The Epithelial-Mesenchymal Transition (EMT) allows polarized, immotile epithelial cells to transform into motile mesenchymal cells, which is a fundamental cellular process that governs embryonic development, tumor cell metastasis, organ fibrosis, tissue regeneration and so on. EMT is regulated by many signaling pathways.The TGF-b signaling pathway has an established role in promoting EMT by down-regulating E-cadherin via transcription factors (TFs), such as Twist, Snail and Slug. Multiple TF-target relationships form a regulatory transcriptional network. Moreover, the post-transcriptional regulatory network consisting of microRNA(miRNA) and long non-coding RNA(lncRNA) also dominates the process of EMT. Comprehensively investigation of co-regulations of regulators(TF, miRNA and lncRNA) on EMT could speed up the elucidation of the potential mechanism of EMT in development, fibrosis and cancer progression. EMT-Regulome database systematically collects the regulations among TF, miRNA, lncRNA and EMT genes and records diverse regulatory motifs involved in EMT process.

For citation: Zhao Z, Zhou W, Han Y, Peng F, Wang R, Yu R, Wang C, Liang H, Guo Z, Gu Y. EMT-Regulome: a database for EMT-related regulatory interactions, motifs and network. Cell Death Dis.2017 Jun 15;8(6):e2871.





  • TargetScan

    Predicting effective microRNA target sites in mammalian mRNAs.

    Elife. 2015;4

  • miRBase

    miRBase: microRNA sequences, targets and gene nomenclature.

    Nucleic Acids Res,2006;34(Database Issue):D140-D144

  • miRTarBase

    miRTarBase: a database curates experimentally validated microRNA-target interaction.

    Nucleic Acids Res,2011;39(Database Issue):D163-9


    TRANSFAC: transcriptional regulation, from patterns to profiles.

    Nucleic Acids Res,2003;31:374-8

  • miRanda

    The resource: targets and expression.

    Nucleic Acids Res,2008;36(Database Issue):D149-53

  • dbEMT

    dbEMT: an epithelial-mesenchymal transition associated gene resource.

    Scientific Reports,2015;5:11459

  • miRcode

    miRcode: a map of putative microRNA target sites in the long non-coding transciptome.

    Bioinformatics 2012;28(15):2062-3

  • starBase v2.0

    starBase v2.0: decoding miRNA-ceRNA, miRNA-ncRNA and protein-RNA interaction networks from large-scale CLIP-Seq data.

    Nucleic Acids Res,2014;42(Database Issue):D92-7

  • MsigDB

    Molecular signatures database(MSigDB) 3.0.


  • ChIPBase

    ChIPBase: a database for decoding the thanscriptional regulation of long non-coding RNA and microRNA genes from ChIP-Seq data.

    Nucleic Acids Res,2013;41(Database Issue):D177-87

  • Transmir

    TransmiR: a transcription factor-microRNA regulation database.

    Nucleic Acids Res,2010;38(Database Issue):D119-22

EMT-Regulome Database Version 1.0

Contact us: