Tissue Disease Species symbol ID Platform Type Expression Target Pathway Method Drug Function PMID Title Year bone primary_myelofibrosis homo_sapiens MIR34A 407040 Gene miRNA up-regulation NA NA immunophenotypic analysis; qRT-PCR; etc. no "Collectively our data unravel the role of mir-34a-5p in hpcs fate decision and suggest that the increased expression of mir-34a-5p in pmf hpcs could be important for the skewing of megakaryopoiesis and the production of monocytes, that are key players in bm fibrosis in pmf patients." 28098757 Role of miR-34a-5p in Hematopoietic Progenitor Cells Proliferation and Fate Decision: Novel Insights into the Pathogenesis of Primary Myelofibrosis 2017 bone primary_myelofibrosis homo_sapiens mir-155 MI0000681 miRBase miRNA up-regulation JARID2; NR4A3; CDC42; HMGB3 NA NA no These findings suggest that overexpression of mir-155-5p and the resulting downregulation of jarid2 may contribute to mk hyperplasia in pmf. 25097177 MiRNA-mRNA integrative analysis in primary myelofibrosis CD34+ cells: role of miR-155/JARID2 axis in abnormal megakaryopoiesis 2014 cell_line neurofibromatosis homo_sapiens mir-10b MI0000267 miRBase miRNA up-regulation NF1 NA microarray; qRT-PCR; etc. no These results suggest that mir-10b may play an important role in nf1 tumorigenesis through targeting neurofibromin and ras signaling. 20550523 MicroRNA-10b regulates tumorigenesis in neurofibromatosis type 1 2010 cell_line neurofibromatosis homo_sapiens mir-103a-1 MI0000109 miRBase miRNA up-regulation NA NA RT-PCR; dual-lucimmunofluorescenceerase reporter assay; etc. no "Using reporter assays, we provided evidence that mir-128 and to a lesser extent mir-137 and mir-103 reduced neurofibromin 1 reporter levels through specific binding to nf1 3-utr. Mutations in all three predicted binding sites eliminated the reporter response. Mir-128 and mir-137, unlike mir-103 that showed a more ubiquitous expression, were predominantly expressed in brain with a distribution that resembled neurofibromin 1 expression in different tissues as well as during the course of neuronal development. In the nervous system, all three micrornas showed highest expression in neurons and least in schwann cells and astrocytes. Overexpression of mir-128 alone or with mir-103 and mir-137 significantly reduced endogenous neurofibromin 1 protein levels, while antisense inhibition of these micrornas enhanced translation of endogenous neurofibromin 1 and reporter in primary cultures of hippocampal neurons." 23056445 Neurofibromin 1 is a miRNA target in neurons 2012 cell_line neurofibromatosis homo_sapiens mir-128-1 MI0000447 miRBase miRNA up-regulation NA NA RT-PCR; dual-lucimmunofluorescenceerase reporter assay; etc. no "Using reporter assays, we provided evidence that mir-128 and to a lesser extent mir-137 and mir-103 reduced neurofibromin 1 reporter levels through specific binding to nf1 3-utr. Mutations in all three predicted binding sites eliminated the reporter response. Mir-128 and mir-137, unlike mir-103 that showed a more ubiquitous expression, were predominantly expressed in brain with a distribution that resembled neurofibromin 1 expression in different tissues as well as during the course of neuronal development. In the nervous system, all three micrornas showed highest expression in neurons and least in schwann cells and astrocytes. Overexpression of mir-128 alone or with mir-103 and mir-137 significantly reduced endogenous neurofibromin 1 protein levels, while antisense inhibition of these micrornas enhanced translation of endogenous neurofibromin 1 and reporter in primary cultures of hippocampal neurons." 23056445 Neurofibromin 1 is a miRNA target in neurons 2012 cell_line neurofibromatosis homo_sapiens mir-137 MI0000454 miRBase miRNA up-regulation NA NA RT-PCR; dual-lucimmunofluorescenceerase reporter assay; etc. no "Using reporter assays, we provided evidence that mir-128 and to a lesser extent mir-137 and mir-103 reduced neurofibromin 1 reporter levels through specific binding to nf1 3-utr. Mutations in all three predicted binding sites eliminated the reporter response. Mir-128 and mir-137, unlike mir-103 that showed a more ubiquitous expression, were predominantly expressed in brain with a distribution that resembled neurofibromin 1 expression in different tissues as well as during the course of neuronal development. In the nervous system, all three micrornas showed highest expression in neurons and least in schwann cells and astrocytes. Overexpression of mir-128 alone or with mir-103 and mir-137 significantly reduced endogenous neurofibromin 1 protein levels, while antisense inhibition of these micrornas enhanced translation of endogenous neurofibromin 1 and reporter in primary cultures of hippocampal neurons." 23056445 Neurofibromin 1 is a miRNA target in neurons 2012 eye cataract homo_sapiens mir-30a MI0000088 miRBase miRNA down-regulation SNAI1 NA q-PCR; dual-lucimmunofluorescenceerase reporter assay etc. no "It is concluded that emt is involved in human diabetic cataract, and upregulation of mir-30a can repress emt through its targeting of snai1 in lens epithelial cells, which make mir-30a a novel target of therapeutic intervention for human diabetic cataract." 28442786 MicroRNA-30a Regulation of Epithelial-Mesenchymal Transition in Diabetic Cataracts Through Targeting SNAI1 2017 eye lens_fibrosis homo_sapiens mir-146a MI0000477 miRBase miRNA down-regulation NA NA qRT-PCR; no "Mir-146a plays a role as a negative regulator in the production of tgf-beta-induced fibrotic markers. Thus, mir-146a may be involved in the regulation of fibrosis in orbital fibroblasts from patients with go." 29101123 Role of microRNA-146a in regulation of fibrosis in orbital fibroblasts from patients with Graves' orbitopathy 2018 eye vitreoretinopathy_proliferative homo_sapiens mir-34a MI0000268 miRBase miRNA up-regulation LGR4 NA dual-lucimmunofluorescenceerase reporter assay; immunofluorescence; etc. no "Mir-34a gene expression upregulation inhibits arpe-19 cell proliferation, migration and adhesion partly by suppressing lgr4 expression. These results substantiate earlier indications that both mir-34a and lgr4 are potential drug targets to prevent fibrosis in a clinical setting." 27977785 LGR4 Is a Direct Target of MicroRNA-34a and Modulates the Proliferation and Migration of Retinal Pigment Epithelial ARPE-19 Cells 2016 eye proliferative_diabetic_retinopathy homo_sapiens mir-34a MI0000268 miRBase miRNA up-regulation LGR4 NA dual-lucimmunofluorescenceerase reporter assay; immunofluorescence; etc. no "Mir-34a gene expression upregulation inhibits arpe-19 cell proliferation, migration and adhesion partly by suppressing lgr4 expression. These results substantiate earlier indications that both mir-34a and lgr4 are potential drug targets to prevent fibrosis in a clinical setting." 27977785 LGR4 Is a Direct Target of MicroRNA-34a and Modulates the Proliferation and Migration of Retinal Pigment Epithelial ARPE-19 Cells 2016 eye conjunctival_fibrosis homo_sapiens mir-200a MI0000737 miRBase miRNA dna methylation NA NA qRT-PCR; immunoblot; immunocytochemistry etc. no "Our results indicate that dna demethylation of promoters of mir-200 loci is critically important for stopping and reverting the emt in human conjunctival epithelial cells, suggesting the potential for the development of novel epigenetic-based therapeutic strategies for treating conjunctival conditions associated with emt." 32387379 DNA methylation of miR-200 clusters promotes epithelial to mesenchymal transition in human conjunctival epithelial cells 2020 eye proliferative_vitreoretinal_disease homo_sapiens mir-21a MI0000569 miRBase miRNA dysregulation NA NA qRT-PCR; cell migration assay; immunocytocH&E stainingmical analysis etc. no Our studies have identified mir-21 as a potential disease-modifying mirna in the vitreous humor that is involved in the development of retinal fibrosis and may be a novel marker of pvd. 27351379 Pregulation of Mir-21 Levels in the Vitreous Humor Is Associated with Development of Proliferative Vitreoretinal Disease 2016 eye conjunctival_fibrosis homo_sapiens mir-143 MI0000459 miRBase miRNA dysregulation NA NA RT-PCR; dual-lucimmunofluorescenceerase reporter assay etc. no "Tgf-beta1-induced human subconjunctival fibrosis was mediated by the expression of microrna 143;145, Mainly via smad-independent pathways. Inhibition of tgf-beta1-induced microrna 143;145 Expression in htfs might represent a novel strategy to prevent subconjunctival fibrosis." 31081880 Transforming Growth Factor-beta1-induced Human Subconjunctival Fibrosis is Mediated by MicroRNA 143/145 Expression 2019 eye white_dot_syndromes homo_sapiens mir-34a MI0000268 miRBase miRNA up-regulation KLOTHO NA NA no "The hif-1alfa;P53;Mirna-34a;Klotho axis in rpe cells promoted subretinal fibrosis, thus aggravating the formation of cnv." 33438362 The HIF-1alfa/p53/miRNA-34a/Klotho axis in retinal pigment epithelial cells promotes subretinal fibrosis and exacerbates choroidal neovascularization 2021 eye lens_fibrosis homo_sapiens mir-21a MI0000569 miRBase miRNA dysregulation MIRNA-21? TGF-BETA SIGNALING PATHWAY; SMAD SIGNALING PATHWAY RT-PCR; cell prolimmunofluorescenceeration etc. no "The present study shows that mir-21 regulates cell proliferation, apoptosis, and differentiation in orbital fibroblasts from tao, and acts as a mediator in tgf-beta1-induced collagen production. These data predict a close association between mir-21 and orbital muscle fibrosis, and provide a novel therapeutic target for tao." 25873777 MiRNA-21 promotes fibrosis in orbital fibroblasts from thyroid-associated ophthalmopathy 2015 eye cataract homo_sapiens miR-22-3p MIMAT0000077 miRBase miRNA a-tubulin acetylation HDAC 6 NA immunofluorescence; q-PCR; etc. no These findings suggest that mir-22-3p prevents lens fibrotic progression by targeting hdac6 thereby promoting alfa-tubulin acetylation. The 'mir-22-hdac6-alfa-tubulin (de)acetylation' signalling axis may be therapeutic targets for the treatment of fibrotic cataract. 32985730 MiR-22-3p inhibits fibrotic cataract through inactivation of HDAC6 and increase of alfa-tubulin acetylation 2020 eye glaucoma homo_sapiens mir-139 MI0000261 miRBase miRNA dysregulation NA WNT SIGNALING PATHWAY; CATENIN BETA 1 RT-PCR; immunofluorescence; dual-lucimmunofluorescenceerase reporter assay etc. no "We demonstrated a new mechanism of htf activation and proliferation from the perspective of mirna regulation, which may provide new strategies for improving the fibrosis after the glaucoma filtration surgery." 30648255 The Smad2/3/4 complex binds miR-139 promoter to modulate TGFbeta-induced proliferation and activation of human Tenon's capsule fibroblasts through the Wnt pathway 2019 eye lens_fibrosis homo_sapiens mir-26a-1 MI0000083 miRBase miRNA dysregulation JAGGED-1 JAG1; NOTCH SIGNALING PATHWAY RT-PCR; dual-lucimmunofluorescenceerase reporter assay etc. no "We revealed that the mechanisms of anti-emt effects of mir-26a and -26b are via directly targeting jagged-1 and suppressing jagged-1;Notch signaling. Furthermore, we provided in vitro and in vivo evidence that jagged-1;Notch signaling is activated in tgfbeta2-stimulated emt, and blockade of notch signaling can reverse lens epithelial cells (lecs) emt and lens fibrosis.?" 28622289 MicroRNA-26a and -26b inhibit lens fibrosis and cataract by negatively regulating Jagged-1/Notch signaling pathway 2017 eye lens_fibrosis homo_sapiens mir-26b MI0000084 miRBase miRNA dysregulation JAGGED-1 JAG1; NOTCH SIGNALING PATHWAY RT-PCR; dual-lucimmunofluorescenceerase reporter assay etc. no "We revealed that the mechanisms of anti-emt effects of mir-26a and -26b are via directly targeting jagged-1 and suppressing jagged-1;Notch signaling. Furthermore, we provided in vitro and in vivo evidence that jagged-1;Notch signaling is activated in tgfbeta2-stimulated emt, and blockade of notch signaling can reverse lens epithelial cells (lecs) emt and lens fibrosis.?" 28622289 MicroRNA-26a and -26b inhibit lens fibrosis and cataract by negatively regulating Jagged-1/Notch signaling pathway 2017 eye corneal_scarring homo_sapiens mir-145 MI0000461 miRBase miRNA dysregulation MIR-145 NA RT-PCR; immunofluorescence etc. no We suggest mir-145 as a promising therapeutic target for mirna-based gene therapy to prevent or treat visual loss caused by corneal fibrosis. 26165705 MiR-145 Is a Promising Therapeutic Target to Prevent Cornea Scarring 2015 heart endomyocardial_fibrosis homo_sapiens mir-208a MI0000251 miRBase miRNA up-regulation NA TGF-BETA SIGNALING PATHWAY NA no Cyclic mechanical stretch enhances miR208a expression in cultured rat cardiac myoblasts. The stretch-induced miR208a is mediated by TGF-beta. miR208a activates endoglin expression and may result in cardiac fibrosis. 22941949 Mechanical stretch via transforming growth factor-beta1 activates microRNA208a to regulate endoglin expression in cultured rat cardiac myoblasts 2013 heart endomyocardial_fibrosis homo_sapiens mir-367 MI0000775 miRBase miRNA down-regulation CD69 NA dual-luciferase reporter assay; qRT-PCR; etc. no Decrease in miR-367-3p levels may be associated with cardiac fibrosis. 30015935 Dysregulation of CD69 by overexpression of microRNA-367-3p associated with post-myocardial infarction cardiac fibrosis 2018 heart aortic_coarctation homo_sapiens mir-19b-1 MI0000074 miRBase miRNA down-regulation NA NA Echocardiography no Decreased miR-19b may be involved in myocardial lox up-regulation and excessive CCL. 28091585 MicroRNA-19b is a potential biomarker of increased myocardial collagen cross-linking in patients with aortic stenosis and heart failure 2017 heart myocardical_ischemia homo_sapiens mir-126 MI0000471 miRBase miRNA down-regulation NA NA immunofluorescence; PCR etc. no Decreasing miR-126 expression may contribute to cardiac dysfunction after stroke in mice. 28101763 MiR-126 Affects Brain-Heart Interaction after Cerebral Ischemic Stroke 2018 heart endomyocardial_fibrosis homo_sapiens mir-29a MI0000087 miRBase miRNA down-regulation NA NA PCR; dual-luciferase reporter assay etc. no "Down-regulation of miR-29 with anti-miRs in vitro and in vivo induces the expression of collagens, whereas over-expression of miR-29 in fibroblasts reduces collagen expression." 18723672 Dysregulation of microRNAs after myocardial infarction reveals a role of miR-29 in cardiac fibrosis 2008 heart diabetic_cardiomyopathy homo_sapiens mir-30c-2 MI0000254 miRBase miRNA down-regulation CDC42;PAK1 NA NA no Downregulation of miR-30c mediates prohypertrophic effects of hyperglycemia in diabetes cardiomyopathy (DCM) by upregulation of Cdc42 and Pak1 genes. 25781190 MiR-30c Mediates Upregulation of Cdc42 and Pak1 in Diabetic Cardiomyopathy 2015 heart diabetic_cardiomyopathy homo_sapiens mir-30c-1 MI0000736 miRBase miRNA down-regulation CDC42;PAK1 NA NA no Downregulation of miR-30c mediates prohypertrophic effects of hyperglycemia in diabetes cardiomyopathy (DCM) by upregulation of Cdc42 and Pak2 genes. 25781190 MiR-30c Mediates Upregulation of Cdc42 and Pak1 in Diabetic Cardiomyopathy 2015 heart cardiomegaly homo_sapiens mir-133a-1 MI0000450 miRBase miRNA down-regulation NA NA PCR; CHIP etc. no "HDAC inhibition prevented this significant decrease 2 weeks post tac and maintained miR-133a expression,and the study revealed that a decrease in connective tissue growth factor expression,a reduction in cardiac fibrosis and left atrium diameter." 26371176 HDACs Regulate miR-133a Expression in Pressure Overload Induced Cardiac Fibrosis 2015 heart cardiomegaly homo_sapiens mir-133a-1 MI0000450 miRBase miRNA down-regulation NA NA PCR; CHIP etc. no "HDAC inhibition prevented this significant decrease 2 weeks post tac and maintained miR-134a expression,and the study revealed that a decrease in connective tissue growth factor expression,a reduction in cardiac fibrosis and left atrium diameter." 26371176 HDACs Regulate miR-133a Expression in Pressure Overload Induced Cardiac Fibrosis 2015 heart heart_failure homo_sapiens mir-377 MI0000785 miRBase miRNA up-regulation NA NA PCR no "Heart failure(HF) increased miR-377 expression in the myocardium, which is detrimental to stem cell function, and transplantation of miR-377 knockdown HCD34(+) cells into ischemic myocardium promoted their angiogenic ability, attenuating left ventricular remodeling and cardiac fibrosis." 26564600 Enhanced Cardiac Regenerative Ability of Stem Cells After Ischemia-Reperfusion Injury: Role of Human CD34+ Cells Deficient in MicroRNA-377 2015 heart cardiomegaly homo_sapiens mir-221 MI0000298 miRBase miRNA down-regulation NA TGF-BETA SIGNALING PATHWAY NA no Heart failure-associated downregulation of the miRNA-221/222 family enables profibrotic signaling in the pressure-overloaded heart. 29255073 MicroRNA-221/222 Family Counteracts Myocardial Fibrosis in Pressure Overload-Induced Heart Failure 2018 heart cardiomegaly homo_sapiens mir-222 MI0000299 miRBase miRNA down-regulation NA TGF-BETA SIGNALING PATHWAY NA no Heart failure-associated downregulation of the miRNA-221/222 family enables profibrotic signaling in the pressure-overloaded heart. 29255073 MicroRNA-221/222 Family Counteracts Myocardial Fibrosis in Pressure Overload-Induced Heart Failure 2018 heart atrial_fibrillation homo_sapiens mir-4443 MI0016786 miRBase miRNA down-regulation THBS1 TGF-BETA SIGNALING PATHWAY dual-luciferase reporter assay; etc. no Hsa-miR-4443 protected atrial fibrillation(AF) by targeting THBS1 and regulated TGF-beta/alfa-SMA/collagen pathway to inhibit HCFB proliferation and collagen synthesis. 33681892 Hsa-miR-4443 inhibits myocardial fibroblast proliferation by targeting THBS1 to regulate TGF-beta1/alpha-SMA/collagen signaling in atrial fibrillation 2021 heart myocardical_ischemia homo_sapiens mir-377 MI0000785 miRBase miRNA down-regulation VEGF NA dual-luciferase reporter assay; no "Hypoxia-responsive miR-377 directly targets vegf in mesenchymal stem cells (MSCs), and knockdown of endogenous miR-378 promotes MSC-induced angiogenesis in the infarcted myocardium." 25251394 MicroRNA-377 regulates mesenchymal stem cell-induced angiogenesis in ischemic hearts by targeting VEGF 2014 heart atrial_fibrillation homo_sapiens mir-210 MI0000286 miRBase miRNA up-regulation FOXP3 NA qRT-PCR; H&E staining etc. no IL-6-miR-210 suppresses regulatory T cell function and promotes atrial fibrosis by targeting FOXP3. 32345003 IL-6-miR-210 Suppresses Regulatory T Cell Function and Promotes Atrial Fibrosis by Targeting Foxp3 2020 heart endomyocardial_fibrosis homo_sapiens mir-34a MI0000268 miRBase miRNA up-regulation NA VEGF SIGNALING PATHWAY PCR; dual-luciferase reporter assay etc. no "Improved outcome in lna-antimiR-34-treated myocardial infarction (MI) and transverse aortic constriction (TAC) mice was accompanied by up-regulation of several direct miR-34 targets, including vascular endothelial growth factors, vinculin, protein o-fucosyltranferase 1, NOTCH1, and semaphorin 4b, silencing of the entire miR-34 family can protect the heart against pathological cardiac remodeling and improve function." 23047694 Therapeutic inhibition of the miR-34 family attenuates pathological cardiac remodeling and improves heart function 2012 heart endomyocardial_fibrosis homo_sapiens mir-34c MI0000743 miRBase miRNA up-regulation NA VEGF SIGNALING PATHWAY PCR; dual-luciferase reporter assay etc. no "Improved outcome in lna-antimiR-34-treated myocardial infarction (MI) and transverse aortic constriction (TAC) mice was accompanied by up-regulation of several direct miR-34 targets, including vascular endothelial growth factors, vinculin, protein o-fucosyltranferase 1, NOTCH1, and semaphorin 4b, silencing of the entire miR-35 family can protect the heart against pathological cardiac remodeling and improve function." 23047694 Therapeutic inhibition of the miR-34 family attenuates pathological cardiac remodeling and improves heart function 2012 heart endomyocardial_fibrosis homo_sapiens mir-27b MI0000440 miRBase miRNA up-regulation FBW7 NA MTT ASSAY no Inhibition of miR-27b abrogated the coronary artery ligation (CAL) induced cardiac fibrosis in vivo. 31881012 MicroRNA 27b promotes cardiac fibrosis by targeting the FBW7/Snail pathway 2019 heart endomyocardial_fibrosis homo_sapiens mir-652 MI0003667 miRBase miRNA up-regulation JAGGED-1 NA Echocardiography; PCR etc. no Jagged1 (a notch1 ligand) as a novel direct target of miR-652.miR-652 protects the heart against pathological remodeling and improves heart function. 25145628 Therapeutic silencing of miR-652 restores heart function and attenuates adverse remodeling in a setting of established pathological hypertrophy 2014 heart endomyocardial_fibrosis homo_sapiens let-7i MI0000434 miRBase miRNA down-regulation IL-6 COLLAGEN NA PCR; immunohistochemistry etc. no Let-7i acts as a novel negative regulator of angiotensin ii-induced cardiac inflammation and fibrosis by suppressing the expression of interleukin-6 and multiple collagens in the heart. 26259595 MicroRNA Let-7i Negatively Regulates Cardiac Inflammation and Fibrosis 2015 heart myocardial_infarction homo_sapiens mir-153-2 MI0000464 miRBase miRNA down-regulation NA VEGF SIGNALING PATHWAY enzyme-linked immunosorbent assay; no Mesenchymal stem cells (MSCs)-derived exosomes with low-expressed miR-153-3p notably promotes the activation of angpt1 and the VEGF/CEGFR2 /PI3k/Akt/Enos pathways. 33164880 Blocking exosomal miRNA-153-3p derived from bone marrow mesenchymal stem cells ameliorates hypoxia-induced myocardial and microvascular damage by targeting the ANGPT1-mediated VEGF/PI3k/Akt/eNOS pathway 2021 heart myocardial_infarction homo_sapiens mir-153-1 MI0000463 miRBase miRNA down-regulation NA VEGF SIGNALING PATHWAY enzyme-linked immunosorbent assay; no Mesenchymal stem cells (MSCs)-derived exosomes with low-expressed miR-153-3p notably promotes the activation of angpt1 and the VEGF/CEGFR2 /PI4k/Akt/Enos pathways. 33164880 Blocking exosomal miRNA-153-3p derived from bone marrow mesenchymal stem cells ameliorates hypoxia-induced myocardial and microvascular damage by targeting the ANGPT1-mediated VEGF/PI3k/Akt/eNOS pathway 2021 heart myocardial_infarction homo_sapiens mir-216b MI0005569 miRBase miRNA down-regulation COX-2 NA qRT-PCR; dual-luciferase reporter assay; cell counting kit-8 analysis etc. no Miat overturned the inhibitory effect of miR-216a-3p overexpression and cox-2 knockdown on the activation and proliferation of hpastecs. 30582203 Long noncoding RNA myocardial infarction-associated transcript regulated the pancreatic stellate cell activation to promote the fibrosis process of chronic pancreatitis 2019 heart myocardial_infarction homo_sapiens mir-216a MI0000292 miRBase miRNA down-regulation COX-2 NA qRT-PCR; dual-luciferase reporter assay; cell counting kit-9 analysis etc. no Miat overturned the inhibitory effect of miR-216a-3p overexpression and cox-2 knockdown on the activation and proliferation of hpastecs. 30582203 Long noncoding RNA myocardial infarction-associated transcript regulated the pancreatic stellate cell activation to promote the fibrosis process of chronic pancreatitis 2019 heart aortic_coarctation homo_sapiens mir-122 MI0000442 miRBase miRNA down-regulation NA NA PCR; immunohistochemistry etc. no "miR-122 was inversely correlated with the CVF, TGF-beta1 and the TGF-beta1-regulated PCPE-1 (procollagen c-terminal proteinase enhancer-1),myocardial down-regulation of miR-122 might be involved in myocardial fibrosis in as patients, probably through TGF-beta1 up-regulation." 24168656 MicroRNA-122 down-regulation may play a role in severe myocardial fibrosis in human aortic stenosis through TGF-B1 up-regulation 2014 heart endomyocardial_fibrosis homo_sapiens mir-125b-1 MI0000446 miRBase miRNA up-regulation SFRP5 NA PCR; flow cytometery etc. no "miR-125b promotes the proliferation and migration of cardiac fibroblasts (CFs) and inhibits their apoptosis, while Sfrp5 exhibits the opposite effects.These results indicate that miR-125b can regulate Sfrp5 expression and thus influence the growth and activation of CFs." 27592695 MiR-125b Regulates SFRP5 Expression to Promote Growth and Activation of Cardiac Fibroblasts 2016 heart endomyocardial_fibrosis homo_sapiens mir-125b-2 MI0000470 miRBase miRNA up-regulation SFRP5 NA PCR; flow cytometery etc. no "miR-125b promotes the proliferation and migration of cardiac fibroblasts (CFs) and inhibits their apoptosis, while Sfrp5 exhibits the opposite effects.These results indicate that miR-125b can regulate Sfrp6 expression and thus influence the growth and activation of CFs." 27592695 MiR-125b Regulates SFRP5 Expression to Promote Growth and Activation of Cardiac Fibroblasts 2016 heart myocardial_infarction homo_sapiens mir-130a MI0000448 miRBase miRNA up-regulation PPAR gama NA RT-PCR; enzyme-linked immunosorbent assay etc. no miR-130 knockdown alleviates infarction-induced myocardial injury by promoting PPAR-gama expression. 29761875 MiR-130 aggravates acute myocardial infarction-induced myocardial injury by targeting PPAR-gama 2018 heart atrial_fibrillation homo_sapiens mir-132 MI0000449 miRBase miRNA down-regulation CTGF NA PCR; dual-luciferase reporter assay no miR-132 may suppress CTGF expression by binding to its 3'-untranslated region. 28731126 MiR-132 in atrial fibrillation directly targets connective tissue growth factor 2017 heart endomyocardial_fibrosis homo_sapiens mir-133a-1 MI0000450 miRBase miRNA down-regulation CTGF NA PCR; immunohistochemistry no "miR-133 directly downregulates CTGF, a key profibrotic protein, and thereby establish an important role for these miRNAs in the control of structural changes in the extracellular matrix of the myocardium.miR-133 and miR-30 in pathological left ventricular hypertrophy allowsCTGF levels to increase, which contributes to collagen synthesis." 19096030 MiR-133 and miR-30 regulate connective tissue growth factor: implications for a role of microRNAs in myocardial matrix remodeling 2009 heart endomyocardial_fibrosis homo_sapiens mir-133a-1 MI0000450 miRBase miRNA down-regulation CTGF NA PCR; immunohistochemistry no "miR-133 directly downregulates CTGF, a key profibrotic protein, and thereby establish an important role for these miRNAs in the control of structural changes in the extracellular matrix of the myocardium.miR-133 and miR-31 in pathological left ventricular hypertrophy allowsCTGF levels to increase, which contributes to collagen synthesis." 19096030 MiR-133 and miR-30 regulate connective tissue growth factor: implications for a role of microRNAs in myocardial matrix remodeling 2009 heart endomyocardial_fibrosis homo_sapiens mir-133b MI0000822 miRBase miRNA down-regulation CTGF NA PCR; immunohistochemistry no "miR-133 directly downregulates CTGF, a key profibrotic protein, and thereby establish an important role for these miRNAs in the control of structural changes in the extracellular matrix of the myocardium.miR-133 and miR-32 in pathological left ventricular hypertrophy allowsCTGF levels to increase, which contributes to collagen synthesis." 19096030 MiR-133 and miR-30 regulate connective tissue growth factor: implications for a role of microRNAs in myocardial matrix remodeling 2009 heart heart_failure homo_sapiens mir-133a-1 MI0000450 miRBase miRNA down-regulation NA PI3K-AKT SIGNALING PATHWAY PCR; immunofluorescence etc. no miR-133a increased the expression of phosphorylated akt in the heart of chronic heart failure rats.miR-133a mimic and miR-133a overexpression caused a decrease in the heart weight/body weight (hw/bw). 