-023-02404-w.
  13. Shanqi Xu # , Xin Li # , Jianxiong Geng, Yingyue Cao, Yan Yu * Lishuang Qi * . Sec61γ is a vital protein in the endoplasmic reticulum membrane promoting tumor metastasis and invasion in lung adenocarcinoma. British Journal of Cancer.  2023 Apr;128(8):1478-1490. doi: 10.1038/s41416-023-02150-z.
  14. Bo Chen # , Pengfei Li # , Mingyue Liu # , Kaidong Liu, Min Zou, Yiding Geng, Shuping Zhuang, Huanhuan Xu, Linzhu Wang, Tingting Chen, Yawei Li, Zhangxiang Zhao, Lishuang Qi * Yunyan Gu * . A genetic map of the chromatin regulators to drug response in cancer cells. Journal of Translational Medicine.  2022 Sep 30;20(1):438. doi: 10.1186/s12967-022-03651-w.
  15. Tingting Chen # , Tong Yu # , Shuping Zhuang, Yiding Geng, Junwen Xue, Jiayi Wang, Liqiang Ai, Bo Chen, Zhangxiang Zhao, Yawei Li, Jinghao Wang, Haihai Liang, Yan Xu * Yunyan Gu * . Upregulation of CXCL1 and LY9 contributes to BRCAness in ovarian cancer and mediates response to PARPi and immune checkpoint blockade. British Journal of Cancer.  2022 Sep;127(5):916-926. doi: 10.1038/s41416-022-01836-0.
  16. Kaidong Liu # , Yiding Geng # , Linzhu Wang # , Huanhuan Xu, Min Zou, Yawei Li, Zhangxiang Zhao, Tingting Chen, Fengyan Xu, Liang Sun, Shuliang Wu * Yunyan Gu * . Systematic exploration of the underlying mechanism of gemcitabine resistance in pancreatic adenocarcinoma. Molecular Oncology.  2022 Aug;16(16):3034-3051. doi: 10.1002/1878-0261.13279.
  17. Hailong Zheng # , Jiajing Xie # , Kai Song, Jing Yang, Huiting Xiao, Jiashuai Zhang, Keru Li, Rongqiang Yuan, Yuting Zhao,  Yunyan Gu * and Wenyuan Zhao * . StemSC: a cross-dataset human stemness index for single-cell samples. Stem Cell Research & Therapy.  2022 Mar 21;13(1):115. doi: 10.1186/s13287-022-02803-5.
  18. Zhangxiang Zhao # , YingYing Guo # , Yaoyao Liu # , Lichun Sun, Bo Chen, Chengyu Wang, Tingting Chen, Yuquan Wang, Yawei Li, Qi Dong, Liqiang Ai, Ran Wang,  Yunyan Gu * , Xia Li * . Individualized lncRNA differential expression profile reveals heterogeneity of breast cancer.  Oncogene.  2021 Jul;40(27):4604-4614. doi: 10.1038/s41388-021-01883-6.
  19. Tingting Chen # , Yingying Guo # , Jiayi Wang # , Liqiang Ai, Lu Ma, Wenxin He, Zhixin Li, Xiaojiang Yu, Jinrui Li, Xingxing Fan,  Yunyan Gu * , Haihai Liang * . LncRNA CTD-2528L19.6 prevents the progression of IPF by alleviating fibroblast activation.  Cell Death & Disease.  2021 Jun 10;12(6):600. doi: 10.1038/s41419-021-03884-5.
  20. Haihai Liang # , Mengxue Yu # , Rui Yang # , Lu Zhang , Lijia Zhang, Di Zhu, Hongwei Luo, Yaozhen Hong, Tong Yu, Jian Sun, Hongli Shan * Yunyan Gu * . A PTAL-miR-101-FN1 axis promotes EMT and invasion-metastasis in serous ovarian cancer. Molecular Therapy–Oncolytics.  2019 Dec 11:16:53-62. doi: 10.1016/j.omto.2019.12.002.
