Tissue Disease Species symbol ID Platform Type Expression Target Pathway Method Drug Function PMID Title Year heart endomyocardial_fibrosis rattus_norvegicus mir-1 MI0003489 miRBase miRNA up-regulation NA NA NA no "miR-1 gene silencing inhibits myocardial fibrosis induced by high glucose, its mechanism may be related to the up-regulation of p-ampk." 29402364 [Role of microRNA-1-mediated AMP-activated protein kinase pathway in cardiac fibroblasts induced by high glucose in rats] 2018 heart cardiomegaly rattus_norvegicus mir-1 MI0003489 miRBase miRNA down-regulation TWINFILIN-1 NA dual-luciferase reporter assay no "Reduction of miR-1 by hypertrophic stimuli induces the upregulation of twinfilin-1, which in turn evokes hypertrophy through the regulation of cardiac cytoskeleton." 20571053 Attenuation of microRNA-1 derepresses the cytoskeleton regulatory protein twinfilin-1 to provoke cardiac hypertrophy 2010 heart cardiomegaly rattus_norvegicus mir-1 MI0003489 miRBase miRNA down-regulation FBLN2 MAPK SIGNALING PATHWAY immunofluorescence; PCR etc. no "Targeted overexpression of miR-1 has a potential therapeutic effect in the treatment of cardiac hypertrophy and the prevention of poor cardiac remodeling, while miR-1 replacement therapy can reduce the incidence of myocardial fibrosis." 23612897 Therapeutic Cardiac-Targeted Delivery of miR-1 Reverses Pressure Overload-Induced Cardiac Hypertrophy and Attenuates Pathological Remodeling 2013 heart ventricular_dysfunction rattus_norvegicus mir-1 MI0003489 miRBase miRNA down-regulation NA NA qRCR no The significant dysregulation of microrna-1 processing in the heart associated with aging and arterial hypertension. 31104265 Altered biogenesis of microRNA-1 is associated with cardiac dysfunction in aging of spontaneously hypertensive rats 2019 heart endomyocardial_fibrosis rattus_norvegicus mir-1 MI0003489 miRBase miRNA down-regulation NA NA NA no NA 31157242 MicroRNA-1-Mediated Inhibition of Cardiac Fibroblast Proliferation Through Targeting Cyclin D2 and CDK6 2019 liver liver_cirrhosis rattus_norvegicus miR-378a-3p MIMAT0003379 miRBase miRNA down-regulation WNT-10A WNT SIGNALING PATHWAY PCR; dual-lucimmunofluorescenceerase reporter assay etc. yes Activation of hepatic stellate cells is inhibited by microrna-378a-3p via wnt10a. 27832641 Activation of Hepatic Stellate Cells is Inhibited by microRNA-378a-3p via Wnt10a 2016 liver liver_cirrhosis rattus_norvegicus mir-27b MI0000859 miRBase miRNA up-regulation RETINOID X RECEPTOR ALPHA NA PCR; dual-lucimmunofluorescenceerase reporter assay etc. yes "Downregulation of mirnas mir-27a and 27b transforms activated rat hsc into a resting hsc phenotype, reducing cell proliferation and fat accumulation." 19185571 Over-expressed microRNA-27a and 27b influence fat accumulation and cell proliferation during rat hepatic stellate cell activation 2009 liver liver_cirrhosis rattus_norvegicus mir-27a MI0000860 miRBase miRNA up-regulation RETINOID X RECEPTOR ALPHA NA PCR; dual-lucimmunofluorescenceerase reporter assay etc. yes "Downregulation of mirnas mir-27a and 27b transforms activated rat hsc into a resting hsc phenotype, reducing cell proliferation and fat accumulation." 19185571 Over-expressed microRNA-27a and 27b influence fat accumulation and cell proliferation during rat hepatic stellate cell activation 2009 liver liver_cirrhosis rattus_norvegicus mir-181b-1 MI0000926 miRBase miRNA up-regulation PTEN; AKT PTEN; PI3K-AKT SIGNALING PATHWAY PCR; dual-lucimmunofluorescenceerase reporter assay yes Hepatic stellate cell is activated by microrna-181b via pten;Akt pathway. 25148875 Hepatic stellate cell is activated by microRNA-181b via PTEN/Akt pathway 2015 liver non-alcoholic_fatty_liver_disease rattus_norvegicus mir-21a MI0000850 miRBase miRNA up-regulation NA NA PCR yes "In non-alcoholic steatohepatitis rat models, microrna-21 is associated with fibrosis and serves as a plasma biomarker for fibrotic liver disease." 27320964 MicroRNA-21 is associated with fibrosis in a rat model of nonalcoholic steatohepatitis and serves as a plasma biomarker for fibrotic liver disease 2016 liver liver_cirrhosis rattus_norvegicus miR-17-5p MIMAT0000786 miRBase miRNA down-regulation WNT; B-CATENIN WNT SIGNALING PATHWAY; CATENIN BETA 1 PCR; dual-lucimmunofluorescenceerase reporter assay; etc. yes "Increased expression of mir-17-5p, decreased expression of wif1, activation of wnt pathway, occurrence of fibrosis, and inhibition of mir-17-5p expression by salb." 26637809 MicroRNA-17-5p-activated Wnt/B-catenin pathway contributes to the progression of liver fibrosis 2015 liver liver_cirrhosis rattus_norvegicus mir-194-1 MI0000937 miRBase miRNA down-regulation C-MYB; RAC NA enzyme-linked immunosorbent assay; PCR etc. yes "Liver fibrosis causes downregulation of mirna-150 and mirna-194 in hepatic stellate cells, and their overexpression causes decreased stellate cell activation." 19892940 "Liver fibrosis causes downregulation of miRNA-150 and miRNA-194 in hepatic stellate cells, and their overexpression causes decreased stellate cell activation" 2010 liver liver_cirrhosis rattus_norvegicus mir-150 MI0000920 miRBase miRNA down-regulation C-MYB; RAC NA enzyme-linked immunosorbent assay; PCR etc. yes "Liver fibrosis causes downregulation of mirna-150 and mirna-194 in hepatic stellate cells, and their overexpression causes decreased stellate cell activation." 19892940 "Liver fibrosis causes downregulation of miRNA-150 and miRNA-194 in hepatic stellate cells, and their overexpression causes decreased stellate cell activation" 2010 liver liver_cirrhosis rattus_norvegicus mir-133b MI0003490 miRBase miRNA down-regulation PPARY PPAR SIGNALING PATHWAY PCR; dual-lucimmunofluorescenceerase reporter assay yes Microrna-130a and -130b enhance activation of hepatic stellate cells by suppressing ppary expression. 26255201 MicroRNA-130a and -130b enhance activation of hepatic stellate cells by suppressing PPARY expression: A rat fibrosis model study 2015 liver liver_cirrhosis rattus_norvegicus mir-133a-1 MI0000159 miRBase miRNA down-regulation PPARY PPAR SIGNALING PATHWAY PCR; dual-lucimmunofluorescenceerase reporter assay yes Microrna-130a and -130b enhance activation of hepatic stellate cells by suppressing ppary expression. 26255201 MicroRNA-130a and -130b enhance activation of hepatic stellate cells by suppressing PPARY expression: A rat fibrosis model study 2015 liver liver_cirrhosis rattus_norvegicus miR-146a-5p MIMAT0000852 miRBase miRNA down-regulation TGFB1; LIPOPOLYSACCHARIDE TGF-BETA SIGNALING PATHWAY NA yes Microrna-146a-5p attenuates hepatic fibrosis by inhibiting the pro-fibrosis of tgf-b1 and lipopolysaccharide. 28739486 MicroRNA-146a-5p attenuates liver fibrosis by suppressing profibrogenic effects of TGFB1 and lipopolysaccharide 2017 liver liver_cirrhosis rattus_norvegicus miR-17-5p MIMAT0000786 miRBase miRNA up-regulation SMAD7 TGF-BETA SIGNALING PATHWAY PCR; dual-lucimmunofluorescenceerase reporter assay yes Microrna-17-5p activates hepatic stellate cells through targeting of smad7. 25915722 MicroRNA-17-5p activates hepatic stellate cells through targeting of Smad7 2015 liver liver_cirrhosis rattus_norvegicus mir-19b MI0000847 miRBase miRNA down-regulation GRB2 NA PCR; dual-lucimmunofluorescenceerase reporter assay yes Microrna-19b reduces hepatic stellate cell proliferation by targeting grb2 in hepatic fibrosis models in vivo and in vitro as part of the inhibitory effect of estradiol. 25650006 MicroRNA-19b reduces hepatic stellate cell proliferation by targeting GRB2 in hepatic fibrosis models in vivo and in vitro as part of the inhibitory effect of estradiol 2015 liver liver_cirrhosis rattus_norvegicus mir-30c-2 MI0000871 miRBase miRNA down-regulation PAI-1 NA dual-lucimmunofluorescenceerase reporter assay; PCR; yes "Microrna-30a is involved in the activation of hepatic stellate cells by inhibiting plasminogen activator inhibitor-1, and can be used as biomarkers of hepatic fibrosis ; Cirrhosis. Ang ii stimulation can reduce the expression of mir-30a." 27142827 Involvement of miR-30c in hepatic stellate cell activation through the repression of plasminogen activator inhibitor-1 2016 liver liver_cirrhosis rattus_norvegicus mir-34a MI0000877 miRBase miRNA up-regulation ACSL1 NA PCR; dual-lucimmunofluorescenceerase reporter assay yes Microrna-34a promotes hepatic stellate cell activation via targeting acsl1. 26437572 MicroRNA-34a Promotes Hepatic Stellate Cell Activation via Targeting ACSL1 2015 liver liver_cirrhosis rattus_norvegicus mir-370 MI0003486 miRBase miRNA down-regulation SMOOTHENED NA PCR; dual-lucimmunofluorescenceerase reporter assay yes Microrna-370 attenuates hepatic fibrogenesis by targeting smoothened. 25686745 MicroRNA-370 Attenuates Hepatic Fibrogenesis by Targeting Smoothened 2015 liver liver_cirrhosis rattus_norvegicus mir-200a MI0000943 miRBase miRNA down-regulation SIRT1 SIRT1; NOTCH SIGNALING PATHWAY immunohistochemistry; dual-lucimmunofluorescenceerase reporter assay etc. yes Mir-200a inhibits hepatic stellate cell activation and fibrosis by inhibiting the sirt1 ; Notch1 signaling pathway. 28025657 MiR-200a controls hepatic stellate cell activation and fibrosis via SIRT1/Notch1 signal pathway 2017 liver liver_cirrhosis rattus_norvegicus mir-21a MI0000569 miRBase miRNA up-regulation ERK1; SPRY2 ERK PCR; dual-lucimmunofluorescenceerase reporter assay no Mir-21 simultaneously regulates erk1 signaling in hsc activation and hepatocyte emt in hepatic fibrosis. 25303175 MiR-21 simultaneously regulates ERK1 signaling in HSC activation and hepatocyte EMT in hepatic fibrosis 2014 liver liver_cirrhosis rattus_norvegicus mir-29a MI0000863 miRBase miRNA down-regulation HSP47; LYSYL OXIDASE NA PCR; dual-lucimmunofluorescenceerase reporter assay etc. no Mir-29b inhibits collagen maturation in hepatic stellate cells by down-regulating the expression of hsp47 and lysyl oxidase. 24650661 MiR-29b inhibits collagen maturation in hepatic stellate cells through down-regulating the expression of HSP47 and lysyl oxidase 2014 liver liver_cirrhosis rattus_norvegicus miR-9a-5p MIMAT0000781 miRBase miRNA down-regulation SIRT1 NA PCR; dual-lucimmunofluorescenceerase reporter assay yes Mir-9a-5p regulates the proliferation and migration of hepatic stellate cells by inhibiting sirt1. 26379395 MiR-9a-5p regulates proliferation and migration of hepatic stellate cells under pressure through inhibition of Sirt1 2015 liver liver_cirrhosis rattus_norvegicus miR-338-3p MIMAT0000581 miRBase miRNA down-regulation CDK4 NA PCR; dual-lucimmunofluorescenceerase reporter assay etc. no Mirna-338-3p;Cdk4 signaling pathway suppressed hepatic stellate cell activation and proliferation. 28095789 MiRNA-338-3p/CDK4 signaling pathway suppressed hepatic stellate cell activation and proliferation 2017 liver liver_cirrhosis rattus_norvegicus miR-483-3p MIMAT0003121 miRBase miRNA down-regulation TGF-B TGF-BETA SIGNALING PATHWAY H&E staining; immunofluorescence etc. yes Overexpression of mir-483-5p;3P cooperate to inhibit mouse liver fibrosis by suppressing the tgf-b stimulated hscs in transgenic mice. 24801603 Overexpression of miR-483-5p/3p cooperate to inhibit mouse liver fibrosis by suppressing the TGF-B stimulated HSCs in transgenic mice 2014 liver liver_cirrhosis rattus_norvegicus mir-200a MI0000943 miRBase miRNA up-regulation WNT; B-CATENIN WNT SIGNALING PATHWAY; CATENIN BETA 1 PCR; dual-lucimmunofluorescenceerase reporter assay etc. no Participation of mir-200a in tgf-b1-mediated hepatic stellate cell activation. 24242045 Participation of miR-200a in TGF-B1-mediated hepatic stellate cell activation 2014 liver liver_cirrhosis rattus_norvegicus mir-31 MI0000872 miRBase miRNA up-regulation MIR-31; FIH1; TGF-B TGF-BETA SIGNALING PATHWAY PCR; dual-lucimmunofluorescenceerase reporter assay etc. yes "Tgf-beta downstream transcription factor smad3 stimulates the transcription activity of mir-31 by direct mir-31 promoter, mir-31 mediates fibrosis by targeting fih1, an inhibitor of hypoxia-inducible factor (hif-1) , overexpression significantly promoted hsc activation." 25728779 The role of the miR-31/FIH1 pathway in TGF-B-induced liver fibrosis 2015 liver liver_cirrhosis rattus_norvegicus mir-29a MI0000863 miRBase miRNA dysregulation FARNESOID X RECEPTOR NA PCR; no "The lipoprotein x receptor (fxr) promotes the expression of mir-29a, inhibits extracellular matrix deposition, thereby inhibiting hepatic stellate cell fibrosis." 21511916 Roles of microRNA-29a in the antifibrotic effect of farnesoid X receptor in hepatic stellate cells 2011 lung pulmonary_fibrosis rattus_norvegicus mir-21 MI0000850 miRBase miRNA down-regulation NA NA qRT-PCR; etc. no "Baicalein can attenuate bleomycin-induced pulmonary fibrosis partly achieved by improving antioxidant activity, alleviating inflammation, repressing miR-21, and inhibiting TGF-B/Smad signaling." 23523661 Baicalein attenuates bleomycin-induced pulmonary fibrosis in rats through inhibition of miR-21 2013 lung pulmonary_fibrosis rattus_norvegicus mir-21 MI0000850 miRBase miRNA down-regulation NA STAT3-RELATED signaling pathway ELISA; qRT-PCR etc. no "By decreasing IFN-Y-induced STAT3/p-STAT3 expression to down-regulate miR-21, sulindac could significantly reverse EMT in A549 cells and prevent BLM-induced PF." 25704671 Sulindac has strong antifibrotic effects by suppressing STAT3-related miR-21 2015 lung idiopathic_pulmonary_fibrosis rattus_norvegicus miR-541-5p MIMAT0003177 miRBase miRNA down-regulation Pde1a NA qRT-PCR; Dual-luciferase reporter assay; ELISA etc. no Cyclic nucleotide phosphodiesterase 1A (PDE1A) can stimulate lung fibroblasts to undergo myofibroblastic changes. MiR-541-5p expression is downregulated in TGF-B-treated lung fibroblasts and the rat pulmonary fibrosis model. Overexpression of miR-541-5p in lung fibroblasts inhibited mortality of human lung fibroblasts by targeting PDE1A. 28816543 MiR-541-5p regulates lung fibrosis by targeting cyclic nucleotide phosphodiesterase 1A 2017 lung pulmonary_hypertension rattus_norvegicus miR-9a-5p MIMAT0000781 miRBase miRNA up-regulation NA NA qRT-pcr; Dual-luciferase reporter assay etc. no HIF-1 alpha-induced up-regulation of miR-9 contributes to enhanced proliferative phenotype in pulmonary artery smooth muscle cells during hypoxia. 24615545 HIF-1 alpha-induced up-regulation of miR-9 contributes to phenotypic modulation in pulmonary artery smooth muscle cells during hypoxia 2014 lung pulmonary_hypertension rattus_norvegicus mir-190a-1 MI0000933 miRBase miRNA up-regulation Kcnq5 NA qRT-PCR; Dual-luciferase reporter assay; etc. no "Hypoxia produced a significant increase of the miR-190 level in the pulmonary artery (PA). MiR-190 mimic enhanced enhanced the pulmonary vasoconstriction responses to phenylephrine (PE) and KCl. The voltage-gated K(+) channel subfamily member, Kcnq5 was a target for miR-190. MiR-190 appears to be a positive regulator of Ca(2+) influx, and plays an important role in hypoxic pulmonary vascular constriction." 24446351 MicroRNA-190 regulates hypoxic pulmonary vasoconstriction by targeting a voltage-gated K channel in arterial smooth muscle cells 2014 lung pulmonary_hypertension rattus_norvegicus mir-328a MI0000602 miRBase miRNA down-regulation L-TYPE CALCIUM CHANNEL-A1C; INSULIN GROWTH FACTOR 1 RECEPTOR NA Dual-luciferase reporter assay; Mtt assay; etc. no "Hypoxia produced a significant inhibition of miRNA-328 expression, which was involved in PA vasoconstriction and remodeling. Overexpressing miRNA-328 in the transgenic mice remarkably decreased the right ventricular systolic pressure and PA wall thickness under both normoxia and hypoxia. MiRNA-328 inhibited L-type calcium channel-a1C expression through a miRNA-328 binding site within the 3' untranslational region of L-type calcium channel-a1C. The L-type calcium channel-a1C inhibition attenuated the PA response to KCl. Furthermore, miRNA-328 suppressed the insulin growth factor 1 receptor, ultimately leading to apoptosis of pulmonary arterial smooth muscle cells." 