25960234 MicroRNA-133a improves the cardiac function and fibrosis through inhibiting Akt in heart failure rats 2015 heart endomyocardial_fibrosis homo_sapiens mir-133b MI0000822 miRBase miRNA down-regulation CTGF NA qRT-PCR; dual-luciferase reporter assay no miR-133b may affect the activation and proliferation of cardiac fibroblasts by targeting CTGF and thus improve cardiac fibrosis. 31699187 Effect of microRNA-133b on Myocardial Fibrosis 2019 heart endomyocardial_fibrosis homo_sapiens mir-142 MI0000458 miRBase miRNA down-regulation NA TGF-BETA SIGNALING PATHWAY qRT-PCR; no "miR-142-3p also mediated its anti-endothelial-to-mesenchymal transition (EndMT) action by inactivation of TGF-beta/smad pathway, as demonstrated by downregulation of TGF-beta, phospho-smad2 and phospho-smad2." 31938215 MicroRNA-142-3p inhibits high-glucose-induced endothelial-to-mesenchymal transition through targeting TGF-beta1/Smad pathway in primary human aortic endothelial cells 2018 heart myocardial_infarction homo_sapiens mir-143 MI0000459 miRBase miRNA up-regulation SPRY3 MAPK SIGNALING PATHWAY dual-luciferase reporter assay no "miR-143-3p promoted fibrosis along with SPRY3 degradation and the activation of its downstream p38, ERK, and JNK pathways." 30878395 MicroRNA-143-3p promotes human cardiac fibrosis via targeting sprouty3 after myocardial infarction 2019 heart atrial_fibrillation homo_sapiens mir-146b MI0003129 miRBase miRNA up-regulation TIMP4 NA dual-luciferase reporter assay; PCR no "miR-146b-5p, matrix metallopeptidase 9, and collagen content were upregulated whereas TIMP-4 was downregulated in patients with atrial fibrillation,miR-146b-5p probably acts as an intracellular mediator in the maladaptive remodeling in atrial fibrosis." 25617731 Integrated analysis of microRNA and mRNA expression profiles in the left atrium of patients with non-valvular paroxysmal atrial fibrillation: Role of miR-146b-5p in atrial fibrosis 2015 heart myocardial_infarction homo_sapiens mir-154 MI0000480 miRBase miRNA up-regulation GSK-3beta WNT SIGNALING PATHWAY qRT-PCR; dual-luciferase reporter assay no "miR-154 can inhibit GSK-3beta expression by activating wnt/beta-catenin signaling pathway, which promotes myocardial fibrosis." 29687862 MiR-154 promotes myocardial fibrosis through beta-catenin signaling pathway 2018 heart cardiomegaly homo_sapiens mir-155 MI0000681 miRBase miRNA up-regulation JARID2 NA NA no miR-155 as an inducer of pathological cardiomyocyte hypertrophy and suggest that inhibition of endogenous miR-155 might have clinical potential to suppress cardiac hypertrophy and heart failure. 24657879 Loss of MicroRNA-155 protects the heart from pathological cardiac hypertrophy 2014 heart endomyocardial_fibrosis homo_sapiens mir-1908 MI0008329 miRBase miRNA down-regulation TGF-beta1 TGF-BETA SIGNALING PATHWAY RT-PCR; Masson's trichrome staining no miR-1908 can improve the myocardial fibrosis through the target gene TGF-beta. 29687863 MiR-1908 improves cardiac fibrosis after myocardial infarction by targeting TGF-beta1 2018 heart heart_failure homo_sapiens mir-197 MI0000239 miRBase miRNA up-regulation NA NA NA no miR-197-5p is a circulation miRNA that correlates with myocardial fibrosis and adverse cardiac events in heart failure(HF) patients under the age of 50 years. 30836355 "Association of miR-197-5p, a Circulating Biomarker for Heart Failure, with Myocardial Fibrosis and Adverse Cardiovascular Events among Patients with Stage C or D Heart Failure" 2018 heart endomyocardial_fibrosis homo_sapiens mir-19a MI0000073 miRBase miRNA down-regulation TGF-betaRIII NA qRT-PCR; immunohistochemistry etc. no miR-19a-3p/19b-3p inhibits autophagy-mediated fibrogenesis by targeting TGF-betaRii. 27098600 Autophagy inhibition of hsa-miR-19a-3p/19b-3p by targeting TGF-beta R II during TGF-beta1-induced fibrogenesis in human cardiac fibroblasts 2016 heart endomyocardial_fibrosis homo_sapiens mir-19b-1 MI0000074 miRBase miRNA down-regulation TGF-betaRIII NA qRT-PCR; immunohistochemistry etc. no miR-19a-3p/19b-3p inhibits autophagy-mediated fibrogenesis by targeting TGF-betaRii. 27098600 Autophagy inhibition of hsa-miR-19a-3p/19b-3p by targeting TGF-beta R II during TGF-beta1-induced fibrogenesis in human cardiac fibroblasts 2016 heart endomyocardial_fibrosis homo_sapiens mir-19b-2 MI0000075 miRBase miRNA down-regulation TGF-betaRIII NA qRT-PCR; immunohistochemistry etc. no miR-19a-3p/19b-3p inhibits autophagy-mediated fibrogenesis by targeting TGF-betaRii. 27098600 Autophagy inhibition of hsa-miR-19a-3p/19b-3p by targeting TGF-beta R II during TGF-beta1-induced fibrogenesis in human cardiac fibroblasts 2016 heart atrial_fibrillation homo_sapiens mir-21 MI0000077 miRBase miRNA up-regulation WWP-1 TGF-BETA SIGNALING PATHWAY PCR; MTT ASSAY etc. no miR-21 inhibits cardiac fibroblasts proliferation by inactivating the TGF-beta1/smad2 signaling pathway via up-regulation of WWP-1. 28495464 MicroRNA-21 via Dysregulation of WW Domain-Containing Protein 1 Regulate Atrial Fibrosis in Atrial Fibrillation 2017 heart myocardial_infarction homo_sapiens mir-26a-1 MI0000083 miRBase miRNA up-regulation PTEN PI3K-AKT SIGNALING PATHWAY qRT-PCR; dual-luciferase reporter assay no "miR-26a upregulation may play a role in myocardial fibrosis after acute myocardial infarction (AMI) by suppressing PTEN, enhancing pi3k/akt signaling pathway and mmp-9 levels." 29424913 The targeted regulation of miR-26a on PTEN-PI3K/AKT signaling pathway in myocardial fibrosis after myocardial infarction 2018 heart myocarditis homo_sapiens mir-27a MI0000085 miRBase miRNA down-regulation NA NF-KAPPA B SIGNALING PATHWAY qRT-PCR; immunohistochemistry etc. no miR-27 inhibits h/r-induced cardiomyocyte injury by mediating TGF-betaR1 and inhibiting NF-KB signaling pathway 31169351 MiR-27 alleviates myocardial cell damage induced by hypoxia/reoxygenation via targeting TGFBR1 and inhibiting NF-KB pathway 2019 heart atrial_fibrillation homo_sapiens mir-29b-1 MI0000105 miRBase miRNA down-regulation COL1A1;COL3A1;FBN NA PCR; immunofluorescence etc. no "miR-29b can adjust the extracellular matrix col1a1, col3a1, and the expression of FBN, knockdown of miR-29b in mice significantly increased atrial COL1A1 mrna expression and cardiac tissue collagen content." 23459615 MicroRNA29 A Mechanistic Contributor and Potential Biomarker in Atrial Fibrillation 2013 heart atrial_fibrillation homo_sapiens mir-30c-1 MI0000736 miRBase miRNA down-regulation TGF-betaRIII NA in vivo and in vitro experiments no "miR-30c attenuates atrial fibrosis via inhibition of cardiac fibroblast proliferation, differentiation, migration and collagen production by targeting TGF-betaRii." 29532993 MicroRNA-30c suppresses the pro-fibrogenic effects of cardiac fibroblasts induced by TGF-beta1 and prevents atrial fibrosis by targeting TGFbetaRII 2018 heart atrial_fibrillation homo_sapiens mir-324 MI0000813 miRBase miRNA down-regulation TGF-beta1 PI3K-AKT SIGNALING PATHWAY NA no miR-324-3p mimics treatment suppressed the PI3k/Akt signaling pathway in fibroblast. 33191361 MiR-324-3p Regulates Fibroblast Proliferation via Targeting TGF-beta1 in Atrial Fibrillation 2020 heart endomyocardial_fibrosis homo_sapiens mir-574 MI0003581 miRBase miRNA up-regulation ARID3A NA Healing assay; Transwell assays no miR-574-5p plays a pivotal role in human cardiac fibroblasts (HCFs) myofibroblast differentiation and demonstrates that miR-574-5p and ARDI3a may be a novel therapeutic target for cardiac fibrosis. 31672272 MiR-574-5p promotes the differentiation of human cardiac fibroblasts via regulating ARID3A 2020 heart myocardial_infarction homo_sapiens mir-93 MI0000095 miRBase miRNA down-regulation NA TGF-BETA SIGNALING PATHWAY enzyme-linked immunosorbent assay; RT-PCR; etc. no miR-9 can alleviate the myocardial fibrosis in rats by inhibiting the TGF-beta/smads signaling pathway. 31486510 Effect of miR-9 on myocardial fibrosis in rats via TGF-beta1/Smads signaling pathway 2019 heart cardiomegaly homo_sapiens mir-15a MI0000069 miRBase miRNA up-regulation TGFBRI;SMAD3;SMAD7;P53 P53 SIGNALING PATHWAY;TGF-BETA SIGNALING PATHWAY PCR; Masson's trichrome staining etc. no "miRNA-15 family,inhibits the TGF-beta-pathway by targeting of TGF-betaR1 and several other genes within this pathway directly or indirectly, including p38, smad3, smad7, and endoglin, miR-15 family as a novel regulator of cardiac hypertrophy and fibrosis acting by inhibition of the TGF-pathway." 25103110 The microRNA-15 family inhibits the TGFB-pathway in the heart 2014 heart endomyocardial_fibrosis homo_sapiens mir-15b MI0000438 miRBase miRNA up-regulation TGFBRI;SMAD3;SMAD7;P53 P53 SIGNALING PATHWAY;TGF-BETA SIGNALING PATHWAY PCR; Masson's trichrome staining etc. no "miRNA-15 family,inhibits the TGF-beta-pathway by targeting of TGF-betaR1 and several other genes within this pathway directly or indirectly, including p38, smad3, smad7, and endoglin, miR-18 family as a novel regulator of cardiac hypertrophy and fibrosis acting by inhibition of the TGF-pathway." 25103110 The microRNA-15 family inhibits the TGFB-pathway in the heart 2014 heart endomyocardial_fibrosis homo_sapiens mir-29a MI0000087 miRBase miRNA down-regulation VEGF-A MAPK SIGNALING PATHWAY PCR; immunohistochemistry etc. no miRNA-29a suppresses cardiac fibrosis and fibroblasts proliferation via targeting VEGF-alfa/MAPK signal pathway implicating that miRNA-29a might play a role in the treatment of cardiac fibrosis. 27060017 MicroRNA-29a suppresses cardiac fibroblasts proliferation via targeting VEGF-A/MAPK signal pathway 2016 heart endomyocardial_fibrosis homo_sapiens mir-663a MI0003672 miRBase miRNA down-regulation NA TGF-BETA SIGNALING PATHWAY Pearson's correlation analysis; receiver operating characteristic curve analysis no "miRNA-663 may participate in myocardial fibrosis, possibly through interaction with TGF-beta." 31572558 MicroRNA-663 participates in myocardial fibrosis through interaction with TGF-beta1 2019 heart endomyocardial_fibrosis homo_sapiens mir-663b MI0006336 miRBase miRNA down-regulation NA TGF-BETA SIGNALING PATHWAY Pearson's correlation analysis; receiver operating characteristic curve analysis no "miRNA-663 may participate in myocardial fibrosis, possibly through interaction with TGF-beta." 31572558 MicroRNA-663 participates in myocardial fibrosis through interaction with TGF-beta1 2019 heart diabetic_cardiomyopathy homo_sapiens mir-208a MI0000251 miRBase miRNA up-regulation MHC NA RT-PCR; follow-up study no Myocardial expression of miR-208 is associated with alpha-myosin heavy chain (MHC) mrna expression and with poor clinical outcomes in patients with diabetes cardiomyopathy (DCM). 20447577 Expression of microRNA-208 is associated with adverse clinical outcomes in human dilated cardiomyopathy 2010 heart heart_failure homo_sapiens mir-18a MI0000072 miRBase miRNA up-regulation CTGF;TSP-1 NA PCR; immunofluorescence etc. no "Our data support a role for cardiomyocyte-derived miR-18 during cardiac aging, in the fine-tuning of cardiac extracellular matrix protein levels. During aging, decreased miR-18 and increased CTGF and TSP-2 levels identify the failure-prone heart." 21501375 MicroRNA-18 and microRNA-19 regulate CTGF and TSP-1 expression in age-related heart failure 2011 heart ventricular_dysfunction homo_sapiens mir-208a MI0000251 miRBase miRNA down-regulation NA APOPTOSIS PATHWAY RT-PCR; MTT ASSAYS no Overexpression of miR-208 family alleviated ang ii-induced cell apoptosis and miR-208a assisted in the protective effect of ghrelin. 30244257 Ghrelin Alleviates Angiotensin II-Induced H9c2 Apoptosis: Impact of the miR-208 Family 2018 heart ventricular_dysfunction homo_sapiens mir-208b MI0005570 miRBase miRNA down-regulation NA APOPTOSIS PATHWAY RT-PCR; MTT ASSAYS no Overexpression of miR-208 family alleviated ang ii-induced cell apoptosis and miR-208a assisted in the protective effect of ghrelin. 30244257 Ghrelin Alleviates Angiotensin II-Induced H9c2 Apoptosis: Impact of the miR-208 Family 2018 heart myocardial_infarction homo_sapiens mir-21 MI0000077 miRBase miRNA up-regulation NA NA RT-PCR no Plasma miR-21 may be a novel biomarker for the diagnosis of acute myocardial infarction (AMI). 26875904 Plasma microRNA-21 is a potential diagnostic biomarker of acute myocardial infarction 2016 heart cardiomegaly homo_sapiens mir-29a MI0000087 miRBase miRNA up-regulation NA NA qRT-PCR no Plasma miR-29a is primarily of nonmyocardial origin and is correlated significantly with the extent of hemolysis observed in these patients. 28684219 Elevated plasma levels of miR-29a are associated with hemolysis in patients with hypertrophic cardiomyopathy 2017 heart cardiomegaly homo_sapiens mir-29a MI0000087 miRBase miRNA down-regulation NA NA Echocardiography; qRT-PCR no Plasma miRNA-29a level is positively associated with Left ventricular (LV) in hypertensive patients. 30897881 Association between plasma microRNA-29a and left ventricular hypertrophy in patients with hypertension 2019 heart aortic_coarctation homo_sapiens mir-21 MI0000077 miRBase miRNA up-regulation NA NA PCR; immunohistochemistry; Echocardiography no Plasmatic miR-21 in the maladaptive remodeling of the extracellular matrix induced by pressure overload in aortic stenosis (as) patients and the clinical value of miR-21 as a biomarker for pathological myocardial fibrosis. 22882958 Myocardial and circulating levels of microRNA-21 reflect left ventricular fibrosis in aortic stenosis patients 2013 heart myocardial_infarction homo_sapiens mir-132 MI0000449 miRBase miRNA down-regulation NA PI3K-AKT SIGNALING PATHWAY molecular analyses no Saphenous vein-derived pericyte progenitor cells (SVPs) transplantation produces long-term improvement of cardiac function through a novel paracrine mechanism involving the secretion of miR-132 and inhibition of its target genes. 21868695 Transplantation of human pericyte progenitor cells improves the repair of infarcted heart through activation of an angiogenic program involving micro-RNA-132 2011 heart endomyocardial_fibrosis homo_sapiens mir-154 MI0000480 miRBase miRNA up-regulation DDK2 WNT SIGNALING PATHWAY PCR; dual-luciferase reporter assay etc. no Targeting of DKK2 by miR-154 leads to upregulation of b-catenin expression and activation of the classical WNT signaling pathway and cardiac fibroblasts (CFs). 27542661 MiR-154 directly Suppresses DKK2 to Activate Wnt Signaling Pathway and Enhance Activation of Cardiac Fibroblasts 2016 heart endomyocardial_fibrosis homo_sapiens mir-378a MI0000786 miRBase miRNA down-regulation NA MAPK SIGNALING PATHWAY northern blot analysis; immunohistochemistry etc. no The miR-378-induced anti-fibrotic effects manifested partially through the suppression of p38 MAP kinase phosphorylation by targeting MKK6 in cardiac fibroblasts. 29721099 MicroRNA-378 suppresses myocardial fibrosis through a paracrine mechanism at the early stage of cardiac hypertrophy following mechanical stress 2018 heart diabetic_cardiomyopathy homo_sapiens mir-18a MI0000072 miRBase miRNA down-regulation NOTCH2 NOTCH SIGNALING PATHWAY PCR; immunofluorescence etc. no The overexpression of miR-18a-5p could downregulate NOTCH3 expression and subsequently suppress endothelial-to-mesenchymal transition (EndMT). 28733035 MiR-18a-5p inhibits endothelial-mesenchymal transition and cardiac fibrosis through the Notch2 pathway 2017 heart endomyocardial_fibrosis homo_sapiens mir-32 MI0000090 miRBase miRNA down-regulation DUSP1 NA flow cytometery; qRT-PCR; no The positive effects of miR-32-5p on cell proliferation and the phenotypic changes in cardiac fibroblasts (CFs) by inhibiting DUSP1 expression. 31438862 MiR-32-5p influences high glucose-induced cardiac fibroblast proliferation and phenotypic alteration by inhibiting DUSP1 2019 heart endomyocardial_fibrosis homo_sapiens mir-33a MI0000091 miRBase miRNA down-regulation CFB TGF-BETA SIGNALING PATHWAY qRT-PCR; cell counting kit-8 analysis no The upregulated phosphorylations were further improved by miR-33 mimic (p <0.05) While reversed by miR-33a inhibitor (p <0.05 Or p < 0.001). miR-33a deficiency inhibits proliferation and fibrosis of CFBS while promotes cardiac fibroblast (CF) apoptosis by inactivation of TGF-beta/smad pathway. 29441904 MicroRNA-33a deficiency inhibits proliferation and fibrosis through inactivation of TGF-beta/Smad pathway in human cardiac fibroblasts 2017 heart endomyocardial_fibrosis homo_sapiens mir-15a MI0000069 miRBase miRNA down-regulation TGFBR1;CTGF;P53 TGF-BETA SIGNALING PATHWAY PCR etc. no "Therapeutic restoration of miR-15a and -15b in HL-1 cardiomyocytes reduced the activation of pro-fibrotic TGF-betaRi and CTGF, and the pro-senescence p53 protein expression, confirming a causal regulation of these fibrotic and senescence mediators by miR-15a/b." 28289072 Down-regulation of miR-15a/b accelerates fibrotic remodelling in the Type 2 diabetic human and mouse heart 2017 heart endomyocardial_fibrosis homo_sapiens mir-15b MI0000438 miRBase miRNA down-regulation TGFBR1;CTGF;P53 TGF-BETA SIGNALING PATHWAY PCR etc. no "Therapeutic restoration of miR-15a and -15b in HL-1 cardiomyocytes reduced the activation of pro-fibrotic TGF-betaRi and CTGF, and the pro-senescence p53 protein expression, confirming a causal regulation of these fibrotic and senescence mediators by miR-16a/b." 28289072 Down-regulation of miR-15a/b accelerates fibrotic remodelling in the Type 2 diabetic human and mouse heart 2017 heart myocardical_ischemia homo_sapiens mir-146a MI0000477 miRBase miRNA down-regulation NA VEGF SIGNALING PATHWAY NA no "These data suggest that miR-146 is a novel miRNA that regulates VEGF expression, and its use may be an effective strategy for enhancing the therapeutic efficacy of human mesenchymal stem cells transplantation into the i/r-injured heart." 28407626 Exogenous miRNA-146a Enhances the Therapeutic Efficacy of Human Mesenchymal Stem Cells by Increasing Vascular Endothelial Growth Factor Secretion in the Ischemia/Reperfusion-Injured Heart 2017 heart atrial_fibrillation homo_sapiens mir-21 MI0000077 miRBase miRNA up-regulation CTGF;SPRY1 NA PCR; immunofluorescence etc. no "Transgenic mice with cardiac overexpression of RAC1, which develop spontaneous atrial fibrillation(AF) and atrial fibrosis with increasing age, showed upregulation of miR-21 expression associated with reduced SPRY1 expression.miR-21 expression and signalling in vivo were prevented by long-term treatment of the mice with statins. Direct inhibition of miR-21 by antagomiR-21 prevented fibrosis of the atrial myocardium post-myocardial infarction." 22760500 Role of miR-21 in the pathogenesis of atrial fibrosis 2012 heart endomyocardial_fibrosis homo_sapiens mir-495 MI0003135 miRBase miRNA down-regulation NA TGF-BETA SIGNALING PATHWAY RT-PCR; dual-luciferase reporter assay; yes "Upregulation of miR-495 ameliorates the high glucose-induced inflammatory, cell differentiation and extracellular matrix accumulation of human cardiac fibroblast by modulating both the NF-KB and TGF-beta1/smad signaling pathways through downregulation of NOD1 expression." 29760746 "MicroRNA-495 inhibits the high glucose-induced inflammation, differentiation and extracellular matrix accumulation of cardiac fibroblasts through downregulation of NOD1" 2018 heart endomyocardial_fibrosis homo_sapiens mir-9-2 MI0000467 miRBase miRNA down-regulation TGFBR2 NA cell counting kit-8 analysis; PCR etc. no "Up-regulation of miR-9 ameliorates high-glucose (HG)-induced proliferation, differentiation and collagen accumulation of human cardiac fibroblasts (HCFs) by down-regulation of TGF-betaR2." 27756824 "MicroRNA-9 inhibits high glucose-induced proliferation, differentiation and collagen accumulation of cardiac fibroblasts bydown-regulation of TGFBR2" 2016 heart endomyocardial_fibrosis homo_sapiens mir-98 MI0000100 miRBase miRNA down-regulation TGFBR1 TGF-BETA SIGNALING PATHWAY PCR; dual-luciferase reporter assay no Upregulation of miR-98 ameliorates TGF-beta1-induced differentiation and collagen accumulation of human cardiac fibroblasts (HCFs) by downregulation of tgfbr1. These results provide further evidence for protective effect of miR-98 overexpression on TGF-beta1-induced cardiac fibrosis. 28251559 MicroRNA-98 inhibits TGF-B1-induced differentiation and collagen production of cardiac fibroblasts by targeting TGFBR1 2017 heart diabetic_cardiomyopathy homo_sapiens mir-185 MI0000482 miRBase miRNA down-regulation NA NA RNA isolation; Taqman microRNA assays no NA 27645404 Circulating miR-185 might be a novel biomarker for clinical outcome in patients with dilated cardiomyopathy 2016 heart endomyocardial_fibrosis homo_sapiens mir-384 MI0001145 miRBase miRNA down-regulation NA WNT SIGNALING PATHWAY RT-PCR; dual-luciferase reporter assay; no NA 30206318 Multipoint targeting of TGF-beta/Wnt transactivation circuit with microRNA 384-5p for cardiac fibrosis 2019 heart endomyocardial_fibrosis homo_sapiens mir-150 MI0000479 miRBase miRNA down-regulation EGR1 NA qRT-PCR; dual-luciferase reporter assay etc. no NA 31122130 MiR-150-5p retards the progression of myocardial fibrosis by targeting EGR1 2019 kidney kidney_diseases homo_sapiens mir-373 MI0000781 miRBase miRNA up-regulation SIRT1 NF-KAPPA B SIGNALING PATHWAY NA no An undesired effect of miR-373 in the regulation of renal injury and fibrosis by targeting sirt1-mediated NF-KB/MMP-9 signaling. 29723660 MiR-373 exacerbates renal injury and fibrosis via NF-KB/MatrixMetalloproteinase-9 signaling by targeting Sirtuin1 2019 kidney diabetic_nephropathy homo_sapiens mir-214 MI0000290 miRBase miRNA up-regulation NA MTOR SIGNALING PATHWAY NA no Anti-miR-214 and mtorc1 inhibition block high glucose-induced hypertrophy and fibronectin expression. 31240704 High glucose increases miR-214 to power a feedback loop involving PTEN and the Akt/mTORC1 signaling axis 2019 kidney kidney_diseases homo_sapiens mir-217 MI0000293 miRBase miRNA down-regulation WNT5A WNT SIGNALING PATHWAY NA no Carrying D2R snps resulting in D2R downregulation have increased TGF-beta1 that is mediated by decreased regulation of the miR-217-wnt5a-Ror2 pathway. 25801876 MiR-217 mediates the protective effects of the dopamine D2 receptor on fibrosis in human renal proximal tubule cells 2015 kidney diabetic_nephropathy homo_sapiens mir-214 MI0000290 miRBase miRNA up-regulation MT-ND6;MT-ND4L NA NA no Demonstrate a pathogenic role of miR-214 in chronic kidney disease (CKD) through the disruption of mitochondrial oxidative phosphorylation. 30955870 MicroRNA-214 promotes chronic kidney disease by disrupting mitochondrial oxidative phosphorylation 2019 kidney kidney_diseases homo_sapiens mir-152 MI0000462 miRBase miRNA down-regulation HPIP NA NA no Downregulation of miR-152 initiates the dedifferentiation of renal tubules and progression of renal fibrosis. 29620271 MiR-152 regulates TGF-beta1-induced epithelial-mesenchymal transition by targeting HPIP in tubular epithelial cells 2018 kidney nephritis_interstitia homo_sapiens mir-181a-1 MI0000289 miRBase miRNA down-regulation EGR1 NA NA no "Egr1 expression, which can be suppressed by miR-181a-5p directly, plays a crucial role in the progression of renal fibrosis in diabetic nephropathies." 28077323 High glucose down-regulates microRNA-181a-5p to increase pro-fibrotic gene expression by targeting early growth response factor 1 in HK-2 cells 2017 kidney nephritis_interstitia homo_sapiens mir-200b MI0000342 miRBase miRNA down-regulation ETS-1 NA NA no Epo attenuated hypoxia-induced epithelial-mesenchymal transition (EMT) by increasing miR-200 expression via the repression of ets-1. 28535509 Erythropoietin Inhibits Hypoxia-Induced Epithelial-To-Mesenchymal Transition via Upregulation of miR-200b in HK-2 Cells 2017 kidney kidney_diseases homo_sapiens mir-34a MI0000268 miRBase miRNA down-regulation NOTCH1;JAGGED1 NOTCH SIGNALING PATHWAY qRT-PCR; dual-luciferase reporter assay no Hypoxia-induced decrease of miR-34a expression could promote diabetic nephropathies in renal tubular epithelial cells by directly targeting Notch1 and Jagged1. 22363487 Hypoxia-induced down-regulation of microRNA-34a promotes EMT by targeting the Notch signaling pathway in tubular epithelial cells 2012 kidney kidney_diseases homo_sapiens mir-155 MI0000681 miRBase miRNA up-regulation NA TGF-BETA SIGNALING PATHWAY NA no "Hypoxia-induced miR-155 was a pro-fibrotic cytokine which was positively regulated by HIf-1alfa, but also revealed that miR-155 promoted the fibrosis of proximal tubule cells by regulating both TGF-beta and the process of epithelial-mesenchymal transition (EMT) under hypoxia." 25672593 Hypoxia-induced microRNA-155 promotes fibrosis in proximal tubule cells 2015 kidney nephritis_hereditary homo_sapiens mir-21 MI0000077 miRBase miRNA up-regulation NA NA qPCR no "Increased levels of miR-21 in human alport kidney samples showed a correlation with kidney disease severity measured by proteinuria, biomarkers of kidney function, and kidney histopathology scores." 30808234 Dysregulated Expression of microRNA-21 and Disease-Related Genes in Human Patients and in a Mus musculus Model of Alport Syndrome 2019 kidney diabetic_nephropathy homo_sapiens mir-196a-1 MI0000238 miRBase miRNA up-regulation NA NA COX REGRESSION ANALYSIS no Increased urinary miR-196a was significantly associated with the progression of renal injury. 30521014 Increased urinary miR-196a level predicts the progression of renal injury in patients with diabetic nephropathy 2020 kidney diabetic_nephropathy homo_sapiens mir-196a-2 MI0000279 miRBase miRNA up-regulation NA NA COX REGRESSION ANALYSIS no Increased urinary miR-196a was significantly associated with the progression of renal injury. 30521014 Increased urinary miR-196a level predicts the progression of renal injury in patients with diabetic nephropathy 2020 kidney diabetic_nephropathy homo_sapiens mir-199b MI0000282 miRBase miRNA up-regulation SIRT1 TGF-BETA SIGNALING PATHWAY dual-luciferase reporter assay; immunohistochemistry etc. no Inhibition of miR-133b and miR-199b attenuated TGF-beta-induced epithelial-mesenchymal transition (EMT) and renal fibrosis by upregulating sirt1. 30125566 MiR-133b and miR-199b knockdown attenuate TGF-beta1-induced epithelial to mesenchymal transition and renal fibrosis by targeting SIRT1 in diabetic nephropathy 2018 kidney diabetic_nephropathy homo_sapiens mir-133b MI0000822 miRBase miRNA up-regulation SIRT1 TGF-BETA SIGNALING PATHWAY dual-luciferase reporter assay; immunohistochemistry etc. no Inhibition of miR-133b and miR-199b attenuated TGF-beta-induced epithelial-mesenchymal transition (EMT) and renal fibrosis by upregulating sirt1. 30125566 MiR-133b and miR-199b knockdown attenuate TGF-beta1-induced epithelial to mesenchymal transition and renal fibrosis by targeting SIRT1 in diabetic nephropathy 2018 kidney diabetic_nephropathy homo_sapiens mir-135a-2 MI0000453 miRBase miRNA up-regulation SIRT1 TGF-BETA SIGNALING PATHWAY qRT-PCR; dual-luciferase reporter assay no Knockdown of miR-135a-5p inhibits TGF-beta1-induced renal fibrosis by targeting sirt1 and inactivating smad3 signaling. 