  21. Chengyu Wang # , Fan Yang # , Tingting Chen, Qi Dong, Zhangxiang Zhao, Yaoyao Liu, Bo Chen, Haihai Liang, Huike Yang * Yunyan Gu * . RHPCG: a database of the Regulation of the Hippo Pathway in Cancer Genome. Database (Oxford).  2019 Jan 1:2019:baz135. doi: 10.1093/database/baz135.
  22. Ruiping Wang # , Yue Han # , Zhangxiang Zhao, Fan Yang, Ya Han, Tingting Chen, Xianlong Wang, Lishuang Qi, Wenyuan Zhao, Zheng Guo * Yunyan Gu * . Link synthetic lethality to drug sensitivity of cancer cells. Briefings in Bioinformatics.  2019 Sep 6:17:688-700. doi: 10.1016/j.omtn.2019.07.003.
  23. Yunyan Gu # , Ruiping Wang # , Yue Han, Wenbin Zhou, Zhangxiang Zhao, Tingting Chen, Yuanyuan Zhang, Fuduan Peng, Haihai Liang, Lishuang Qi, Wenyuan Zhao, Da Yang * , Zheng Guo * . A landscape of synthetic viable interactions in cancer. Briefings in Bioinformatics.  2018 Jul 20;19(4):644-655. doi: 10.1093/bib/bbw142.
  24. Wenbin Zhou # , Zhangxiang Zhao # , Ruiping Wang, Yue Han, Chengyu Wang, Fan Yang, Ya Han, Haihai Liang, Lishuang Qi, Chenguang Wang, Zheng Guo * Yunyan Gu* * . Identification of driver copy number alterations in diverse cancer types and application in drug repositioning. Molecular oncology.  2017 Oct;11(10):1459-1474. doi: 10.1002/1878-0261.12112.
  25. Fuduan Peng # , Ruiping Wang # , Yuanyuan Zhang # , Zhangxiang Zhao, Wenbin Zhou, Zhiqiang Chang, Haihai Liang, Wenyuan Zhao, Lishuang Qi, Zheng Guo * Yunyan Gu * . Differential expression analysis at the individual level reveals a lncRNA prognostic signature for lung adenocarcinoma. Molecular Cancer.  2017 Jun 6;16(1):98. doi: 10.1186/s12943-017-0666-z.
  26. Zhangxiang Zhao # , Wenbin Zhou # , Yue Han, Fuduan Peng, Ruiping Wang, Ruihan Yu, Chengyu Wang, Haihai Liang, Zheng Guo * Yunyan Gu * . EMT-Regulome: a database for EMT-related regulatory interactions, motifs and network. Cell Death & Disease.  2017 Jun 15;8(6):e2872. doi: 10.1038/cddis.2017.267.
  27. Fuduan Peng, Yuanyuan Zhang, Ruiping Wang, Wenbin Zhou, Zhangxiang Zhao, Haihai Liang, Lishuang Qi, Wenyuan Zhao, Hongwei Wang, Chenguang Wang, Zheng Guo * Yunyan Gu * . Identification of differentially expressed miRNAs in individual breast cancer patient and application in personalized medicine. Oncogenesis.  2016 Feb 15;5(2):e194. doi: 10.1038/oncsis.2016.4.
  28. Haihai Liang # Yunyan Gu # , Tianyu Li, Ying Zhang, Longtao Huangfu, Meiyu Hu, Dandan Zhao, Yang Chen, Shanshan Liu, Yuechao Dong, Li Xuelian, Lu Yanjie, Yang Baofeng*,Shan Hongli * . Integrated analyses identify the involvement of microRNA-26a in epithelial-mesenchymal transition during idiopathic pulmonary fibrosis. Cell Death & Disease.  2014 May 22;5(5):e1238. doi: 10.1038/cddis.2014.207.
  29. Yunyan Gu # , Da Yang # , Jinfeng Zou, Wencai Ma, Ruihong Wu, Wenyuan Zhao, Yuannv Zhang, Hui Xiao, Xue Gong, Min Zhang, Zhu Jing, Zheng Guo * . Systematic interpretation of comutated genes in large-scale cancer mutation profiles. Molecular Cancer Therapeutics.  2010 Aug;9(8):2186-95. doi: 10.1158/1535-7163.MCT-10-0022.
(*(co-)corresponding author, #(co-)first author)