22392900 The microRNA-328 regulates hypoxic pulmonary hypertension by targeting at insulin growth factor 1 receptor and L-type calcium channel-a1C 2012 lung pulmonary_hypertension rattus_norvegicus miR-29a-3p MIMAT0000802 miRBase miRNA down-regulation NA NA Vector construction; Virus production; Animal experiments etc. no "Hypoxia-induced pulmonary adventitial fibroblasts activation was accompanied with a drastic decrease of miR-29a-3p expression. Knockdown of hypoxia-inducible factor-1 a or Smad3 reversed the hypoxia-induced decrease of miR-29-3p in cultured pulmonary adventitial fibroblasts. In vitro, miR-29a-3p mimic inhibited the hypoxia-induced proliferation, migration, and secretion of pulmonary adventitial fibroblasts, suppressed the hypoxia-induced expression of a-smooth muscle actin and extracellular matrix collagen in pulmonary adventitial fibroblasts. Preventative or therapeutic administration of miR-29a-3p significantly decreased pulmonary artery pressure and right ventricle hypertrophy index and ameliorated pulmonary vascular remodeling in hypoxic pulmonary hypertension rats." 25421979 MiR-29a-3p attenuates hypoxic pulmonary hypertension by inhibiting pulmonary adventitial fibroblast activation 2015 lung pulmonary_hypertension rattus_norvegicus mir-208a MI0000949 miRBase miRNA down-regulation Med13 MED13/NCOR1-MEF2 AXIS signaling pathway Animal model of RV failure; Cardiomyocytes isolation and culture etc. no "Mef2c expression was sharply increased in compensating phase of RVH tissues but was lost in decompensation phase of RVH. Myocardium-specific miR-208 was progressively downregulated as RV failure progressed. MiR-208 inhibition, as well as tumor necrosis factor-a, activates the MED13/NCoR1 axis, which in turn promotes Mef2 inhibition, closing a self-limiting feedback loop, driving the transition from compensating phase of RVH toward decompensation phase of RVH. In our model, serum tumor necrosis factor-a levels progressively increased with time while serum miR-208 levels decreased, mirroring its levels in RV myocardium." 25287062 A miR-208-Mef2 axis drives the decompensation of right ventricular function in pulmonary hypertension 2015 lung pulmonary_hypertension rattus_norvegicus miR-124-3p MIMAT0000828 miRBase miRNA down-regulation NA NA qRT-PCR; Immunohistochemistry etc. no "MiR-124 expression is decreased in hypertensive fibroblasts. Overexpression of miR-124 significantly attenuated proliferation, migration, and monocyte chemotactic protein-1 expression of hypertensive fibroblasts by targeting polypyrimidine tract-binding protein 1 and subsequent regulation of Notch1/phosphatase and tensin homolog/FOXO3/p21Cip1 and p27Kip1 signaling. MiR-124 expression is suppressed by histone deacetylases and that treatment of hypertensive fibroblasts with histone deacetylase inhibitors increased miR-124 expression and decreased proliferation and monocyte chemotactic protein-1 production." 24122720 "MicroRNA-124 controls the proliferative, migratory, and inflammatory phenotype of pulmonary vascular fibroblasts" 2014 lung pulmonary_hypertension rattus_norvegicus mir-17-1 MI0000845 miRBase miRNA up-regulation P21 NA Immunohistochemistry; qRT-PCR; etc. no MiR-17 antagomir A-17 improves heart and lung function in experimental PH by interfering with lung vascular and right ventricular remodeling. The beneficial effects may be related to the up-regulation of p21. 22161164 Inhibition of microRNA-17 improves lung and heart function in experimental pulmonary hypertension 2012 lung pulmonary_arterial_hypertension rattus_norvegicus mir-204 MI0000946 miRBase miRNA down-regulation Shp2 STAT3-MIR-204-SRC-STAT3-NFAT signaling pathway? TLDAS; qRT-PCR; Dual-luciferase reporter assay etc. no "MiR-204 expression in PASMCs is down-regulated in both human and rodent PAH. MiR-204 down-regulation correlates with PAH severity and accounts for the proliferative and antiapoptotic phenotypes of PAH-PASMCs. STAT3 activation suppresses miR-204 expression, and miR-204 directly targets SHP2 expression, thereby SHP2 up-regulation, by miR-204 down-regulation, activates the Src kinase and nuclear factor of activated T cells (NFAT). STAT3 also directly induces NFATc2 expression. NFAT and SHP2 were needed to sustain PAH-PASMC proliferation and resistance to apoptosis. Finally, delivery of synthetic miR-204 to the lungs of animals with PAH significantly reduced disease severity." 21321078 Role for miR-204 in human pulmonary arterial hypertension 2011 lung idiopathic_pulmonary_fibrosis rattus_norvegicus mir-30a MI0000870 miRBase miRNA down-regulation Drp-1 NA qRT-PCR; Immunofluorescence; etc. no "MiR-30a decreased in lung fibrosis; MiR-30a inhibited AECs-II apoptosis by repressing the mitochondrial fission dependent on Drp-1, and could function as a novel therapeutic target for lung fibrosis." 