32705273 Inhibition of miRNA-135a-5p ameliorates TGF-beta1-induced human renal fibrosis by targeting SIRT1 in diabetic nephropathy 2020 kidney diabetic_nephropathy homo_sapiens mir-135a-1 MI0000452 miRBase miRNA up-regulation SIRT1 TGF-BETA SIGNALING PATHWAY qRT-PCR; dual-luciferase reporter assay no Knockdown of miR-135a-5p inhibits TGF-beta1-induced renal fibrosis by targeting sirt1 and inactivating smad3 signaling. 32705273 Inhibition of miRNA-135a-5p ameliorates TGF-beta1-induced human renal fibrosis by targeting SIRT1 in diabetic nephropathy 2020 kidney glomerulonephritis_iga homo_sapiens mir-192 MI0000234 miRBase miRNA down-regulation NA NA qRT-PCR no "Lower serum miR-192 in iga nephropathy patients indicates lower intrarenal miR-192 expression, more severe tubular atrophy, interstitial inflammation, and fibrotic tendency." 30808829 Serum miR-192 Is Related to Tubulointerstitial Lesion and Short-Term Disease Progression in IgA Nephropathy 2019 kidney diabetic_nephropathy homo_sapiens mir-488 MI0003123 miRBase miRNA up-regulation NA TGF-BETA SIGNALING PATHWAY qRT-PCR; no Microrna-488 regulates the development of diabetic nephropathy-induced fibrosis by TGF-beta pathway. 31173306 MicroRNA-488 regulates diabetic nephropathy via TGF-beta1 pathway 2019 kidney kidney_diseases homo_sapiens mir-493 MI0003132 miRBase miRNA up-regulation STMN-1 NA NA no Microrna-493 targets STMN-1 and promotes hypoxia-induced epithelial cell cycle arrest in G2/M and renal fibrosis. 30183377 MicroRNA-493 targets STMN-1 and promotes hypoxia-induced epithelial cell cycle arrest in G 2/M and renal fibrosis 2019 kidney kidney_diseases homo_sapiens mir-101-2 MI0000739 miRBase miRNA down-regulation NA NA RT-PCR; Masson's trichrome staining etc. no "miR-101 overexpression mitigated hypoxic hk-2 cell damage. Collagen, type x, alpha 1 and transforming growth factor beta receptor 1 levels were downregulated in hypoxic cells transfected with miR-101 mimic." 32633566 Upregulated miR-101 inhibits acute kidney injury-chronic kidney disease transition by regulating epithelial-mesenchymal transition 2020 kidney kidney_diseases homo_sapiens mir-101-1 MI0000103 miRBase miRNA down-regulation NA NA RT-PCR; Masson's trichrome staining etc. no "miR-101 overexpression mitigated hypoxic hk-2 cell damage. Collagen, type x, alpha 1 and transforming growth factor beta receptor 1 levels were downregulated in hypoxic cells transfected with miR-101 mimic." 32633566 Upregulated miR-101 inhibits acute kidney injury-chronic kidney disease transition by regulating epithelial-mesenchymal transition 2020 kidney kidney_diseases homo_sapiens mir-103a-1 MI0000109 miRBase miRNA up-regulation SNRK NF-KAPPA B SIGNALING PATHWAY NA no miR-103a-3p/snrk/NF-KB/p65 as a regulatory axis of angii-induced renal inflammation and fibrosis. 31086184 Circulating miR-103a-3p contributes to angiotensin II-induced renal inflammation and fibrosis via a SNRK/NF-KB/p65 regulatory axis/Publisher Correction: Circulating miR-103a-3p contributes to angiotensin II-induced renal inflammation and fibrosis via a SNRK/NF-KB/p65 regulatory axis 2019 kidney kidney_diseases homo_sapiens mir-103a-2 MI0000108 miRBase miRNA up-regulation SNRK NF-KAPPA B SIGNALING PATHWAY NA no miR-103a-3p/snrk/NF-KB/p65 as a regulatory axis of angii-induced renal inflammation and fibrosis. 31086184 Circulating miR-103a-3p contributes to angiotensin II-induced renal inflammation and fibrosis via a SNRK/NF-KB/p65 regulatory axis/Publisher Correction: Circulating miR-103a-3p contributes to angiotensin II-induced renal inflammation and fibrosis via a SNRK/NF-KB/p65 regulatory axis 2019 kidney kidney_diseases homo_sapiens miR-103a-3p MIMAT0000101 miRBase miRNA up-regulation SNRK NF-KAPPA B SIGNALING PATHWAY NA no miR-103a-3p/snrk/NF-KB/p65 as a regulatory axis of angii-induced renal inflammation and fibrosis. 31086184 Circulating miR-103a-3p contributes to angiotensin II-induced renal inflammation and fibrosis via a SNRK/NF-KB/p65 regulatory axis/Publisher Correction: Circulating miR-103a-3p contributes to angiotensin II-induced renal inflammation and fibrosis via a SNRK/NF-KB/p65 regulatory axis 2019 kidney kidney_diseases homo_sapiens mir-129-1 MI0000252 miRBase miRNA down-regulation PDPK1 NA dual-luciferase reporter assay no miR-129-5p may function as a suppressor in renal fibrosis by targeting Pdpk1. 26884980 MicroRNA profiling identifies miR-129-5p as a regulator of epithelial-mesenchymal transition (EMT) in tubular epithelial cells 2015 kidney kidney_diseases homo_sapiens mir-129-2 MI0000473 miRBase miRNA down-regulation PDPK1 NA dual-luciferase reporter assay no miR-129-5p may function as a suppressor in renal fibrosis by targeting Pdpk1. 26884980 MicroRNA profiling identifies miR-129-5p as a regulator of epithelial-mesenchymal transition (EMT) in tubular epithelial cells 2015 kidney kidney_diseases homo_sapiens mir-130a MI0000448 miRBase miRNA up-regulation SNON TGF-BETA SIGNALING PATHWAY qRT-PCR; dual-luciferase reporter assay no miR-130a-3p facilitates the TGF-beta/smad pathway in renal tubular epithelial cells and may participate in renal fibrosis by targeting snon. 31836508 MiR-130a-3p inhibition protects against renal fibrosis in vitro via the TGF-beta1/Smad pathway by targeting SnoN 2020 kidney diabetic_nephropathy homo_sapiens mir-130b MI0000748 miRBase miRNA up-regulation NA TGF-BETA SIGNALING PATHWAY NA no miR-130b in HMC cells plays an important role in fibrosis regulation and may thus be involved with the pathogenesis of diabetic nephropathies. 30260005 MiR-130b increases fibrosis of HMC cells by regulating the TGF-beta1 pathway in diabetic nephropathy 2019 kidney nephritis_interstitia homo_sapiens mir-140 MI0000456 miRBase miRNA down-regulation TGFBR TGF-BETA SIGNALING PATHWAY dual-luciferase reporter assay no miR-140-5p may have a therapeutic potential for preventing fibrotic kidney diseases through inhibiting the TGF-beta/smad signaling pathway by directly targeting TGF-betaR1. 33013464 MicroRNA-140-5p Mediates Renal Fibrosis Through TGF-beta1/Smad Signaling Pathway by Directly Targeting TGFBR1 2020 kidney kidney_diseases homo_sapiens mir-141 MI0000457 miRBase miRNA down-regulation HIPK2 APELIN SIGNALING PATHWAY NA no miR-141 in regulating renal fibrosis via the TGF-beta1/miR-141/hipk2/epithelial-mesenchymal transition (EMT) axis. 25421593 MiR-141 regulates TGF-beta1-induced epithelial-mesenchymal transition through repression of HIPK2 expression in renal tubular epithelial cells 2015 kidney lupus_nephritis homo_sapiens mir-146a MI0000477 miRBase miRNA down-regulation IRAK1;TRAF6 NA qRT-PCR no miR-146a exerts a protective effect through negative regulation of inflammation by suppressing Irak1 and Traf6. 32803682 "Urinary exosomal miR-146a as a marker of albuminuria, activity changes and disease flares in lupus nephritis" 2020 kidney acute_kidney_injury homo_sapiens mir-146a MI0000477 miRBase miRNA up-regulation HMGA2 CHEMOKINE SIGNALING PATHWAY NA no "miR-146a is a key mediator of the renal tubular response to iri that limits the consequences of inflammation, a key process in the development of acute kidney injury (AKI) and chronic kidney disease (CKD)." 27444565 MicroRNA-146a in Human and Experimental Ischemic AKI: CXCL8-Dependent Mechanism of Action 2017 kidney kidney_diseases homo_sapiens mir-1908 MI0008329 miRBase miRNA down-regulation NA TGF-BETA SIGNALING PATHWAY qRT-PCR; dual-luciferase reporter assay no miR-1908 could inhibit renal fibrosis through targeting TGF-beta. 26648305 Transfected miR-1908 inhibits renal fibrosis via targeting transforming growth factor beta 1 2015 kidney diabetic_nephropathy homo_sapiens mir-192 MI0000234 miRBase miRNA down-regulation EGR1 NA qRT-PCR; dual-luciferase reporter assay no miR-192 causes degradation of TGF-beta and fibronectin (FN) through targeting Egr1 and affects the progression of tubulointerstitial fibrosis (TIF) and even diabetic nephropathies. 30024615 MiR-192 prevents renal tubulointerstitial fibrosis in diabetic nephropathy by targeting Egr1 2018 kidney nephritis_interstitia homo_sapiens mir-192 MI0000234 miRBase miRNA up-regulation NA P53 SIGNALING PATHWAY NA no miR-192 in mediating proximal tubular epithelial cell G2/M arrest after toxic injury by aristolochic acid 24508230 MiR-192 induces G2/M growth arrest in aristolochic acid nephropathy 2014 kidney kidney_failure_chronic homo_sapiens mir-192 MI0000234 miRBase miRNA down-regulation ZEB-1;ZEB-2 NA NA no "miR-192-driven anti-and pro-fibrotic effects via the repression of zeb1 and zeb2 (zinc finger e-box-binding homeobox proteins 1 and 2), resulting in changes in extracellular matrix deposition and cell differentiation." 22817730 Pleiotropy of microRNA-192 in the kidney 2012 kidney kidney_failure_chronic homo_sapiens mir-193b MI0003137 miRBase miRNA up-regulation NA NA RT-PCR no miR-193b-3p overexpression was associated with tubule-interstitial inflammation and fibrosis. 27802451 MicroRNA 193b-3p as a predictive biomarker of chronic kidney disease in patients undergoing radical nephrectomy for renal cell carcinoma 2016 kidney renal_insufficiency homo_sapiens mir-194-1 MI0000488 miRBase miRNA down-regulation RHEB NA dual-luciferase reporter assay no miR-194 protect against h/r-induced injury in human Kidney 2 (HK-2) cells through direct targeting Rheb. 30485514 MicroRNA-194 overexpression protects against hypoxia/reperfusion-induced HK-2 cell injury through direct targeting Rheb 2018 kidney renal_insufficiency homo_sapiens mir-194-2 MI0000732 miRBase miRNA down-regulation RHEB NA dual-luciferase reporter assay no miR-194 protect against h/r-induced injury in human Kidney 2 (HK-3) cells through direct targeting Rheb. 30485514 MicroRNA-194 overexpression protects against hypoxia/reperfusion-induced HK-2 cell injury through direct targeting Rheb 2018 kidney kidney_diseases homo_sapiens mir-196a1 MI0000238 miRBase miRNA down-regulation TGF-betaRIII TGF-BETA SIGNALING PATHWAY qRT-PCR no "miR-196a/b silenced TGF-beta-smad signaling, decreased the expression of collagen 1 and alfa-smooth muscle action, and attenuated renal fibrosis." 26940097 MicroRNA-196a/b Mitigate Renal Fibrosis by Targeting TGF-beta Receptor 2 2016 kidney kidney_diseases homo_sapiens mir-21 MI0000077 miRBase miRNA up-regulation DDAH1 WNT SIGNALING PATHWAY dual-luciferase reporter assay no miR-21 may regulate renal fibrosis by the wnt pathway via directly targeting DDAH1. 26455824 MicroRNA21 promotes interstitial fibrosis via targeting DDAH1: a potential role in renal fibrosis 2016 kidney acute_kidney_injury homo_sapiens mir-21 MI0000077 miRBase miRNA up-regulation PDCD4 NA dual-luciferase reporter assay no miR-21 protected renal cells against contrast medium (CM)-induced apoptosis by regulating Pdcd4 expression. 28901491 MiR-21 attenuates contrast-induced renal cell apoptosis by targeting PDCD4 2017 kidney nephritis_interstitia homo_sapiens mir-214 MI0000290 miRBase miRNA up-regulation NA TGF-BETA SIGNALING PATHWAY NA no miR-214 functions to promote fibrosis in renal injury independent of TGF-beta signaling in vivo. 24158985 MicroRNA-214 antagonism protects against renal fibrosis 2014 kidney kidney_diseases homo_sapiens mir-23a MI0000079 miRBase miRNA up-regulation SNON NA dual-luciferase reporter assay no miR-23a and snon significantly impact on the progression of epithelial-mesenchymal transition (EMT) and renal fibrogenesis in vitro. 28707079 Down-regulation of miR-23a inhibits high glucose-induced EMT and renal fibrogenesis by up-regulation of SnoN 2018 kidney diabetic_nephropathy homo_sapiens mir-23b MI0000439 miRBase miRNA down-regulation HMGA2 PI3K-AKT SIGNALING PATHWAY NA no miR-23b acts as a suppressor of epithelial-mesenchymal transition (EMT) in diabetic nephropathy through repressing PI3k-Akt signalling pathway activation by targeting HMG2. 26646104 Effects and mechanism of miR-23b on glucose-mediated epithelial-to-mesenchymal transition in diabetic nephropathy 2016 kidney kidney_diseases homo_sapiens mir-27b MI0000440 miRBase miRNA down-regulation STAT1 NA dual-luciferase reporter assay no miR-27b-3p overexpression could alleviate renal fibrosis via suppressing stat1 in vivo and in vitro. 33454903 MiR-27b-3p inhibits the progression of renal fibrosis via suppressing STAT1 2021 kidney kidney_failure_chronic homo_sapiens mir-133a-1 MI0000450 miRBase miRNA down-regulation NA TGF-BETA SIGNALING PATHWAY NA no miR-294/miR-133 overexpression prevented smad2/3 and erk1/2 phosphorylation in human Kidney 2 (HK-2) cells during TGF-beta1-mediated epithelial-mesenchymal transition (EMT). 32641100 Protective effect of miRNA-containing extracellular vesicles derived from mesenchymal stromal cells of old rats on renal function in chronic kidney disease 2020 kidney kidney_failure_chronic homo_sapiens mir-133a-2 MI0000451 miRBase miRNA down-regulation NA TGF-BETA SIGNALING PATHWAY NA no miR-294/miR-133 overexpression prevented smad2/3 and erk1/2 phosphorylation in human Kidney 2 (HK-2) cells during TGF-beta1-mediated epithelial-mesenchymal transition (EMT). 32641100 Protective effect of miRNA-containing extracellular vesicles derived from mesenchymal stromal cells of old rats on renal function in chronic kidney disease 2020 kidney kidney_failure_chronic homo_sapiens mir-133b MI0000822 miRBase miRNA down-regulation NA TGF-BETA SIGNALING PATHWAY NA no miR-294/miR-133 overexpression prevented smad2/3 and erk1/2 phosphorylation in human Kidney 2 (HK-2) cells during TGF-beta1-mediated epithelial-mesenchymal transition (EMT). 32641100 Protective effect of miRNA-containing extracellular vesicles derived from mesenchymal stromal cells of old rats on renal function in chronic kidney disease 2020 kidney nephritis_interstitia homo_sapiens mir-29c MI0000735 miRBase miRNA down-regulation COL2A1;TPM1 NA NA no miR-29c is downregulated in renal interstitial fibrosis in humans and rats and restored by activation of hif-alfa that attenuates fibrosis. 23467423 MiR-29c is downregulated in renal interstitial fibrosis in humans and rats and restored by HIF-alpha activation 2013 kidney kidney_diseases homo_sapiens mir-29c MI0000735 miRBase miRNA up-regulation AMPK AMPK SIGNALING PATHWAY;MTOR SIGNALING PATHWAY NA no miR-29c silencing may inhibit the diabetic nephropathies renal fibrosis through AMPK/mTOR signals. 31364127 Effect of miR-29c on renal fibrosis in diabetic rats via the AMPK/mTOR signaling pathway 2019 kidney kidney_failure_chronic homo_sapiens mir-302a MI0000738 miRBase miRNA up-regulation ZEB1 NA RT-PCR; no miR-302a-3p may play a protective role by targeting zeb1 in renal epithelial-mesenchymal transition (EMT) in diabetic kidney disease (DKD). 29227974 MiR302a-3p May Modulate Renal Epithelial-Mesenchymal Transition in Diabetic Kidney Disease by Targeting ZEB1 2018 kidney diabetic_nephropathy homo_sapiens mir-30c-1 MI0000736 miRBase miRNA down-regulation JAK1 NA qRT-PCR; dual-luciferase reporter assay no miR-30c-5p evidently inhibited hg-induced epithelial-mesenchymal transition (EMT) and renal fibrogenesis by down-regulation Jak1 in diabetic nephropathies. 32096183 MiR-30c-5p inhibits high glucose-induced EMT and renal fibrogenesis by down-regulation of JAK1 in diabetic nephropathy 2020 kidney diabetic_nephropathy homo_sapiens mir-342 MI0000805 miRBase miRNA up-regulation SOX6 NA qRT-PCR; dual-luciferase reporter assay no miR-342-3p suppresses the progression of diabetic kidney disease by inducing the degradation of Sox6. 31746345 MiRNA-342 suppresses renal interstitial fibrosis in diabetic nephropathy by targeting SOX6 2020 kidney kidney_diseases homo_sapiens mir-363 MI0000764 miRBase miRNA up-regulation TWIST WNT SIGNALING PATHWAY microarray analysis no miR-363 induces transdifferentiation of human kidney tubular cells via upregulation of twist/canonical WNT pathway. 26373846 MiR-363 induces transdifferentiation of human kidney tubular cells to mesenchymal phenotype 2016 kidney diabetic_nephropathy homo_sapiens mir-377 MI0000785 miRBase miRNA up-regulation SOD2 FOXO SIGNALING PATHWAY microRNA microarray; qPCR no "miR-377 led to reduced expressions of p21-activated kinase and superoxide dismutase, which enhanced fibronectin protein production. Thus, overexpression of miR-377 in diabetic nephropathy indirectly leads to increased fibronectin protein production." 18716028 MicroRNA-377 is up-regulated and can lead to increased fibronectin production in diabetic nephropathy 2008 kidney diabetic_nephropathy homo_sapiens mir-455 MI0003513 miRBase miRNA down-regulation ROCK2 NA Masson's trichrome staining no miR-455-3p plays an essential role in the treatment of renal fibrosis through repressing rock2 expression. 29932921 MiR-455-3p suppresses renal fibrosis through repression of ROCK2 expression in diabetic nephropathy 2018 kidney nephritis_interstitia homo_sapiens mir-542 MI0003686 miRBase miRNA up-regulation AGO1 NA histological experiments; dual-luciferase reporter assay no miR-542-3p induced kidney fibrogenesis both in vivo and in vitro through targeting Ago1. 32470449 MiR-542-3p drives renal fibrosis by targeting AGO1 in vivo and in vitro 2020 kidney diabetic_nephropathy homo_sapiens mir-544a MI0003515 miRBase miRNA down-regulation FASN NF-KAPPA B SIGNALING PATHWAY dual-luciferase reporter assay no miR-544 attenuates diabetic renal injury via suppressing glomerulosclerosis and inflammation by targeting FASN. 31323309 MicroRNA-544 attenuates diabetic renal injury via suppressing glomerulosclerosis and inflammation by targeting FASN 2020 kidney kidney_diseases homo_sapiens mir-802 MI0003906 miRBase miRNA down-regulation NRF NF-KAPPA B SIGNALING PATHWAY NA no miR-802/NRF signalling was an important pathway in mediating obesity-related nephropathy. 30729676 MiR-802 causes nephropathy by suppressing NF-KB-repressing factor in obese mice and human 2019 kidney kidney_diseases homo_sapiens mir-9-1 MI0000466 miRBase miRNA down-regulation NA NA NA no miR-9-5p elicits a protective response to chronic kidney injury and renal fibrosis by inducing reprogramming of the metabolic derangement and mitochondrial dysfunction affecting tubular epithelial cells. 31914684 MiR-9-5p protects from kidney fibrosis by metabolic reprogramming 2020 kidney nephritis_interstitia homo_sapiens mir-200a MI0000737 miRBase miRNA down-regulation CTNNB1 NA qPCR; MIGRATION ASSAY; immunofluorescence; dual-luciferase reporter assay no miRNA-200a inhibits TGF-beta1-induced epithelial-mesenchymal transition (EMT) by directly targeting beta-catenin in proximal tubule epithelial cells. 28817830 MicroRNA-200a Inhibits Transforming Growth Factor beta1-Induced Proximal Tubular Epithelial-Mesenchymal Transition by Targeting beta-Catenin 2017 kidney kidney_diseases homo_sapiens mir-21 MI0000077 miRBase miRNA up-regulation NA TGF-BETA SIGNALING PATHWAY NA yes Modulation of miR-21-5p/smad-7 signal may be involved in the anti-fibrotic effect of pioglitazone in the kidney of unilateral ureteral obstruction (UUO) mice. 31254585 Pioglitazone attenuates kidney fibrosis via miR-21-5p modulation 2019 kidney diabetic_nephropathy homo_sapiens mir-27a MI0000085 miRBase miRNA up-regulation PPAR gama TGF-BETA SIGNALING PATHWAY NA no Monitoring plasma miR-27a level and its association with PPAR gama can be used to reflect the severity of renal tubulointerstitial fibrosis (TIF). 27351287 MicroRNA-27a promotes renal tubulointerstitial fibrosis via suppressing PPARgama pathway in diabetic nephropathy 2016 kidney kidney_diseases homo_sapiens mir-129-2 MI0000473 miRBase miRNA down-regulation NA NA NA no Neat1 sponged miR-129 to modulate the epithelial-mesenchymal transition process and inflammation response of renal fibrosis by regulation of collagen type i. 32475133 Long noncoding RNA NEAT1 sponges miR-129 to modulate renal fibrosis by regulation of collagen type I 2020 kidney kidney_diseases homo_sapiens mir-129-1 MI0000252 miRBase miRNA down-regulation NA NA NA no Neat1 sponged miR-129 to modulate the epithelial-mesenchymal transition process and inflammation response of renal fibrosis by regulation of collagen type i. 32475133 Long noncoding RNA NEAT1 sponges miR-129 to modulate renal fibrosis by regulation of collagen type I 2020 kidney kidney_diseases homo_sapiens mir-200b MI0000342 miRBase miRNA down-regulation NA NA NA no Non-proximal renal tubule-derived urinary exosomal miR-200b is a biomarker of renal fibrosis. 29539618 Non-Proximal Renal Tubule-Derived Urinary Exosomal miR-200b as a Biomarker of Renal Fibrosis 2018 kidney kidney_diseases homo_sapiens mir-199a-1 MI0000242 miRBase miRNA up-regulation SOCS7 P53 SIGNALING PATHWAY CHIP analysis no Novel p53/miR-199a-3p/Socs7/STAT3 pathway in renal interstitial fibrosis. 28240316 P53 induces miR199a-3p to suppress SOCS7 for STAT3 activation and renal fibrosis in UUO 2017 kidney diabetic_nephropathy homo_sapiens mir-93 MI0000095 miRBase miRNA down-regulation ORAIL TGF-BETA SIGNALING PATHWAY NA no Orai1 and miR-93 significantly impact on the progression of TGF-beta-mediated epithelial-mesenchymal transition (EMT) and fibrogenesis in human Kidney 2 (HK-2) cells. 29551286 Up-regulation of microRNA-93 inhibits TGF-beta1-induced EMT and renal fibrogenesis by down-regulation of Orai1 2018 kidney kidney_diseases homo_sapiens mir-29c MI0000735 miRBase miRNA down-regulation NA TGF-BETA SIGNALING PATHWAY qRT-PCR; no "Overall, miR-29c correlated with the degree of renal chronicity but not with renal function" 26040904 MiR-29c in urinary exosomes as predictor of early renal fibrosis in lupus nephritis 2015 kidney kidney_failure_chronic homo_sapiens mir-26a-1 MI0000083 miRBase miRNA down-regulation NA NA qPCR no Overexpression of miR-26a in muscle prevented chronic kidney disease (CKD)-induced muscle wasting and attenuated cardiomyopathy via exosome-mediated miR-26a transfer. 31037144 MiR-26a Limits Muscle Wasting and Cardiac Fibrosis through Exosome-Mediated microRNA Transfer in Chronic Kidney Disease 2019 kidney kidney_failure_chronic homo_sapiens mir-148a MI0000253 miRBase miRNA down-regulation NA NA PCR no Plasma cell-free miRNA-148a correlated with renal function and histological grades. 30320905 Cell-free microRNA-148a is associated with renal allograft dysfunction: Implication for biomarker discovery 2019 kidney glomerulosclerosis_focal_segmental homo_sapiens mir-196a-1 MI0000238 miRBase miRNA up-regulation NA NA qRT-PCR no Prediction accuracy of end-stage renal disease (ESRD) was significantly improved by combining urinary miR-196a with other indicators including EGFR and proteinuria. 29636065 Urinary miR-196a predicts disease progression in patients with chronic kidney disease 2018 kidney nephritis_interstitia homo_sapiens mir-21 MI0000077 miRBase miRNA up-regulation PTEN PI3K-AKT SIGNALING PATHWAY RT-PCR; yes "Pure total flavonoids from Smilax glabra Roxb (PTFS) has strong anti-diabetic nephropathies and antifibrosis effects both in vitro and in vivo. The mechanism underlying these effects may be related to inhibition of TGF-beta/smad, and their downstream miR-21/PTEN signaling, leading to blocks of diabetic nephropathies process during renal interstitial fibrosis (RIF)." 30304552 Total flavonoids from Smilax glabra Roxb blocks epithelial-mesenchymal transition and inhibits renal interstitial fibrosis by targeting miR-21/PTEN signaling 2019 kidney nephritis_interstitia homo_sapiens mir-30e MI0000749 miRBase miRNA down-regulation SNAIL;SLUG;ZEB2 NA dual-luciferase reporter assay yes "Schisandrin B (Sch B) can decrease the expression of snail, slug, and zeb2, thereby attenuating the emt of proximal tubular cells (PTCs) during tubulointerstitial fibrosis (TIF) by upregulating miR-30e." 31697999 Schisandrin B attenuates renal fibrosis via miR-30e-mediated inhibition of EMT 2019 kidney diabetic_nephropathy homo_sapiens mir-217 MI0000293 miRBase miRNA up-regulation NA NA qRT-PCR; enzyme-linked immunosorbent assay no "Serum microrna-217 may be involved in the development of diabetic kidney disease by promoting chronic inflammation, renal fibrosis, and angiogenesis." 27522360 Changes of serum Mir-217 and the correlation with the severity in type 2 diabetes patients with different stages of diabetic kidney disease 2017 kidney diabetic_nephropathy homo_sapiens mir-130b MI0000748 miRBase miRNA down-regulation NA NA RT-PCR; immunohistochemistry no Serum miR-130b levels were significantly decreased in type 2 diabetes mellitus (T2DM). 25952368 The changes in miR-130b levels in human serum and the correlation with the severity of diabetic nephropathy 2015 kidney nephritis_interstitia homo_sapiens mir-21 MI0000077 miRBase miRNA up-regulation NA MAPK SIGNALING PATHWAY NA no Silenced miR-21 probably suppresses renal interstitial fibrosis (RIF) via the Erk1/2 signaling pathway. 31389582 Silenced miR-21 inhibits renal interstitial fibrosis via targeting ERK1/2 signaling pathway in mice 2019 kidney nephritis_interstitia homo_sapiens mir-34a MI0000268 miRBase miRNA up-regulation SIRT1 NA NA no Sirt1 which is vital in the evolution of renal tubulointerstitial fibrosis (TIF) in diabetic nephropathies can be directly suppressed by miR-34a-5p. 29371016 High glucose up-regulates microRNA-34a-5p to aggravate fibrosis by targeting SIRT1 in HK-2 cells 2018 kidney kidney_diseases homo_sapiens mir-185 MI0000482 miRBase miRNA down-regulation MEG3 NA NA no That the modulation of the miR-185/ DNMT1/ meg3 pathway exerted important roles in TGF-beta-induced renal fibrosis. 30095214 "MiR-185 affected the EMT, cell viability, and proliferation via DNMT1/MEG3 pathway in TGF-beta1-induced renal fibrosis" 2019 kidney kidney_diseases homo_sapiens mir-106b MI0000734 miRBase miRNA down-regulation NA NA RT-PCR no "The miR-106b-25 cluster may contribute to diabetic nephropathies in the kidney, and is involved in the protective effect of sal b." 25094038 Expression of miR-106b-25 induced by salvianolic acid B inhibits epithelial-to-mesenchymal transition in HK-2 cells 2014 kidney diabetic_nephropathy homo_sapiens mir-130b MI0000748 miRBase miRNA down-regulation SNAIL NA NA no The miR-130b-snail axis in fostering epithelial-mesenchymal transition (EMT) and progression toward increased tubulointerstitial fibrosis in diabetic nephropathies. 26837280 MicroRNA-130b improves renal tubulointerstitial fibrosis via repression of Snail-induced epithelial-mesenchymal transition in diabetic nephropathy 2016 kidney kidney_tubular_necrosis_acute homo_sapiens mir-378a MI0000786 miRBase miRNA down-regulation NA MAPK SIGNALING PATHWAY qPCR no "The protective function of MAPK1, regulated by miR-378, in the induction of kidney cell fibrosis and mesangial hypertrophy." 28053239 MiR-378 reduces mesangial hypertrophy and kidney tubular fibrosis via MAPK signalling 2017 kidney diabetic_nephropathy homo_sapiens mir-2467 MI0017432 miRBase miRNA down-regulation TWIST1 NA NA no "The reduction of miR-2467-3p promotes expression of twist1, inducing epithelial-to-mesenchymal transition (emt), resulting in renal fibrosis and kidney dysfunction." 32050151 Diabetic nephropathy execrates epithelial-to-mesenchymal transition (EMT) via miR-2467-3p/Twist1 pathway 2020 kidney diabetic_nephropathy homo_sapiens mir-155 MI0000681 miRBase miRNA up-regulation SIRT1 P53 SIGNALING PATHWAY dual-luciferase reporter assays; CHIP assay no "Under high glucose conditions, over expression of miR-155 decreased the expression of lc3-ii and atg5 in human Kidney 2 (HK-2) cells." 