Tissue Disease Species symbol ID Platform Type Expression Target Pathway Method Drug Function PMID Title Year heart atrial_fibrillation mus_musculus Miat ENSMUSG00000097767 Ensembl lncrna up-regulation MIR-133A-3P NA qPCR no "Atrial fibrillation(AF)-induced myocardial fibrosis, and the functional regulatory pathway of Miat targeting miR-133a-3p." 32130618 LncRNA MIAT/miR-133a-3p axis regulates atrial fibrillation and atrial fibrillation-induced myocardial fibrosis https://pubmed.ncbi.nlm.nih.gov/32130618/ 2020 heart myocardial_infarction mus_musculus Mirt1 ENSMUSG00000097636 Ensembl lncrna down-regulation NA NF-KAPPA B SIGNALING PATHWAY NA no Down-regulation of miRt1 improves myocardial i/r injury in aged diabetic rats by inhibition of activation of NF-KB signaling pathway. 30611788 Down-regulation of myocardial infarction associated transcript 1 improves myocardial ischemia-reperfusion injury in aged diabetic rats by inhibition of activation of NF-KB signaling pathway https://pubmed.ncbi.nlm.nih.gov/30611788/ 2019 heart endomyocardial_fibrosis mus_musculus Gas5 ENSMUSG00000053332 Ensembl lncrna down-regulation PTEN-MMP2 PI3K-AKT SIGNALING PATHWAY PCR; immunofluorescence etc. no Gas5 plays a suppressive role in cardiac fibrosis via negative regulation of miR-21. Gas5 that upregulated or downregulated the expression of PTEN through miR-21 in cardiac fibroblasts. 28526319 LncRNA GAS5 controls cardiac fibroblast activation and fibrosis by targeting miR-21 via PTEN/MMP-2 signaling pathway https://pubmed.ncbi.nlm.nih.gov/28526319/ 2017 heart endomyocardial_fibrosis mus_musculus H19 ENSMUSG00000000031 Ensembl lncrna up-regulation DUSP5 MAPK SIGNALING PATHWAY PCR; Masson's trichrome staining etc. no "H19 endogenous expression is overexpressed in cardiac fibroblast and fibrosis tissues, and an opposite pattern is observed for Dusp5. H19 ectopic overexpression reduces Dusp5 abundance and increases the proliferation of cardiac fibroblast, whereas h19 silencing causes the opposite effects." 27318893 Long noncoding RNA H19 controls DUSP5/ERK1/2 axis in cardiac fibroblast proliferation and fibrosis https://pubmed.ncbi.nlm.nih.gov/21412773/ 2016 heart endomyocardial_fibrosis mus_musculus H19 ENSMUSG00000000031 Ensembl lncrna up-regulation CTGF NA PCR; dual-luciferase reporter assay etc. no "H19 knockdown could enhance the antifibrotic role of miR-455 and attenuate the CTGF expression and further decrease fibrosis-associated protein synthesis (collagen i, iii, and alfa-SMA)." 28753062 Long Noncoding RNA H19 Acts as a Competing Endogenous RNA to Mediate CTGF Expression by Sponging miR-455 in Cardiac Fibrosis https://pubmed.ncbi.nlm.nih.gov/28753062/ 2017 heart heart_failure mus_musculus Kcnq1ot1 ENSMUSG00000101609 Ensembl lncrna down-regulation FUS NA qRT-PCR; no "Kcnq1ot1 ovexpression improved myocardial histopathological changes, reduced myocardial fibrosis areas, down-regulated FUS expression, and inhibited cell apoptosis of heart failure(HF) mice." 32497620 LncRNA KCNQ1OT1 contributes to cardiomyocyte apoptosis by targeting FUS in heart failure https://pubmed.ncbi.nlm.nih.gov/32497620/ 2020 heart diabetic_cardiomyopathy mus_musculus Kcnq1ot1 ENSMUSG00000101609 Ensembl lncrna up-regulation NA NOD-LIKE RECEPTOR SIGNALING PATHWAY dual-luciferase reporter assay no Kcnq1ot1/miR-214-3p/caspase-1/TGF-beta signal pathway presents a new mechanism of diabetes cardiomyopathy (DCM) progression and could potentially be a novel therapeutic target. 30250027 Silencing long non-coding RNA Kcnq1ot1 alleviates pyroptosis and fibrosis in diabetic cardiomyopathy https://pubmed.ncbi.nlm.nih.gov/30250027/ 2018 heart endomyocardial_fibrosis mus_musculus Miat ENSMUSG00000097767 Ensembl lncrna up-regulation MIR-24;FURIN TGF-BETA SIGNALING PATHWAY PCR; dual-luciferase reporter assay etc. no Knockdown of endogenous miat by its sirna reduced cardiac fibrosis and improved cardiac function and restored the deregulated expression of the fibrosis-related regulators. 28198439 MIAT Is a Pro-fibrotic Long Noncoding RNA Governing Cardiac Fibrosis in Post-infarct Myocardium https://pubmed.ncbi.nlm.nih.gov/28198439/ 2016 heart cardiovascular_diseases mus_musculus Gas5 ENSMUSG00000053332 Ensembl lncrna up-regulation MIRI PI3K-AKT SIGNALING PATHWAY dual-luciferase reporter assay no Lncrna gas5 was able to regulate miRNA through the PI3k/Akt apoptosis pathway by sponging miR-532-5p. 31985016 Long non-coding RNA GAS5 regulates myocardial ischemia-reperfusion injury through the PI3K/AKT apoptosis pathway by sponging miR-532-5p https://pubmed.ncbi.nlm.nih.gov/31985016/ 2020 heart myocardial_infarction mus_musculus Malat1 ENSMUSG00000092341 Ensembl lncrna up-regulation MIR-145 TGF-BETA SIGNALING PATHWAY qRT-PCR; Masson's trichrome staining no Lncrna malat1 promotes cardiac fibrosis and deteriorates cardiac function post-myocardial infarction (MI) by regulating TGF-beta activity via miR-145. 30146700 Long noncoding RNA MALAT1 mediates cardiac fibrosis in experimental postinfarct myocardium mice model https://pubmed.ncbi.nlm.nih.gov/30146700/ 2019 heart endomyocardial_fibrosis mus_musculus Snhg7 ENSMUSG00000086775 Ensembl lncrna up-regulation MIR-34-5P NA qRT-PCR; dual-luciferase reporter assay etc. no Lncrna snhg7 could promote cardiac fibrosis via targeting miR-34-5p through acting as a ceRNA in mice aftermyocardial infarction (MI). 32507765 LncRNA SNHG7 promotes cardiac remodeling by upregulating ROCK1 via sponging miR-34-5p https://pubmed.ncbi.nlm.nih.gov/32507765/ 2020 heart heart_failure mus_musculus Fendrr ENSMUSG00000097336 Ensembl lncrna up-regulation TAC NA qRT-PCR yes "Loss-function of fendrr significantly alleviated the cardiac fibrosis phenotypes induced by TAC, indicating that fendrr is required for the pathogenesis of cardiac fibrosis." 31982134 Fendrr involves in the pathogenesis of cardiac fibrosis via regulating miR-106b/SMAD3 axis https://pubmed.ncbi.nlm.nih.gov/31982134/ 2020 heart endomyocardial_fibrosis mus_musculus Rmrp ENSMUSG00000115420 Ensembl lncrna up-regulation NA NA dual-luciferase reporter assay no miR-613 was indicated to mediate the promoting effect of RMRP on cardiac fibroblast activation. 31485650 Upregulation of lncRNA RMRP promotes the activation of cardiac fibroblasts by regulating miR-613 https://pubmed.ncbi.nlm.nih.gov/31485650/ 2019 heart diabetic_cardiomyopathy mus_musculus Crnde ENSMUSG00000031736 Ensembl lncrna down-regulation NA TGF-BETA SIGNALING PATHWAY NA no Overexpression of Crnde attenuated cardiac fibrosis and enhanced cardiac function in mice with diabetes cardiomyopathy (DCM). 30748104 Long noncoding RNA Crnde attenuates cardiac fibrosis via Smad3-Crnde negative feedback in diabetic cardiomyopathy https://pubmed.ncbi.nlm.nih.gov/30748104/ 2019 heart endomyocardial_fibrosis mus_musculus Gas5 ENSMUSG00000053332 Ensembl lncrna down-regulation NA PI3K-AKT SIGNALING PATHWAY RT-PCR; no "Overexpression of gas5 after injection with PCDNA-gas5 could attenuate cardiac fibrosis and improve cardiac function through increasing the expression of PTEN and decreasing the expression of MMP-2, alfa-SMA, and collagen i." 31173316 Overexpression of lncRNA GAS5 attenuates cardiac fibrosis through regulating PTEN/MMP-2 signal pathway in mice https://pubmed.ncbi.nlm.nih.gov/31173316/ 2019 heart endomyocardial_fibrosis mus_musculus Gas5 ENSMUSG00000053332 Ensembl lncrna up-regulation HMGB1 NF-KAPPA B SIGNALING PATHWAY qRT-PCR; cell counting kit-8 analysis etc. yes Palmitic acid (PA) can induce gas5 expression and that the downregulation of gas5 alleviated pa-induced myocardial inflammatory injury through the miR-26a/HMGB1/NF-KB axis. 30365114 Downregulation of growth arrest-specific transcript 5 alleviates palmitic acid-induced myocardial inflammatory injury through the miR-26a/HMGB1/NF-KB axis https://pubmed.ncbi.nlm.nih.gov/30365114/ 2018 heart endomyocardial_fibrosis mus_musculus Rassf1 ENSMUSG00000010067 Ensembl lncrna up-regulation NA NA dual-luciferase reporter assay no Rassf1-as1 inhibits the translation of rassf1a to exacerbate cardiac fibrosis in mice. 30571844 "RASSF1-AS1, an antisense lncRNA of RASSF1A, inhibits the translation of RASSF1A to exacerbate cardiac fibrosis in mice" https://pubmed.ncbi.nlm.nih.gov/30571844/ 2019 heart endomyocardial_fibrosis mus_musculus Sail NA NA lncrna down-regulation NA TGF-BETA SIGNALING PATHWAY NA no "SAIL inhibited the fibrotic process by directly binding with SAFB via 23 conserved nucleotide sequences, in turn blocked the access of SAFB to RNA pol II (RNA polymerase II) and reduced the transcription of fibrosis-related genes. Intriguingly,the human conserved fragment of SAIL (hSAIL) significantly suppressed the proliferation and collagen production of human cardiac fibroblasts." 