25284615 MiRNA-30a inhibits AECs-II apoptosis by blocking mitochondrial fission dependent on Drp-1 2014 lung idiopathic_pulmonary_fibrosis rattus_norvegicus mir-375 MI0006140 miRBase miRNA down-regulation Frizzled 8 Wnt/B-catenin signaling pathway Dual-luciferase reporter assay; qRT-PCR etc. no MiR-375 was downregulated during AEC trans-differentiation; MiR-375 regulates AEC trans-differentiation through the Wnt/B-catenin pathway by targeting Frizzled 8. 23396279 MiR-375 regulates rat alveolar epithelial cell trans-differentiation by inhibiting Wnt/B-catenin pathway 2013 lung idiopathic_pulmonary_fibrosis rattus_norvegicus mir-98 MI0000882 miRBase miRNA down-regulation Stat3 NA Immunofluorescence; qRT-PCR etc. no "MiR-98 decreased in the fibrotic lung tissues, while its target gene Stat3 was activated with PF development and the expression of Stat3 and p-Stat3 was significantly increased in BLM-induced PF. Arsenic trioxide prevented rat PF by up-regulation of miR-98 and inhibition of its downstream Stat3 signals." 25123535 Arsenic trioxide prevents rat pulmonary fibrosis via miR-98 overexpression 2014 lung idiopathic_pulmonary_fibrosis rattus_norvegicus let-7i-5p MIMAT0000779 miRBase miRNA up-regulation N4bp2; Plxna4 NA lncRNA sequence analysis; miRNA-target prediction of MRAK088388 and MRAK081523; qRT-PCR etc. no "MRAK088388 and MRAK081523 were analysed as long-intergenic non-coding RNAs (lincRNAs), and identified as orthologues of mouse lncRNAs AK088388 and AK081523, respectively. They were significantly up-regulated in BLM-induced pulmonary fibrosis model, and located in the cytoplasm of interstitial lung cells. MRAK088388 and MRAK081523 could regulate N4bp2 and Plxna4 expression by sponging miR-29b-3p and let-7i-5p, respectively, and possessed regulatory functions as ceRNAs." 24702795 Analysing the relationship between lncRNA and protein-coding gene and the role of lncRNA as ceRNA in pulmonary fibrosis 2014 lung idiopathic_pulmonary_fibrosis rattus_norvegicus miR-29b-3p MIMAT0000801 miRBase miRNA up-regulation N4bp2; Plxna4 NA lncRNA sequence analysis; miRNA-target prediction of MRAK088388 and MRAK081523; qRT-PCR etc. no "MRAK088388 and MRAK081523 were analysed as long-intergenic non-coding RNAs (lincRNAs), and identified as orthologues of mouse lncRNAs AK088388 and AK081523, respectively. They were significantly up-regulated in BLM-induced pulmonary fibrosis model, and located in the cytoplasm of interstitial lung cells. MRAK088388 and MRAK081523 could regulate N4bp2 and Plxna4 expression by sponging miR-29b-3p and let-7i-5p, respectively, and possessed regulatory functions as ceRNAs." 24702795 Analysing the relationship between lncRNA and protein-coding gene and the role of lncRNA as ceRNA in pulmonary fibrosis 2014 lung pulmonary_hypertension rattus_norvegicus mir-193a MI0000936 miRBase miRNA down-regulation NA NA qRT-PCR; Immunohistochemistry; Chromatin immunoprecipitation assay etc. no Plasma levels of oxidized lipids were significantly elevated in PH. Apolipoprotein A-I mimetic peptide 4F treatment reduced these levels and rescued preexisting PH in both models. MicroRNA-193-3p (miR193) was significantly downregulated in the lung tissue and serum from both patients with pulmonary arterial hypertension and rodents with PH. In vivo miR193 overexpression in the lungs rescued preexisting PH and resulted in downregulation of lipoxygenases and insulin-like growth factor-1 receptor. 4F restored PH-induced miR-193 expression via transcription factor retinoid X receptor a. 24963038 ApoA-I Mimetic Peptide 4F Rescues Pulmonary Hypertension by Inducing MicroRNA-193-3p 2014 lung idiopathic_pulmonary_fibrosis rattus_norvegicus mir-338 MI0000618 miRBase miRNA up-regulation Lpa1 NA qRT-PCR; Mtt assay; etc. no "Tectorigenin inhibits the proliferation of pulmonary fibroblasts in vitro and enhances miR-338* expression, which might in turn downregulate LPA1. This indicates a potential inhibitory role of tectorigenin on the pathogenesis of IPF." 20600766 Tectorigenin inhibits the in vitro proliferation and enhances miR-338* expression of pulmonary fibroblasts in rats with idiopathic pulmonary fibrosis 2010 lung pulmonary_hypertension rattus_norvegicus mir-451 MI0001731 miRBase miRNA up-regulation NA NA HPASMCS; Gene targets for miR-451; miRNA expression etc. no "Transient inhibition of miR-451 attenuated the development of PAH in hypoxia-exposed rats. Genetic deletion of miR-451 had no beneficial effect on indices of PAH, potentially because of pathway redundancy compensating for the loss of miR-451." 25006399 Transient but not genetic loss of miR-451 is protective in the development of pulmonary arterial hypertension 2013 pancreas pancreatitis rattus_norvegicus miR-214-3p MIMAT0000885 miRBase miRNA up-regulation NA NA enzyme-linked immunosorbent assay; RT-PCR; etc. no "Mir-214-3p is indicated to exacerbate the tissue damages and inflammatory response caused by hp complicated with acute renal injury, which may provide a novel therapeutic perspective targeting mir-214-3p to treat hp with acute renal injury." 31790686 MiR-214-3p exacerbates kidney damages and inflammation induced by hyperlipidemic pancreatitis complicated with acute renal injury 2020 pancreas cystic_fibrosis rattus_norvegicus mir-143 MI0000916 miRBase miRNA up-regulation NA NA RT-PCR; mirna microarray; qRT-PCR etc. no "Upon activation, 42 mirnas were upregulated (>2.0-Fold) and 42 mirnas were downregulated (<0.5-Fold). Upregulated mirnas included mir-31, mir-143, and mir-221. Downregulated mirnas included mir-126, mir-146a, and mir-150." 