29848325 Role of p53/miR-155-5p/sirt1 loop in renal tubular injury of diabetic kidney disease 2018 kidney nephritis_interstitia homo_sapiens mir-382 MI0000790 miRBase miRNA up-regulation HSPD1 NA NA no Upregulation of miR-382/3-nt and downregulation of hspd1/TRX were also observed in iga nephropathy patients with renal interstitial fibrosis. 28680529 MiR-382 Contributes to Renal Tubulointerstitial Fibrosis by Downregulating HSPD1 2017 kidney kidney_failure_chronic homo_sapiens mir-1238 MI0006328 miRBase miRNA down-regulation GDF11 TGF-BETA SIGNALING PATHWAY qRT-PCR; dual-luciferase reporter assay no Upregulation of miRNA-1228-3p markedly inhibited the progression of renal fibrosis in vitro. 32720699 Upregulation of miRNA-1228-3p alleviates TGF-beta-induced fibrosis in renal tubular epithelial cells 2020 kidney kidney_diseases homo_sapiens mir-192 MI0000234 miRBase miRNA up-regulation SMAD3 NA RT-PCR; no "VEGF suppressed smad3 and miR-192, and subsequently inhibited epithelial-mesenchymal transition (EMT) induced by TGF-beta." 23588932 "VEGF suppresses epithelial-mesenchymal transition by inhibiting the expression of Smad3 and miR-192, a Smad3-dependent microRNA" 2013 kidney glomerulosclerosis_focal_segmental homo_sapiens mir-192 MI0000234 miRBase miRNA up-regulation NA NA qRT-PCR no NA 23463342 Serum microRNAs levels in primary focal segmental glomerulosclerosis 2013 kidney glomerulosclerosis_focal_segmental homo_sapiens mir-205 MI0000285 miRBase miRNA up-regulation NA NA qRT-PCR no NA 23463342 Serum microRNAs levels in primary focal segmental glomerulosclerosis 2013 kidney kidney_diseases homo_sapiens mir-21 MI0000077 miRBase miRNA up-regulation NA NA NA no NA 23469132 Increased circulating miR-21 levels are associated with kidney fibrosis 2013 kidney kidney_diseases homo_sapiens mir-29c MI0000735 miRBase miRNA down-regulation NA NA NA no NA 23806282 Sp1 mediates microRNA-29c-regulated type I collagen production in renal tubular epithelial cells 2013 kidney diabetic_nephropathy homo_sapiens mir-21 MI0000077 miRBase miRNA up-regulation SMAD3 NA NA no NA 26415649 MiR-21 promotes renal fibrosis in diabetic nephropathy by targeting PTEN and SMAD7 2015 kidney kidney_failure_chronic homo_sapiens mir-211 MI0000287 miRBase miRNA down-regulation NA NA ROC curve analyses no NA 26725559 Altered Expression of MicroRNAs Following Chronic Allograft Dysfunction with Interstitial Fibrosis and Tubular Atrophy 2015 kidney kidney_failure_chronic homo_sapiens mir-142 MI0000458 miRBase miRNA up-regulation NA NA ROC curve analysis no NA 26725559 Altered Expression of MicroRNAs Following Chronic Allograft Dysfunction with Interstitial Fibrosis and Tubular Atrophy 2015 kidney lupus_nephritis homo_sapiens mir-21 MI0000077 miRBase miRNA up-regulation NA NA qPCR; ROC curve analysis no NA 31209193 "Plasma levels of miR-21, miR-150, miR-423 in patients with lupus nephritis" 2019 kidney lupus_nephritis homo_sapiens mir-150 MI0000479 miRBase miRNA down-regulation NA NA qPCR; ROC curve analysis no NA 31209193 "Plasma levels of miR-21, miR-150, miR-424 in patients with lupus nephritis" 2019 kidney diabetic_nephropathy homo_sapiens mir-1228 MI0006318 miRBase miRNA down-regulation NA NA NA no NA 31388051 Urinary miRNA-27b-3p and miRNA-1228-3p correlate with the progression of Kidney Fibrosis in Diabetic Nephropathy 2019 kidney diabetic_nephropathy homo_sapiens mir-27b MI0000440 miRBase miRNA down-regulation NA NA NA no NA 31388051 Urinary miRNA-27b-3p and miRNA-1228-3p correlate with the progression of Kidney Fibrosis in Diabetic Nephropathy 2019 liver liver_cirrhosis homo_sapiens mir-29b-1 MI0000105 miRBase miRNA dna methylation PTEN ERK; PI3K-AKT SIGNALING PATHWAY RT-PCR; etc. no A histone deacetylase-4-dependent mechanism underlies the epigenetic silencing of mmp genes during tissue fibrogenesis. 28129115 HOTAIR Epigenetically Modulates PTEN Expression via MicroRNA-29b: A Novel Mechanism in Regulation of Liver Fibrosis 2017 liver liver_cirrhosis homo_sapiens miR-378a-3p MIMAT0000732 miRBase miRNA down-regulation WNT-10A WNT SIGNALING PATHWAY PCR; dual-lucimmunofluorescenceerase reporter assay etc. yes Activation of hepatic stellate cells is inhibited by microrna-378a-3p via wnt10a. 27832641 Activation of Hepatic Stellate Cells is Inhibited by microRNA-378a-3p via Wnt10a 2016 liver liver_cirrhosis homo_sapiens mir-92a-1 MI0000093 miRBase miRNA down-regulation NA NA microarray analysis; PCR; flow cytometric no Altered expression of mir-92a correlates with th17 cell frequency in patients with primary biliary cirrhosis. 27246196 Altered expression of miR-92a correlates with Th17 cell frequency in patients with primary biliary cirrhosis 2016 liver liver_cirrhosis homo_sapiens mir-18a MI0000072 miRBase miRNA phosphorylated perk and hnrnpa1 NA NA grp78; immunoblottings; qRT-PCR etc. no Brivanib reduces liver fibrosis in three different animal models and decreases human hepatic stellate cell activation. Brivanib may represent a novel therapeutic approach to treatment of liver fibrosis and prevention of liver cancer. 26435271 Endoplasmic Reticulum Stress in Hepatic Stellate Cells Promotes Liver Fibrosis via PERK-Mediated Degradation of HNRNPA1 and Up-regulation of SMAD2 2016 liver hepatitis homo_sapiens mir-122 MI0000442 miRBase miRNA up-regulation NA NA PCR etc. no Circulating mirna-122 levels are associated with hepatic necroinflammation and portal hypertension in hiv;Hcv coinfection. 25646812 Circulating miRNA-122 levels are associated with hepatic necroinflammation and portal hypertension in HIV/HCV coinfection 2015 liver liver_cirrhosis homo_sapiens mir-29b-1 MI0000105 miRBase miRNA dna methylation;down-regelation PTEN PTEN qRT-PCR; dual-lucimmunofluorescenceerase reporter assay etc. no Dna methylation and mecp2 may provide molecular mechanisms for silencing of ptch1. 24138392 Curcumin up-regulates phosphatase and tensin homologue deleted on chromosome 10 through microRNA-mediated control of DNA methylation--a novel mechanism suppressing liver fibrosis 2014 liver liver_cirrhosis homo_sapiens mir-378a MI0000786 miRBase miRNA dna methylation TGF-B2 TGF-BETA SIGNALING PATHWAY qRT-PCR; dual-lucimmunofluorescenceerase reporter assay etc. no Dna methylation and mecp2 may provide molecular mechanisms for silencing of ptch1. 27855367 The Epigenetically-Regulated microRNA-378a Targets TGF-B2 in TGF-B1-Treated Hepatic Stellate Cells 2016 liver liver_cirrhosis homo_sapiens mir-122 MI0000442 miRBase miRNA up-regulation NA NA PCR; yes Elevated mir-122 serum levels are an independent marker of liver injury in inflammatory diseases. 25039534 Elevated miR-122 serum levels are an independent marker of liver injury in inflammatory diseases 2015 liver liver_cirrhosis homo_sapiens mir-221 MI0000298 miRBase miRNA down-regulation OPN NA immunohistochemistry; PCR etc. yes Epigallocatechin-3-gallate upregulates mir-221 to inhibit osteopontin-dependent hepatic fibrosis. 27935974 Epigallocatechin-3-Gallate Upregulates miR-221 to Inhibit Osteopontin-Dependent Hepatic Fibrosis 2016 liver liver_cirrhosis homo_sapiens mir-454 MI0003820 miRBase miRNA down-regulation SMAD4 TGF-BETA SIGNALING PATHWAY PCR; dual-lucimmunofluorescenceerase reporter assay etc. no Expression of microrna-454 in tgf-b1-stimulated hepatic stellate cells and in mouse livers infected with schistosoma japonicum. 24685242 Expression of microRNA-454 in TGF-B1-stimulated hepatic stellate cells and in mouse livers infected with Schistosoma japonicum 2014 liver liver_cirrhosis homo_sapiens mir-29a MI0000087 miRBase miRNA down-regulation PDGF-C; IGF NA enzyme-linked immunosorbent assay; PCR etc. yes Expression of platelet-derived growth factor-c and insulin-like growth factor i in hepatic stellate cells is inhibited by mir-29. 22565577 Expression of platelet-derived growth factor-C and insulin-like growth factor I in hepatic stellate cells is inhibited by miR-29 2012 liver liver_cirrhosis homo_sapiens mir-15a MI0000069 miRBase miRNA down-regulation SMAD7; TGF-B TGF-BETA SIGNALING PATHWAY PCR; dual-lucimmunofluorescenceerase reporter assay etc. yes Hepatitis b virus regulates apoptosis and tumorigenesis through the microrna-15a-smad7-transforming growth factor beta pathway. 25540364 Hepatitis B virus regulates apoptosis and tumorigenesis through the microRNA-15a-Smad7-transforming growth factor beta pathway 2015 liver hepatitis homo_sapiens mir-200c MI0000650 miRBase miRNA up-regulation FAP-1 NA enzyme-linked immunosorbent assay; PCR no "Hepatitis c virus induced mir200c down modulates fap-1, a negative regulator of src signaling and promotes hepatic fibrosis." 23950995 "Hepatitis C virus induced miR200c down modulates FAP-1, a negative regulator of Src signaling and promotes hepatic fibrosis" 2013 liver hepatitis homo_sapiens mir-16-1 MI0000070 miRBase miRNA down-regulation SMAD7 TGF-BETA SIGNALING PATHWAY enzyme-linked immunosorbent assay; PCR etc. no "Hepatitis c virus infection induced mir-16 up-regulation, by down-regulating hepatocyte growth factor and smad7 to promote liver fibrosis." 26071245 Increased miR-16 expression induced by hepatitis C virus infection promotes liver fibrosis through downregulation of hepatocyte growth factor and Smad7 2015 liver hepatitis homo_sapiens mir-192 MI0000234 miRBase miRNA up-regulation TGF-B; ZEB1 TGF-BETA SIGNALING PATHWAY PCR; dual-lucimmunofluorescenceerase reporter assay no "Hepatitis c virus infection stimulates the expression of tgf-b1 by up-regulating mir-192, eliciting fibrosis." 27350618 Hepatitis C virus infection stimulates transforming growth factor-1 expression through up-regulating miR-192 2016 liver hepatitis homo_sapiens mir-449a MI0001648 miRBase miRNA down-regulation NOTCH NOTCH SIGNALING PATHWAY PCR; dual-lucimmunofluorescenceerase reporter assay etc. no Hepatitis c virus mediated changes in mirna-449a modulates inflammatory biomarker ykl40 through components of the notch signaling pathway. 23226395 Hepatitis C virus mediated changes in miRNA-449a modulates inflammatory biomarker YKL40 through components of the NOTCH signaling pathway 2012 liver liver_cirrhosis homo_sapiens mir-24-1 MI0000080 miRBase miRNA down-regulation MENIN NA PCR; dual-lucimmunofluorescenceerase reporter assay etc. yes Inhibition of microrna-24 increases liver fibrosis by enhanced menin expression in mdr2(-/-) Mice. 28602220 Inhibition of microRNA-24 increases liver fibrosis by enhanced menin expression in Mdr2(-/-) mice 2017 liver liver_cirrhosis homo_sapiens mir-21a MI0000569 miRBase miRNA up-regulation NA NA immunofluorescence; PCR etc. yes Knockout of microrna-21 can reduce bile hyperplasia and hepatic fibrosis in biliary cholangiocarcinoma mice. 27775690 Knockout of microRNA-21 reduces biliary hyperplasia and liver fibrosis in cholestatic bile duct ligated mice 2016 liver non-alcoholic_fatty_liver_disease homo_sapiens miR-128-3p MIMAT0000424 miRBase miRNA down-regulation PPARY PPAR SIGNALING PATHWAY RT-PCR; immunofluorescence etc. yes "Lipid-induced hepatocyte-derived extracellular vesicles are mediated by ppar-gamma-mirna-128-3p-mediated hepatic stellate cells, mirna-128-3p inhibits ppary-inhibited hepatic stellate cell activation." 26783552 Lipid-induced hepatocyte-derived extracellular vesicles regulate hepatic stellate cell via microRNAs targeting PPAR-gama 2015 liver non-alcoholic_fatty_liver_disease homo_sapiens mir-21a MI0000569 miRBase miRNA up-regulation PPARA PPAR SIGNALING PATHWAY H&E staining; RT-PCR; immunofluorescence etc. yes "Liver microrna-21 overexpression in non-alcoholic steatohepatitis, inhibition of ppara, promotion of hepatocyte injury, inflammation and fibrosis." 26338827 Liver microRNA-21 is overexpressed in non-alcoholic steatohepatitis and contributes to the disease in experimental models by inhibiting PPARalfa expression 2016 liver liver_cirrhosis homo_sapiens mir-29b-1 MI0000105 miRBase miRNA down-regulation SMAD3 PI3K-AKT SIGNALING PATHWAY NA no Mecp2 positively regulates ash1 expression and therefore identify ash1 as a key transcriptional activator component of the mecp2 epigenetic relay pathway that orchestrates coordinated induction of multiple profibrogenic genes. 25356754 MicroRNA-29b prevents liver fibrosis by attenuating hepatic stellate cell activation and inducing apoptosis through targeting PI3K/AKT pathway 2015 liver liver_cirrhosis homo_sapiens mir-200a MI0000737 miRBase miRNA down-regulation GLI2 HEDGEHOG SIGNALING PATHWAY PCR; dual-lucimmunofluorescenceerase reporter assay etc. yes Microrna 200a suppresses epithelial to mesenchymal transition in rat hepatic stellate cells via gli family zinc finger 2. 26499180 MicroRNA 200a suppresses epithelial to mesenchymal transition in rat hepatic stellate cells via GLI family zinc finger 2 2015 liver liver_cirrhosis homo_sapiens mir-122 MI0000442 miRBase miRNA down-regulation HYPOXIA-INDUCIBLE FACTOR-1; VIMENTIN NA PCR; transfection etc. yes Microrna-122 regulates hypoxia-inducible factor-1 and vimentin in hepatocytes and is associated with fibrosis in dietary-induced steatohepatitis. 25040043 MicroRNA-122 regulates hypoxia-inducible factor-1 and vimentin in hepatocytes and correlates with fibrosis in diet-induced steatohepatitis 2014 liver liver_cirrhosis homo_sapiens mir-145 MI0000461 miRBase miRNA down-regulation ZEB1 WNT SIGNALING PATHWAY; CATENIN BETA 1 PCR; flow cytometric etc. yes Microrna-145 inhibits hepatic stellate cell activation and proliferation by targeting zeb2 through wnt;B-catenin pathway. 27289031 MicroRNA-145 inhibits hepatic stellate cell activation and proliferation by targeting ZEB2 through Wnt-catenin pathway 2016 liver liver_cirrhosis homo_sapiens mir-155 MI0000681 miRBase miRNA down-regulation TCF4; AGTR1; ERK1 TCF4-12; AGTR1; ERK2 enzyme-linked immunosorbent assay; PCR etc. no Microrna-155 attenuates activation of hepatic stellate cell by simultaneously preventing emt process and erk1 signalling pathway. 25142507 MicroRNA-155 attenuates activation of hepatic stellate cell by simultaneously preventing EMT process and ERK1 signalling pathway 2014 liver liver_cirrhosis homo_sapiens miR-17-5p MIMAT0000070 miRBase miRNA up-regulation SMAD7 TGF-BETA SIGNALING PATHWAY PCR; dual-lucimmunofluorescenceerase reporter assay yes Microrna-17-5p activates hepatic stellate cells through targeting of smad7. 25915722 MicroRNA-17-5p activates hepatic stellate cells through targeting of Smad7 2015 liver liver_cirrhosis homo_sapiens mir-200a MI0000737 miRBase miRNA down-regulation KEAP1 NA PCR etc. yes Microrna-200a controls the proliferation of hepatic stellate cells and the activation of nrf2 in fibrosis by targeting keap1. 25049078 MicroRNA-200a controls Nrf2 activation by target Keap1 in hepatic stellate cellproliferation and fibrosis 2014 liver liver_cirrhosis homo_sapiens mir-222 MI0000299 miRBase miRNA up-regulation NF-KB NF-KAPPA B SIGNALING PATHWAY PCR; immunoblotting; dual-lucimmunofluorescenceerase reporter assay etc. yes Microrna-221;222 Upregulation indicates the activation of stellate cells and the progression of liver fibrosis. 22267590 MicroRNA-221/222 upregulation indicates the activation of stellate cells and the progression of liver fibrosis 2012 liver liver_cirrhosis homo_sapiens mir-221 MI0000298 miRBase miRNA up-regulation NF-KB NF-KAPPA B SIGNALING PATHWAY PCR; immunoblotting; dual-lucimmunofluorescenceerase reporter assay etc. yes Microrna-221;222 Upregulation indicates the activation of stellate cells and the progression of liver fibrosis. 22267590 MicroRNA-221/222 upregulation indicates the activation of stellate cells and the progression of liver fibrosis 2012 liver liver_cirrhosis homo_sapiens mir-29a MI0000087 miRBase miRNA down-regulation PI3K; AKT PI4K-AKT SIGNALING PATHWAY PCR; dual-lucimmunofluorescenceerase reporter assay etc. yes Microrna-29b prevents hepatic fibrosis by reducing hepatic stellate cell activation and inducing apoptosis by targeting the pi3k ; Akt pathway. 25356754 MicroRNA-29b prevents liver fibrosis by attenuating hepatic stellate cell activation and inducing apoptosis through targeting PI3K/AKT pathway 2015 liver liver_cirrhosis homo_sapiens mir-34a MI0000268 miRBase miRNA down-regulation PPARY PPAR SIGNALING PATHWAY PCR; dual-lucimmunofluorescenceerase reporter assay no Microrna-34a and microrna-34c promote the activation of human hepatic stellate cells by targeting peroxisome proliferator-activated receptor y. 25370690 MicroRNA-34a and microRNA-34c promote the activation of human hepatic stellate cells by targeting peroxisome proliferator-activated receptor Y 2015 liver liver_cirrhosis homo_sapiens mir-34c MI0000743 miRBase miRNA down-regulation PPARY PPAR SIGNALING PATHWAY PCR; dual-lucimmunofluorescenceerase reporter assay no Microrna-34a and microrna-34c promote the activation of human hepatic stellate cells by targeting peroxisome proliferator-activated receptor y. 25370690 MicroRNA-34a and microRNA-34c promote the activation of human hepatic stellate cells by targeting peroxisome proliferator-activated receptor Y 2015 liver hepatitis homo_sapiens mir-4717 MI0017352 miRBase miRNA down-regulation PD1 NA PCR; dual-lucimmunofluorescenceerase reporter assay no Microrna-4717 differentially interacts with its polymorphic target in the pd1 3' untranslated region: a mechanism for regulating pd-1 expression and function in hbv-associated liver diseases. 25895129 MicroRNA-4717 differentially interacts with its polymorphic target in the PD1 3' untranslated region: A mechanism for regulating PD-1 expression and function in HBV-associated liver diseases 2015 liver liver_cirrhosis homo_sapiens mir-122 MI0000442 miRBase miRNA down-regulation KLF6 NA PCR; dual-lucimmunofluorescenceerase reporter assay etc. yes "Mir-122 overexpression reverses liver disease. The incidence of hepatic fibrosis may be attributed in part to the role of the mir-122a target klf6 transcript. In addition, the mir122a -/- Liver is shown to be interrupted in a series of pathways, many of which are very similar to those found in human hcc." 22820290 MicroRNA-122 plays a critical role in liver homeostasis and hepatocarcinogenesis 2012 liver hepatitis homo_sapiens miR-1273g-3p MIMAT0022742 miRBase miRNA up-regulation PTEN PTEN PCR; dual-lucimmunofluorescenceerase reporter assay etc. no Mir-1273g-3p modulates activation and apoptosis of hepatic stellate cells by directly targeting pten in hcv-related liver fibrosis. 27423040 MiR-1273g-3p modulates activation and apoptosis of hepatic stellate cells by directly targeting PTEN in HCV-related liver fibrosis 2016 liver non-alcoholic_fatty_liver_disease homo_sapiens miR-146a-5p MIMAT0000449 miRBase miRNA down-regulation WNT1; WNT5A WNT SIGNALING PATHWAY PCR; dual-lucimmunofluorescenceerase reporter assay yes Mir-146a-5p suppresses activation and proliferation of hepatic stellate cells in nonalcoholic fibrosing steatohepatitis through directly targeting wnt1 and wnt5a. 26537990 MiR-146a-5p suppresses activation and proliferation of hepatic stellate cells in nonalcoholic fibrosing steatohepatitis through directly targeting Wnt1 and Wnt5a 2015 liver carcinoma_hepatocellular homo_sapiens mir-148a MI0000253 miRBase miRNA down-regulation IKB KINASEA; NUMB NOTCH SIGNALING PATHWAY PCR yes "Mir-148a is an inhibitor of ikb kinase a ; Numb ; Notch pathway and a hepatocyte differentiation inducer, and its expression disorder promotes the development of hcc. Differentiated targeted therapy may be a promising strategy for the treatment and prevention of hcc." 26599259 Differentiation therapy for hepatocellular carcinoma: Multifaceted effects of mmiR-148a on tumor growth and phenotype and liver fibrosis 2016 liver liver_cirrhosis homo_sapiens mir-150 MI0000479 miRBase miRNA down-regulation SP1; COL4A4 NA PCR; dual-lucimmunofluorescenceerase reporter assay etc. no "Mir-150 can directly target sp1 and col4a4, inhibit cell proliferation and expression of extracellular matrix proteins and alpha-smooth muscle actin (a-sma)." 23604143 Activation of hepatic stellate cells is suppressed by microRNA-150 2013 liver liver_cirrhosis homo_sapiens mir-181a-2 MI0000269 miRBase miRNA down-regulation TGF-B TGF-BETA SIGNALING PATHWAY PCR; dual-lucimmunofluorescenceerase reporter assay etc. no Mir-181a mediates tgf-b-induced hepatocyte emt and is dysregulated in cirrhosis and hepatocellular cancer. 24576072 MiR-181a mediates TGF-B-induced hepatocyte EMT and is dysregulated in cirrhosis and hepatocellular cancer 2014 liver liver_cirrhosis homo_sapiens mir-181b-1 MI0000270 miRBase miRNA up-regulation P27 NA PCR no Mir-181b promotes hepatic stellate cells proliferation by targeting p27. 22446332 MiR-181b promotes hepatic stellate cells proliferation by targeting p27 and is elevated in the serum of cirrhosis patients 2012 liver liver_cirrhosis homo_sapiens mir-21a MI0000569 miRBase miRNA up-regulation ERK1; SPRY2 ERK PCR; dual-lucimmunofluorescenceerase reporter assay no Mir-21 simultaneously regulates erk1 signaling in hsc activation and hepatocyte emt in hepatic fibrosis. 25303175 MiR-21 simultaneously regulates ERK1 signaling in HSC activation and hepatocyte EMT in hepatic fibrosis 2014 liver liver_cirrhosis homo_sapiens mir-22 MI0000078 miRBase miRNA up-regulation BMP7 NA PCR; dual-lucimmunofluorescenceerase reporter assay etc. yes Mir-22 suppresses bmp7 in the development of cirrhosis. 26112332 MiR-22 Suppresses BMP7 in the Development of Cirrhosis 2015 liver liver_cirrhosis homo_sapiens mir-221 MI0000298 miRBase miRNA up-regulation P27 NA H&E staining; q-PCR; etc. no Mir-221 overexpression contributes to liver tumorigenesis. 20018759 MiR-221 overexpression contributes to liver tumorigenesis 2010 liver liver_cirrhosis homo_sapiens mir-222 MI0000299 miRBase miRNA up-regulation P27 NA H&E staining; q-PCR; etc. no Mir-221 overexpression contributes to liver tumorigenesis. 20018759 MiR-221 overexpression contributes to liver tumorigenesis 2010 liver liver_cirrhosis homo_sapiens mir-29a MI0000087 miRBase miRNA down-regulation TGF-B; NF-KB TGF-BETA SIGNALING PATHWAY; NF-KAPPA B SIGNALING PATHWAY array analysis yes Mir-29 mediates the regulation of hepatic fibrosis and is part of the signaling linkages involving tgf- [beta] and nf- [kappa] b. 20890893 Micro-RNA profiling reveals a role for miR-29 in human and murine liver fibrosis 2011 liver liver_cirrhosis homo_sapiens mir-30c-2 MI0000254 miRBase miRNA up-regulation TGF-B TGF-BETA SIGNALING PATHWAY PCR; dual-lucimmunofluorescenceerase reporter assay etc. yes Mir-30 and mir-193 are mirnas that modulate tgf-b-dependent regulation of extracellular matrix-related genes in hscs in the manifestation and regression of hepatic fibrosis. 26120970 MiR-30c and miR-193 are a part of the TGF-B-dependent regulatory network controlling extracellular matrix genes in liver fibrosis 2015 liver liver_cirrhosis homo_sapiens mir-193 MI0010077 miRBase miRNA up-regulation TGF-B TGF-BETA SIGNALING PATHWAY PCR; dual-lucimmunofluorescenceerase reporter assay etc. yes Mir-30 and mir-193 are mirnas that modulate tgf-b-dependent regulation of extracellular matrix-related genes in hscs in the manifestation and regression of hepatic fibrosis. 26120970 MiR-30c and miR-193 are a part of the TGF-B-dependent regulatory network controlling extracellular matrix genes in liver fibrosis 2015 liver liver_cirrhosis homo_sapiens mir-33a MI0000091 miRBase miRNA down-regulation PI3K; AKT PI4K-AKT SIGNALING PATHWAY PCR; dual-lucimmunofluorescenceerase reporter assay etc. no Mir-33a targeting inhibition of akt inhibits hepatic fibrosis. 24100264 Profibrotic effect of miR-33a with Akt activation in hepatic stellate cells 2014 liver liver_cirrhosis homo_sapiens mir-33a MI0000091 miRBase miRNA down-regulation SMAD7 TGF-BETA SIGNALING PATHWAY PCR; dual-lucimmunofluorescenceerase reporter assay etc. yes Mir-33a targeting smad7 regulates chronic hbv-induced liver fibrosis. 25155445 MiR-33a levels in hepatic and serum after chronic HBV-induced fibrosis 2015 liver liver_cirrhosis homo_sapiens mir-34a MI0000268 miRBase miRNA down-regulation RXR-alpha NA PCR; dual-lucimmunofluorescenceerase reporter assay etc. no Mir-34a negatively regulates rxra expression by promoting mrna degradation. 24832862 Retinoid X receptor a in human liver is regulated by miR-34a 2014 liver liver_cirrhosis homo_sapiens Mir9 100314397 Gene miRNA down-regulation JAK1; STAT3 JAK1; STAT4 enzyme-linked immunosorbent assay; PCR no "Mir-9 and tetramethylpyrazine inhibit the activation of hepatic stellate cells by inhibiting jak1 ; Stat3, and tetramethylpyrazine promotes the expression of mir-9." 25560232 Effects of miR-9 and tetramethylpyrazine on activation of hepatic stellate cells 2015 liver liver_cirrhosis homo_sapiens mir-29b-1 MI0000105 miRBase miRNA down-regulation TGF-B; SMAD3 TGF-BETA SIGNALING PATHWAY dual-lucimmunofluorescenceerase reporter assay; PCR; etc. no "Overexpression of mir-29b inhibits the expression of smad3 and tgf-b1, inhibits the expression of (a-sma) and type 1 collagen (col-1), inhibits hepatic stellate cell activation." 27273381 Suppressive effect of microRNA-29b on hepatic stellate cell activation and its crosstalk with TGF-B1/Smad3 2016 liver liver_cirrhosis homo_sapiens miR-615-5p MIMAT0004804 miRBase miRNA down-regulation IGF-II NA MTT cell viability assay; dual-lucimmunofluorescenceerase reporter assay; PCR etc. no Overexpression of mir-615-5p alleviates tumorigenesis in hepatocellular carcinoma by targeting tumor suppressor igf-ii in hcc. 22819824 MiR-615-5p is restrictedly expressed in cirrhotic and cancerous liver tissues and its overexpression alleviates the tumorigenic effects in hepatocellular carcinoma 2012 liver liver_cirrhosis homo_sapiens mir-506 MI0003193 miRBase miRNA up-regulation "TYPE III INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR" NA PCR; dual-lucimmunofluorescenceerase reporter assay no "Post-translational regulation of the type iii inositol 1,4,5-trisphosphate receptor by mirna-506." 25378392 "Post-translational regulation of the type III inositol 1,4,5-trisphosphate receptor by miRNA-506" 2015 liver liver_cirrhosis homo_sapiens mir-210 MI0000286 miRBase miRNA up-regulation NA NA RT-PCR no Serum microrna-210 levels in different groups of chronic hepatitis b patients. 26319884 Serum microRNA-210 levels in different groups of chronic hepatitis B patients 2015 liver liver_cirrhosis homo_sapiens miR-219-5p MIMAT0036551 miRBase miRNA up-regulation KGF NA immunofluorescence; PCR etc. yes Suppression of microrna-219-5p activates keratinocyte growth factor to mitigate severity of experimental cirrhosis. 27855391 Suppression of MicroRNA-219-5p Activates Keratinocyte Growth Factor to Mitigate Severity of Experimental Cirrhosis 2016 liver liver_cirrhosis homo_sapiens mir-29a MI0000087 miRBase miRNA up-regulation NA NA PCR; microrna array yes Systemic delivery of scaav8-encoded mir-29a ameliorates hepatic fibrosis in carbon tetrachloride-treated mice. 25923107 Systemic Delivery of scAAV8-Encoded MiR-29a Ameliorates Hepatic Fibrosis in Carbon Tetrachloride-Treated Mice 2015 liver liver_cirrhosis homo_sapiens mir-31 MI0000089 miRBase miRNA up-regulation MIR-31; FIH1; TGF-B TGF-BETA SIGNALING PATHWAY PCR; dual-lucimmunofluorescenceerase reporter assay etc. yes "Tgf-beta downstream transcription factor smad3 stimulates the transcription activity of mir-31 by direct mir-31 promoter, mir-31 mediates fibrosis by targeting fih1, an inhibitor of hypoxia-inducible factor (hif-1) , overexpression significantly promoted hsc activation." 25728779 The role of the miR-31/FIH1 pathway in TGF-B-induced liver fibrosis 2015 liver liver_cirrhosis homo_sapiens mir-21a MI0000569 miRBase miRNA up-regulation MIR-21; PDCD4; AP-1 NA PCR; dual-lucimmunofluorescenceerase reporter assay etc. no The autoregulatory feedback loop of microrna-21;Programmed cell death protein 4;Activation protein-1 (mir-21;Pdcd4;Ap-1) as a driving force for hepatic fibrosis development. 24196965 The autoregulatory feedback loop of microRNA-21/programmed cell death protein 4/activation protein-1 (MiR-21/PDCD4/AP-1) as a driving force for hepatic fibrosis development 2013 liver liver_cirrhosis homo_sapiens mir-122 MI0000442 miRBase miRNA down-regulation NA NA NA no "The expression of mir-122 was reduced in advanced fibrosis, and the correlation between mir-122 and fibrosis staging and ls values was different in various causes of liver fibrosis." 26167081 MiR-122 negatively correlates with liver fibrosis as detected by histology and FibroScan 2015 liver liver_cirrhosis homo_sapiens mir-155 MI0000681 miRBase miRNA dysregulation CRISPLD NA qRT-PCR; etc. no The inhibitory effect of endotoxin-binding protein crispld depends on the trl4 signaling of mir-155 and is time-dependent. Crispld inhibition can block high mobility group protein 1 (hmgb1) -induced inflammation. 26624800 HMGB1 induced inflammatory effect is blocked by CRISPLD2 via MiR155 in hepatic fibrogenesis 2016 liver liver_cirrhosis homo_sapiens mir-29a MI0000087 miRBase miRNA dysregulation FARNESOID X RECEPTOR NA PCR; no "The lipoprotein x receptor (fxr) promotes the expression of mir-29a, inhibits extracellular matrix deposition, thereby inhibiting hepatic stellate cell fibrosis." 21511916 Roles of microRNA-29a in the antifibrotic effect of farnesoid X receptor in hepatic stellate cells 2011 liver liver_cirrhosis homo_sapiens mir-133a-1 MI0000450 miRBase miRNA down-regulation TGF-B TGF-BETA SIGNALING PATHWAY NA yes "The total mir-133a expression level remained unchanged in total rna extracts from fibrotic and human liver. However, mir-133a was specifically down-regulated in hsc during fibrogenesis. In turn, overexpression of mir-133a in primary mouse hsc leads to a decrease in collagen expression. Indicating that mir-33a has anti-fibrosis effect." 23183523 MiR-133a mediates TGF-B-dependent derepression of collagen synthesis in hepatic stellate cells during liver fibrosis 2013 liver liver_cirrhosis homo_sapiens mir-200b MI0000342 miRBase miRNA up-regulation FOG2 NA PCR; dual-lucimmunofluorescenceerase reporter assay etc. no The upregulation of mir-200b in patients with biliary atresia promotes the proliferation and migration of hepatic stagnant cells by activating pi3k ; Akt signaling. 24412919 Up-regulation of miR-200b in biliary atresia patients accelerates proliferation and migration of hepatic stallate cells by activating PI3K/Akt signaling 2014 liver liver_cirrhosis homo_sapiens miR-378a-3p MIMAT0000732 miRBase miRNA down-regulation NA NF-KAPPA B SIGNALING PATHWAY; HEDGEHOG SIGNALING PATHWAY dual-lucimmunofluorescenceerase reporter assay; hydroxyproline assay etc. no Toll like receptor 2 knock-out attenuates carbon tetrachloride (ccl4)-induced liver fibrosis by downregulating mapk and nf-kb signaling pathways. 27001906 MicroRNA-378 limits activation of hepatic stellate cells and liver fibrosis by suppressing Gli3 expression 2016 liver liver_cirrhosis homo_sapiens mir-1269a MI0006406 miRBase miRNA up-regulation NF-KB NF-KAPPA B SIGNALING PATHWAY dual-lucimmunofluorescenceerase reporter assay; PCR; no Upregulation of microrna-126 in hepatic stellate cells may affect pathogenesis of liver fibrosis through the nf-kb pathway. 25974152 Upregulation of microRNA-126 in hepatic stellate cells may affect pathogenesis of liver fibrosis through the NF-KB pathway 2015 liver liver_cirrhosis homo_sapiens SCAR NA NA miRNA dysregulation SCAR NA NA no We identify a mitochondrial circrna that drives metaflammation and serves as a therapeutic target for nash. 32931733 Targeting Mitochondria-Located circRNA SCAR Alleviates NASH via Reducing mROS Output 2020 lung Hypertension_Pulmonary homo_sapiens let-7b MI0000063 miRBase miRNA down-regulation ET-1; TGFBR1 NA qRT-PCR; ELISA etc. no "35 MicroRNAs were differentially expressed in CTEPH patients, among which, a signature of 17 microRNAs was shown to be related to the disease pathogenesis by in silico analysis. Let-7b, one of the down-regulated anti-oncogenic microRNAs in the signature, was validated to decrease in CTEPH patients. ET-1 and TGFBR1 were direct targets of let-7b. Altering let-7b level influenced ET-1 and TGFBR1 expression in pulmonary arterial endothelial cells (PAECs) as well as the migration of PAECs and pulmonary arterial smooth muscle cells (PASMCs). CTEPH patients had aberrant microRNA signature which might provide some clue for pathogenesis study and biomarker screening. Reduced let-7b might be involved in the pathogenesis of CTEPH by affecting ET-1 expression and the function of PAECs and PASMCs." 24978044 Differentially Expressed Plasma MicroRNAs and the Potential Regulatory Function of Let-7b in Chronic Thromboembolic Pulmonary Hypertension 2014 lung idiopathic_pulmonary_fibrosis homo_sapiens mir-154 MI0000480 miRBase miRNA up-regulation NA Wnt/B-catenin signaling pathway qRT-PCR; Analysis of 14q32 cluster; Chromatin immunoprecipitation assay etc. no "43 Significantly up-regulated microRNAs were identified in IPF lungs and 24 of the 43 increased microRNAs were localized to the chromosome 14q32 microRNA cluster where there are multiple SMAD3-binding elements. TGF-B1 stimulation of normal human lung fibroblasts (NHLF) caused up-regulation of microRNAs on chr14q32 that were also increased in IPF lungs. Chromatin immunoprecipitation confirmed binding of SMAD3 to the putative promoter of miR-154. Mir-154 was increased in IPF fibroblasts, and transfection of NHLF with miR-154 caused significant increases in cell proliferation,migration and activation of the WNT pathway ." 23043088 Profibrotic role of miR-154 in pulmonary fibrosis 2012 lung idiopathic_pulmonary_fibrosis homo_sapiens mir-21 MI0000077 miRBase miRNA dysregulation NA NA microRNA Target Prediction And Pathway Analysis; TaqMan miRNA Assay For Individual miRNAs etc. no "47 Significantly differentially expressed serum miRNAs were found in rapid progressive or slowly progressive IPF patients compared to healthy controls, including 21 up-regulated miRNAs and 26 down-regulated miRNAs. Bioinformatic analysis by DIANA-mirPath demonstrated that 53 KEGG biological processes were significantly enriched among differentially expressed serum miRNAs, including TGF-Beta signaling pathway, MAPK signaling pathway, PI3K-Akt signaling pathway, Wnt signaling pathway, HIF-1 signaling pathway, regulation of actin cytoskeleton, Jak-STAT signaling pathway, Notch signaling pathway, and Cytokine-cytokine receptor interaction. MiR-21, miR-199a-5p, and miR-200c were significantly increased in serums of IPF patients while miR-31, let-7a, and let-7d were significantly under expressed in serums of IPF patients compared to healthy controls." 25725128 Discovery and validation of extracellular/circulating microRNAs during idiopathic pulmonary fibrosis disease progression 2015 lung idiopathic_pulmonary_fibrosis homo_sapiens miR-199a-5p MIMAT0000231 miRBase miRNA dysregulation NA NA microRNA Target Prediction And Pathway Analysis; TaqMan miRNA Assay For Individual miRNAs etc. no "47 Significantly differentially expressed serum miRNAs were found in rapid progressive or slowly progressive IPF patients compared to healthy controls, including 21 up-regulated miRNAs and 26 down-regulated miRNAs. Bioinformatic analysis by DIANA-mirPath demonstrated that 53 KEGG biological processes were significantly enriched among differentially expressed serum miRNAs, including TGF-Beta signaling pathway, MAPK signaling pathway, PI3K-Akt signaling pathway, Wnt signaling pathway, HIF-1 signaling pathway, regulation of actin cytoskeleton, Jak-STAT signaling pathway, Notch signaling pathway, and Cytokine-cytokine receptor interaction. MiR-21, miR-199a-5p, and miR-200c were significantly increased in serums of IPF patients while miR-31, let-7a, and let-7d were significantly under expressed in serums of IPF patients compared to healthy controls." 25725128 Discovery and validation of extracellular/circulating microRNAs during idiopathic pulmonary fibrosis disease progression 2015 lung idiopathic_pulmonary_fibrosis homo_sapiens mir-200c MI0000650 miRBase miRNA dysregulation NA NA microRNA Target Prediction And Pathway Analysis; TaqMan miRNA Assay For Individual miRNAs etc. no "47 Significantly differentially expressed serum miRNAs were found in rapid progressive or slowly progressive IPF patients compared to healthy controls, including 21 up-regulated miRNAs and 26 down-regulated miRNAs. Bioinformatic analysis by DIANA-mirPath demonstrated that 53 KEGG biological processes were significantly enriched among differentially expressed serum miRNAs, including TGF-Beta signaling pathway, MAPK signaling pathway, PI3K-Akt signaling pathway, Wnt signaling pathway, HIF-1 signaling pathway, regulation of actin cytoskeleton, Jak-STAT signaling pathway, Notch signaling pathway, and Cytokine-cytokine receptor interaction. MiR-21, miR-199a-5p, and miR-200c were significantly increased in serums of IPF patients while miR-31, let-7a, and let-7d were significantly under expressed in serums of IPF patients compared to healthy controls." 25725128 Discovery and validation of extracellular/circulating microRNAs during idiopathic pulmonary fibrosis disease progression 2015 lung idiopathic_pulmonary_fibrosis homo_sapiens mir-21 MI0000077 miRBase miRNA dysregulation NA NA microRNA microarray analysis; qRT-PCR etc. no "Altered expression levels of miR-21, miR-155 and miR-101-3p in the serum of patients with IPF were associated with forced vital capacity (FVC) and radiological features in IPF." 24676360 Expression analysis of serum microRNAs in idiopathic pulmonary fibrosis 2014 lung idiopathic_pulmonary_fibrosis homo_sapiens mir-155 MI0000681 miRBase miRNA dysregulation NA NA microRNA microarray analysis; qRT-PCR etc. no "Altered expression levels of miR-21, miR-155 and miR-101-3p in the serum of patients with IPF were associated with forced vital capacity (FVC) and radiological features in IPF." 24676360 Expression analysis of serum microRNAs in idiopathic pulmonary fibrosis 2014 lung idiopathic_pulmonary_fibrosis homo_sapiens miR-101-3p MIMAT0000099 miRBase miRNA dysregulation NA NA microRNA microarray analysis; qRT-PCR etc. no "Altered expression levels of miR-21, miR-155 and miR-101-3p in the serum of patients with IPF were associated with forced vital capacity (FVC) and radiological features in IPF." 24676360 Expression analysis of serum microRNAs in idiopathic pulmonary fibrosis 2014 lung idiopathic_pulmonary_fibrosis homo_sapiens mir-26a-1 MI0000083 miRBase miRNA dysregulation CTGF; SMAD4 NA qRT-PCR; Masson's trichrome staining; etc. no "Downregulation of miR-26a in the lungs of mice with experimental pulmonary fibrosis and in IPF resulted in posttranscriptional derepression of connective tissue growth factor (CTGF), and induced collagen production. Inhibition of miR-26a in the lungs caused pulmonary fibrosis in vivo, whereas overexpression of miR-26a repressed transforming growth factor (TGF)-B1-induced fibrogenesis in MRC-5 cells and attenuated experimental pulmonary fibrosis in mice. MiR-26a was downregulated by TGF-B1-mediated phosphorylation of Smad3. Moreover, miR-26a inhibited the nuclear translocation of p-Smad3 through directly targeting Smad4, which determines the nuclear translocation of p-Smad2/Smad3." 24594795 The antifibrotic effects and mechanisms of microRNA-26a action in idiopathic pulmonary fibrosis 2014 lung pulmonary_hypertension homo_sapiens mir-17 MI0000071 miRBase miRNA up-regulation BMPR2 STAT3-miR-17/92-BMPR2 signaling pathway qRT-PCR; Quantification of Mature miR-20a; etc. no "Ectopic overexpression of miR-17/92 resulted in a strong reduction of the BMPR2 protein, and a reporter gene system showed that BMPR2 is directly targeted by miR-17-5p and miR-20a. By stimulation experiments, we found that the miR-17/92 cluster is modulated by interleukin (IL)-6, a cytokine involved in the pathogenesis of pulmonary hypertension. " 19390056 Interleukin-6 modulates the expression of the bone morphogenic protein receptor type II through a novel STAT3-microRNA cluster 17/92 pathway 2009 lung pulmonary_hypertension homo_sapiens mir-20a MI0000076 miRBase miRNA up-regulation BMPR2 STAT3-miR-17/92-BMPR2 signaling pathway qRT-PCR; Quantification of Mature miR-20a; etc. no "Ectopic overexpression of miR-17/92 resulted in a strong reduction of the BMPR2 protein, and a reporter gene system showed that BMPR2 is directly targeted by miR-17-5p and miR-20a. By stimulation experiments, we found that the miR-17/92 cluster is modulated by interleukin (IL)-6, a cytokine involved in the pathogenesis of pulmonary hypertension. " 19390056 Interleukin-6 modulates the expression of the bone morphogenic protein receptor type II through a novel STAT3-microRNA cluster 17/92 pathway 2009 lung silicosis homo_sapiens mir-19a MI0000073 miRBase miRNA down-regulation NA NA qRT-PCR; etc. no "Eighteen differential miRNAs in leukocytes were up-regulated and twenty differential miRNAs were down-regulated in the silicosis group, compared with the control group. The sensitivity and specificity for miR-19a at a cut-off value of 3.6828 Were 95% and 95%, respectively. Thus, miR-19a in peripheral blood leukocyte could be used as an effective biomarker for silicosis." 27312312 Down-Regulation of miR-19a as a Biomarker for Early Detection of Silicosis 2016 lung pulmonary_hypertension homo_sapiens let-7d MI0000065 miRBase miRNA down-regulation NA NA qRT-PCR; GO analysis; etc. no "Eighteen miRNAs were differentially expressed in PASMCs from CTEPH patients, including 12 upregulated miRNAs and 6 downregulated miRNAs; Among the latter, let-7d decreased 0.58-Fold in CTEPH patients. Let-7d could inhibit the proliferation of PASMCs through upregulation of p21. In conclusion, PASMCs in CTEPH patients have an aberrant miRNA profile and reduced let-7d, which could promote PASMC proliferation and may be involved in the pathogenesis of CTEPH." 24618550 MicroRNA expression profile of pulmonary artery smooth muscle cells and the effect of let-7d in chronic thromboembolic pulmonary hypertension 2013 lung pulmonary_hypertension homo_sapiens mir-21 MI0000077 miRBase miRNA dysregulation MYOCARDIN; SMOOTH MUSCLE MYOSIN HEAVY CHAIN NA Immunohistochemistry; Laser-assisted microdissection and RNA extraction etc. no "Expression levels of miR-143/145 and its target proteins (e.G., Myocardin, smooth muscle myosin heavy chain) were found to be significantly higher in concentric obliterative lesions(CLs) than in plexiform lesions(PLs), whereas miR-126 and VEGF-A were significantly up-regulated in PLs when compared with CLs, indicating a more prominent angiogenic phenotype of PL. Down-regulation of miR-204 as well as an up-regulation of miR-21 in PLs in turn corresponds to enhanced cell proliferation. Morphologic changes of plexiform vasculopathy in the end-stage PAH lung are reflected by alterations at the miRNA level." 22534459 Plexiform vasculopathy of severe pulmonary arterial hypertension and microRNA expression 2012 lung pulmonary_hypertension homo_sapiens mir-126 MI0000471 miRBase miRNA dysregulation MYOCARDIN; SMOOTH MUSCLE MYOSIN HEAVY CHAIN NA Immunohistochemistry; Laser-assisted microdissection and RNA extraction etc. no "Expression levels of miR-143/145 and its target proteins (e.G., Myocardin, smooth muscle myosin heavy chain) were found to be significantly higher in concentric obliterative lesions(CLs) than in plexiform lesions(PLs), whereas miR-126 and VEGF-A were significantly up-regulated in PLs when compared with CLs, indicating a more prominent angiogenic phenotype of PL. Down-regulation of miR-204 as well as an up-regulation of miR-21 in PLs in turn corresponds to enhanced cell proliferation. Morphologic changes of plexiform vasculopathy in the end-stage PAH lung are reflected by alterations at the miRNA level." 22534459 Plexiform vasculopathy of severe pulmonary arterial hypertension and microRNA expression 2012 lung pulmonary_hypertension homo_sapiens mir-204 MI0000284 miRBase miRNA dysregulation MYOCARDIN; SMOOTH MUSCLE MYOSIN HEAVY CHAIN NA Immunohistochemistry; Laser-assisted microdissection and RNA extraction etc. no "Expression levels of miR-143/145 and its target proteins (e.G., Myocardin, smooth muscle myosin heavy chain) were found to be significantly higher in concentric obliterative lesions(CLs) than in plexiform lesions(PLs), whereas miR-126 and VEGF-A were significantly up-regulated in PLs when compared with CLs, indicating a more prominent angiogenic phenotype of PL. Down-regulation of miR-204 as well as an up-regulation of miR-21 in PLs in turn corresponds to enhanced cell proliferation. Morphologic changes of plexiform vasculopathy in the end-stage PAH lung are reflected by alterations at the miRNA level." 22534459 Plexiform vasculopathy of severe pulmonary arterial hypertension and microRNA expression 2012 lung pulmonary_hypertension homo_sapiens mir-145 MI0000461 miRBase miRNA dysregulation MYOCARDIN; SMOOTH MUSCLE MYOSIN HEAVY CHAIN NA Immunohistochemistry; Laser-assisted microdissection and RNA extraction etc. no "Expression levels of miR-143/145 and its target proteins (e.G., Myocardin, smooth muscle myosin heavy chain) were found to be significantly higher in concentric obliterative lesions(CLs) than in plexiform lesions(PLs), whereas miR-126 and VEGF-A were significantly up-regulated in PLs when compared with CLs, indicating a more prominent angiogenic phenotype of PL. Down-regulation of miR-204 as well as an up-regulation of miR-21 in PLs in turn corresponds to enhanced cell proliferation. Morphologic changes of plexiform vasculopathy in the end-stage PAH lung are reflected by alterations at the miRNA level." 22534459 Plexiform vasculopathy of severe pulmonary arterial hypertension and microRNA expression 2012 lung pulmonary_hypertension homo_sapiens mir-143 MI0000459 miRBase miRNA dysregulation MYOCARDIN; SMOOTH MUSCLE MYOSIN HEAVY CHAIN NA Immunohistochemistry; Laser-assisted microdissection and RNA extraction etc. no "Expression levels of miR-143/145 and its target proteins (e.G., Myocardin, smooth muscle myosin heavy chain) were found to be significantly higher in concentric obliterative lesions(CLs) than in plexiform lesions(PLs), whereas miR-126 and VEGF-A were significantly up-regulated in PLs when compared with CLs, indicating a more prominent angiogenic phenotype of PL. Down-regulation of miR-204 as well as an up-regulation of miR-21 in PLs in turn corresponds to enhanced cell proliferation. Morphologic changes of plexiform vasculopathy in the end-stage PAH lung are reflected by alterations at the miRNA level." 22534459 Plexiform vasculopathy of severe pulmonary arterial hypertension and microRNA expression 2012 lung pulmonary_hypertension homo_sapiens mir-21 MI0000077 miRBase miRNA up-regulation DDAH1 NA qRT-PCR; Dual-luciferase reporter assay etc. no "Hypoxia inhibited DDAH1 and DDAH2 expression and increased ADMA levels in cultured human pulmonary endothelial cells. In contrast, in human pulmonary smooth muscle cells, only DDAH2 was reduced whereas ADMA levels remained unchanged. Endothelium-specific down-regulation of DDAH1 by miR-21 in hypoxia induced endothelial dysfunction and was prevented by overexpression of DDAH1 and miR-21 blockade. DDAH1, but not DDAH2, mRNA levels were reduced, whereas miR-21 levels were elevated in lung tissues from patients with pulmonary arterial hypertension and mice with pulmonary hypertension exposed to 2 weeks of hypoxia." 24895913 MiR-21/DDAH1 pathway regulates pulmonary vascular responses to hypoxia 2014 lung idiopathic_pulmonary_fibrosis homo_sapiens mir-210 MI0000286 miRBase miRNA up-regulation MNT NA qRT-PCR; Immunohistochemistry etc. no "Hypoxia potently stimulates miR-210 expression via HIF-2a, and high miR-210 expression drives fibroblast proliferation by repressing the c-myc inhibitor, MNT." 24951777 MiR-210 promotes IPF fibroblast proliferation in response to hypoxia 2014 lung pulmonary_fibrosis homo_sapiens miR-130a-3p MIMAT0000425 miRBase miRNA down-regulation SOCS1; PPARY STAT6 signaling pathway qRT-PCR; Dual-luciferase reporter assay; EMSA etc. no "IL-4 and IL-13 induce miR-142-5p and downregulate miR-130a-3p in macrophages; These changes sustain the profibrogenic effect of macrophages. In vitro, miR-142-5p mimic prolongs STAT6 phosphorylation by targeting its negative regulator, SOCS1. Blocking miR-130a relieves its inhibition of PPARY, which coordinates STAT6 signalling. In vivo, inhibiting miR-142-5p and increasing miR-130a-3p expression inhibits CCL4-induced liver fibrosis and bleomycin-induced lung fibrosis in mice. Furthermore, macrophages from the tissue samples of patients with liver cirrhosis and idiopathic pulmonary fibrosis display increased miR-142-5p and decreased miR-130a-3p expression. Therefore, miR-142-5p and miR-130a-3p regulate macrophage profibrogenic gene expression in chronic inflammation." 26436920 MiR-142-5p and miR-130a-3p are regulated by IL-4 and IL-13 and control profibrogenic macrophage program 2015 lung pulmonary_fibrosis homo_sapiens miR-142-5p MIMAT0000433 miRBase miRNA up-regulation SOCS1; PPARY STAT6 signaling pathway qRT-PCR; Dual-luciferase reporter assay; EMSA etc. no "IL-4 and IL-13 induce miR-142-5p and downregulate miR-130a-3p in macrophages; These changes sustain the profibrogenic effect of macrophages. In vitro, miR-142-5p mimic prolongs STAT6 phosphorylation by targeting its negative regulator, SOCS1. Blocking miR-130a relieves its inhibition of PPARY, which coordinates STAT6 signalling. In vivo, inhibiting miR-142-5p and increasing miR-130a-3p expression inhibits CCL4-induced liver fibrosis and bleomycin-induced lung fibrosis in mice. Furthermore, macrophages from the tissue samples of patients with liver cirrhosis and idiopathic pulmonary fibrosis display increased miR-142-5p and decreased miR-130a-3p expression. Therefore, miR-142-5p and miR-130a-3p regulate macrophage profibrogenic gene expression in chronic inflammation." 26436920 MiR-142-5p and miR-130a-3p are regulated by IL-4 and IL-13 and control profibrogenic macrophage program 2015 lung idiopathic_pulmonary_fibrosis homo_sapiens miR-25-3p MIMAT0000081 miRBase miRNA dysregulation NA NA ROC analysis; qRT-PCR; Signaling pathways prediction etc. no "Let-7d-5p was decreased in S-IPF and further decreased in AE-IPF, when compared to NC. While miR-25-3p was obviously decreased in S-IPF but significantly increased in AE-IPF. MiR-25-3p and let-7d-5p in plasma were differentially expressed between AE-IPF and S-IPF. A combination of these two miRNAs may be a potential biomarker for AE-IPF from IPF. Acute exacerbation of idiopathic pulmonary fibrosis (AE-IPF), Stable-IPF (S-IPF) ." 27881157 Plasma microRNAs are associated with acute exacerbation in idiopathic pulmonary fibrosis 2016 lung idiopathic_pulmonary_fibrosis homo_sapiens let-7d-5p MIMAT0000065 miRBase miRNA dysregulation NA NA ROC analysis; qRT-PCR; Signaling pathways prediction etc. no "Let-7d-5p was decreased in S-IPF and further decreased in AE-IPF, when compared to NC. While miR-25-3p was obviously decreased in S-IPF but significantly increased in AE-IPF. MiR-25-3p and let-7d-5p in plasma were differentially expressed between AE-IPF and S-IPF. A combination of these two miRNAs may be a potential biomarker for AE-IPF from IPF. Acute exacerbation of idiopathic pulmonary fibrosis (AE-IPF), Stable-IPF (S-IPF)." 27881157 Plasma microRNAs are associated with acute exacerbation in idiopathic pulmonary fibrosis 2016 lung Scleroderma_Systemic homo_sapiens mir-155 MI0000681 miRBase miRNA up-regulation NA NA qRT-PCR; Microarray Data Clustering; MicroRNA And RNA Nanostring Technology etc. no Lung miRNA microarray data distinguished patients with SSc-ILD from healthy controls with 185 miRNA differentially expressed (q < 0.25). DIANA-miRPath revealed 57 Kyoto Encyclopedia of Genes and Genomes pathways related to the most dysregulated miRNA. MiR-155 and miR-143 were strongly correlated with progression of the HRCT score. MiR-155 PBMC expression strongly correlated with lung function tests in SSc-ILD. 27377409 MiR-155 in the progression of lung fibrosis in systemic sclerosis 2016 lung idiopathic_pulmonary_fibrosis homo_sapiens mir-21 MI0000077 miRBase miRNA dysregulation NA NA qRT-PCR; ISH; Isolation of alveolar epithelial type II cells from human lung tissues etc. no MicroRNA-21 is increased in lung epithelial cells during lung fibrosis and that it promotes epithelial-mesenchymal transition. 24063588 The increase of microRNA-21 during lung fibrosis and its contribution to epithelial-mesenchymaltransition in pulmonary epithelial cells 2013 lung idiopathic_pulmonary_fibrosis homo_sapiens mir-424 MI0001446 miRBase miRNA up-regulation SMURF2 NA qRT-PCR; Dual-luciferase reporter assay; etc. no "Micrornas chips and real-time PCR confirmed in A549 EMT model has six, three cut micrornas, the expression level of miR - 424 through targeted Smurf2 enhance TGF - beta signaling pathways regulating muscle into fiber cell differentiation 6 up-regulated and 3 down-regulated miRNAs in a human lung epithelial cell EMT model were validated using miRNA microarray and real-time PCR. Up-regulated miR-424 regulates the myofibroblast differentiation during EMT by potentiating the TGF-B signaling pathway through Smurf2." 25524739 Regulation of myofibroblast differentiation by miR-424 during epithelial-to-mesenchymal transition 2014 lung idiopathic_pulmonary_fibrosis homo_sapiens miR-130b-3p MIMAT0000691 miRBase miRNA down-regulation IGF-1 NA Dual-luciferase reporter assay; ELISA; qRT-PCR etc. no "MiR-130b-3p was downregulated in IPF lungs. MiR-130b-3p downregulation contributed to the activation of fibroblasts and the dysregulated epithelial-mesenchymal crosstalk by promoting IGF-1 secretion from lung epithelium, suggesting a key regulatory role for this miRNA in preventing lung fibrosis." 26953888 MiR-130b-3p Modulates Epithelial-Mesenchymal Crosstalk in Lung Fibrosis by Targeting IGF-1 2016 lung pulmonary_fibrosis homo_sapiens mir-1343 MI0017320 miRBase miRNA dysregulation TGFBR1; TGFBR2 TGF-beta/SMAD signaling pathway qRT-PCR; Immunofluorescence etc. no "MiR-1343 reduces the expression of both TGF-B receptor 1 and 2 by directly targeting their 3'-UTRs. As a result, the abundance of fibrotic markers is reduced, cell migration into a scratch wound impaired and epithelial-to-mesenchymal transition (EMT) repressed. Mature miR-1343 is readily detected in human neutrophils and HL-60 cells and is activated in response to stress in A549 lung epithelial cells. MiR-1343 may have direct therapeutic applications in fibrotic lung disease." 26542979 MiR-1343 attenuates pathways of fibrosis by targeting the TGF-beta receptors 2016 lung idiopathic_pulmonary_fibrosis homo_sapiens mir-145 MI0000461 miRBase miRNA up-regulation KLF4 NA qRT-PCR; Immunofluorescence; etc. no "MiR-145 expression is upregulated in TGF-B1-treated lung fibroblasts and in the lungs of patients with idiopathic pulmonary fibrosis as compared to in normal human lungs. Overexpression of miR-145 in lung fibroblasts increased SMA-a expression, enhanced contractility, and promoted formation of focal and fibrillar adhesions by targeting KLF4, a known negative regulator of SMA-a expression." 23457217 MiR-145 regulates myofibroblast differentiation and lung fibrosis 2013 lung pulmonary_hypertension homo_sapiens mir-145 MI0000461 miRBase miRNA up-regulation NA NA Immunohistochemistry; q-PCR; etc. no "MiR-145 is upregulated in mouse models of PAH. Downregulation of miR-145 protects against the development of PAH. In patient samples of heritable PAH and idiopathic PAH, miR-145 is expressed in remodeled vessels and mutations in BMPR2 lead to upregulation of miR-145 in mice and PAH patients." 22715469 A role for miR-145 in pulmonary arterial hypertension: evidence from mouse models and patient samples 2012 lung idiopathic_pulmonary_fibrosis homo_sapiens miR-199a-5p MIMAT0000231 miRBase miRNA up-regulation CAV1 NA MiRNA targets analysis; Dual-luciferase reporter assay; qRT-PCR etc. no MiR-199a-5p Is upregulated during fibrogenic response to tissue injury and mediates TGFbeta-induced lung fibroblast activation by targeting caveolin-1. 23459460 MiR-199a-5p Is upregulated during fibrogenic response to tissue injury and mediates TGFbeta-inducedlung fibroblast activation by targeting caveolin-1 2013 lung idiopathic_pulmonary_fibrosis homo_sapiens mir-200b MI0000342 miRBase miRNA down-regulation NA NA qRT-PCR; etc. no "MiR-200a, miR-200b, and miR-200c are significantly down-regulated in the lungs of mice with experimental lung fibrosis. Levels of miR-200a and miR-200c were reduced in the lungs of patients with IPF miR-200 had greater expression in AECs than in lung fibroblasts, and AECs from mice with experimental pulmonary fibrosis had diminished expression of miR-200. The miR-200 family members inhibit transforming growth factor-B1-induced epithelial-mesenchymal transition of AECs, reverse the fibrogenic activity of pulmonary fibroblasts from mice with experimental pulmonary fibrosis and from patients with IPF. The introduction of miR-200c diminishes experimental pulmonary fibrosis in mice." 22189082 Participation of miR-200 in pulmonary fibrosis 2012 lung idiopathic_pulmonary_fibrosis homo_sapiens mir-200c MI0000650 miRBase miRNA down-regulation NA NA qRT-PCR; etc. no "MiR-200a, miR-200b, and miR-200c are significantly down-regulated in the lungs of mice with experimental lung fibrosis. Levels of miR-200a and miR-200c were reduced in the lungs of patients with IPF miR-200 had greater expression in AECs than in lung fibroblasts, and AECs from mice with experimental pulmonary fibrosis had diminished expression of miR-200. The miR-200 family members inhibit transforming growth factor-B1-induced epithelial-mesenchymal transition of AECs, reverse the fibrogenic activity of pulmonary fibroblasts from mice with experimental pulmonary fibrosis and from patients with IPF. The introduction of miR-200c diminishes experimental pulmonary fibrosis in mice." 22189082 Participation of miR-200 in pulmonary fibrosis 2012 lung idiopathic_pulmonary_fibrosis homo_sapiens mir-200a MI0000737 miRBase miRNA down-regulation NA NA qRT-PCR; etc. no "MiR-200a, miR-200b, and miR-200c are significantly down-regulated in the lungs of mice with experimental lung fibrosis. Levels of miR-200a and miR-200c were reduced in the lungs of patients with IPF miR-200 had greater expression in AECs than in lung fibroblasts, and AECs from mice with experimental pulmonary fibrosis had diminished expression of miR-200. The miR-200 family members inhibit transforming growth factor-B1-induced epithelial-mesenchymal transition of AECs, reverse the fibrogenic activity of pulmonary fibroblasts from mice with experimental pulmonary fibrosis and from patients with IPF. The introduction of miR-200c diminishes experimental pulmonary fibrosis in mice." 22189082 Participation of miR-200 in pulmonary fibrosis 2012 lung pulmonary_arterial_hypertension homo_sapiens mir-204 MI0000284 miRBase miRNA down-regulation SHP2 STAT3-MIR-204-SRC-STAT3-NFAT signaling pathway TLDAS; qRT-PCR; Dual-luciferase reporter assay etc. no "MiR-204 expression in PASMCs is down-regulated in both human and rodent PAH. MiR-204 down-regulation correlates with PAH severity and accounts for the proliferative and antiapoptotic phenotypes of PAH-PASMCs. STAT3 activation suppresses miR-204 expression, and miR-204 directly targets SHP2 expression, thereby SHP2 up-regulation, by miR-204 down-regulation, activates the Src kinase and nuclear factor of activated T cells (NFAT). STAT3 also directly induces NFATc2 expression. NFAT and SHP2 were needed to sustain PAH-PASMC proliferation and resistance to apoptosis. Finally, delivery of synthetic miR-204 to the lungs of animals with PAH significantly reduced disease severity." 21321078 Role for miR-204 in human pulmonary arterial hypertension 2011 lung idiopathic_pulmonary_fibrosis homo_sapiens mir-21 MI0000077 miRBase miRNA up-regulation SMAD7 NA Northern Blot; qRT-PCR; Dual-luciferase reporter assay etc. no "MiR-21 is up-regulated in the lungs of mice with bleomycin-induced fibrosis and also in the lungs of patients with IPF, and was primarily localized to myofibroblasts. Administration of miR-21 antisense probes diminished the severity of experimental lung fibrosis in mice, even when treatment was started 5-7 d after initiation of pulmonary injury. TGF-Beta1 enhanced miR-21 expression in primary pulmonary fibroblasts. Increasing miR-21 levels promoted, whereas knocking down miR-21 attenuated, the pro-fibrogenic activity of TGF-Beta1 in fibroblasts. A potential mechanism for the role of miR-21 in fibrosis is through regulating the expression of an inhibitory Smad, Smad7." 20643828 MiR-21 mediates fibrogenic activation of pulmonary fibroblasts and lung fibrosis 2010 lung idiopathic_pulmonary_fibrosis homo_sapiens mir-185 MI0000482 miRBase miRNA down-regulation NA "MIR-185/AKT,MIR-29a/COLLAGEN signaling pathway" SDS-PAGE; Immunofluorescence etc. no "MiR-29a and miR-185 were significantly downregulated in IPF BAL cells. Downregulation of miR-29a inversely correlated with the significantly increased levels of COL1A1 mRNA in IPF BAL cells, miR-185 inhibition resulted in significant increase of AKTser473 phosphorylation." 27769060 MiR-185/AKT and miR-29a/collagen 1a pathways are activated in IPF BAL cells 2016 lung idiopathic_pulmonary_fibrosis homo_sapiens mir-29a MI0000087 miRBase miRNA down-regulation NA "MIR-185/AKT,MIR-29a/COLLAGEN signaling pathway" SDS-PAGE; Immunofluorescence etc. no "MiR-29a and miR-185 were significantly downregulated in IPF BAL cells. Downregulation of miR-29a inversely correlated with the significantly increased levels of COL1A1 mRNA in IPF BAL cells, miR-185 inhibition resulted in significant increase of AKTser473 phosphorylation." 27769060 MiR-185/AKT and miR-29a/collagen 1a pathways are activated in IPF BAL cells 2016 lung idiopathic_pulmonary_fibrosis homo_sapiens mir-29a MI0000087 miRBase miRNA down-regulation LOXL2; SERPINH1 NA qRT-PCR; Dual-luciferase reporter assay etc. no "MiR-29a is downregulated in clinical specimens of IPF and lung cancer. Restoration of miR-29a suppressed cancer cell aggressiveness and fibroblast migration.Lysyl oxidase-like 2 (LOXL2) and serpin peptidase inhibitor clade H, member 1 (SERPINH1) were direct targets of miR-29a, contributing significantly to collagen biosynthesis. Overexpression of LOXL2 and SERPINH1 was observed in clinical specimens of lung cancer and fibrotic lesions. Downregulation of miR-29a caused overexpression of LOXL2 and SERPINH1 in lung cancer and IPF, suggesting that these genes are involved in the pathogenesis of these two diseases." 27488440 Regulation of LOXL2 and SERPINH1 by antitumor microRNA-29a in lung cancer with idiopathic pulmonary fibrosis 2016 lung pulmonary_hypertension homo_sapiens miR-648 MIMAT0003318 miRBase miRNA down-regulation ET-1 NA Northern blot; qRT-PCR etc. no "MiR-648 targets the 3' UTR of ET-1 mRNA; MiR-648 is located in a 5'-proximal intron of MICAL3, and was under positive control by PAX5 with MICAL3. PlGF-mediated downregulation of PAX5 attenuates miR-648 expression leading to increased ET-1 levels that are known to induce PHT in SCA." 25403488 MicroRNA 648 Targets ET-1 mRNA and Is Cotranscriptionally Regulated with MICAL3 by PAX5 2015 lung idiopathic_pulmonary_fibrosis homo_sapiens miR-92a-3p MIMAT0000092 miRBase miRNA down-regulation WISP1 NA qRT-PCR; Immunohistochemistry etc. no MiR-92a inhibt TGF-B1-induced WISP1 expression in pulmonary fibrosis. 24953558 MiR-92a regulates TGF-B1-induced WISP1 expression in pulmonary fibrosis 2014 lung idiopathic_pulmonary_fibrosis homo_sapiens miR-21-5p MIMAT0000076 miRBase miRNA up-regulation NA NA Exoscreen assay; MicroRNA PCR array in mouse serum EVS; qRT-PCR etc. no "Serum EV miR-21-5p was elevated in both the acute inflammatory phase (day 7) and the chronic fibrotic phase (day 28) in the mouse model.Serum EV miR-21-5p was significantly higher in IPF patients than in healthy control subjects. The baseline serum EV miR-21-5p was correlated with the rate of decline in vital capacity over 6 months. Furthermore, serum EV miR-21-5p was independently associated with mortality during the following 30 months, even after adjustment for other variables. In the survival analysis, IPF patients whose baseline serum EV miR-21-5p was high had a significantly poorer prognosis over 30 months. Serum EV miR-21-5p has potential as a prognostic biomarker for IPF." 27596748 Serum extracellular vesicular miR-21-5p is a predictor of the prognosis in idiopathic pulmonary fibrosis 2016 lung idiopathic_pulmonary_fibrosis homo_sapiens mir-21 MI0000077 miRBase miRNA dysregulation NA NA qRT-PCR etc. no Serum miR-21 is associated with IPF and the degree of damage indicated by FVC and radiologic examinations could correlate with miR-21 and miR-155 expression in serum. 23822889 Serum miR-21 and miR-155 expression in idiopathic pulmonary fibrosis 2013 lung idiopathic_pulmonary_fibrosis homo_sapiens mir-155 MI0000681 miRBase miRNA dysregulation NA NA qRT-PCR etc. no Serum miR-21 is associated with IPF and the degree of damage indicated by FVC and radiologic examinations could correlate with miR-21 and miR-155 expression in serum. 23822889 Serum miR-21 and miR-155 expression in idiopathic pulmonary fibrosis 2013 lung cystic_fibrosis homo_sapiens mir-144 MI0000460 miRBase miRNA up-regulation CFTR NA Dual-luciferase reporter assay; qRT-PCR; In situ Hybridization etc. no The Cystic Fibrosis Transmembrane conductance Regulator (CFTR) is a chloride channel that plays a critical role in the lung by maintaining fluid homeostasis. Absence or malfunction of CFTR leads to Cystic Fibrosis; Chronic cigarette smoking up-regulates miR-101 and that this miRNA could contribute to suppression of CFTR in the lungs of COPD patients. 23226399 MiR-101 and miR-144 regulate the expression of the CFTR chloride channel in the lung 2012 lung cystic_fibrosis homo_sapiens mir-101-1 MI0000103 miRBase miRNA up-regulation CFTR NA Dual-luciferase reporter assay; qRT-PCR; In situ Hybridization etc. no The Cystic Fibrosis Transmembrane conductance Regulator (CFTR) is a chloride channel that plays a critical role in the lung by maintaining fluid homeostasis. Absence or malfunction of CFTR leads to Cystic Fibrosis; Chronic cigarette smoking up-regulates miR-101 and that this miRNA could contribute to suppression of CFTR in the lungs of COPD patients. 23226399 MiR-101 and miR-144 regulate the expression of the CFTR chloride channel in the lung 2012 lung pulmonary_fibrosis homo_sapiens miR-486-5p MIMAT0002177 miRBase miRNA down-regulation SMAD2 NA qRT-PCR; Dual-luciferase reporter assay; Immunoblot etc. no "The dysregulation of five miRNAs, including miR-21, miR-455, miR-151-3p, miR-486-5p and miR-3107, were confirmed by qRT-PCRs in silica-induced mouse model of pulmonary fibrosis and were also confirmed in a bleomycin (BLM)-induced mouse lung fibrosis. Notably, miR-486-5p levels were decreased in the serum samples of patients with silicosis, as well as in the lung tissues of patients with silicosis and idiopathic pulmonary fibrosis (IPF). SMAD2 was identified to be one of target genes of miR-486-5p. MiR-486-5p expression significantly decreased both the distribution and severity of lung lesions compared with the silica group (P < 0.01)." 26370615 The Anti-fibrotic Effects and Mechanisms of MicroRNA-486-5p in Pulmonary Fibrosis 2015 lung idiopathic_pulmonary_fibrosis homo_sapiens mir-186 MI0000483 miRBase miRNA down-regulation COL5A1 NA qRT-PCR; Dual-luciferase reporter assay; etc. no "The expression levels of miR-185 and miR-186 were decreased in the lungs of idiopathic pulmonary fibrosis patients.Attenuated expression of miR-185 and miR-186 may be responsible for collagen V overexpression during idiopathic pulmonary fibrosis, and these miRNAs may serve as pathogenesis-related biomarkers and treatment targets." 27392970 Regulation of Collagen V Expression and Epithelial-Mesenchymal Transition by miR-185 and miR-186 during Idiopathic Pulmonary Fibrosis 2016 lung idiopathic_pulmonary_fibrosis homo_sapiens mir-185 MI0000482 miRBase miRNA down-regulation COL5A1 NA qRT-PCR; Dual-luciferase reporter assay; etc. no "The expression levels of miR-185 and miR-186 were decreased in the lungs of idiopathic pulmonary fibrosis patients.Attenuated expression of miR-185 and miR-186 may be responsible for collagen V overexpression during idiopathic pulmonary fibrosis, and these miRNAs may serve as pathogenesis-related biomarkers and treatment targets." 27392970 Regulation of Collagen V Expression and Epithelial-Mesenchymal Transition by miR-185 and miR-186 during Idiopathic Pulmonary Fibrosis 2016 lung idiopathic_pulmonary_fibrosis homo_sapiens mir-34a MI0000268 miRBase miRNA up-regulation NA NA Immunohistochemistry; Immunoblot; qRT-PCR etc. no "The relative levels of senescence-associated miRNAs miR-34a, miR-34b, and miR-34c were significantly higher in type II AECs from IPF patients. Overexpression of miR-34a, miR-34b, or miR-34c in lung epithelial cells was associated with higher SA-Bgal activity (27.8%, 35.1%, And 38.2%, Respectively) relative to control treated cells (8.8%). Targets of miR-34 miRNAs, including E2F1, c-Myc, and cyclin E2, were lower in IPF type II AECs. MiR-34 family of miRNAs regulate senescence in IPF type II AECs." 27362652 MiR-34 miRNAs Regulate Cellular Senescence in Type II Alveolar Epithelial Cells of Patients with Idiopathic Pulmonary Fibrosis 2016 lung idiopathic_pulmonary_fibrosis homo_sapiens let-7d MI0000065 miRBase miRNA dysregulation HMGA2 NA qRT-PCR; Dual-luciferase reporter assay etc. no "Transfection of primary fibroblasts with let-7d caused a decrease in expression of the mesenchymal markers a-smooth muscle actin, N-cadherin, fibroblast-specific protein-1, and fibronectin, as well as an increase in the epithelial markers tight junction protein-1 and keratin 19. Phenotypic changes were also present, including a delay in wound healing, reduced motility, and proliferation of fibroblasts following transfection. Let-7d transfection significantly attenuated high-mobility group-A2 protein induction by TGF-B. Our results indicate that administration of the epithelial microRNA let-7d can significantly alter the phenotype of primary fibroblasts." 24441869 Let-7d microRNA affects mesenchymal phenotypic properties of lung fibroblasts 2014 lung idiopathic_pulmonary_fibrosis homo_sapiens miR-9-5p MIMAT0000441 miRBase miRNA dysregulation TGFBR2; NOX4 NA Dual-luciferase reporter assay; ISH etc. no "Transforming growth factor-B1 (TGF-B1) stimulates the production of NADPH oxidase 4 (NOX4)-dependent ROS, promoting lung fibrosis (LF). MiR-9-5p has an inhibitory effect on TGF-B receptor type II (TGFBR2) and NOX4 expression. Increased expression of miR-9-5p abrogates TGF-B1-dependent myofibroblast phenotypic transformation. In the mouse model of bleomycin-induced LF, miR-9-5p dramatically reduces fibrogenesis and inhibition of miR-9-5p prevents its anti-fibrotic effect both in vitro and in vivo. In lung specimens from patients with IPF, high levels of miR-9-5p are found. TGF-B1 induces miR-9-5p expression as a self-limiting homeostatic response." 26315535 MiR-9-5p suppresses pro-fibrogenic transformation of fibroblasts and prevents organ fibrosis by targeting NOX4 and TGFBR2 2015 lung idiopathic_pulmonary_fibrosis homo_sapiens let-7d MI0000065 miRBase miRNA down-regulation NA NA qRT-PCR; Chromatin immunoprecipitation assay; Dual-luciferase reporter assay etc. no "Transforming growth factor-beta down-regulated let-7d expression, and SMAD3 binding to the let-7d promoter was demonstrated. Inhibition of let-7d caused increases in mesenchymal markers N-cadherin-2, vimentin, and alpha-smooth muscle actin (ACTA2) as well as HMGA2 in multiple epithelial cell lines. Let-7d was significantly reduced in IPF lungs and the number of epithelial cells expressing let-7d correlated with pulmonary functions. HMGA2 was increased in alveolar epithelial cells of IPF lungs. Let-7d inhibition in vivo caused alveolar septal thickening and increases in collagen, ACTA2, and S100A4 expression in SFTPC (pulmonary-associated surfactant protein C) expressing alveolar epithelial cells." 20395557 Inhibition and role of let-7d in idiopathic pulmonary fibrosis 2010 lung idiopathic_pulmonary_fibrosis homo_sapiens mir-29a MI0000087 miRBase miRNA down-regulation NA PI3K/AKT signaling pathway qRT-PCR; Mtt assay; etc. no "Treatment of the human embryonic lung fibroblast cell line IMR90 with TGFB1 caused a decrease in expression of miR-29a/b/c. TGFB1 stimulation increased cell proliferation, colony formation and up-regulated expression of COL1A1, which was reversed by miR-29a/b/c mimics. TGFB1 activate PI3k-Akt pathway in these embryonic fibroblasts and miR29 blocks this activation." 23238947 MiR-29 mediates TGFB1-induced extracellular matrix synthesis through activation of PI3K-AKT pathwayin human lung fibroblasts 2013 lung pulmonary_fibrosis homo_sapiens mir-29a MI0000087 miRBase miRNA down-regulation NA NA qRT-PCR; Mtt assay etc. no "Treatment of the human IMR-90 cells with TGFB 1 caused a decrease in the expression of miR-29a/b/c,while cell proliferation, colony formation and expression of COL1A1 were increased. MiR-29a/b/c mimics blocked DKK1, wnt3a, and phosphorylation of B -catenin and decreased expression of COL1A1 induced by TGFB 1 treatment." 26410313 MiR-29 mediates TGFB 1-induced extracellular matrix synthesis through activation of Wnt/B -catenin pathway in human pulmonary fibroblasts 2015 lung idiopathic_pulmonary_fibrosis homo_sapiens mir-26a-1 MI0000083 miRBase miRNA dysregulation LIN28B NA Masson's trichrome staining; Immunohistochemistry; qRT-PCR etc. no Upregulation of Lin28B contributes to idiopathic pulmonary fibrosis. Lin28B causes epithelial-mesenchymal transition (EMT) by inhibition of let-7d. Lin28B is one of the targets of microRNA-26a. MiR-26a enhances the expression of let-7d via targeting regulation of Lin28B. A regulatory network among miRNAs involved in the progression of IPF. 26787543 MiR-26a suppresses EMT by disrupting the Lin28B/let-7d axis: potential cross-talks among miRNAs in IPF 2016 lung idiopathic_pulmonary_fibrosis homo_sapiens mir-96 MI0000098 miRBase miRNA up-regulation FOXO3A NA qRT-PCR; In Situ Hybridization For miR-96 etc. no "When IPF fibroblasts interact with collagen-rich matrix, pathologically increased miR-96 expression inhibits FoxO3a function, causing IPF fibroblasts to maintain their pathological phenotype, which may contribute to the progression of IPF." 25172912 MicroRNA-96 inhibits FoxO3a function in IPF fibroblasts on type I collagen matrix 2014 nerve neurofibromatosis homo_sapiens mir-21a MI0000569 miRBase miRNA up-regulation PTEN NA qRT-PCR; etc. no "Because pten regulates signaling through the growth-promoting phosphoinositide 3-kinase;Akt pathway, our findings suggest that mir-21 may be a suitable molecular target for therapies aimed specifically at reducing vs growth." 20856158 MicroRNA-21 overexpression contributes to vestibular schwannoma cell proliferation and survival 2010 nerve neurofibromatosis homo_sapiens miR-486-3p MIMAT0004762 miRBase miRNA up-regulation PTEN NA microarray; qRT-PCR etc. no "To comprehensively characterize the role of micrornas in nf1 tumorigenesis, we analyzed 377 mirnas expression in a large panel of dermal and plexiform neurofibromas, and mpnsts. The most significantly upregulated mirna in plexiform neurofibromas was mir-486-3p that targets the major tumor suppressor gene, pten. We confirmed pten downregulation at mrna level. In plexiform neurofibromas, we also report aberrant expression of four mirnas involved in the ras-mapk pathway (mir-370, mir-143, mir-181a, and mir-145). ." 23848554 MicroRNAome profiling in benign and malignant neurofibromatosis type 1-associated nerve sheath tumors: evidences of PTEN pathway alterations in early NF1 tumorigenesis 2013 nerve neurofibromatosis homo_sapiens mir-185 MI0000482 miRBase miRNA up-regulation NA NA microarray; qRT-PCR etc. no "To comprehensively characterize the role of micrornas in nf1 tumorigenesis, we analyzed 377 mirnas expression in a large panel of dermal and plexiform neurofibromas, and mpnsts. The most significantly upregulated mirna in plexiform neurofibromas was mir-486-3p that targets the major tumor suppressor gene, pten. We confirmed pten downregulation at mrna level. In plexiform neurofibromas, we also report aberrant expression of four mirnas involved in the ras-mapk pathway (mir-370, mir-143, mir-181a, and mir-145). ." 23848554 MicroRNAome profiling in benign and malignant neurofibromatosis type 1-associated nerve sheath tumors: evidences of PTEN pathway alterations in early NF1 tumorigenesis 2013 nerve neurofibromatosis homo_sapiens mir-362 MI0000762 miRBase miRNA up-regulation NA NA microarray; qRT-PCR etc. no "To comprehensively characterize the role of micrornas in nf1 tumorigenesis, we analyzed 377 mirnas expression in a large panel of dermal and plexiform neurofibromas, and mpnsts. The most significantly upregulated mirna in plexiform neurofibromas was mir-486-3p that targets the major tumor suppressor gene, pten. We confirmed pten downregulation at mrna level. In plexiform neurofibromas, we also report aberrant expression of four mirnas involved in the ras-mapk pathway (mir-370, mir-143, mir-181a, and mir-145). ." 23848554 MicroRNAome profiling in benign and malignant neurofibromatosis type 1-associated nerve sheath tumors: evidences of PTEN pathway alterations in early NF1 tumorigenesis 2013 nerve neurofibromatosis homo_sapiens mir-370 MI0000778 miRBase miRNA up-regulation NA NA microarray; qRT-PCR etc. no "To comprehensively characterize the role of micrornas in nf1 tumorigenesis, we analyzed 377 mirnas expression in a large panel of dermal and plexiform neurofibromas, and mpnsts. The most significantly upregulated mirna in plexiform neurofibromas was mir-486-3p that targets the major tumor suppressor gene, pten. We confirmed pten downregulation at mrna level. In plexiform neurofibromas, we also report aberrant expression of four mirnas involved in the ras-mapk pathway (mir-370, mir-143, mir-181a, and mir-145). ." 23848554 MicroRNAome profiling in benign and malignant neurofibromatosis type 1-associated nerve sheath tumors: evidences of PTEN pathway alterations in early NF1 tumorigenesis 2013 nerve neurofibromatosis homo_sapiens mir-491 MI0003126 miRBase miRNA up-regulation NA NA microarray; qRT-PCR etc. no "To comprehensively characterize the role of micrornas in nf1 tumorigenesis, we analyzed 377 mirnas expression in a large panel of dermal and plexiform neurofibromas, and mpnsts. The most significantly upregulated mirna in plexiform neurofibromas was mir-486-3p that targets the major tumor suppressor gene, pten. We confirmed pten downregulation at mrna level. In plexiform neurofibromas, we also report aberrant expression of four mirnas involved in the ras-mapk pathway (mir-370, mir-143, mir-181a, and mir-145). ." 23848554 MicroRNAome profiling in benign and malignant neurofibromatosis type 1-associated nerve sheath tumors: evidences of PTEN pathway alterations in early NF1 tumorigenesis 2013 nerve neurofibromatosis homo_sapiens mir-143 MI0000459 miRBase miRNA up-regulation NA NA microarray; qRT-PCR etc. no "To comprehensively characterize the role of micrornas in nf1 tumorigenesis, we analyzed 377 mirnas expression in a large panel of dermal and plexiform neurofibromas, and mpnsts. The most significantly upregulated mirna in plexiform neurofibromas was mir-486-3p that targets the major tumor suppressor gene, pten. We confirmed pten downregulation at mrna level. In plexiform neurofibromas, we also report aberrant expression of four mirnas involved in the ras-mapk pathway (mir-370, mir-143, mir-181a, and mir-145). ." 23848554 MicroRNAome profiling in benign and malignant neurofibromatosis type 1-associated nerve sheath tumors: evidences of PTEN pathway alterations in early NF1 tumorigenesis 2013 nerve neurofibromatosis homo_sapiens miR-193a-5p MIMAT0004614 miRBase miRNA up-regulation NA NA microarray; qRT-PCR etc. no "To comprehensively characterize the role of micrornas in nf1 tumorigenesis, we analyzed 377 mirnas expression in a large panel of dermal and plexiform neurofibromas, and mpnsts. The most significantly upregulated mirna in plexiform neurofibromas was mir-486-3p that targets the major tumor suppressor gene, pten. We confirmed pten downregulation at mrna level. In plexiform neurofibromas, we also report aberrant expression of four mirnas involved in the ras-mapk pathway (mir-370, mir-143, mir-181a, and mir-145). ." 23848554 MicroRNAome profiling in benign and malignant neurofibromatosis type 1-associated nerve sheath tumors: evidences of PTEN pathway alterations in early NF1 tumorigenesis 2013 nerve neurofibromatosis homo_sapiens mir-483 MI0002467 miRBase miRNA up-regulation NA NA microarray; qRT-PCR etc. no "To comprehensively characterize the role of micrornas in nf1 tumorigenesis, we analyzed 377 mirnas expression in a large panel of dermal and plexiform neurofibromas, and mpnsts. The most significantly upregulated mirna in plexiform neurofibromas was mir-486-3p that targets the major tumor suppressor gene, pten. We confirmed pten downregulation at mrna level. In plexiform neurofibromas, we also report aberrant expression of four mirnas involved in the ras-mapk pathway (mir-370, mir-143, mir-181a, and mir-145). ." 23848554 MicroRNAome profiling in benign and malignant neurofibromatosis type 1-associated nerve sheath tumors: evidences of PTEN pathway alterations in early NF1 tumorigenesis 2013 nerve neurofibromatosis homo_sapiens mir-181a-1 MI0000289 miRBase miRNA up-regulation NA NA microarray; qRT-PCR etc. no "To comprehensively characterize the role of micrornas in nf1 tumorigenesis, we analyzed 377 mirnas expression in a large panel of dermal and plexiform neurofibromas, and mpnsts. The most significantly upregulated mirna in plexiform neurofibromas was mir-486-3p that targets the major tumor suppressor gene, pten. We confirmed pten downregulation at mrna level. In plexiform neurofibromas, we also report aberrant expression of four mirnas involved in the ras-mapk pathway (mir-370, mir-143, mir-181a, and mir-145). ." 23848554 MicroRNAome profiling in benign and malignant neurofibromatosis type 1-associated nerve sheath tumors: evidences of PTEN pathway alterations in early NF1 tumorigenesis 2013 nerve neurofibromatosis homo_sapiens mir-145 MI0000461 miRBase miRNA up-regulation NA NA microarray; qRT-PCR etc. no "To comprehensively characterize the role of micrornas in nf1 tumorigenesis, we analyzed 377 mirnas expression in a large panel of dermal and plexiform neurofibromas, and mpnsts. The most significantly upregulated mirna in plexiform neurofibromas was mir-486-3p that targets the major tumor suppressor gene, pten. We confirmed pten downregulation at mrna level. In plexiform neurofibromas, we also report aberrant expression of four mirnas involved in the ras-mapk pathway (mir-370, mir-143, mir-181a, and mir-145). ." 23848554 MicroRNAome profiling in benign and malignant neurofibromatosis type 1-associated nerve sheath tumors: evidences of PTEN pathway alterations in early NF1 tumorigenesis 2013 nerve neurofibromatosis homo_sapiens mir-203a MI0000283 miRBase miRNA down-regulation NA NA microarray; qRT-PCR etc. no "To comprehensively characterize the role of micrornas in nf1 tumorigenesis, we analyzed 377 mirnas expression in a large panel of dermal and plexiform neurofibromas, and mpnsts. The most significantly upregulated mirna in plexiform neurofibromas was mir-486-3p that targets the major tumor suppressor gene, pten. We confirmed pten downregulation at mrna level. In plexiform neurofibromas, we also report aberrant expression of four mirnas involved in the ras-mapk pathway (mir-370, mir-143, mir-181a, and mir-145). ." 23848554 MicroRNAome profiling in benign and malignant neurofibromatosis type 1-associated nerve sheath tumors: evidences of PTEN pathway alterations in early NF1 tumorigenesis 2013 nerve neurofibromatosis homo_sapiens mir-365b MI0000769 miRBase miRNA differentially expressed NA NA real-time RT-PCR etc. no "We investigated the expression of nf1, the other 16 protein-coding genes and the 2 micrornas located in the 1.4-Mb microdeletion by means of real-time quantitative reverse-transcription polymerase chain reaction (rt-PCR) in a large series of human dermal and plexiform neurofibromas and mpnsts." 20844836 Identification of genes potentially involved in the increased risk of malignancy in NF1-microdeleted patients 2011 nerve neurofibromatosis homo_sapiens mir-193a MI0000487 miRBase miRNA differentially expressed NA NA real-time RT-PCR etc. no "We investigated the expression of nf1, the other 16 protein-coding genes and the 2 micrornas located in the 1.4-Mb microdeletion by means of real-time quantitative reverse-transcription polymerase chain reaction (rt-PCR) in a large series of human dermal and plexiform neurofibromas and mpnsts." 20844836 Identification of genes potentially involved in the increased risk of malignancy in NF1-microdeleted patients 2011 pancreas cystic_fibrosis homo_sapiens mir-16-1 MI0000070 miRBase miRNA up-regulation BCL-2; SMAD 5 TGF-BETA SIGNALING PATHWAY; SMADS SIGNALING PATHWAY RT-PCR; immunofluorescence etc. no "These results suggested that hdac inhibition protects against cp by promoting apoptosis and tgf-beta;Smads signaling pathways, and indicated that hdac inhibition is a potential therapy to alleviate cp patients in clinic, and these need to be explored further." 32524326 HDAC inhibitors promote pancreatic stellate cell apoptosis and relieve pancreatic fibrosis by upregulating miR-15/16 in chronic pancreatitis 2020 pancreas cystic_fibrosis homo_sapiens mir-15 MI0015483 miRBase miRNA up-regulation BCL-2; SMAD 5 TGF-BETA SIGNALING PATHWAY; SMADS SIGNALING PATHWAY RT-PCR; immunofluorescence etc. no "These results suggested that hdac inhibition protects against cp by promoting apoptosis and tgf-beta;Smads signaling pathways, and indicated that hdac inhibition is a potential therapy to alleviate cp patients in clinic, and these need to be explored further." 32524326 HDAC inhibitors promote pancreatic stellate cell apoptosis and relieve pancreatic fibrosis by upregulating miR-15/16 in chronic pancreatitis 2020 skin skin_fibrosis homo_sapiens mir-29b-1 MI0000105 miRBase miRNA dysregulation TRANSCRIPTION FACTOR SPECIFICITY PROTEIN 1 (SP1) NA enzyme-linked immunosorbent assay; emsa etc. no A hitherto unidentified pathway of xt-i regulation via microrna-29b;Sp1 was determined in this study. Our observations will facilitate the understanding of complex molecular fibrotic pathways and provide new opportunities to investigate microrna-based antifibrotic tools. 30542210 MicroRNA-29b mediates fibrotic induction of human xylosyltransferase-I in human dermal fibroblasts via the Sp1 pathway 2018 skin scleroderma_systemic homo_sapiens mir-29a MI0000087 miRBase miRNA down-regulation MIR-21; MIR-29S NA RT-PCR; transfection experiments; etc. no Focusing on mir-21 and mir-29s as therapeutic targets would be effective in patients with ssc or other fibrotic diseases which show aberrant expression of collagen expression. 31155965 MicroRNA-21 and microRNA-29a modulate the expression of collagen in dermal fibroblasts of patients with systemic sclerosis 2019 skin scleroderma_systemic homo_sapiens mir-21a MI0000569 miRBase miRNA up-regulation MIR-21; MIR-29S NA RT-PCR; transfection experiments; etc. no Focusing on mir-21 and mir-29s as therapeutic targets would be effective in patients with ssc or other fibrotic diseases which show aberrant expression of collagen expression. 31155965 MicroRNA-21 and microRNA-29a modulate the expression of collagen in dermal fibroblasts of patients with systemic sclerosis 2019 skin cicatrix_hypertrophic homo_sapiens miR-31-5p MIMAT0000089 miRBase miRNA dysregulation NA HIF1A qRT-PCR; dual-lucimmunofluorescenceerase reporter assay etc. no "Hsa-mir31 -5p plays an important role in hs formation by inhibiting fih and regulating the hif-1alfa pathway. Therefore, hsa-mir31 -5p may be a novel therapeutic target for hs." 29056521 Study on the role of Hsa-miR-31-5p in hypertrophic scar formation and the mechanism 2017 skin skin_fibrosis homo_sapiens miR-145-5p MIMAT0000437 miRBase miRNA dysregulation JAG1 NA qRT-PCR; no Mir-145-5p and its targets (e.G. Jag1) could represent relevant molecules for the development of novel therapeutic strategies to counteract fibrosis progression in patients with rdeb. 30816994 MicroRNA-145-5p regulates fibrotic features of recessive dystrophic epidermolysis bullosa skin fibroblasts 2019 skin scleroderma_systemic homo_sapiens mir-21a MI0000569 miRBase miRNA up-regulation SMAD7 NA qRT-PCR; dual-lucimmunofluorescenceerase reporter assay etc. yes "Mir-21 may function in an amplifying circuit to enhance tgf-beta signaling events in ssc fibrosis, and suggesting that mir-21 may act as a potential therapeutic target." 23657402 MicroRNA-21 in scleroderma fibrosis and its function in TGF-beta-regulated fibrosis-related genes expression 2013 skin skin_fibrosis homo_sapiens mir-34a MI0000268 miRBase miRNA dysregulation NA NA immunofluorescence; qRT-PCR etc. no Our data indicate that the ezh2-dependent epigenetic phenotype of myofibroblasts is driven by hotair and is linked to mirna-34a repression-dependent activation of notch signalling. 32041748 Long non-coding RNA HOTAIR drives EZH2-dependent myofibroblast activation in systemic sclerosis through miRNA 34a-dependent activation of NOTCH 2020 skin lupus_erythematosus_cutaneous homo_sapiens mir-31 MI0000089 miRBase miRNA dysregulation PEROXISOME PGC-1A NF-KAPPA B SIGNALING PATHWAY immunofluorescence; flow cytometry etc. no Our findings suggest that overexpression of mir-31 and mir-485-p contribute to skin inflammation in dle lesions by regulating the production of inflammatory mediators and attracting neutrophils and intermediate monocytes to the skin. 30130620 MicroRNA Expression Profiling Identifies miR-31 and miR-485-3p as Regulators in the Pathogenesis of Discoid Cutaneous Lupus 2019 skin lupus_erythematosus_cutaneous homo_sapiens miR-485-3p MIMAT0002176 miRBase miRNA dysregulation PEROXISOME PGC-1A NF-KAPPA B SIGNALING PATHWAY immunofluorescence; flow cytometry etc. no Our findings suggest that overexpression of mir-31 and mir-485-p contribute to skin inflammation in dle lesions by regulating the production of inflammatory mediators and attracting neutrophils and intermediate monocytes to the skin. 30130620 MicroRNA Expression Profiling Identifies miR-31 and miR-485-3p as Regulators in the Pathogenesis of Discoid Cutaneous Lupus 2019 skin keloid homo_sapiens mir-181a-2 MI0000269 miRBase miRNA up-regulation MIR-181A NA qRT-PCR; dual-lucimmunofluorescenceerase reporter assay etc. no "Our results highlight a novel pathway mediated by mir-181a, which may be effectively used as a therapeutic target for treatment of keloids." 27915346 MiR-181a Targets PHLPP2 to Augment AKT Signaling and Regulate Proliferation and Apoptosis in Human Keloid Fibroblasts 2016 skin cicatrix_hypertrophic homo_sapiens mir-200b MI0000342 miRBase miRNA down-regulation MIR-200B NA RT-PCR; apoptosis assay etc. no Our study provides evidence to support that mir-200b may be a useful target for hypertrophic scarring management. 25228082 Overexpression of miR-200b inhibits the cell proliferation and promotes apoptosis of human hypertrophic scar fibroblasts in vitro 2014 skin keloid homo_sapiens miR-1224-5p MIMAT0005458 miRBase miRNA down-regulation NA NA immunofluorescence; flow cytometry etc. no "Overexpression of mir-1224-5p led to inhibition of keloid fibroblast proliferation, promotion of apoptosis and decrease of migration and invasion. Our results suggest that downregulation of mir-1224-5p may be one of the mechanisms involved in the occurrence and development of keloids." 29050938 "Tumor suppressive role of miR-1224-5p in keloid proliferation, apoptosis and invasion via the TGF-beta1/Smad3 signaling pathway" 2018 skin sclerosis homo_sapiens mir-7 MI0000263 miRBase miRNA down-regulation NA NA PCR; in situ hybridization; immunoblotting etc. no "Systemic or local down-regulation of mir-7 may contribute to the pathogenesis of lsc via the overexpression of alfa2(i) collagen, and serum mir-7 may be useful as a disease marker. Investigation of the regulatory mechanisms of lsc by mirna may lead to new treatments by the transfection into the lesional skin of this disease." 22965811 MicroRNA-7 down-regulation mediates excessive collagen expression in localized scleroderma 2013 skin skin_fibrosis homo_sapiens mir-206 MI0000490 miRBase miRNA up-regulation NA MTOR SIGNALING PATHWAY cck-8; RT-PCR; etc. no "The expressions of microrna-206, mmp-9, and bax were upregulated, while the expressions of mtor, bcl-2, and cyclin d1 were downregulated. To sum up, laser irradiation can significantly inhibit the proliferation of hsf cells, affect cell cycle, and increase cell apoptosis and migratory ability." 31850679 Effects of photoelectric therapy on proliferation and apoptosis of scar cells by regulating the expression of microRNA-206 and its related mechanisms 2020 skin keloid homo_sapiens mir-34a MI0000268 miRBase miRNA up-regulation NA P53 SIGNALING PATHWAY qRT-PCR etc. yes The ingenol mebutate treatment used here was effective in reducing keloid fibroblast growth in cell culture experiments and the expression of particular mirnas modulated the pro apoptotic gene expression following ingenol-mebutate treatment. 29568916 MiR-34 modulates apoptotic gene expression in Ingenol mebutate treated keloid fibroblasts 2018 skin skin_fibrosis homo_sapiens mir-21a MI0000569 miRBase miRNA dysregulation NA NA NA no "The regulation of the relevant signaling pathways involved in mir-21 will produce new diagnostic and therapeutic options. However, the application of mir21 in the future is still a great challenge." 28726006 MicroRNA-21 in Skin Fibrosis: Potential for Diagnosis and Treatment 2017 skin keloid homo_sapiens miR-199a-5p MIMAT0000231 miRBase miRNA down-regulation NA NA miRNA microarray chip detection; qRT-PCR etc. no "The significantly lower expression of mirna-199a-5p in keloids likely influences the cell cycle of kfs and restrains their proliferation, suggesting that mir-199a-5p probably plays a role in the regulation of kf proliferation." 24782087 Keloid microRNA expression analysis and the influence of miR-199a-5p on the proliferation of keloid fibroblasts 2014 skin scleroderma_systemic homo_sapiens miR-202-3p MIMAT0002811 miRBase miRNA up-regulation MMP1 NA qRT-PCR; dual-lucimmunofluorescenceerase reporter assay etc. no These findings suggest that mir-202-3p may function as a novel pro-fibrotic mirna in ssc by inhibition the expression of mmp1. 28068631 MicroRNA-202-3p regulates scleroderma fibrosis by targeting matrix metalloproteinase 1 2017 skin scleroderma_systemic homo_sapiens miR-16-5p MIMAT0000069 miRBase miRNA down-regulation NA NA dual-lucimmunofluorescenceerase reporter assay; qRT-PCR; etc. no These results indicate that mir-16-5p suppresses myofibroblast activation by suppressing notch signaling. 33411678 MiR-16-5p suppresses myofibroblast activation in systemic sclerosis by inhibiting NOTCH signaling 2020 skin scleroderma_systemic homo_sapiens mir-5196 MI0018175 miRBase miRNA dysregulation NA NA gene expression study; enzyme-linked immunosorbent assay; oxidative stress measurement etc. no "These results suggest that microrna-5196 can be used as a potential biomarker characterising ssc. Overall, this study may open new possibilities for the development of microrna-5196-based diagnostics and therapy in early phases of ssc." 28639412 The role of microRNA-5196 in the pathogenesis of systemic sclerosis 2017 skin skin_fibrosis homo_sapiens mir-145 MI0000461 miRBase miRNA up-regulation MIR-145 NA RT-PCR; immunofluorescence etc. no These results suggest that mir-145 is a promising therapeutic target to prevent or reduce hypertrophic scarring of the skin. 25876136 MiR-145 Contributes to Hypertrophic Scarring of the Skin by Inducing Myofibroblast Activity 2015 skin skin_fibrosis homo_sapiens mir-130b MI0000748 miRBase miRNA up-regulation MICRORNA-130B NA immunofluorescence etc. no "These studies demonstrated that mir-130b played important profibrotic roles in ssc fibrosis, and enhanced tgf-beta signaling through negative regulation of ppar_gama expression. Mir-130b may be a potential therapeutic target in ssc fibrosis." 25547017 MicroRNA-130b regulates scleroderma fibrosis by targeting peroxisome proliferator-activated receptor gama 2015 skin scleroderma_systemic homo_sapiens mir-1269a MI0006406 miRBase miRNA dysregulation NA NA qRT-PCR; etc. no We conclude that egfl7 and its specific microrna mir-126 may be involved in the pathogenesis of ssc vasculopathy and fibrosis. 30872612 Epidermal Growth Factor Like-domain 7 and miR-126 are abnormally expressed in diffuse Systemic Sclerosis fibroblasts 2019 skin keloid homo_sapiens mir-203a MI0000283 miRBase miRNA down-regulation EGR1; FGF2 NA qRT-PCR; dual-lucimmunofluorescenceerase reporter assay etc. no "We demonstrated for the first time that mir-203 decreased the proliferation, invasion, and ecm production of keloid fibroblasts by repressing egr1 and fgf2 expression, suggesting a potential role of mir-203 in preventing and treating keloids." 30372829 "MiR-203 regulates keloid fibroblast proliferation, invasion, and extracellular matrix expression by targeting EGR1 and FGF2" 2018 skin scleroderma_systemic homo_sapiens mir-150 MI0000479 miRBase miRNA dna methylation NA NA qRT-PCR; dual-lucimmunofluorescenceerase reporter assay etc. no "We found that mir-150 is detectable and quantitative in serum. Serum mir-150 levels were decreased in ssc patients, and the ssc patients with lower serum mir-150 levels tended to have more severe clinical manifestations. Mir-150 may play an important role in the pathogenesis of ssc via overexpression of integrin beta3. Investigation of the regulatory mechanisms of tissue fibrosis by mir-150 could lead to development of new diagnostic tools and new treatments using mirna." 23159943 MiR-150 down-regulation contributes to the constitutive type I collagen overexpression in scleroderma dermal fibroblasts via the induction of integrin beta3 2013 spleen hypersplenism homo_sapiens Mir615 751557 Gene miRNA up-regulation LCOR NA qRT-PCR; dual-lucimmunofluorescenceerase reporter assay; etc. no "High expression of mir-615-3p in over-activated splenic macrophages depresses lcor expression, low level of lcor derepresses the expression of ppar_gama and finally upregulated ppar_gama enhances the phagocytic capacity of splenic macrophages. This finding might be useful in the study of hypersplenism and other macrophage-associated diseases." 21565892 MiR-615-3p promotes the phagocytic capacity of splenic macrophages by targeting ligand-dependent nuclear receptor corepressor in cirrhosis-related portal hypertension 2011 uterus idiopathic_pulmonary_fibrosis homo_sapiens let-7a-5p MIMAT0000062 miRBase miRNA dysregulation OLR1 NA Dual-luciferase reporter assay; qRT-PCR; etc. no "Mechanistically, Let-7 was able to regulate the expression of lectin-like oxidized low-density lipoprotein receptor-1 (LOX1) through binding to its 3'-UTR region. Forced expression of LOX1 promoted the expression of apoptosis-related protein and mtDNA damage markers via regulating NLRP3 which was also confirmed in BLM model mice under the combination therapy of the exosome and Let-7 inhibitor. Collectively, this study demonstrates that exosomal Let-7 from MenSCs remits pulmonary fibrosis through regulating ROS, mtDNA damage, and NLRP3 inflammasome activation. This provides a new approach of exocytosis on the treatment of fibrotic lung disease." 31949877 Exosomal miRNA Let-7 from Menstrual Blood-Derived Endometrial Stem Cells Alleviates Pulmonary Fibrosis through Regulating Mitochondrial DNA Damage 2019 uterus idiopathic_pulmonary_fibrosis homo_sapiens let-7b MI0000063 miRBase miRNA dysregulation OLR1 NA Dual-luciferase reporter assay; qRT-PCR; etc. no "Mechanistically, Let-7 was able to regulate the expression of lectin-like oxidized low-density lipoprotein receptor-1 (LOX1) through binding to its 3'-UTR region. Forced expression of LOX1 promoted the expression of apoptosis-related protein and mtDNA damage markers via regulating NLRP3 which was also confirmed in BLM model mice under the combination therapy of the exosome and Let-7 inhibitor. Collectively, this study demonstrates that exosomal Let-7 from MenSCs remits pulmonary fibrosis through regulating ROS, mtDNA damage, and NLRP3 inflammasome activation. This provides a new approach of exocytosis on the treatment of fibrotic lung disease." 31949877 Exosomal miRNA Let-7 from Menstrual Blood-Derived Endometrial Stem Cells Alleviates Pulmonary Fibrosis through Regulating Mitochondrial DNA Damage 2019 uterus idiopathic_pulmonary_fibrosis homo_sapiens let-7c MI0000064 miRBase miRNA dysregulation OLR1 NA Dual-luciferase reporter assay; qRT-PCR; etc. no "Mechanistically, Let-7 was able to regulate the expression of lectin-like oxidized low-density lipoprotein receptor-1 (LOX1) through binding to its 3'-UTR region. Forced expression of LOX1 promoted the expression of apoptosis-related protein and mtDNA damage markers via regulating NLRP3 which was also confirmed in BLM model mice under the combination therapy of the exosome and Let-7 inhibitor. Collectively, this study demonstrates that exosomal Let-7 from MenSCs remits pulmonary fibrosis through regulating ROS, mtDNA damage, and NLRP3 inflammasome activation. This provides a new approach of exocytosis on the treatment of fibrotic lung disease." 31949877 Exosomal miRNA Let-7 from Menstrual Blood-Derived Endometrial Stem Cells Alleviates Pulmonary Fibrosis through Regulating Mitochondrial DNA Damage 2019 eye white_dot_syndromes homo_sapiens mir-34a MI0000268 miRBase miRNA up-regulation KLOTHO NA NA no "The hif-1alfa;P53;Mirna-34a;Klotho axis in rpe cells promoted subretinal fibrosis, thus aggravating the formation of cnv." 33438362 The HIF-1alfa/p53/miRNA-34a/Klotho axis in retinal pigment epithelial cells promotes subretinal fibrosis and exacerbates choroidal neovascularization 2021 heart atrial_fibrillation homo_sapiens mir-4443 MI0016786 miRBase miRNA down-regulation THBS1 TGF-BETA SIGNALING PATHWAY dual-luciferase reporter assay etc. no Hsa-miR-4443 protected atrial fibrillation(AF) by targeting THBS1 and regulated TGF-beta/alfa-SMA/collagen pathway to inhibit HCFB proliferation and collagen synthesis. 33681892 Hsa-miR-4443 inhibits myocardial fibroblast proliferation by targeting THBS1 to regulate TGF-beta1/alpha-SMA/collagen signaling in atrial fibrillation 2021 heart myocardial_infarction homo_sapiens mir-153-2 MI0000464 miRBase miRNA down-regulation NA VEGF SIGNALING PATHWAY enzyme-linked immunosorbent assay; no Mesenchymal stem cells (MSCs)-derived exosomes with low-expressed miR-153-3p notably promotes the activation of angpt1 and the VEGF/CEGFR2 /PI3k/Akt/Enos pathways. 33164880 Blocking exosomal miRNA-153-3p derived from bone marrow mesenchymal stem cells ameliorates hypoxia-induced myocardial and microvascular damage by targeting the ANGPT1-mediated VEGF/PI3k/Akt/eNOS pathway 2021 heart myocardial_infarction homo_sapiens mir-153-1 MI0000463 miRBase miRNA down-regulation NA VEGF SIGNALING PATHWAY enzyme-linked immunosorbent assay; no Mesenchymal stem cells (MSCs)-derived exosomes with low-expressed miR-153-3p notably promotes the activation of angpt1 and the VEGF/CEGFR2 /PI4k/Akt/Enos pathways. 33164880 Blocking exosomal miRNA-153-3p derived from bone marrow mesenchymal stem cells ameliorates hypoxia-induced myocardial and microvascular damage by targeting the ANGPT1-mediated VEGF/PI3k/Akt/eNOS pathway 2021 kidney kidney_diseases homo_sapiens mir-27b MI0000440 miRBase miRNA down-regulation STAT1 NA dual-luciferase reporter assay no miR-27b-3p overexpression could alleviate renal fibrosis via suppressing stat1 in vivo and in vitro. 33454903 MiR-27b-3p inhibits the progression of renal fibrosis via suppressing STAT1 2021 liver hepatitis homo_sapiens mir-21 MI0000569 miRBase miRNA dysregulation NA NA qRT-PCR etc. no miR-21 is a valuable biomarker for the early diagnosis of HCC. 34266326 Value of miR-21 levels as potential biomarkers in the early diagnosis of hepatocellular carcinoma:a meta-analysis 2021 liver non-alcoholic_fatty_liver_disease homo_sapiens mir-155 NA NA miRNA dysregulation NA NA NA yes "Our results propose a regulatory role for Mastiha in circulating levels of miR-155, a critical player in T helper-17 (Th17) differentiation and function." 34224858 Mastiha has efficacy in immune-mediated inflammatory diseases through a microRNA-155 Th17 dependent action 2021 pancreas pancreatitis homo_sapiens mir-41 NA NA miRNA dysregulation NA NA Chromatin immunoprecipitation assay etc. yes "In a pilot cohort of PDAC patients undergoing FOLFIRONX chemotherapy, circulating MIR1307 correlates with clinical outcome." 34795259 Modulation of pancreatic cancer cell sensitivity to FOLFIRINOX through microRNA-mediated regulation of DNA damage 2021 pancreas pancreatitis homo_sapiens mir-84 MI0025556 miRBase miRNA dysregulation NA NA Chromatin immunoprecipitation assay etc. yes "In a pilot cohort of PDAC patients undergoing FOLFIRONX chemotherapy, circulating MIR1307 correlates with clinical outcome." 34795259 Modulation of pancreatic cancer cell sensitivity to FOLFIRINOX through microRNA-mediated regulation of DNA damage 2021 lung idiopathic_pulmonary_fibrosis homo_sapiens let-7d MI0000065 miRBase miRNA down-regulation NA NA qRT-PCR; Western Blot etc. no "In the current study what emerged is let-7d down-regulation and, unexpectedly, miR-16 significant down-regulation. Moreover, through a cross-sectional analysis, a clustering of the expression of miR-16, miR-21 and miR-26a was found." 34088304 Downregulation of exosomal let-7d and miR-16 in idiopathic pulmonary fibrosis 2021 lung idiopathic_pulmonary_fibrosis homo_sapiens mir-16-1 MI0000070 miRBase miRNA down-regulation NA NA qRT-PCR; Western Blot etc. no "In the current study what emerged is let-7d down-regulation and, unexpectedly, miR-16 significant down-regulation. Moreover, through a cross-sectional analysis, a clustering of the expression of miR-16, miR-21 and miR-26a was found." 34088304 Downregulation of exosomal let-7d and miR-16 in idiopathic pulmonary fibrosis 2021 lung idiopathic_pulmonary_fibrosis homo_sapiens mir-21 MI0000077 miRBase miRNA down-regulation NA NA qRT-PCR; Western Blot etc. no "In detail, miR-26a and let-7d have evidence as being antifibrotic, and so does miR-16, even if scientific evidence is limited to rat hepatic fibrosis; on the contrary, miR-21 and miR-210 have been demonstrated to be profibrotic agents. Although we were expecting down-regulation of antifibrotic and up-regulation of profibrotic miRNA comparing to healthy controls, our results showed down-regulation of all the analysed miRNAs." 34088304 Downregulation of exosomal let-7d and miR-16 in idiopathic pulmonary fibrosis 2021 lung idiopathic_pulmonary_fibrosis homo_sapiens mir-210 MI0000286 miRBase miRNA down-regulation NA NA qRT-PCR; Western Blot etc. no "In detail, miR-26a and let-7d have evidence as being antifibrotic, and so does miR-16, even if scientific evidence is limited to rat hepatic fibrosis; on the contrary, miR-21 and miR-210 have been demonstrated to be profibrotic agents. Although we were expecting down-regulation of antifibrotic and up-regulation of profibrotic miRNA comparing to healthy controls, our results showed down-regulation of all the analysed miRNAs." 34088304 Downregulation of exosomal let-7d and miR-16 in idiopathic pulmonary fibrosis 2021 lung idiopathic_pulmonary_fibrosis homo_sapiens mir-26a-1 MI0000083 miRBase miRNA down-regulation NA NA qRT-PCR; Western Blot etc. no "In detail, miR-26a and let-7d have evidence as being antifibrotic, and so does miR-16, even if scientific evidence is limited to rat hepatic fibrosis; on the contrary, miR-21 and miR-210 have been demonstrated to be profibrotic agents. Although we were expecting down-regulation of antifibrotic and up-regulation of profibrotic miRNA comparing to healthy controls, our results showed down-regulation of all the analysed miRNAs." 34088304 Downregulation of exosomal let-7d and miR-16 in idiopathic pulmonary fibrosis 2021 lung idiopathic_pulmonary_fibrosis homo_sapiens mir-657 MI0003681 miRBase miRNA up-regulation NA NA co-expression gene pair analysis; functional enrichment analysis etc. no "A total of 343 DEGs and 21 DEMs were identified between IPF and normal samples. CLDN18, COL6A3, MYRF, PRSS8, RRAS, and SBNO1 were identified as potential IPF biomarkers. In addition, 17 miRNA-target relationship pairs were obtained. The up-regulation of hsa-miR-657, hsa-miR-671-5p, hsa-miR-198, and hsa-miR-940 could regulate the down-regulation of MYRF and the up-regulation of hsa-miR-198 and hsa-miR-373-3p could regulate the down-regulation of RRAS and CLDN18, respectively. Our data indicated that PRSS8, hsa-miR-614, and hsa-miR-503-5p might be involved in the migration and invasion of IPF related cells." 