33675440 SAIL: a new conserved anti-fibrotic lncRNA in the heart https://pubmed.ncbi.nlm.nih.gov/33675440/ 2021 heart heart_failure mus_musculus Sox2ot ENSMUSG00000105265 Ensembl lncrna up-regulation NA TGF-BETA SIGNALING PATHWAY qRT-PCR; dual-luciferase reporter assay etc. no Sox2ot/smad3 feedback loop promotes cardiac fibrosis in heart failure(HF). 32959533 LncRNA SOX2OT/Smad3 feedback loop promotes myocardial fibrosis in heart failure https://pubmed.ncbi.nlm.nih.gov/32959533/ 2020 heart endomyocardial_fibrosis mus_musculus AK081284 NA NA lncrna up-regulation NA NA RT-PCR no "The levels of long noncoding RNA-AK081284 were increased in the cardiac fibroblasts (CFs) treated with high glucose or interleukin-17(IL-17). Knockout of IL-17 abrogated high glucose induced upregulation of AK081284. Overexpression of AK081284 in cultured CFs promoted the production of collagen and TGF-beta1. Both high glucose and IL-17 induced collagen and TGF-beta1 production were mitigated by the application of the siRNA for AK081284. In summary, deletion of IL-17 is able to mitigate myocardial fibrosis and improve cardiac function of diabetic mice. The IL-17/AK081284/TGFbeta1 signaling pathway mediates high glucose induced collagen production." 29305939 Ablation of interleukin-17 alleviated cardiac interstitial fibrosis and improved cardiac function via inhibiting long non-coding RNA-AK081284 in diabetic mice https://pubmed.ncbi.nlm.nih.gov/29305939/ 2018 heart myocardial_infarction mus_musculus H19 ENSMUSG00000000031 Ensembl lncrna down-regulation KDM3A NA dual-luciferase reporter assays;qRT-PCR; etc. no NA 31755219 LncRNA H19 ameliorates myocardial infarction-induced myocardial injury and maladaptive cardiac remodelling by regulating KDM3A https://pubmed.ncbi.nlm.nih.gov/31755219/ 2020 heart endomyocardial_fibrosis mus_musculus Miat ENSMUSG00000097767 Ensembl lncrna up-regulation MIR-29 NA dual-luciferase reporter assay no NA 32795172 Mechanism underlying increased cardiac extracellular matrix deposition in perinatal nicotine-exposed offspring https://pubmed.ncbi.nlm.nih.gov/32795172/ 2020 heart ventricular_dysfunction mus_musculus Miat ENSMUSG00000097767 Ensembl lncrna up-regulation MIR-29 NA dual-luciferase reporter assay no NA 32795172 Mechanism underlying increased cardiac extracellular matrix deposition in perinatal nicotine-exposed offspring https://pubmed.ncbi.nlm.nih.gov/32795172/ 2020 intestine colorectal_neoplasms mus_musculus Trp53cor1 100504267 Gene lncrna dysregulation NA NA qRT-PCR etc. NA "One of them, lincRNA-p21, was regulated by p53 and contributed to apoptosis in mouse embryonic fibroblasts." 24012455 Clinical significance of long intergenic noncoding RNA-p21 in colorectal cancer https://pubmed.ncbi.nlm.nih.gov/24012455/ 2013 kidney diabetic_nephropathy mus_musculus Cyp4b1-ps1 ENSMUSG00000081006 Ensembl lncrna down-regulation NA NA Microarray no A novel long non-coding RNA CYP4B1 PS1-001 regulates proliferation and fibrosis in diabetic nephropathy. 26923441 A novel long non-coding RNA CYP4B1-PS1-001 regulates proliferation and fibrosis in diabetic nephropathy https://pubmed.ncbi.nlm.nih.gov/26923441/ 2016 kidney kidney_failure_chronic mus_musculus Gas5 ENSMUSG00000053332 Ensembl lncrna down-regulation NA NA qRT-PCR; no Activation of lncrna-gas5 attenuates kidney fibrosis by modulating miR-21 activity. 32791063 Long noncoding RNA-GAS5 retards renal fibrosis through repressing miR-21 activity https://pubmed.ncbi.nlm.nih.gov/32791063/ 2020 kidney diabetic_nephropathy mus_musculus Neat1 ENSMUSG00000092274 Ensembl lncrna up-regulation NA PI3K-AKT SIGNALING PATHWAY cell counting kit-8 analysis; MTT ASSAY no Decrease of neat1 repressed the proliferation and fibrosis in diabetic nephropathies via activating the Akt/mTOR signaling pathway. 30515796 Long noncoding RNA NEAT1 accelerates the proliferation and fibrosis in diabetic nephropathy through activating Akt/mTOR signaling pathway https://pubmed.ncbi.nlm.nih.gov/30515796/ 2019 kidney acute_kidney_injury mus_musculus Malat1 ENSMUSG00000092341 Ensembl lncrna up-regulation NA NA small-RNA sequencing; whole genome expression analysis no Hypoxia-induced long non-coding RNA malat1 (metastasis associated lung adenocarcinoma transcript 1) to be upregulated in renal i/r injury. 29467431 Hypoxia-induced long non-coding RNA Malat1 is dispensable for renal ischemia/reperfusion-injury https://pubmed.ncbi.nlm.nih.gov/29467431/ 2018 kidney nephritis_interstitia mus_musculus Arid2 ENSMUSG00000033237 Ensembl lncrna up-regulation NA TGF-BETA SIGNALING PATHWAY qPCR; no "In vitro knockdown of Arid2-IR from tubular epithelial cells produced no effect on TGF-beta-induced Smad3 signaling and fibrosis but inhibited interleukin-1beta-stimulated NF-KB-dependent inflammatory response. In contrast, overexpression of Arid2-IR promoted interleukin-1beta-induced NF-KB signaling and inflammatory cytokine expression without alteration of TGF-beta-induced fibrotic response. Furthermore, treatment of obstructed kidney with Arid2-IR shRNA blunted NF-KB-driven renal inflammation without effect on TGF-beta/Smad3-mediated renal fibrosis." 25743111 Long Noncoding RNA Arid2-IR Is a Novel Therapeutic Target for Renal Inflammation https://pubmed.ncbi.nlm.nih.gov/25743111/ 2015 kidney diabetic_nephropathy mus_musculus Gas5 ENSMUSG00000053332 Ensembl lncrna down-regulation FN1 NA NA no "Knockdown of lncrna gas5 leads to antifibrosis by competitively binding miR-96-5p, which inhibits the expression of FN1." 31810140 LncRNA GAS5 exacerbates renal tubular epithelial fibrosis by acting as a competing endogenous RNA of miR-96-5p https://pubmed.ncbi.nlm.nih.gov/31810140/ 2020 kidney diabetic_nephropathy mus_musculus Gm4419 ENSMUSG00000097055 Ensembl lncrna up-regulation P50 NF-KAPPA B SIGNALING PATHWAY qRT-PCR no "Lincrna-gm4419 may participate in the inflammation, fibrosis and proliferation in mesangial cells under high-glucose condition through NF-KB/Nlrp3 inflammasome signaling pathway." 28151474 LincRNA-Gm4419 knockdown ameliorates NF-KB/NLRP3 inflammasome-mediated inflammation in diabetic nephropathy https://pubmed.ncbi.nlm.nih.gov/28151474/ 2017 kidney diabetic_nephropathy mus_musculus Hottip ENSMUSG00000055408 Ensembl lncrna up-regulation NA WNT SIGNALING PATHWAY qRT-PCR; MTT assay etc. no "Lncrna hottip/miR-455-3p/wnt2b axis plays an important role in cell proliferation, inflammation, and extracellular matrix (ecm) accumulation in diabetic nephropathy." 31934070 Long non-coding RNA Hottip modulates high-glucose-induced inflammation and ECM accumulation through miR-455-3p/WNT2B in mus musculus mesangial cells https://pubmed.ncbi.nlm.nih.gov/31934070/ 2019 kidney diabetic_nephropathy mus_musculus Tug1 ENSMUSG00000056579 Ensembl lncrna down-regulation TIMP3 NA dual-luciferase reporter assay no Lncrna tug1 inhibited high glucose-stimulated NRK-52e cell fibrosis and renal fibrosis in diabetic nephropathies mice. 31933879 LncRNA TUG1 ameliorates diabetic nephropathy by inhibiting miR-21 to promote TIMP3-expression https://pubmed.ncbi.nlm.nih.gov/31933879/ 2019 kidney kidney_failure_chronic mus_musculus Zfas1 ENSMUSG00000074578 Ensembl lncrna up-regulation NA WNT SIGNALING PATHWAY dual-luciferase reporter assay no LncRNA ZFAS1 from HCM could promote cardiac fibrosis through WNT/beta-catenin signal via exosome pathways. 33640882 Exosome-derived long non-coding RNA ZFAS1 controls cardiac fibrosis in chronic kidney disease https://pubmed.ncbi.nlm.nih.gov/33640882/ 2021 kidney diabetic_nephropathy mus_musculus Tmcc3 ENSMUSG00000020023 Ensembl lncrna down-regulation NA NA qRT-PCR; no Long non-coding RNA ENSMUST00000147869 protects mesangial cells from proliferation and fibrosis induced by diabetic nephropathy. 27083175 Long non-coding RNA ENSMUST00000147869 protects mesangial cells from proliferation and fibrosis induced by diabetic nephropathy https://pubmed.ncbi.nlm.nih.gov/27083175/ 2016 kidney diabetic_nephropathy mus_musculus Malat1 ENSMUSG00000092341 Ensembl lncrna up-regulation ZEB2 NA qRT-PCR; dual-luciferase reporter assay no "Malat1 functions as a sponge RNA for miR-145 to derepress the expression of target gene zeb3, thereby inducing epithelial-mesenchymal transition (EMT) and fibrosis." 31081103 LncRNA MALAT1 facilities high glucose induced endothelial to mesenchymal transition and fibrosis via targeting miR-145/ZEB2 axis https://pubmed.ncbi.nlm.nih.gov/31081103/ 2019 kidney diabetic_nephropathy mus_musculus Oip5os1 ENSMUSG00000085438 Ensembl lncrna down-regulation NA HIF-1 SIGNALING PATHWAY dual-luciferase reporter assay no Overexpression of 1700020i14rik inhibited cell proliferation and expressions of renal fibrosis markers through miR-34a-5p/sirt1/hif-1 alfa pathway in mouse mesangial cells under high glucose condition. 29700282 LincRNA 1700020I14Rik alleviates cell proliferation and fibrosis in diabetic nephropathy via miR-34a-5p/Sirt1/HIF-1alpha signaling https://pubmed.ncbi.nlm.nih.gov/29700282/ 2018 kidney diabetic_nephropathy mus_musculus Xist ENSMUSG00000086503 Ensembl lncrna up-regulation CDKN1A NA dual-luciferase reporter assay no Silenced xist inducing miR-93-5p-dependent cdkn1a inhibition was beneficial for preventing renal interstitial fibrosis in diabetic nephropathies. 31545928 Silencing of long noncoding RNA XIST protects against renal interstitial fibrosis in diabetic nephropathy via microRNA-93-5p-mediated inhibition of CDKN1A https://pubmed.ncbi.nlm.nih.gov/31545928/ 2019 kidney nephritis_interstitia mus_musculus Hotair ENSMUSG00000086903 Ensembl lncrna up-regulation NOTCH1 NA qRT-PCR; no "Silencing lncrna hotair can up-regulate miR-124 to block notch2 pathway, and thereby alleviating epithelial-mesenchymal transition and renal interstitial fibrosis." 29717517 LncRNA HOTAIR promotes renal interstitial fibrosis by regulating Notch1 pathway via the modulation of miR-124 https://pubmed.ncbi.nlm.nih.gov/29717517/ 2019 kidney diabetic_nephropathy mus_musculus Neat1 ENSMUSG00000092274 Ensembl lncrna up-regulation NA MAPK SIGNALING PATHWAY NA no Silencing neat1 can reverse the activation of epithelial-mesenchymal transition and fibrosis caused by klotho silencing in a manner dependent on the erk1/3 signaling pathway. 32054986 Long noncoding RNA NEAT1 is involved in the protective effect of Klotho on renal tubular epithelial cells in diabetic kidney disease through the ERK1/2 signaling pathway https://pubmed.ncbi.nlm.nih.gov/32054986/ 2020 kidney nephritis_interstitia mus_musculus Hotair ENSMUSG00000086903 Ensembl lncrna up-regulation NOTCH1 NOTCH SIGNALING PATHWAY NA yes "The contributory effect of lncrna hotair on renal interstitial fibrosis by activating the notch1/jagged1 signaling pathway via inhibition of miR-124, whereas administration of PAE can alleviate the effects of hotair on renal interstitial fibrosis." 30714138 Paeonol reverses promoting effect of the HOTAIR/miR-124/Notch1 axis on renal interstitial fibrosis in a rat model https://pubmed.ncbi.nlm.nih.gov/30714138/ 2019 kidney nephritis_interstitia mus_musculus Tug1 ENSMUSG00000056579 Ensembl lncrna up-regulation NA TGF-BETA SIGNALING PATHWAY immunofluorescence etc. no Tug1 promotes epithelial-mesenchymal transition in TGF-beta-induced human renal proximal tubular epithelial cells via upregulation of beta-catenin levels by sponging miR-141-3p. 33135476 Silencing of the lncRNA TUG1 attenuates the epithelial-mesenchymal transition of renal tubular epithelial cells by sponging miR-141-3p via regulating beta-catenin https://pubmed.ncbi.nlm.nih.gov/33135476/ 2020 kidney diabetic_nephropathy mus_musculus Snhg18 ENSMUSG00000096956 Ensembl lncrna down-regulation NA NA qRT-PCR no Twelve lncRNAs displayed the same expressional tendencies in both renal tissues and mesangial cells. 28151474 LincRNA-Gm4419 knockdown ameliorates NF-KB/NLRP3 inflammasome-mediated inflammation in diabetic nephropathy https://pubmed.ncbi.nlm.nih.gov/28151474/ 2017 kidney diabetic_nephropathy mus_musculus 1500026H17Rik ENSMUSG00000097383 Ensembl lncrna up-regulation NA NA qRT-PCR no Twelve lncRNAs displayed the same expressional tendencies in both renal tissues and mesangial cells. 28151474 LincRNA-Gm4419 knockdown ameliorates NF-KB/NLRP3 inflammasome-mediated inflammation in diabetic nephropathy https://pubmed.ncbi.nlm.nih.gov/28151474/ 2017 kidney diabetic_nephropathy mus_musculus 2610035D17Rik ENSMUSG00000087259 Ensembl lncrna down-regulation NA NA qRT-PCR no Twelve lncRNAs displayed the same expressional tendencies in both renal tissues and mesangial cells. 28151474 LincRNA-Gm4419 knockdown ameliorates NF-KB/NLRP3 inflammasome-mediated inflammation in diabetic nephropathy https://pubmed.ncbi.nlm.nih.gov/28151474/ 2017 kidney diabetic_nephropathy mus_musculus 4930556M19Rik ENSMUSG00000096971 Ensembl lncrna down-regulation NA NA qRT-PCR no Twelve lncRNAs displayed the same expressional tendencies in both renal tissues and mesangial cells. 28151474 LincRNA-Gm4419 knockdown ameliorates NF-KB/NLRP3 inflammasome-mediated inflammation in diabetic nephropathy https://pubmed.ncbi.nlm.nih.gov/28151474/ 2017 kidney diabetic_nephropathy mus_musculus 6030443J06Rik ENSMUSG00000097207 Ensembl lncrna up-regulation NA NA qRT-PCR no Twelve lncRNAs displayed the same expressional tendencies in both renal tissues and mesangial cells. 28151474 LincRNA-Gm4419 knockdown ameliorates NF-KB/NLRP3 inflammasome-mediated inflammation in diabetic nephropathy https://pubmed.ncbi.nlm.nih.gov/28151474/ 2017 kidney diabetic_nephropathy mus_musculus C330002G04Rik ENSMUSG00000097930 Ensembl lncrna down-regulation NA NA qRT-PCR no Twelve lncRNAs displayed the same expressional tendencies in both renal tissues and mesangial cells. 28151474 LincRNA-Gm4419 knockdown ameliorates NF-KB/NLRP3 inflammasome-mediated inflammation in diabetic nephropathy https://pubmed.ncbi.nlm.nih.gov/28151474/ 2017 kidney diabetic_nephropathy mus_musculus D630029K05Rik ENSMUSG00000031294 Ensembl lncrna down-regulation NA NA qRT-PCR no Twelve lncRNAs displayed the same expressional tendencies in both renal tissues and mesangial cells. 28151474 LincRNA-Gm4419 knockdown ameliorates NF-KB/NLRP3 inflammasome-mediated inflammation in diabetic nephropathy https://pubmed.ncbi.nlm.nih.gov/28151474/ 2017 kidney diabetic_nephropathy mus_musculus Snhg6 ENSMUSG00000098234 Ensembl lncrna down-regulation NA NA qRT-PCR no Twelve lncRNAs displayed the same expressional tendencies in both renal tissues and mesangial cells. 28151474 LincRNA-Gm4419 knockdown ameliorates NF-KB/NLRP3 inflammasome-mediated inflammation in diabetic nephropathy https://pubmed.ncbi.nlm.nih.gov/28151474/ 2017 kidney diabetic_nephropathy mus_musculus 1700020I14Rik ENSMUSG00000085438 Ensembl lncrna down-regulation NA NA qRT-PCR no Twelve lncRNAs displayed the same expressional tendencies in both renal tissues and mesangial cells. 28151474 LincRNA-Gm4419 knockdown ameliorates NF-KB/NLRP3 inflammasome-mediated inflammation in diabetic nephropathy https://pubmed.ncbi.nlm.nih.gov/28151474/ 2017 kidney diabetic_nephropathy mus_musculus AV099323 ENSMUSG00000087377 Ensembl lncrna down-regulation NA NA qRT-PCR no Twelve lncRNAs displayed the same expressional tendencies in both renal tissues and mesangial cells. 28151474 LincRNA-Gm4419 knockdown ameliorates NF-KB/NLRP3 inflammasome-mediated inflammation in diabetic nephropathy https://pubmed.ncbi.nlm.nih.gov/28151474/ 2017 kidney diabetic_nephropathy mus_musculus C920006O11Rik ENSMUSG00000097574 Ensembl lncrna down-regulation NA NA qRT-PCR no Twelve lncRNAs displayed the same expressional tendencies in both renal tissues and mesangial cells. 28151474 LincRNA-Gm4419 knockdown ameliorates NF-KB/NLRP3 inflammasome-mediated inflammation in diabetic nephropathy https://pubmed.ncbi.nlm.nih.gov/28151474/ 2017 kidney renal_fibrosis mus_musculus 3110045C21Rik ENSMUSG00000097503 Ensembl lncrna down-regulation NA NA qPCR no "We identified a long list of differentially expressed lncRNA genes in a statistical significant manner (P<0.05).In particular, we identified 62 lncRNAs that were differentially expressed in SO vs 2D, 110 lncRNAs in SO vs 8D and 24 in 2D vs 10D ." 27189340 Whole-transcriptome analysis of UUO mouse model of renal fibrosis reveals new molecular players in kidney diseases https://pubmed.ncbi.nlm.nih.gov/27189340/ 2016 kidney renal_fibrosis mus_musculus 3110099E03Rik ENSMUSG00000085582 Ensembl lncrna down-regulation NA NA qPCR no "We identified a long list of differentially expressed lncRNA genes in a statistical significant manner (P<0.05).In particular, we identified 62 lncRNAs that were differentially expressed in SO vs 2D, 110 lncRNAs in SO vs 8D and 24 in 2D vs 11D ." 27189340 Whole-transcriptome analysis of UUO mouse model of renal fibrosis reveals new molecular players in kidney diseases https://pubmed.ncbi.nlm.nih.gov/27189340/ 2016 kidney renal_fibrosis mus_musculus 3300005D01Rik ENSMUSG00000096965 Ensembl lncrna up-regulation NA NA qPCR no "We identified a long list of differentially expressed lncRNA genes in a statistical significant manner (P<0.05).In particular, we identified 62 lncRNAs that were differentially expressed in SO vs 2D, 110 lncRNAs in SO vs 8D and 24 in 2D vs 12D ." 27189340 Whole-transcriptome analysis of UUO mouse model of renal fibrosis reveals new molecular players in kidney diseases https://pubmed.ncbi.nlm.nih.gov/27189340/ 2016 kidney renal_fibrosis mus_musculus 4833418N02Rik ENSMUSG00000085287 Ensembl lncrna down-regulation NA NA qPCR no "We identified a long list of differentially expressed lncRNA genes in a statistical significant manner (P<0.05).In particular, we identified 62 lncRNAs that were differentially expressed in SO vs 2D, 110 lncRNAs in SO vs 8D and 24 in 2D vs 13D ." 27189340 Whole-transcriptome analysis of UUO mouse model of renal fibrosis reveals new molecular players in kidney diseases https://pubmed.ncbi.nlm.nih.gov/27189340/ 2016 kidney renal_fibrosis mus_musculus 9130409J20Rik ENSMUSG00000085683 Ensembl lncrna down-regulation NA NA qPCR no "We identified a long list of differentially expressed lncRNA genes in a statistical significant manner (P<0.05).In particular, we identified 62 lncRNAs that were differentially expressed in SO vs 2D, 110 lncRNAs in SO vs 8D and 24 in 2D vs 14D ." 27189340 Whole-transcriptome analysis of UUO mouse model of renal fibrosis reveals new molecular players in kidney diseases https://pubmed.ncbi.nlm.nih.gov/27189340/ 2016 kidney renal_fibrosis mus_musculus 9330175E14Rik ENSMUSG00000097194 Ensembl lncrna up-regulation NA NA qPCR no "We identified a long list of differentially expressed lncRNA genes in a statistical significant manner (P<0.05).In particular, we identified 62 lncRNAs that were differentially expressed in SO vs 2D, 110 lncRNAs in SO vs 8D and 24 in 2D vs 15D ." 27189340 Whole-transcriptome analysis of UUO mouse model of renal fibrosis reveals new molecular players in kidney diseases https://pubmed.ncbi.nlm.nih.gov/27189340/ 2016 kidney renal_fibrosis mus_musculus A730020E08Rik ENSMUSG00000097924 Ensembl lncrna up-regulation NA NA qPCR no "We identified a long list of differentially expressed lncRNA genes in a statistical significant manner (P<0.05).In particular, we identified 62 lncRNAs that were differentially expressed in SO vs 2D, 110 lncRNAs in SO vs 8D and 24 in 2D vs 16D ." 27189340 Whole-transcriptome analysis of UUO mouse model of renal fibrosis reveals new molecular players in kidney diseases https://pubmed.ncbi.nlm.nih.gov/27189340/ 2016 kidney renal_fibrosis mus_musculus AI504432 ENSMUSG00000056145 Ensembl lncrna up-regulation NA NA qPCR no "We identified a long list of differentially expressed lncRNA genes in a statistical significant manner (P<0.05).In particular, we identified 62 lncRNAs that were differentially expressed in SO vs 2D, 110 lncRNAs in SO vs 8D and 24 in 2D vs 17D ." 27189340 Whole-transcriptome analysis of UUO mouse model of renal fibrosis reveals new molecular players in kidney diseases https://pubmed.ncbi.nlm.nih.gov/27189340/ 2016 kidney renal_fibrosis mus_musculus AI662270 ENSMUSG00000087107 Ensembl lncrna up-regulation NA NA qPCR no "We identified a long list of differentially expressed lncRNA genes in a statistical significant manner (P<0.05).In particular, we identified 62 lncRNAs that were differentially expressed in SO vs 2D, 110 lncRNAs in SO vs 8D and 24 in 2D vs 18D ." 27189340 Whole-transcriptome analysis of UUO mouse model of renal fibrosis reveals new molecular players in kidney diseases https://pubmed.ncbi.nlm.nih.gov/27189340/ 2016 kidney renal_fibrosis mus_musculus D630024D03Rik ENSMUSG00000085772 Ensembl lncrna down-regulation NA NA qPCR no "We identified a long list of differentially expressed lncRNA genes in a statistical significant manner (P<0.05).In particular, we identified 62 lncRNAs that were differentially expressed in SO vs 2D, 110 lncRNAs in SO vs 8D and 24 in 2D vs 19D ." 27189340 Whole-transcriptome analysis of UUO mouse model of renal fibrosis reveals new molecular players in kidney diseases https://pubmed.ncbi.nlm.nih.gov/27189340/ 2016 kidney renal_fibrosis mus_musculus D630029K05Rik ENSMUSG00000031294 Ensembl lncrna down-regulation NA NA qPCR no "We identified a long list of differentially expressed lncRNA genes in a statistical significant manner (P<0.05).In particular, we identified 62 lncRNAs that were differentially expressed in SO vs 2D, 110 lncRNAs in SO vs 8D and 24 in 2D vs 20D ." 27189340 Whole-transcriptome analysis of UUO mouse model of renal fibrosis reveals new molecular players in kidney diseases https://pubmed.ncbi.nlm.nih.gov/27189340/ 2016 kidney renal_fibrosis mus_musculus Gdap10 100504486 Gene lncrna up-regulation NA NA qPCR no "We identified a long list of differentially expressed lncRNA genes in a statistical significant manner (P<0.05).In particular, we identified 62 lncRNAs that were differentially expressed in SO vs 2D, 110 lncRNAs in SO vs 8D and 24 in 2D vs 21D ." 27189340 Whole-transcriptome analysis of UUO mouse model of renal fibrosis reveals new molecular players in kidney diseases https://pubmed.ncbi.nlm.nih.gov/27189340/ 2016 kidney renal_fibrosis mus_musculus Gm10069 ENSMUSG00000059659 Ensembl lncrna up-regulation NA NA qPCR no "We identified a long list of differentially expressed lncRNA genes in a statistical significant manner (P<0.05).In particular, we identified 62 lncRNAs that were differentially expressed in SO vs 2D, 110 lncRNAs in SO vs 8D and 24 in 2D vs 22D ." 27189340 Whole-transcriptome analysis of UUO mouse model of renal fibrosis reveals new molecular players in kidney diseases https://pubmed.ncbi.nlm.nih.gov/27189340/ 2016 kidney renal_fibrosis mus_musculus Gm10804 ENSMUSG00000075025 Ensembl lncrna down-regulation NA NA qPCR no "We identified a long list of differentially expressed lncRNA genes in a statistical significant manner (P<0.05).In particular, we identified 62 lncRNAs that were differentially expressed in SO vs 2D, 110 lncRNAs in SO vs 8D and 24 in 2D vs 23D ." 27189340 Whole-transcriptome analysis of UUO mouse model of renal fibrosis reveals new molecular players in kidney diseases https://pubmed.ncbi.nlm.nih.gov/27189340/ 2016 kidney renal_fibrosis mus_musculus Gm11752 ENSMUSG00000087404 Ensembl lncrna down-regulation NA NA qPCR no "We identified a long list of differentially expressed lncRNA genes in a statistical significant manner (P<0.05).In particular, we identified 62 lncRNAs that were differentially expressed in SO vs 2D, 110 lncRNAs in SO vs 8D and 24 in 2D vs 24D ." 27189340 Whole-transcriptome analysis of UUO mouse model of renal fibrosis reveals new molecular players in kidney diseases https://pubmed.ncbi.nlm.nih.gov/27189340/ 2016 kidney renal_fibrosis mus_musculus Gm12678 ENSMUSG00000084854 Ensembl lncrna down-regulation NA NA qPCR no "We identified a long list of differentially expressed lncRNA genes in a statistical significant manner (P<0.05).In particular, we identified 62 lncRNAs that were differentially expressed in SO vs 2D, 110 lncRNAs in SO vs 8D and 24 in 2D vs 25D ." 27189340 Whole-transcriptome analysis of UUO mouse model of renal fibrosis reveals new molecular players in kidney diseases https://pubmed.ncbi.nlm.nih.gov/27189340/ 2016 kidney renal_fibrosis mus_musculus Gm13412 ENSMUSG00000085017 Ensembl lncrna down-regulation NA NA qPCR no "We identified a long list of differentially expressed lncRNA genes in a statistical significant manner (P<0.05).In particular, we identified 62 lncRNAs that were differentially expressed in SO vs 2D, 110 lncRNAs in SO vs 8D and 24 in 2D vs 26D ." 27189340 Whole-transcriptome analysis of UUO mouse model of renal fibrosis reveals new molecular players in kidney diseases https://pubmed.ncbi.nlm.nih.gov/27189340/ 2016 kidney renal_fibrosis mus_musculus Gm16685 ENSMUSG00000097804 Ensembl lncrna up-regulation NA NA qPCR no "We identified a long list of differentially expressed lncRNA genes in a statistical significant manner (P<0.05).In particular, we identified 62 lncRNAs that were differentially expressed in SO vs 2D, 110 lncRNAs in SO vs 8D and 24 in 2D vs 27D ." 27189340 Whole-transcriptome analysis of UUO mouse model of renal fibrosis reveals new molecular players in kidney diseases https://pubmed.ncbi.nlm.nih.gov/27189340/ 2016 kidney renal_fibrosis mus_musculus Gm9951 ENSMUSG00000054618 Ensembl lncrna up-regulation NA NA qPCR no "We identified a long list of differentially expressed lncRNA genes in a statistical significant manner (P<0.05).In particular, we identified 62 lncRNAs that were differentially expressed in SO vs 2D, 110 lncRNAs in SO vs 8D and 24 in 2D vs 28D ." 27189340 Whole-transcriptome analysis of UUO mouse model of renal fibrosis reveals new molecular players in kidney diseases https://pubmed.ncbi.nlm.nih.gov/27189340/ 2016 kidney renal_fibrosis mus_musculus Malat1 ENSMUSG00000092341 Ensembl lncrna up-regulation NA NA qPCR no "We identified a long list of differentially expressed lncRNA genes in a statistical significant manner (P<0.05).In particular, we identified 62 lncRNAs that were differentially expressed in SO vs 2D, 110 lncRNAs in SO vs 8D and 24 in 2D vs 29D ." 27189340 Whole-transcriptome analysis of UUO mouse model of renal fibrosis reveals new molecular players in kidney diseases https://pubmed.ncbi.nlm.nih.gov/27189340/ 2016 kidney renal_fibrosis mus_musculus Neat1 ENSMUSG00000092274 Ensembl lncrna up-regulation NA NA qPCR no "We identified a long list of differentially expressed lncRNA genes in a statistical significant manner (P<0.05).In particular, we identified 62 lncRNAs that were differentially expressed in SO vs 2D, 110 lncRNAs in SO vs 8D and 24 in 2D vs 30D ." 27189340 Whole-transcriptome analysis of UUO mouse model of renal fibrosis reveals new molecular players in kidney diseases https://pubmed.ncbi.nlm.nih.gov/27189340/ 2016 kidney renal_fibrosis mus_musculus Snhg6 ENSMUSG00000098234 Ensembl lncrna up-regulation NA NA qPCR no "We identified a long list of differentially expressed lncRNA genes in a statistical significant manner (P<0.05).In particular, we identified 62 lncRNAs that were differentially expressed in SO vs 2D, 110 lncRNAs in SO vs 8D and 24 in 2D vs 34D ." 27189340 Whole-transcriptome analysis of UUO mouse model of renal fibrosis reveals new molecular players in kidney diseases https://pubmed.ncbi.nlm.nih.gov/27189340/ 2016 kidney renal_fibrosis mus_musculus 1810034E14Rik ENSMUSG00000097101 Ensembl lncrna down-regulation NA NA qPCR no "We identified a long list of differentially expressed lncRNA genes in a statistical significant manner (P<0.05).In particular, we identified 62 lncRNAs that were differentially expressed in SO vs 2D, 110 lncRNAs in SO vs 8D and 24 in 2D vs 8D ." 27189340 Whole-transcriptome analysis of UUO mouse model of renal fibrosis reveals new molecular players in kidney diseases https://pubmed.ncbi.nlm.nih.gov/27189340/ 2016 kidney renal_fibrosis mus_musculus Epb41l4aos ENSMUSG00000087590 Ensembl lncrna up-regulation NA NA qPCR no "We identified a long list of differentially expressed lncRNA genes in a statistical significant manner (P<0.05).In particular, we identified 62 lncRNAs that were differentially expressed in SO vs 2D, 110 lncRNAs in SO vs 8D and 24 in 2D vs 9D ." 27189340 Whole-transcriptome analysis of UUO mouse model of renal fibrosis reveals new molecular players in kidney diseases https://pubmed.ncbi.nlm.nih.gov/27189340/ 2016 kidney kidney_diseases mus_musculus Miat ENSMUSG00000097767 Ensembl lncrna up-regulation NA NA qRT-PCR; pathway analysis; immunohistochemistry no NA 30914951 Long Non-coding RNAs Rian and Miat Mediate Myofibroblast Formation in Kidney Fibrosis https://pubmed.ncbi.nlm.nih.gov/30914951/ 2019 kidney kidney_diseases mus_musculus Meg8 ENSMUSG00000097451 Ensembl lncrna down-regulation NA NA qRT-PCR; pathway analysis; immunohistochemistry no NA 30914951 Long Non-coding RNAs Rian and Miat Mediate Myofibroblast Formation in Kidney Fibrosis https://pubmed.ncbi.nlm.nih.gov/30914951/ 2019 kidney kidney_diseases mus_musculus Neat1 ENSMUSG00000092274 Ensembl lncrna up-regulation NA NA NA no NA 32475133 Long noncoding RNA NEAT1 sponges miR-130 to modulate renal fibrosis by regulation of collagen type I https://pubmed.ncbi.nlm.nih.gov/32475134/ 2020 liver liver_cirrhosis mus_musculus H19 ENSMUSG00000000031 Ensembl lncrna dysregulation LNCRNA H19 NA flow cytometry etc. no Cholangiocyte-derived exosomal h19 plays a critical role in the progression of cholestatic liver fibrosis by promoting hsc differentiation and activation and represents a potential diagnostic biomarker and therapeutic target for cholangiopathies. 30985008 Cholangiocyte-Derived Exosomal Long Noncoding RNA H19 Promotes Hepatic Stellate Cell Activation and Cholestatic Liver Fibrosis https://pubmed.ncbi.nlm.nih.gov/30985008/ 2019 liver liver_cirrhosis mus_musculus LFAR1 NA NA lncrna down-regulation LNC-LFAR1 TGF-BETA SIGNALING PATHWAY; NOTCH SIGNALING PATHWAY qRT-PCR; etc. no "Demonstrate that a liver-enriched lncrna, lnc-lfar1, promotes liver fibrosis and hsc activation by activating tgfbeta and notch signaling." 28747678 The liver-enriched lnc-LFAR1 promotes liver fibrosis by activating TGFbeta and Notch pathways https://pubmed.ncbi.nlm.nih.gov/28747678/ 2017 liver carcinoma_hepatocellular mus_musculus Malat1 ENSMUSG00000092341 Ensembl lncrna dysregulation NA NA NA NA "HCC and HPBL have clearly different patterns of gene expression, with genes IGF2, Fibronectin, DLK1, TGFb1, MALAT1 and MIG6 being over-expressed in HPBL versus HCC" 17006932 Transcriptomic and genomic analysis of human hepatocellular carcinomas and hepatoblastomas https://pubmed.ncbi.nlm.nih.gov/17006932/ 2006 liver liver_cirrhosis mus_musculus H19 ENSMUSG00000000031 Ensembl lncrna up-regulation NA TGF-BETA SIGNALING PATHWAY qRT-PCR; immunohistochemistry etc. no Histone deacetylase inhibition suppresses the transforming growth factor beta1-induced epithelial-to-mesenchymal transition in hepatocytes. 27350269 MeCP2 silencing of LncRNA H19 controls hepatic stellate cell proliferation by targeting IGF1R https://pubmed.ncbi.nlm.nih.gov/27350269/ 2016 liver liver_cirrhosis mus_musculus LNCRNA-ATB 114004396 Gene lncrna up-regulation LNCRNA-ATB NA qRT-PCR; immunocytocH&E stainingmistry etc. no Lncrna-atb;Mir-200a;beta-Catenin regulatory axis likely contributed to the development of liver fibrosis in hcv patients. Knockdown of lncrna-atb might be a novel therapeutic target for hcv-related liver fibrosis. 28302418 LncRNA-ATB/microRNA-200a/beta-catenin regulatory axis involved in the progression of HCV-related hepatic fibrosis https://pubmed.ncbi.nlm.nih.gov/28302418/ 2017 liver liver_cirrhosis mus_musculus Neat1 ENSMUSG00000092274 Ensembl lncrna dysregulation NA NA NA yes Neat1 was significantly increased in ccl4-induced mice and activated hscs. Loss of neat1 suppressed liver fibrosis in vivo and in vitro. Klf6 and mir-122 were required for the effects of neat1 on hsc activation. Neat1 contributes to hsc activation via competitively binding mir-122. We disclose a novel neat1-mir-122-klf6 signaling cascade. 28864835 NEAT1 accelerates the progression of liver fibrosis via regulation of microRNA-122 and Kruppel-like factor 6 https://pubmed.ncbi.nlm.nih.gov/28864835/ 2017 liver liver_cirrhosis mus_musculus H19 ENSMUSG00000000031 Ensembl lncrna dysregulation LNCRNA-H19 AMPKA RT-PCR; immunofluorescence etc. no "Our results highlighted the role of lncrna-h19 in the metabolism of lipid droplets in hscs, and revealed a new molecular target for alleviating liver fibrosis." 32445757 HIF-1alfa-upregulated lncRNA-H19 regulates lipid droplet metabolism through the AMPKalfa pathway in hepatic stellate cells https://pubmed.ncbi.nlm.nih.gov/32445757/ 2020 liver liver_cirrhosis mus_musculus Scarna10 ENSMUSG00000089617 Ensembl lncrna up-regulation SCARNA10 NA miRNA microarray chip detection etc. no "Our study identified a crucial role of scarna10 in liver fibrosis, providing a proof of this molecule as a potential diagnostic marker and a possible therapeutic target against liver fibrosis." 31281502 "SCARNA10, a nuclear-retained long non-coding RNA, promotes liver fibrosis and serves as a potential biomarker" https://pubmed.ncbi.nlm.nih.gov/31281502/ 2019 liver liver_cirrhosis mus_musculus Mical2 ENSMUSG00000038244 Ensembl lncrna down-regulation P66SHC MICAL2; MIR-230-3P; P66SHC qRT-PCR; dual-lucimmunofluorescenceerase reporter assay etc. no "Our study reveals that p66shc is critical for liver fibrosis and that mical2, journal pre-proof journal pre-proof 4 mir-203a-3p and p66shc compose a novel regulatory pathway in liver fibrosis." 32659284 LncRNA Mical2/miR-203a-3p sponge participates in epithelial-mesenchymal transition by targeting p66Shc in liver fibrosis https://pubmed.ncbi.nlm.nih.gov/32659284/ 2020 liver liver_cirrhosis mus_musculus Pvt1 ENSMUSG00000097039 Ensembl lncrna patched2 demethylation NA HEDGEHOG SIGNALING PATHWAY qRT-PCR; dual-lucimmunofluorescenceerase reporter assay etc. no "Pvt1 epigenetically down-regulates ptch1 expression via competitively binding mir-152, contributing to emt process in liver fibrosis." 27588491 Long non-coding RNA PVT1 activates hepatic stellate cells through competitively binding microRNA-152 https://pubmed.ncbi.nlm.nih.gov/27588491/ 2016 liver liver_cirrhosis mus_musculus Meg3 ENSMUSG00000021268 Ensembl lncrna down-regulation NA NA qRT-PCR; etc. no "Serum level of lncrna-meg3 is lowly expressed in chb patients, which is negatively correlated to the liver fibrotic degree. Lncrna-meg3 may serve as a diagnostic biomarker for chb." 31173310 Diagnostic value of LncRNA-MEG3 as a serum biomarker in patients with hepatitis B complicated with liver fibrosis https://pubmed.ncbi.nlm.nih.gov/31173310/ 2019 liver liver_cirrhosis mus_musculus Mecp2 ENSMUSG00000031393 Ensembl lncrna phosphorylation NA NA sirna transfection; hyaluronic acid quantimmunofluorescenceication yes Strategies to inhibit mecp2 phosphorylation at s80 might be developed for treatment of liver fibrosis. 31352003 Fibrogenic Activity of MECP2 Is Regulated by Phosphorylation in Hepatic Stellate Cells https://pubmed.ncbi.nlm.nih.gov/31352003/ 2019 liver liver_cirrhosis mus_musculus H19 ENSMUSG00000000031 Ensembl lncrna up-regulation NA NA q-PCR; dual-lucimmunofluorescenceerase reporter assay etc. no The activation of hepatic h19rna promoted cholestatic liver fibrosis in mice through the zeb1;Epcam signaling pathway. 28407375 H19 promotes cholestatic liver fibrosis by preventing ZEB1-mediated inhibition of EpCAM https://pubmed.ncbi.nlm.nih.gov/28407375/ 2017 liver liver_cirrhosis mus_musculus Trp53cor1 100504267 Gene lncrna dysregulation LINCRNA-P21 TGF-BETA SIGNALING PATHWAY flow cytometry; H&E staining; etc. no The pleiotropic roles of hepatocyte lincrna-p21 suggest that it may represent an unknown paradigm in liver fibrosis and serve as a potential target for therapy. 28592847 TGF-beta-induced hepatocyte lincRNA-p21 contributes to liver fibrosis in mice https://pubmed.ncbi.nlm.nih.gov/28592847/ 2017 liver liver_cirrhosis mus_musculus Meg3 ENSMUSG00000021268 Ensembl lncrna hypermethylation MEG3 NA qRT-PCR; immunofluorescence etc. yes These findings suggested that meg3 may play an important role in stellate cell activation and liver fibrosis progression and act as a novel potential therapeutic target for liver fibrosis. 25201080 Inhibitory effects of long noncoding RNA MEG3 on hepatic stellate cells activation and liver fibrogenesis https://pubmed.ncbi.nlm.nih.gov/25201080/ 2014 liver liver_cirrhosis mus_musculus HULC 728655 Gene lncrna up-regulation NA NA qRT-PCR; etc. no "We confirmed the effects of hulc on tregs differentiation in hbv-related liver cirrhosis. In addition, it was proved that hulc regulates the function of tregs through down-regulated the level of p18 directly." 25952928 LncRNA HULC affects the differentiation of Treg in HBV-related liver cirrhosis https://pubmed.ncbi.nlm.nih.gov/25952928/ 2015 liver liver_cirrhosis mus_musculus Gpr137b-ps ENSMUSG00000097715 Ensembl lncrna up-regulation LNCRNA GPR137B-PS AND CXCL14 NA NA yes We demonstrated a lncrna gpr137b-ps;Mir-200a-3p;Cxcl14 axis that modulates hsc activation and might exert an effect on the pathogenesis of liver fibrosis. 33069761 A lncRNA Gpr137b-ps/miR-200a-3p/CXCL14 axis modulates hepatic stellate cell (HSC) activation https://pubmed.ncbi.nlm.nih.gov/33069761/ 2021 liver liver_cirrhosis mus_musculus Hottip ENSMUSG00000055408 Ensembl lncrna up-regulation SRF NA q-PCR; dual-lucimmunofluorescenceerase reporter assay etc. no We provide a novel hottip-mir-150-srf signalling cascade in liver fibrosis. 30548190 Long noncoding RNA HOTTIP mediates SRF expression through sponging miR-150 in hepatic stellate cells https://pubmed.ncbi.nlm.nih.gov/30548190/ 2019 liver liver_cirrhosis mus_musculus Xist ENSMUSG00000086503 Ensembl lncrna up-regulation NA NA enzyme-linked immunosorbent assay; qRT-PCR; etc. no Xist enhances ethanol-induced hscs autophagy and activation via mir-29b;Hmgb1 axis. 31418997 Long noncoding RNA XIST enhances ethanol-induced hepatic stellate cells autophagy and activation via miR-29b/HMGB1 axis https://pubmed.ncbi.nlm.nih.gov/31418997/ 2019 lung idiopathic_pulmonary_fibrosis mus_musculus Mir17hg ENSMUSG00000089726 Gene lncrna dysregulation NA NA qRT-PCR; Examination of DNA methylation patterns; Dual-luciferase reporter assay etc. no "Compared with control samples, miR-17~92 expression was reduced in lung biopsies and lung fibroblasts from patients with IPF, whereas DNMT-1 expression and methylation of the miR-17~92 promoter was increased. Several miRNAs from the miR-17~92 cluster targeted DNMT-1 expression resulting in a negative feedback loop. Similarly, miR-17~92 expression was reduced in the lungs of bleomycin-treated mice. Treatment with 5'-aza-2'-deoxycytidine in a murine bleomycin-induced pulmonary fibrosis model reduced fibrotic gene and DNMT-1 expression, enhanced miR-17~92 cluster expression, and attenuated pulmonary fibrosis." 23306545 Epigenetic regulation of miR-17~92 contributes to the pathogenesis of pulmonary fibrosis https://www.atsjournals.org/doi/full/10.1164/rccm.201205-0888OC 2013 lung idiopathic_pulmonary_fibrosis mus_musculus H19 ENSMUSG00000000031 Ensembl lncrna up-regulation Col1a1 NA qRT-PCR; Dual-luciferase reporter assay etc. no "H19 play a promotive role in bleomycin-induced epithelial-mesenchymal transition of alveolar epithelial cell through miR-29b regulation. H19 expression was positively correlated with COL1A1 and Acta2 expression; H19 knockdown inhibited COL1A1 and Acta2 expression. Moreover, H19 interacted with miR-29b through directly binding to the 3'UTR; MiR-29b inhibited COL1A1 expression by directly binding to the 3'UTR. In conclusion, we revealed the promotive effect of H19 on BLM-induced IPF, and demonstrated the mechanism by which H19/miR-29b interaction exerts its effect on regulating pulmonary fibrosis." 