24404812 Alteration of the microRNA expression profile during the activation of pancreatic stellate cells 2014 pancreas cystic_fibrosis rattus_norvegicus mir-221 MI0000961 miRBase miRNA up-regulation NA NA RT-PCR; mirna microarray; qRT-PCR etc. no "Upon activation, 42 mirnas were upregulated (>2.0-Fold) and 42 mirnas were downregulated (<0.5-Fold). Upregulated mirnas included mir-31, mir-143, and mir-221. Downregulated mirnas included mir-126, mir-146a, and mir-150." 24404812 Alteration of the microRNA expression profile during the activation of pancreatic stellate cells 2014 pancreas cystic_fibrosis rattus_norvegicus mir-146a MI0000919 miRBase miRNA down-regulation NA NA RT-PCR; mirna microarray; qRT-PCR etc. no "Upon activation, 42 mirnas were upregulated (>2.0-Fold) and 42 mirnas were downregulated (<0.5-Fold). Upregulated mirnas included mir-31, mir-143, and mir-221. Downregulated mirnas included mir-126, mir-146a, and mir-150." 24404812 Alteration of the microRNA expression profile during the activation of pancreatic stellate cells 2014 pancreas cystic_fibrosis rattus_norvegicus mir-150 MI0000920 miRBase miRNA down-regulation NA NA RT-PCR; mirna microarray; qRT-PCR etc. no "Upon activation, 42 mirnas were upregulated (>2.0-Fold) and 42 mirnas were downregulated (<0.5-Fold). Upregulated mirnas included mir-31, mir-143, and mir-221. Downregulated mirnas included mir-126, mir-146a, and mir-150." 24404812 Alteration of the microRNA expression profile during the activation of pancreatic stellate cells 2014 pancreas cystic_fibrosis rattus_norvegicus mir-31 MI0000872 miRBase miRNA up-regulation NA NA RT-PCR; mirna microarray; qRT-PCR etc. no "Upon activation, 42 mirnas were upregulated (>2.0-Fold) and 42 mirnas were downregulated (<0.5-Fold). Upregulated mirnas included mir-31, mir-143, and mir-221. Downregulated mirnas included mir-126, mir-146a, and mir-150." 24404812 Alteration of the microRNA expression profile during the activation of pancreatic stellate cells 2014 pancreas cystic_fibrosis rattus_norvegicus mir-126a MI0000898 miRBase miRNA down-regulation NA NA RT-PCR; mirna microarray; qRT-PCR etc. no "Upon activation, 42 mirnas were upregulated (>2.0-Fold) and 42 mirnas were downregulated (<0.5-Fold). Upregulated mirnas included mir-31, mir-143, and mir-221. Downregulated mirnas included mir-126, mir-146a, and mir-150." 24404812 Alteration of the microRNA expression profile during the activation of pancreatic stellate cells 2014 heart heart_failure rattus_norvegicus mir-30d MI0000869 miRBase miRNA down-regulation MAP4K4 NA NA no "Ower expression of miR-30d in the heart and plasma extracellular vesicles is associated with adverse remodeling in rodent models and human subjects and is linked to whole-blood expression of genes implicated in fibrosis and inflammation, consistent with observations in model systems." 33092465 Mir-30d Regulates Cardiac Remodeling by Intracellular and Paracrine Signaling 2021 heart myocardial_infarction rattus_norvegicus mir-369 MI0003551 miRBase miRNA down-regulation TRPV3 NA qRT-PCR; enzyme-linked immunosorbent assay; no "miR-369 overexpression significantly suppressed cell apoptosis and inflammatory factor production triggered by hypoxia, whereas miR-369 inhibition had an opposite effect." 33470394 MicroRNA-369 attenuates hypoxia-induced cardiomyocyte apoptosis and inflammation via targeting TRPV3 2021 kidney acute_kidney_injury rattus_norvegicus mir-183 MI0000928 miRBase miRNA up-regulation SIRT1 NA NA no Down-regulated miR-183-3p or up-regulated sirt1 attenuates acute kidney injury (AKI) via puma inhibition induced by foxo3a deacetylation. 33450262 Depleting microRNA-183-3p improves renal tubulointerstitial fibrosis after acute kidney injury via SIRT1/PUMA/FOXO3a deacetylation 2021 heart atrial_fibrillation rattus_norvegicus miR-223-3p MIMAT0000892 miRBase miRNA up-regulation FOXO3 NA NA yes "Quercetin (Que) can effectively inhibit the expression of miR-223-3p in atrial fibrillation model cells and rats myocardial tissues, and meanwhile enhance the expression of FOXO3 and activate the autophagy pathway, and significantly inhibit myocardial fibrosis, and improve myocardial remodeling in atrial fibrillation." 34097559 Quercetin prevents isoprenaline-induced myocardial fibrosis by promoting autophagy via regulating miR-223-3p/FOXO3 2021 heart diabetic_cardiomyopathy rattus_norvegicus miR-195-5p MIMAT0000870 miRBase miRNA down-regulation Smad7 TGF-BETA SIGNALING PATHWAY NA no MiR-195-5p downregulation blocked endothelial mesenchymal transition (EndMT) by inhibiting TGF-beta1-smads pathway. Smad7 was the direct target of miR-195-5p and silencing miR-195-5p inhibited EndMT by promoting Smad7 expression. 34658906 MicroRNA-195-5p Downregulation Inhibits Endothelial Mesenchymal Transition and Myocardial Fibrosis in Diabetic Cardiomyopathy by Targeting Smad7 and Inhibiting Transforming Growth Factor Beta 1-Smads-Snail Pathway 2021 heart myocardial_infarction rattus_norvegicus mir-133b MI0003490 miRBase miRNA down-regulation CTGF NA luciferase activity;RIP experiments no TUG1 mediates CTGF expression by sponging miR-133b in the activation of cardiac myofibroblasts. 34553456 LncRNA TUG1 acts as a competing endogenous RNA to mediate CTGF expression by sponging miR-133b in myocardial fibrosis after myocardial infarction 2021 heart pulmonary_arterial_hypertension rattus_norvegicus miR-325-3p MIMAT0004639 miRBase miRNA down-regulation HE4 PI3K-AKT SIGNALING PATHWAY dual-luciferase reporter assay yes MiR-325-3p could target HE4 to relieve right ventricular fibrosis in rats with pulmonary artery hypertension. 35136419 MicroRNA-325-3p Targets Human Epididymis Protein 4 to Relieve Right Ventricular Fibrosis in Rats with Pulmonary Arterial Hypertension 2022 heart heart_failure rattus_norvegicus miR-99b-3p MIMAT0004725 miRBase miRNA up-regulation GSK-3beta NA NA no MiR-99b-3p contributes to Ang II-induced cardiac fibrosis at least partially through GSK-3 beta. 32814818 MicroRNA-99b-3p promotes angiotensin II-induced cardiac fibrosis in mice by targeting GSK-3beta 2021 heart endomyocardial_fibrosis rattus_norvegicus miR-122-5p MIMAT0000827 miRBase miRNA down-regulation NA TGF-BETA SIGNALING PATHWAY NA no MiRNA-122-5p is an essential regulator of autophagy and apoptosis in rat cardiofibroblasts via the apelin/AMPK/mTOR signaling pathway. 35133561 MiRNA-122-5p inhibitor abolishes angiotensin II-mediated loss of autophagy and promotion of apoptosis in rat cardiofibroblasts by modulation of the apelin-AMPK-mTOR signaling 2022 heart heart_failure rattus_norvegicus mir-320 MI0000972 miRBase miRNA up-regulation NA JAK-STAT SIGNALING PATHWAY NA no MiR-320 mimics aggravated the pressure overload and induced cardiac hypertrophy and fibrosis via the IL6/STAT3/PTEN axis. 34582362 miR-320 accelerates chronic heart failure with cardiac fibrosis through activation of the IL6/STAT3 axis 2021 heart myocardial_infarction rattus_norvegicus miR-363-3p MIMAT0003210 miRBase miRNA down-regulation p53;JMY NA immunoblotting;qRT-PCR;luciferase reporter assays no Protective ability of EPC-Exos against myocardial infarction was mediated by the shuttled miR-218-5p or miR-363-3p via targeting of the p53/JMY signaling pathway. 34326916 Exosomal miR-218-5p/miR-363-3p from Endothelial Progenitor Cells Ameliorate Myocardial Infarction by Targeting the p53/JMY Signaling Pathway 2021 heart chronic_heart_failure rattus_norvegicus miR-129-5p MIMAT0000600 miRBase miRNA down-regulation Smurf1 NA NA no "MiR-129-5p targeted Smurf1 and repressed the ubiquitination of PTEN, and promoted PTEN expression, thus improving the cardiac function of chronic heart failure rats." 35034538 miR-129-5p restores cardiac function in rats with chronic heart failure by targeting the E3 ubiquitin ligase Smurf1 and promoting PTEN expression 2022 heart myocardial_infarction rattus_norvegicus mir-30e MI0000867 miRBase miRNA down-regulation LOX1 NF-KAPPA B SIGNALING PATHWAY NA no "Exosomal miR-30e from rat bone marrow-derived mesenchymal stem cells (BMMSCs) markedly inhibited LOX1 expression, thereby downregulating the activity of the NF-KAPPA B p65/Caspase-9 signaling and ameliorating heart failure after myocardial infarction in rats." 34149995 Exosomes released from mesenchymal stem cells overexpressing microRNA-30e ameliorate heart failure in rats with myocardial infarction 2021 heart acute_myocardial_infarction rattus_norvegicus mir-146a MI0000919 miRBase miRNA up-regulation CXCR4 NA qRT-PCR;flow cytometry yes "MiR-146a mimics suppressed CXCR4, and atorvastatin pretreatment no longer ameliorated mesenchymal stem cells migration because of decreased CXCR4." 34260048 Atorvastatin Pretreatment Ameliorates Mesenchymal Stem Cell Migration through miR-146a/CXCR4 Signaling 2021 heart endomyocardial_fibrosis rattus_norvegicus miR-210-5p MIMAT0017156 miRBase miRNA down-regulation TGFBR1 NA bioinformatics analysis;luciferase reporter assays no The upregulation of miR-210-5p could attenuate cardiac fibroblast activation in NRCFS via targeting TGFBR1. 34678242 MicroRNA-210-5p alleviates cardiac fibrosis via targeting transforming growth factor-beta type I receptor in rats on high sodium chloride (NaCl)-based diet 2021 heart myocardial_infarction rattus_norvegicus miR-1-3p MIMAT0003125 miRBase miRNA down-regulation ATG13 PI3K-AKT SIGNALING PATHWAY RT-PCR;western blotting;dual luciferase reporter assay etc. no "The circulating exosomal miR-1-3p after myocardial infarction inhibited the contrast medium-induced apoptosis and autophagy of renal tubular epithelial cells, and improved the renal function of rats by targeting ATG13 and activating the AKT signaling pathway." 33867822 Circulating Exosomal miR-1-3p from Rats with Myocardial Infarction Plays a Protective Effect on Contrast-Induced Nephropathy via Targeting ATG13 and activating the AKT Signaling Pathway 2021 heart heart_failure rattus_norvegicus mir-137 MI0000910 miRBase miRNA up-regulation NA NA qRT-PCR no "MiR-137 in the pathogenesis of heart failure(HF) and that cyclocreatine phosphate treatment prevented ischemic injury in ""non-HF rats"" and significantly reduced Nourin gene expression levels in a dose-response manner." 