27613097 The effect of H19-miR-29b interaction on bleomycin-induced mouse model of idiopathic pulmonary fibrosis https://linkinghub.elsevier.com/retrieve/pii/S0006291X16314772 2016 lung pulmonary_hypertension mus_musculus Mir17hg ENSMUSG00000089726 Gene lncrna down-regulation Pdlim5? NA Isolation of Mouse PASMC; Lentivirus-based miR-17?92 Overexpression in HPASMC; PDLIM5 3'-Untranslated Region Luciferase Reporter Assay no "Human PASMC (HPASMC) from patients with PAH expressed decreased levels of the miR-17 92 cluster, TGF-B, and SMC markers. Knockdown of Smad3 but not Smad2 prevented miR-17 92-induced expression of SMC markers. SMC-specific knockout of miR-17 92 attenuated hypoxia-induced pulmonary hypertension (PH) in mice, whereas reconstitution of miR-17 92 restored hypoxia-induced PH in these mice. PDLIM5 is a direct target of miR-17/20a, and hypertensive HPASMC and mouse PASMC expressed elevated PDLIM5 levels. Suppression of PDLIM5 increased expression of SMC markers and enhanced TGF-B/Smad2/3 activity in vitro and enhanced hypoxia-induced PH in vivo, whereas overexpression of PDLIM5 attenuated hypoxia-induced PH." 25647182 Loss of MicroRNA-17 92 in Smooth Muscle Cells Attenuates Experimental Pulmonary Hypertension via Induction of PDZ and LIM Domain 5 https://www.atsjournals.org/doi/10.1164/rccm.201405-0941OC 2015 lung pulmonary_fibrosis mus_musculus NONMMUT021928.2 URS00009B9A54_10090 RNAcentral lncrna up-regulation miR-18a NA qRT-PCR; Immunohistochemistry etc. no "In the present study, we identified that lncRNA NONMMUT021928, designated as pulmonary fibrosis-associated lncRNA (PFAL), was up-regulated in the lungs of mice with experimental lung fibrosis, and in TGF-beta1-induced fibrotic lung fibroblasts. Further study showed that overexpression of PFAL promoted cell proliferation, migration, and fibroblast-myofibroblast transition. Overexpression further resulted in extracellular matrix deposition and fibrogenesis in lung fibroblasts through regulation of microRNA-18a (miR-18a). Importantly, knockdown of PFAL alleviated lung fibrosis both in vitro and in vivo. Mechanistically, our study showed that PFAL promoted lung-fibroblast activation and fibrogenesis by acting as a competing endogenous RNA for miR-18a: forced expression of PFAL inhibited the expression and activity of miR-18a, whereas silencing of PFAL had the opposite effect. Furthermore, we found that miR-18a was decreased during lung fibrosis in vitro and in vivo, as well as in patients with IPF. Moreover, knockdown of miR-18a led to fibrogenesis in lung fibroblasts, whereas enhanced expression of miR-18a attenuated TGF-beta1-induced lung fibrosis by directly targeting the regulation of connecting tissue growth factor." 29683732 lncRNA PFAL promotes lung fibrosis through CTGF by competitively binding miR-18a https://faseb.onlinelibrary.wiley.com/doi/full/10.1096/fj.201800055R 2018 lung silicosis mus_musculus Chrf 105463121 Gene lncrna up-regulation Myd88; Smad3 NA qRT-PCR; Dual-luciferase reporter assay etc. no "Levels were reduced in both macrophages that were exposed to silica and fibroblasts that were exposed to TGF-B1. MiR-489 inhibited silica-induced pulmonary fibrosis primarily by repressing its target genes MyD88 and Smad3. Moreover, the up-regulated lncRNA cardiac hypertrophy-related factor (CHRF) reversed the inhibitory effect of miR-489 on MyD88 and Smad3 and then triggered the inflammation and fibrotic signaling pathways." 27506999 MiR-489 inhibits silica-induced pulmonary fibrosis by targeting MyD88 and Smad3 and is negatively regulated by lncRNA CHRF https://www.nature.com/articles/srep30921 2016 lung respiratory_distress_syndrome_acute mus_musculus Trp53cor1 100504267 Gene lncrna up-regulation NA NA BAL; qRT-PCR; etc. no LincRNA-p21 expression was time-dependently increased and Thy-1 expression was time-dependently reduced in a mouse model of ARDS and in LPS-treated lung fibroblasts. LincRNA-p21 overexpression dramatically inhibited acetylation of H3 and H4 at the Thy-1 promoter and Thy-1 expression levels in HLF1 cells.LincRNA-p21 interference rescued LPS-induced increase of lung and BAL collagen contents. LincRNA-p21 could lead to pulmonary fibrosis in ARDS by inhibition of the expression of Thy-1. 27392907 Lipopolysaccharide promotes pulmonary fibrosis in acute respiratory distress syndrome (ARDS) via lincRNA-p21 induced inhibition of Thy-1 expression https://link.springer.com/article/10.1007%2Fs11010-016-2745-7 2016 lung respiratory_distress_syndrome_acute mus_musculus Trp53cor1 100504267 Gene lncrna histone deacetylation NA NA BAL; qRT-PCR; etc. no LincRNA-p21 expression was time-dependently increased and Thy-1 expression was time-dependently reduced in a mouse model of ARDS and in LPS-treated lung fibroblasts. LincRNA-p21 overexpression dramatically inhibited acetylation of H3 and H4 at the Thy-1 promoter and Thy-1 expression levels in HLF1 cells.LincRNA-p21 interference rescued LPS-induced increase of lung and BAL collagen contents. LincRNA-p21 could lead to pulmonary fibrosis in ARDS by inhibition of the expression of Thy-1. 27392907 Lipopolysaccharide promotes pulmonary fibrosis in acute respiratory distress syndrome (ARDS) via lincRNA-p21 induced inhibition of Thy-1 expression https://link.springer.com/article/10.1007%2Fs11010-016-2745-7 2016 lung idiopathic_pulmonary_fibrosis mus_musculus H19 ENSMUSG00000000031 Ensembl lncrna interact with miRNA Lsp1; Tnnt3; Mrpl23; Igf2; AC013548.1 NA qPCR; Knockdown etc. no "Moreover, H19 interacted with miR-29b through directly binding to the 3'UTR; miR-29b inhibited COL1A1 expression by directly binding to the 4'UTR." 27613097 The effect of H19-miR-29b interaction on bleomycin-induced mouse model of idiopathic pulmonary fibrosis https://linkinghub.elsevier.com/retrieve/pii/S0006291X16314772 2016 lung idiopathic_pulmonary_fibrosis mus_musculus Hoxaas3 ENSMUSG00000085696 Ensembl lncrna dysregulation NA NA Immunohistochemistry; Immunofluorescence; etc. no Overexpression of uc.77 or 2700086A05Rik in human lung epithelial cells induced EMT as demonstrated by changes in gene and protein expression of various EMT markers and cell morphology. 26824344 Integrated long non-coding RNA analyses identify novel regulators of epithelial-mesenchymal transition in the mouse model of pulmonary fibrosis https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4929291/ 2016 liver liver_cirrhosis mus_musculus Gpr137b-ps ENSMUSG00000097715 Ensembl lncrna up-regulation LNCRNA GPR137B-PS AND CXCL14 NA NA yes We demonstrated a lncrna gpr137b-ps;Mir-200a-3p;Cxcl14 axis that modulates hsc activation and might exert an effect on the pathogenesis of liver fibrosis. 33069761 A lncRNA Gpr137b-ps/miR-200a-3p/CXCL14 axis modulates hepatic stellate cell (HSC) activation https://pubmed.ncbi.nlm.nih.gov/33069761/ 2021 heart endomyocardial_fibrosis mus_musculus Sail NA NA lncrna down-regulation NA TGF-BETA SIGNALING PATHWAY NA no "SAIL inhibited the fibrotic process by directly binding with SAFB via 23 conserved nucleotide sequences, in turn blocked the access of SAFB to RNA pol II (RNA polymerase II) and reduced the transcription of fibrosis-related genes. Intriguingly,the human conserved fragment of SAIL (hSAIL) significantly suppressed the proliferation and collagen production of human cardiac fibroblasts." 33675440 SAIL: a new conserved anti-fibrotic lncRNA in the heart https://pubmed.ncbi.nlm.nih.gov/33675440/ 2021 kidney kidney_failure_chronic mus_musculus Zfas1 ENSMUSG00000074578 Ensembl lncrna up-regulation NA WNT SIGNALING PATHWAY dual-luciferase reporter assay no LncRNA ZFAS1 from HCM could promote cardiac fibrosis through WNT/beta-catenin signal via exosome pathways. 33640882 Exosome-derived long non-coding RNA ZFAS1 controls cardiac fibrosis in chronic kidney disease https://pubmed.ncbi.nlm.nih.gov/33640882/ 2021 lung pulmonary_fibrosis mus_musculus NONMMUT060091 NA NA lncrna down-regulation SRSF1 NA qRT-PCR; Immunofluorescence; Western Blot etc. no "A series of molecular assays to assess the role of the novel lncRNA NONMMUT060091, designated as pulmonary fibrosis inhibitor (PFI), which was significantly downregulated in lung fibrosis. Functionally, knockdown of endogenous PFI by smart silencer promoted proliferation, differentiation, and extracellular matrix (ECM) deposition in primary mouse lung fibroblasts (MLFs)." 33981019 The long non-coding RNA PFI protects against pulmonary fibrosis by interacting with splicing regulator SRSF1 https://pubmed.ncbi.nlm.nih.gov/33981019/ 2021 heart myocardial_infarction mus_musculus Mhrt ENSMUSG00000097652 Ensembl lncrna up-regulation NA NA qRT-PCR;western blot;MTT and EdU assays etc. no "Overexpression of MHRT promoted collagen production and CF proliferation, while silencing of MHRT showed the opposite effect." 34334583 LncRNA MHRT Promotes Cardiac Fibrosis via miR-3185 Pathway Following Myocardial Infarction https://pubmed.ncbi.nlm.nih.gov/34334583/ 2021 heart acute_myocardial_infarction mus_musculus Norad ENSMUSG00000102869 Ensembl lncrna up-regulation NA NA RT-qRT-PCR;flow cytometry;western blot no NORAD aggravates acute myocardial infarction by promoting fibrosis and apoptosis via the miR-577/COBLL1 axis. 34355838 Long non-coding RNA NORAD aggravates acute myocardial infarction by promoting fibrosis and apoptosis via miR-577/COBLL1 axis https://pubmed.ncbi.nlm.nih.gov/34355838/ 2021 heart diabetic_cardiomyopathy mus_musculus Norad ENSMUSG00000102869 Ensembl lncrna down-regulation NA NA NA no NORAD lentivirus shRNA improved cardiac function and fibrosis and reduced inflammatory responses in diabetic cardiomyopathy mice via the ceRNA network of NORAD/miR-125a-3p/Fyn. 34591118 NORAD lentivirus shRNA mitigates fibrosis and inflammatory responses in diabetic cardiomyopathy via the ceRNA network of NORAD/miR-125a-3p/Fyn https://pubmed.ncbi.nlm.nih.gov/34591118/ 2021 heart diabetic_cardiomyopathy mus_musculus Gas5 ENSMUSG00000053332 Ensembl lncrna up-regulation NA NA qRT-PCR;luciferase reporter assay;RNA immunoprecipitation assay no GAS5 promotes diabetic cardiomyopathy progression by regulating miR-26a/b-5p. 34091757 Silencing lncRNA GAS5 alleviates apoptosis and fibrosis in diabetic cardiomyopathy by targeting miR-26a/b-5p https://pubmed.ncbi.nlm.nih.gov/34091757/ 2021 heart heart_failure mus_musculus Snhg20 ENSMUSG00000086859 Ensembl lncrna down-regulation miR-335 NA qRT-PCR; Cell Counting Kit-8 assays;dual-luciferase reporter assay etc. no "Downregulation of SNHG20 effectively enhanced cell viability and decreased cell size of HL-1 cells and the expression levels of fibrosis-related proteins (fibronectin, collagen IaI, and alpha-SMA) and apoptosis-related proteins (cleaved caspase-3 and cleaved PARP), which were induced by angiotensin II treatment." 34228494 Inhibition of Long Noncoding RNA SNHG20 Improves Angiotensin II-Induced Cardiac Fibrosis and Hypertrophy by Regulating the MicroRNA 335/ Galectin-3 Axis https://pubmed.ncbi.nlm.nih.gov/34228494/ 2021 heart myocardial_infarction mus_musculus Malat1 ENSMUSG00000092341 Ensembl lncrna up-regulation miR-25-3p NA NA no "MALAT1 sponged miR-25-3p to upregulate CDC42. miR-25-3p overexpression promoted oxygen-glucose deprivation-treated cell viability, proliferation, and angiogenesis." 34745428 M1 Bone Marrow-Derived Macrophage-Derived Extracellular Vesicles Inhibit Angiogenesis and Myocardial Regeneration Following Myocardial Infarction via the MALAT1/MicroRNA-25-3p/CDC42 Axis https://pubmed.ncbi.nlm.nih.gov/34745428/ 2021 heart atrial_fibrosis mus_musculus Nron ENSMUSG00000086484 Ensembl lncrna down-regulation miR-23a NA NA no NRON promotes M2 macrophage polarization and alleviates atrial fibrosis through suppressing exosomal miR-23a derived from atrial myocytes. 33246743 LncRNA NRON promotes M2 macrophage polarization and alleviates atrial fibrosis through suppressing exosomal miR-23a derived from atrial myocytes https://pubmed.ncbi.nlm.nih.gov/33246743/ 2021 heart myocardial_infarction mus_musculus Snhg7 72091 Gene lncrna up-regulation miR-455-3p NA qRT-PCR;western blot;flow cytometry etc. no "LncRNA SNHG7 depletion exerted protective roles in apoptosis, fibrosis, and inflammation in Ang-II-induced cardiac fibroblasts by regulating miR-455-3p/PTAFR axis, providing a potential molecular target for myocardial infarction therapy." 33929392 Long Noncoding RNA Small Nuclear RNA Host Gene 7 Knockdown Protects Mouse Cardiac Fibroblasts Against Myocardial Infarction by Regulating miR-455-3p/Platelet-Activating Factor Receptor Axis https://pubmed.ncbi.nlm.nih.gov/33929392/ 2021 heart myocardial_infarction mus_musculus Miat ENSMUSG00000097767 Ensembl lncrna up-regulation NA NA qRT-PCR;western blot no "Ablation of Miat attenuates pathological hypertrophy and heart failure, in part, by enhancing cardiomyocyte contractility." 34335976 Ablation of lncRNA Miat attenuates pathological hypertrophy and heart failure https://pubmed.ncbi.nlm.nih.gov/34335976/ 2021 kidney renal_fibrosis mus_musculus Gas5 ENSMUSG00000053332 Ensembl lncrna down-regulation NA NA NA no "Long noncoding RNA growth arrest-specific 5 (GAS5), acting in a renoprotective role via the Smad3/miRNA-142-5p axis, that modulates extracellular matrix formation and cell apoptosis." 34486400 LncRNA GAS5 protects against TGF-beta-induced renal fibrosis via the Smad3/miRNA-142-5p axis https://pubmed.ncbi.nlm.nih.gov/34486400/ 2021 kidney diabetic_nephropathy mus_musculus Isg20 ENSMUSG00000039236 Ensembl lncrna up-regulation NA NA RT-qRT-PCR;western blot;luciferase reporter assay etc. no Lnc-ISG20 promotes the renal fibrosis process in diabetic nephropathy by activating AKT through the miR-486-5p/NFAT5 axis. 33939247 LncRNA lnc-ISG20 promotes renal fibrosis in diabetic nephropathy by inducing AKT phosphorylation through miR-486-5p/NFAT5 https://pubmed.ncbi.nlm.nih.gov/33939247/ 2021 kidney renal_fibrosis mus_musculus Xist ENSMUSG00000086503 Ensembl lncrna up-regulation miR-19b NA qRT-PCR;western blot;histology no Knockdown of XIST inhibited apoptosis and inflammation of renal fibrosis via miR-19b-mediated downregulation of SOX6. 34461493 Knockdown of lncRNA XIST inhibited apoptosis and inflammation in renal fibrosis via microRNA-19b-mediated downregulation of SOX6 https://pubmed.ncbi.nlm.nih.gov/34461493/ 2021 kidney diabetic_nephropathy mus_musculus Rmrp ENSMUSG00000088088 Ensembl lncrna up-regulation NA NA NA no Sp1 induced lncRNA Rmrp could drive the expression of JunD via sponging miR-1a-3p in diabetic nephropathy progression. 34512545 Sp1-Induced lncRNA Rmrp Promotes Mesangial Cell Proliferation and Fibrosis in Diabetic Nephropathy by Modulating the miR-1a-3p/JunD Pathway https://pubmed.ncbi.nlm.nih.gov/34512545/ 2021 kidney diabetic_nephropathy mus_musculus Sox2ot ENSMUSG00000105265 Ensembl lncrna down-regulation NA PI3K-AKT SIGNALING PATHWAY immunohistochemistry;immunofluorescence;western blot etc. no LncRNA SOX2OT alleviates the pathogenesis of diabetic nephropathy via regulating Akt/mTOR-mediated autophagy. 34238205 LncRNA SOX2OT alleviates mesangial cell proliferation and fibrosis in diabetic nephropathy via Akt/mTOR-mediated autophagy https://pubmed.ncbi.nlm.nih.gov/34238205/ 2021 kidney chronic_kidney_disease mus_musculus H19 ENSMUSG00000000031 Ensembl lncrna up-regulation NA WNT SIGNALING PATHWAY qRT-PCR;western blot;dual-luciferase reporter etc. no LncRNA-H19 overexpression significantly upregulates Wnt1 and beta-catenin expression in kidney tissues and fibroblasts of mice. 34818249 The Long Noncoding RNA-H19 Mediates the Progression of Fibrosis from Acute Kidney Injury to Chronic Kidney Disease by Regulating the miR-196a/Wnt/beta-Catenin Signaling https://pubmed.ncbi.nlm.nih.gov/34818249/ 2022 kidney acute_kidney_injury mus_musculus H19 ENSMUSG00000000031 Ensembl lncrna up-regulation NA WNT SIGNALING PATHWAY qRT-PCR;western blot;dual-luciferase reporter etc. no LncRNA-H19 overexpression significantly upregulates Wnt1 and beta-catenin expression in kidney tissues and fibroblasts of mice. 34818249 The Long Noncoding RNA-H19 Mediates the Progression of Fibrosis from Acute Kidney Injury to Chronic Kidney Disease by Regulating the miR-196a/Wnt/beta-Catenin Signaling https://pubmed.ncbi.nlm.nih.gov/34818249/ 2022 kidney diabetic_nephropathy mus_musculus Malat1 ENSMUSG00000092341 Ensembl lncrna up-regulation NA NA the luciferase reporter gene;pull-down assays no MALAT1 overexpression may enhance renal fibrosis in diabetic rats and cell damage in high glucose-induced HK-2 cells via the miR-2355-3p/IL6ST axis. 33995063 lncRNA MALAT1 Promotes Renal Fibrosis in Diabetic Nephropathy by Targeting the miR-2355-3p/IL6ST Axis https://pubmed.ncbi.nlm.nih.gov/33995063/ 2021 kidney diabetic_nephropathy mus_musculus Dlx6os1 ENSMUSG00000090063 Ensembl lncrna up-regulation SOX6 NA ELISA;RT-qRT-PCR;western blot etc. no LncRNA Dlx6os1 accelerates the progression of diabetic nephropathy by epigenetically repressing SOX6 via recruiting EZH2. 35038705 LncRNA Dlx6os1 Accelerates Diabetic Nephropathy Progression by Epigenetically Repressing SOX6 via Recruiting EZH2 https://pubmed.ncbi.nlm.nih.gov/35038705/ 2022 kidney diabetic_nephropathy mus_musculus ANRIL ENSMUSG00000086035 Ensembl lncrna down-regulation NA NA NA no "Lnc-ANRIL knock-down suppresses mouse mesangial cell proliferation, fibrosis, inflammation, Wnt/beta-catenin and MEK/ERK pathways in diabetic nephropathy." 32726814 "Knock-Down of Long Non-Coding RNA ANRIL Suppresses Mouse Mesangial Cell Proliferation, Fibrosis, Inflammation via Regulating Wnt/beta-Catenin and MEK/ERK Pathways in Diabetic Nephropathy" https://pubmed.ncbi.nlm.nih.gov/32726814/ 2022