33808213 Nourin-Associated miRNAs: Novel Inflammatory Monitoring Markers for Cyclocreatine Phosphate Therapy in Heart Failure 2021 heart heart_failure rattus_norvegicus miR-106b-5p MIMAT0000825 miRBase miRNA up-regulation NA NA qRT-PCR no "MiR-106b-5p in the pathogenesis of heart failure(HF) and that cyclocreatine phosphate treatment prevented ischemic injury in ""non-HF rats"" and significantly reduced Nourin gene expression levels in a dose-response manner." 33808213 Nourin-Associated miRNAs: Novel Inflammatory Monitoring Markers for Cyclocreatine Phosphate Therapy in Heart Failure 2021 kidney acute_kidney_injury rattus_norvegicus miR-183-3p MIMAT0017141 miRBase miRNA up-regulation SIRT1 NA NA no Down-regulated miR-183-3p or up-regulated SIRT1 attenuates acute kidney injury via PUMA inhibition induced by FOXO3a deacetylation. 33450262 Depleting microRNA-183-3p improves renal tubulointerstitial fibrosis after acute kidney injury via SIRT1/PUMA/FOXO3a deacetylation 2021 kidney diabetic_nephropathy rattus_norvegicus mir-21 MI0000850 miRBase miRNA up-regulation PTEN PI3K-AKT SIGNALING PATHWAY NA no Effect of miR-21 on renal fibrosis induced by Nano-SiO? in diabetic nephropathy rats via PTEN/AKT pathway. 33183446 Effect of miR-21 on Renal Fibrosis Induced by Nano-SiO2 in Diabetic Nephropathy Rats via PTEN/AKT Pathway 2021 kidney diabetic_kidney_disease rattus_norvegicus miR-154-5p MIMAT0000856 miRBase miRNA up-regulation Smurf1 TGF-BETA SIGNALING PATHWAY bioinformatics predicted binding sites;luciferase;Co-IP etc. no MiR-154-5p regulates the TGF beta1/Smads pathway through Smurf1 ubiquitination and promotes the fibrosis process of diabetic kidney disease. 35126820 miR-154-5p Affects the TGF beta 1/Smad3 Pathway on the Fibrosis of Diabetic Kidney Disease via Binding E3 Ubiquitin Ligase Smurf1 2022 kidney hypertensive_renal_injury rattus_norvegicus miR-122-5p MIMAT0000827 miRBase miRNA up-regulation FOXO3 NA NA no "MiR-122-5p augments renal fibrosis, inflammatory and oxidant injury in hypertensive rats by suppressing the expression of FOXO3." 34998813 MicroRNA-122-5p promotes renal fibrosis and injury in spontaneously hypertensive rats by targeting FOXO3 2022 kidney chronic_kidney_disease rattus_norvegicus miR-186-5p MIMAT0000863 miRBase miRNA down-regulation Smad5 NA dual-luciferase reporter assay no Exosomal miR-186-5p derived from mesenchymal stem cells could attenuate renal fibrosis in vitro and in vivo by downregulation of Smad5. 34585365 Exosomes derived from mesenchymal stem cells ameliorate renal fibrosis via delivery of miR-186-5p 2022 kidney renal_interstitial_fibrosis rattus_norvegicus miR-155-5p MIMAT0030409 miRBase miRNA up-regulation SIRT1 NA qRT-PCR;western blot;luciferase reporter assay etc. no MiR-155-5p promotes renal interstitial fibrosis in obstructive nephropathy via inhibiting SIRT1 signaling pathway. 32985331 MiR-155-5p promotes renal interstitial fibrosis in obstructive nephropathy via inhibiting SIRT1 signaling pathway 2021 kidney chronic_kidney_disease rattus_norvegicus miR-150-5p MIMAT0000853 miRBase miRNA up-regulation NA NA NA no Tubular cell-derived exosomal miR-150-5p could negatively regulate the expression of suppressor of cytokine signaling 1 to activate fibroblast. 34671216 Tubular cell-derived exosomal miR-150-5p contributes to renal fibrosis following unilateral ischemia-reperfusion injury by activating fibroblast in vitro and in vivo 2021 kidney acute_kidney_injury rattus_norvegicus miR-150-5p MIMAT0000853 miRBase miRNA up-regulation NA NA NA no Tubular cell-derived exosomal miR-150-5p could negatively regulate the expression of suppressor of cytokine signaling 1 to activate fibroblast. 34671216 Tubular cell-derived exosomal miR-150-5p contributes to renal fibrosis following unilateral ischemia-reperfusion injury by activating fibroblast in vitro and in vivo 2021 kidney diabetic_nephropathy rattus_norvegicus mir-32 MI0000873 miRBase miRNA up-regulation Smad7 NA NA no "Reintroduction of SMAD7 expression rescued miR-32 autophagy suppression, epithelial-mesenchymal transition and renal fibrosis." 32959695 MiR-32-5p knockdown inhibits epithelial to mesenchymal transition and renal fibrosis by targeting SMAD7 in diabetic nephropathy 2021 kidney renal_interstitial_fibrosis rattus_norvegicus mir-101b MI0000648 miRBase miRNA up-regulation TbetaR-I TGF-BETA SIGNALING PATHWAY RT-qRT-PCR no MiR-101 is capable of inhibiting TGF-beta1 induced tubular epithelial-to-mesenchymal transition by targeting TbetaR-I. 33955520 MicroRNA-101 inhibits renal tubular epithelial-to-mesenchymal transition by targeting TGF-beta1 type I receptor 2021 kidney renal_interstitial_fibrosis rattus_norvegicus mir-101a MI0000886 miRBase miRNA up-regulation TbetaR-I TGF-BETA SIGNALING PATHWAY RT-qRT-PCR no MiR-101 is capable of inhibiting TGF-beta1 induced tubular epithelial-to-mesenchymal transition by targeting TbetaR-I. 33955520 MicroRNA-101 inhibits renal tubular epithelial-to-mesenchymal transition by targeting TGF-beta1 type I receptor 2021 kidney diabetic_nephropathy rattus_norvegicus mir-365 MI0001656 miRBase miRNA up-regulation BDNF NA RT-qRT-PCR;western blot;luciferase reporter assay etc. no MiR-365 could regulate BDNF-TrkB signal axis in streptozotocin induced diabetic nephropathy fibrosis and renal function. 33881703 Mechanism of miR-365 in regulating BDNF-TrkB signal axis of HFD/STZ induced diabetic nephropathy fibrosis and renal function 2021