34666057 Screening of Biomarkers Involved in Idiopathic Pulmonary Fibrosis and Regulation of Upstream miRNAs 2022 lung idiopathic_pulmonary_fibrosis homo_sapiens miR-671-5p MIMAT0003880 miRBase miRNA up-regulation NA NA co-expression gene pair analysis; functional enrichment analysis etc. no "A total of 343 DEGs and 21 DEMs were identified between IPF and normal samples. CLDN18, COL6A3, MYRF, PRSS8, RRAS, and SBNO1 were identified as potential IPF biomarkers. In addition, 17 miRNA-target relationship pairs were obtained. The up-regulation of hsa-miR-657, hsa-miR-671-5p, hsa-miR-198, and hsa-miR-940 could regulate the down-regulation of MYRF and the up-regulation of hsa-miR-198 and hsa-miR-373-3p could regulate the down-regulation of RRAS and CLDN18, respectively. Our data indicated that PRSS8, hsa-miR-614, and hsa-miR-503-5p might be involved in the migration and invasion of IPF related cells." 34666057 Screening of Biomarkers Involved in Idiopathic Pulmonary Fibrosis and Regulation of Upstream miRNAs 2022 lung idiopathic_pulmonary_fibrosis homo_sapiens mir-198 MI0000240 miRBase miRNA up-regulation RRAS NA co-expression gene pair analysis; functional enrichment analysis etc. no "A total of 343 DEGs and 21 DEMs were identified between IPF and normal samples. CLDN18, COL6A3, MYRF, PRSS8, RRAS, and SBNO1 were identified as potential IPF biomarkers. In addition, 17 miRNA-target relationship pairs were obtained. The up-regulation of hsa-miR-657, hsa-miR-671-5p, hsa-miR-198, and hsa-miR-940 could regulate the down-regulation of MYRF and the up-regulation of hsa-miR-198 and hsa-miR-373-3p could regulate the down-regulation of RRAS and CLDN18, respectively. Our data indicated that PRSS8, hsa-miR-614, and hsa-miR-503-5p might be involved in the migration and invasion of IPF related cells." 34666057 Screening of Biomarkers Involved in Idiopathic Pulmonary Fibrosis and Regulation of Upstream miRNAs 2022 lung idiopathic_pulmonary_fibrosis homo_sapiens mir-940 MI0005762 miRBase miRNA up-regulation MYRF NA co-expression gene pair analysis; functional enrichment analysis etc. no "A total of 343 DEGs and 21 DEMs were identified between IPF and normal samples. CLDN18, COL6A3, MYRF, PRSS8, RRAS, and SBNO1 were identified as potential IPF biomarkers. In addition, 17 miRNA-target relationship pairs were obtained. The up-regulation of hsa-miR-657, hsa-miR-671-5p, hsa-miR-198, and hsa-miR-940 could regulate the down-regulation of MYRF and the up-regulation of hsa-miR-198 and hsa-miR-373-3p could regulate the down-regulation of RRAS and CLDN18, respectively. Our data indicated that PRSS8, hsa-miR-614, and hsa-miR-503-5p might be involved in the migration and invasion of IPF related cells." 34666057 Screening of Biomarkers Involved in Idiopathic Pulmonary Fibrosis and Regulation of Upstream miRNAs 2022 lung idiopathic_pulmonary_fibrosis homo_sapiens miR-373-3p MIMAT0000726 miRBase miRNA up-regulation CLDN18 NA co-expression gene pair analysis; functional enrichment analysis etc. no "A total of 343 DEGs and 21 DEMs were identified between IPF and normal samples. CLDN18, COL6A3, MYRF, PRSS8, RRAS, and SBNO1 were identified as potential IPF biomarkers. In addition, 17 miRNA-target relationship pairs were obtained. The up-regulation of hsa-miR-657, hsa-miR-671-5p, hsa-miR-198, and hsa-miR-940 could regulate the down-regulation of MYRF and the up-regulation of hsa-miR-198 and hsa-miR-373-3p could regulate the down-regulation of RRAS and CLDN18, respectively. Our data indicated that PRSS8, hsa-miR-614, and hsa-miR-503-5p might be involved in the migration and invasion of IPF related cells." 34666057 Screening of Biomarkers Involved in Idiopathic Pulmonary Fibrosis and Regulation of Upstream miRNAs 2022 lung idiopathic_pulmonary_fibrosis homo_sapiens mir-614 MI0003627 miRBase miRNA dysregulation NA NA co-expression gene pair analysis; functional enrichment analysis etc. no "A total of 343 DEGs and 21 DEMs were identified between IPF and normal samples. CLDN18, COL6A3, MYRF, PRSS8, RRAS, and SBNO1 were identified as potential IPF biomarkers. In addition, 17 miRNA-target relationship pairs were obtained. The up-regulation of hsa-miR-657, hsa-miR-671-5p, hsa-miR-198, and hsa-miR-940 could regulate the down-regulation of MYRF and the up-regulation of hsa-miR-198 and hsa-miR-373-3p could regulate the down-regulation of RRAS and CLDN18, respectively. Our data indicated that PRSS8, hsa-miR-614, and hsa-miR-503-5p might be involved in the migration and invasion of IPF related cells." 34666057 Screening of Biomarkers Involved in Idiopathic Pulmonary Fibrosis and Regulation of Upstream miRNAs 2022 lung idiopathic_pulmonary_fibrosis homo_sapiens miR-503-5p MIMAT0002874 miRBase miRNA dysregulation NA NA co-expression gene pair analysis; functional enrichment analysis etc. no "A total of 343 DEGs and 21 DEMs were identified between IPF and normal samples. CLDN18, COL6A3, MYRF, PRSS8, RRAS, and SBNO1 were identified as potential IPF biomarkers. In addition, 17 miRNA-target relationship pairs were obtained. The up-regulation of hsa-miR-657, hsa-miR-671-5p, hsa-miR-198, and hsa-miR-940 could regulate the down-regulation of MYRF and the up-regulation of hsa-miR-198 and hsa-miR-373-3p could regulate the down-regulation of RRAS and CLDN18, respectively. Our data indicated that PRSS8, hsa-miR-614, and hsa-miR-503-5p might be involved in the migration and invasion of IPF related cells." 34666057 Screening of Biomarkers Involved in Idiopathic Pulmonary Fibrosis and Regulation of Upstream miRNAs 2022 lung idiopathic_pulmonary_fibrosis homo_sapiens mir-520b MI0003155 miRBase miRNA down-regulation NA NA GO and KEGG enrichment analysis; GSVA; Hub gene analysis etc. no "We identified 13 miRNAs (miR-107, miR-125a-5p, miR-133b, miR-140-5p, miR-142-3p, miR-199a-3p, miR-199a-5p, miR-199b-5p, miR-28-5p, miR-324-5p, miR-34c-5p, miR-429, and miR-520b) and 13 mRNAs (WNT3A, CDH5, DAPK2, EMP2, GPM6A, STXBP6, VEGFA, LRRC32, ADRB1, SLC6A4, CCDC85A, FOXF1, and CXCL14). All miRNAs were upregulated except miR-520b. All genes for these mRNAs were downregulated except CXCL14." 34522168 Integrated analysis of the molecular mechanisms in idiopathic pulmonary fibrosis 2021 lung idiopathic_pulmonary_fibrosis homo_sapiens mir-107 MI0000114 miRBase miRNA up-regulation NA NA GO and KEGG enrichment analysis; GSVA; Hub gene analysis etc. no "We identified 13 miRNAs (miR-107, miR-125a-5p, miR-133b, miR-140-5p, miR-142-3p, miR-199a-3p, miR-199a-5p, miR-199b-5p, miR-28-5p, miR-324-5p, miR-34c-5p, miR-429, and miR-520b) and 13 mRNAs (WNT3A, CDH5, DAPK2, EMP2, GPM6A, STXBP6, VEGFA, LRRC32, ADRB1, SLC6A4, CCDC85A, FOXF1, and CXCL14). All miRNAs were upregulated except miR-520b. All genes for these mRNAs were downregulated except CXCL14." 34522168 Integrated analysis of the molecular mechanisms in idiopathic pulmonary fibrosis 2021 lung idiopathic_pulmonary_fibrosis homo_sapiens miR-125a-5p MIMAT0000443 miRBase miRNA up-regulation NA NA GO and KEGG enrichment analysis; GSVA; Hub gene analysis etc. no "We identified 13 miRNAs (miR-107, miR-125a-5p, miR-133b, miR-140-5p, miR-142-3p, miR-199a-3p, miR-199a-5p, miR-199b-5p, miR-28-5p, miR-324-5p, miR-34c-5p, miR-429, and miR-520b) and 13 mRNAs (WNT3A, CDH5, DAPK2, EMP2, GPM6A, STXBP6, VEGFA, LRRC32, ADRB1, SLC6A4, CCDC85A, FOXF1, and CXCL14). All miRNAs were upregulated except miR-520b. All genes for these mRNAs were downregulated except CXCL14." 34522168 Integrated analysis of the molecular mechanisms in idiopathic pulmonary fibrosis 2021 lung idiopathic_pulmonary_fibrosis homo_sapiens mir-133b MI0000822 miRBase miRNA up-regulation NA NA GO and KEGG enrichment analysis; GSVA; Hub gene analysis etc. no "We identified 13 miRNAs (miR-107, miR-125a-5p, miR-133b, miR-140-5p, miR-142-3p, miR-199a-3p, miR-199a-5p, miR-199b-5p, miR-28-5p, miR-324-5p, miR-34c-5p, miR-429, and miR-520b) and 13 mRNAs (WNT3A, CDH5, DAPK2, EMP2, GPM6A, STXBP6, VEGFA, LRRC32, ADRB1, SLC6A4, CCDC85A, FOXF1, and CXCL14). All miRNAs were upregulated except miR-520b. All genes for these mRNAs were downregulated except CXCL14." 34522168 Integrated analysis of the molecular mechanisms in idiopathic pulmonary fibrosis 2021 lung idiopathic_pulmonary_fibrosis homo_sapiens miR-140-5p MIMAT0000431 miRBase miRNA up-regulation NA NA GO and KEGG enrichment analysis; GSVA; Hub gene analysis etc. no "We identified 13 miRNAs (miR-107, miR-125a-5p, miR-133b, miR-140-5p, miR-142-3p, miR-199a-3p, miR-199a-5p, miR-199b-5p, miR-28-5p, miR-324-5p, miR-34c-5p, miR-429, and miR-520b) and 13 mRNAs (WNT3A, CDH5, DAPK2, EMP2, GPM6A, STXBP6, VEGFA, LRRC32, ADRB1, SLC6A4, CCDC85A, FOXF1, and CXCL14). All miRNAs were upregulated except miR-520b. All genes for these mRNAs were downregulated except CXCL14." 34522168 Integrated analysis of the molecular mechanisms in idiopathic pulmonary fibrosis 2021 lung idiopathic_pulmonary_fibrosis homo_sapiens miR-142-3p MIMAT0000434 miRBase miRNA up-regulation NA NA GO and KEGG enrichment analysis; GSVA; Hub gene analysis etc. no "We identified 13 miRNAs (miR-107, miR-125a-5p, miR-133b, miR-140-5p, miR-142-3p, miR-199a-3p, miR-199a-5p, miR-199b-5p, miR-28-5p, miR-324-5p, miR-34c-5p, miR-429, and miR-520b) and 13 mRNAs (WNT3A, CDH5, DAPK2, EMP2, GPM6A, STXBP6, VEGFA, LRRC32, ADRB1, SLC6A4, CCDC85A, FOXF1, and CXCL14). All miRNAs were upregulated except miR-520b. All genes for these mRNAs were downregulated except CXCL14." 34522168 Integrated analysis of the molecular mechanisms in idiopathic pulmonary fibrosis 2021 lung idiopathic_pulmonary_fibrosis homo_sapiens miR-199a-3p MIMAT0000232 miRBase miRNA up-regulation NA NA GO and KEGG enrichment analysis; GSVA; Hub gene analysis etc. no "We identified 13 miRNAs (miR-107, miR-125a-5p, miR-133b, miR-140-5p, miR-142-3p, miR-199a-3p, miR-199a-5p, miR-199b-5p, miR-28-5p, miR-324-5p, miR-34c-5p, miR-429, and miR-520b) and 13 mRNAs (WNT3A, CDH5, DAPK2, EMP2, GPM6A, STXBP6, VEGFA, LRRC32, ADRB1, SLC6A4, CCDC85A, FOXF1, and CXCL14). All miRNAs were upregulated except miR-520b. All genes for these mRNAs were downregulated except CXCL14." 34522168 Integrated analysis of the molecular mechanisms in idiopathic pulmonary fibrosis 2021 lung idiopathic_pulmonary_fibrosis homo_sapiens miR-199a-5p MIMAT0000231 miRBase miRNA up-regulation NA NA GO and KEGG enrichment analysis; GSVA; Hub gene analysis etc. no "We identified 13 miRNAs (miR-107, miR-125a-5p, miR-133b, miR-140-5p, miR-142-3p, miR-199a-3p, miR-199a-5p, miR-199b-5p, miR-28-5p, miR-324-5p, miR-34c-5p, miR-429, and miR-520b) and 13 mRNAs (WNT3A, CDH5, DAPK2, EMP2, GPM6A, STXBP6, VEGFA, LRRC32, ADRB1, SLC6A4, CCDC85A, FOXF1, and CXCL14). All miRNAs were upregulated except miR-520b. All genes for these mRNAs were downregulated except CXCL14." 34522168 Integrated analysis of the molecular mechanisms in idiopathic pulmonary fibrosis 2021 lung idiopathic_pulmonary_fibrosis homo_sapiens miR-28-5p MIMAT0000085 miRBase miRNA up-regulation NA NA GO and KEGG enrichment analysis; GSVA; Hub gene analysis etc. no "We identified 13 miRNAs (miR-107, miR-125a-5p, miR-133b, miR-140-5p, miR-142-3p, miR-199a-3p, miR-199a-5p, miR-199b-5p, miR-28-5p, miR-324-5p, miR-34c-5p, miR-429, and miR-520b) and 13 mRNAs (WNT3A, CDH5, DAPK2, EMP2, GPM6A, STXBP6, VEGFA, LRRC32, ADRB1, SLC6A4, CCDC85A, FOXF1, and CXCL14). All miRNAs were upregulated except miR-520b. All genes for these mRNAs were downregulated except CXCL14." 34522168 Integrated analysis of the molecular mechanisms in idiopathic pulmonary fibrosis 2021 lung idiopathic_pulmonary_fibrosis homo_sapiens miR-324-5p MIMAT0000761 miRBase miRNA up-regulation NA NA GO and KEGG enrichment analysis; GSVA; Hub gene analysis etc. no "We identified 13 miRNAs (miR-107, miR-125a-5p, miR-133b, miR-140-5p, miR-142-3p, miR-199a-3p, miR-199a-5p, miR-199b-5p, miR-28-5p, miR-324-5p, miR-34c-5p, miR-429, and miR-520b) and 13 mRNAs (WNT3A, CDH5, DAPK2, EMP2, GPM6A, STXBP6, VEGFA, LRRC32, ADRB1, SLC6A4, CCDC85A, FOXF1, and CXCL14). All miRNAs were upregulated except miR-520b. All genes for these mRNAs were downregulated except CXCL14." 34522168 Integrated analysis of the molecular mechanisms in idiopathic pulmonary fibrosis 2021 lung idiopathic_pulmonary_fibrosis homo_sapiens miR-34c-5p MIMAT0000686 miRBase miRNA up-regulation NA NA GO and KEGG enrichment analysis; GSVA; Hub gene analysis etc. no "We identified 13 miRNAs (miR-107, miR-125a-5p, miR-133b, miR-140-5p, miR-142-3p, miR-199a-3p, miR-199a-5p, miR-199b-5p, miR-28-5p, miR-324-5p, miR-34c-5p, miR-429, and miR-520b) and 13 mRNAs (WNT3A, CDH5, DAPK2, EMP2, GPM6A, STXBP6, VEGFA, LRRC32, ADRB1, SLC6A4, CCDC85A, FOXF1, and CXCL14). All miRNAs were upregulated except miR-520b. All genes for these mRNAs were downregulated except CXCL14." 34522168 Integrated analysis of the molecular mechanisms in idiopathic pulmonary fibrosis 2021 lung idiopathic_pulmonary_fibrosis homo_sapiens mir-429 MI0001641 miRBase miRNA up-regulation NA NA GO and KEGG enrichment analysis; GSVA; Hub gene analysis etc. no "We identified 13 miRNAs (miR-107, miR-125a-5p, miR-133b, miR-140-5p, miR-142-3p, miR-199a-3p, miR-199a-5p, miR-199b-5p, miR-28-5p, miR-324-5p, miR-34c-5p, miR-429, and miR-520b) and 13 mRNAs (WNT3A, CDH5, DAPK2, EMP2, GPM6A, STXBP6, VEGFA, LRRC32, ADRB1, SLC6A4, CCDC85A, FOXF1, and CXCL14). All miRNAs were upregulated except miR-520b. All genes for these mRNAs were downregulated except CXCL14." 34522168 Integrated analysis of the molecular mechanisms in idiopathic pulmonary fibrosis 2021 heart myocardial_infarction homo_sapiens miR-218-5p MIMAT0000275 miRBase miRNA down-regulation GJA1 (CX43) NA RT-PCR;western blotting;immunohistochemical staining no "GJA1 (CX43) may be the target of miR-218-5p, and overexpressed CX43 can partly block the function of miR-218-5p in fibrosis inhibition." 34587879 MiR-218-5p Mediates Myocardial Fibrosis after Myocardial Infarction by Targeting CX43 2021 heart myocardial_infarction homo_sapiens mir-3185 MI0014227 miRBase miRNA up-regulation MHRT TGF-BETA SIGNALING PATHWAY qRT-PCR;western blot;MTT and EdU assays etc. no Overexpression of miR-3185 inhibited the upregulation of Col I and Col III induced by TGF-beta1.MHRT promoted cardiac fibrosis after MI through miR-3185 and increased myocardial collagen deposition and promoted myocardial fibrosis. 34334583 LncRNA MHRT Promotes Cardiac Fibrosis via miR-3185 Pathway Following Myocardial Infarction 2021 heart hypertrophic_cardiomyopathy homo_sapiens mir-495 MI0003135 miRBase miRNA up-regulation NA NA RT-PCR no Circulating miR-495-3p is elevated in the plasma of hypertrophic cardiomyopathy patients. 34827715 A Novel miRNA Screen Identifies miRNA-4454 as a Candidate Biomarker for Ventricular Fibrosis in Patients with Hypertrophic Cardiomyopathy 2021 heart hypertrophic_cardiomyopathy homo_sapiens mir-4454 MI0016800 miRBase miRNA up-regulation NA NA RT-PCR no Circulating miR-4454 levels is elevated in the plasma of hypertrophic cardiomyopathy patients. 34827715 A Novel miRNA Screen Identifies miRNA-4454 as a Candidate Biomarker for Ventricular Fibrosis in Patients with Hypertrophic Cardiomyopathy 2021 heart atrial_fibrillation homo_sapiens miR-223-3p MIMAT0000280 miRBase miRNA up-regulation FOXO3 NA NA yes "Quercetin (Que) can effectively inhibit the expression of miR-223-3p in atrial fibrillation model cells and rats myocardial tissues, and meanwhile enhance the expression of FOXO4 and activate the autophagy pathway, and significantly inhibit myocardial fibrosis, and improve myocardial remodeling in atrial fibrillation." 34097559 Quercetin prevents isoprenaline-induced myocardial fibrosis by promoting autophagy via regulating miR-223-3p/FOXO3 2021 heart diabetic_cardiomyopathy homo_sapiens miR-195-5p MIMAT0000461 miRBase miRNA down-regulation Smad7 TGF-BETA SIGNALING PATHWAY NA no MiR-195-5p downregulation blocked endothelial mesenchymal transition (EndMT) by inhibiting TGF-beta1-smads pathway. Smad7 was the direct target of miR-195-5p and silencing miR-195-5p inhibited EndMT by promoting Smad7 expression. 34658906 MicroRNA-195-5p Downregulation Inhibits Endothelial Mesenchymal Transition and Myocardial Fibrosis in Diabetic Cardiomyopathy by Targeting Smad7 and Inhibiting Transforming Growth Factor Beta 1-Smads-Snail Pathway 2021 heart atrial_fibrillation homo_sapiens mir-133a-1 MI0000450 miRBase miRNA down-regulation CTGF NA qRT-PCR;western blot;the dual-luciferase reporter yes "Overexpression of miR-133a inhibited the proliferation and migration ability on Ang II-induced HAFs, and decreased the protein expressions of related fibrosis markers and CTGF." 34303273 H2S inhibits atrial fibrillation-induced atrial fibrosis through miR-133a/CTGF axis 2021 heart atrial_fibrillation homo_sapiens mir-133a-2 MI0000451 miRBase miRNA down-regulation CTGF NA qRT-PCR;western blot;the dual-luciferase reporter yes "Overexpression of miR-133a inhibited the proliferation and migration ability on Ang II-induced HAFs, and decreased the protein expressions of related fibrosis markers and CTGF." 34303273 H2S inhibits atrial fibrillation-induced atrial fibrosis through miR-133a/CTGF axis 2021 heart atrial_fibrillation homo_sapiens mir-1202 MI0006334 miRBase miRNA up-regulation nNOS TGF-BETA SIGNALING PATHWAY qRT-PCR;CCK-8 assays;western blot no MiR-1202 promotes human cardiac fibroblasts transformation to a pro-fibrotic phenotype by targeting nNOS through activating the TGF-beta1/Smad2/3 pathway. 34428251 "MiRNA-1202 promotes the TGF-beta1-induced proliferation, differentiation and collagen production of cardiac fibroblasts by targeting nNOS" 2021 heart atrial_fibrillation homo_sapiens mir-1-2 MI0000437 miRBase miRNA down-regulation NA NA NA no MicroRNA-1 is involved in the molecular remodeling of aging atrial fibrillation through the regulation of primers. 34957910 Molecular mechanism of atrial remodeling in patients with aging atrial fibrillation under the expression of microRNA-1 and microRNA-21 2021 heart atrial_fibrillation homo_sapiens mir-1-1 MI0000651 miRBase miRNA down-regulation NA NA NA no MicroRNA-1 is involved in the molecular remodeling of aging atrial fibrillation through the regulation of primers. 34957910 Molecular mechanism of atrial remodeling in patients with aging atrial fibrillation under the expression of microRNA-1 and microRNA-21 2021 heart atrial_fibrillation homo_sapiens mir-21 MI0000077 miRBase miRNA up-regulation NA NA NA no MicroRNA-21 is involved in the molecular remodeling of aging atrial fibrillation through the regulation of primers. 34957910 Molecular mechanism of atrial remodeling in patients with aging atrial fibrillation under the expression of microRNA-1 and microRNA-21 2021 heart myocardial_infarction homo_sapiens mir-27a MI0000085 miRBase miRNA up-regulation GFPT2 TGF-BETA SIGNALING PATHWAY bioinformatic analyses;luciferase assays no Overexpression of GFPT2 counteracted the protective functions of miR-27a against myocardial infarction through the activation of the TGF-beta/Smad2/3 signaling pathway. 33910455 Promoting roles of KLF5 in myocardial infarction in mice involving microRNA-27a suppression and the following GFPT2/TGF-beta/Smad2/3 axis activation 2021 heart chronic_heart_failure homo_sapiens mir-320a MI0000542 miRBase miRNA up-regulation NA PI3K-AKT SIGNALING PATHWAY qRT-PCR;western blot;MTT assays etc. no miR-320a promoted myocardial fibroblast proliferation via regulating the PIK3CA/Akt/mTOR signaling pathway. 34194551 miR-320a in serum exosomes promotes myocardial fibroblast proliferation via regulating the PIK3CA/Akt/mTOR signaling pathway in HEH2 cells 2021 heart myocardial_injury homo_sapiens mir-135a-2 MI0000453 miRBase miRNA down-regulation TLR4 NA luciferase assay no MiR-135a promotes isoprenaline-induced cardiac injury by inhibiting the TLR4 pathway. 34078799 MiR-135a Protects against Myocardial Injury by Targeting TLR4 2021 heart myocardial_injury homo_sapiens mir-135a-1 MI0000452 miRBase miRNA down-regulation TLR4 NA luciferase assay no MiR-135a promotes isoprenaline-induced cardiac injury by inhibiting the TLR4 pathway. 34078799 MiR-135a Protects against Myocardial Injury by Targeting TLR4 2021 heart myocardial_infarction homo_sapiens mir-185 MI0000482 miRBase miRNA up-regulation NA NA RT-PCR no Elevated miR-185 levels at the late stage of STEMI were related to a large amount of myocardial injury and adverse remodeling. 34248121 Serum microRNA-185 Levels and Myocardial Injury in Patients with Acute ST-segment Elevation Myocardial Infarction 2022 heart cardiovascular_diseases homo_sapiens mir-21 MI0000077 miRBase miRNA up-regulation NA NA PCR no MiR-21 is a mediator involved in the pathogenesis of cardiac fibrosis. 33804922 Therapeutic miR-21 Silencing Reduces Cardiac Fibrosis and Modulates Inflammatory Response in Chronic Chagas Disease 2021 heart myocardical_ischemia homo_sapiens mir-106a MI0000113 miRBase miRNA down-regulation Notch3 NA NA no MiR-106a-363 cluster in the extracellular vesicles stimulated cardiomyocyte cell cycle re-entry by repressing Notch3 to induce cell proliferation and augment myocardial self-repair. 33742276 miR-106a-363 cluster in extracellular vesicles promotes endogenous myocardial repair via Notch3 pathway in ischemic heart injury 2021 heart atrial_fibrillation homo_sapiens miR-450a-2-3p MIMAT0031074 miRBase miRNA down-regulation MAPK1 NA RT-qRT-PCR;GO no "The overexpression of miR-450a-2-3p suppressed the MAPK1 expression in cardiac fibroblasts (CFs), thereby inhibiting the expression of alpha-SMA, COL1, and COL3 and preventing CF proliferation." 34257520 Exosomes Containing LINC00636 Inhibit MAPK1 through the miR-450a-2-3p Overexpression in Human Pericardial Fluid and Improve Cardiac Fibrosis in Patients with Atrial Fibrillation 2021 heart atrial_fibrillation homo_sapiens mir-135b MI0000810 miRBase miRNA down-regulation NA TGF-BETA SIGNALING PATHWAY RT-PCR;western blot;dual luciferase reporter assay etc. yes Quercetin may alleviate atrial fibrillation by inhibiting fibrosis of atrial tissues through inhibiting TGF-beta/Smads pathway via promoting miR-135b expression. 34656066 Quercetin improves atrial fibrillation through inhibiting TGF-beta/Smads pathway via promoting MiR-135b expression 2021 heart myocardial_infarction homo_sapiens miR-146b-5p MIMAT0002809 miRBase miRNA up-regulation IRAK1;CEACAM1 NA luciferase assays no "Overexpression of miR-146b-5p activated fibroblast proliferation, migration, and fibroblast-to-myofibroblast transition, impaired endothelial cell function and stress survival, and disturbed macrophage paracrine signaling." 32845445 Therapeutic silencing miR-146b-5p improves cardiac remodeling in a porcine model of myocardial infarction by modulating the wound reparative phenotype 2021 heart diabetic_cardiomyopathy homo_sapiens miR-20a-5p MIMAT0000075 miRBase miRNA down-regulation ROCK2 NF-KAPPA B SIGNALING PATHWAY NA no "MiR-20a-5p may effectively ameliorate diabetic cardiomyopathy through improving cardiac metabolism, and subsequently inhibiting inflammation, apoptosis, hypertrophy, fibrosis and JNK/NF-KAPPA B pathway via modulating ROCK2." 33837411 "MiR-20a-5p overexpression prevented diabetic cardiomyopathy via inhibition of cardiomyocyte apoptosis, hypertrophy, fibrosis and JNK/NF-kappaB signalling pathway" 2021 heart cardiovascular_diseases homo_sapiens mir-618 MI0003632 miRBase miRNA up-regulation TAN NA microarray assay no The induction of miR-618 is indispensable for the function of TAN against the fibrotic process after heart injury. 35014054 Tanshinone IIA from Salvia miltiorrhiza exerts anti-fibrotic effects on cardiac fibroblasts and rat heart tissues by suppressing the levels of pro-fibrotic factors: The key role of miR-618. 2022 heart atrial_fibrillation homo_sapiens miR-15a-5p MIMAT0000068 miRBase miRNA up-regulation NA NA qRT-PCR;western blot;luciferase reporter assay etc. no MiR-15a-5p inhibitor or pcDNA3.1-Smad7 can inhibit LPS-induced fibrosis and cell proliferation. 35036160 miR-15a-5p regulates myocardial fibrosis in atrial fibrillation by targeting Smad7 2021 kidney diabetic_kidney_disease homo_sapiens miR-23a-3p MIMAT0000078 miRBase miRNA down-regulation Egr1 NA NA no MiR-23a-3p attenuates the development of diabetic kidney disease through Egr1. 34608568 miR-23a-3p regulates the inflammatory response and fibrosis in diabetic kidney disease by targeting early growth response 1 2021 kidney renal_fibrosis homo_sapiens miR-27b-3p MIMAT0000419 miRBase miRNA down-regulation STAT1 NA dual-luciferase reporter assay no MiR-27b-3p overexpression could alleviate renal fibrosis via suppressing STAT1 in vivo and in vitro. 33454903 MiR-27b-3p inhibits the progression of renal fibrosis via suppressing STAT1 2021 kidney renal_fibrosis homo_sapiens miR-142-5p MIMAT0000433 miRBase miRNA up-regulation ACTN4 NA rescue assays yes Asiaticoside inhibits renal fibrosis by regulating the miR-142-5p/ACTN4 axis. 33444480 Asiaticoside inhibits renal fibrosis development by regulating the miR-142-5p/ACTN4 axis 2022 kidney chronic_kidney_disease homo_sapiens mir-4516 MI0016882 miRBase miRNA down-regulation SIAH3 NA NA no "MiR-4516 is downregulated and its target SIAH3, an E3 ubiquitin protein ligase that reduces PINK1 accumulation to damaged mitochondria, is upregulated in the renal cortex of chronic kidney disease ." 34359852 Melatonin Treatment Improves Renal Fibrosis via miR-4516/SIAH3/PINK1 Axis 2021 kidney iga_nephropathy homo_sapiens miR-150-5p MIMAT0000451 miRBase miRNA up-regulation NA NA NA no "MiR-150-5p was found in lymphoid infiltrates, and areas of proliferation and fibrosis consistent with the known drivers of progression." 33417998 Differential expression of microRNA miR-150-5p in IgA nephropathy as a potential mediator and marker of disease progression 2021 kidney diabetic_nephropathy homo_sapiens mir-17 MI0000071 miRBase miRNA up-regulation Smad7 TGF-BETA SIGNALING PATHWAY qRT-PCR;western blot;luciferase reporter assay etc. no Downregulation of miR-17 could suppress renal fibrosis mediated by TGF-BETA1 through targeting Smad7. 33797702 Downregulation of miR-17 suppresses TGF-beta1-mediated renal fibrosis through targeting Smad7 2021 kidney renal_interstitial_fibrosis homo_sapiens mir-212 MI0000288 miRBase miRNA up-regulation HIF1AN NA NA no "High expression of miR?212 was closely associated with the occurrence of renal interstitial fibrosis, and that miR-212 may promote its development by targeting HIF1AN." 33495813 miR-212 promotes renal interstitial fibrosis by inhibiting hypoxia-inducible factor 1-alpha inhibitor 2021 kidney renal_fibrosis homo_sapiens miR-21-5p MIMAT0000076 miRBase miRNA up-regulation NA NF-KAPPA B SIGNALING PATHWAY NA no The role of the METTL3-m6 A-miR-21-5p-SPRY1/ERK/NF-kB axis in obstructive renal fibrosis and provides a deeper understanding of renal fibrosis. 34164910 METTL3/N6-methyladenosine/ miR-21-5p promotes obstructive renal fibrosis by regulating inflammation through SPRY1/ERK/NF-kappaB pathway activation 2021 kidney iga_nephropathy homo_sapiens mir-25 MI0000082 miRBase miRNA up-regulation NA NA luciferase reporter assay no Inhibition of miR-25 cluster could promote cell proliferation and increase fibrosis-related protein and transferrin receptor (TFRC) expression in human renal glomerular mesangial cell. 34197043 Deletion of the miR-25/93/106b cluster induces glomerular deposition of immune complexes and renal fibrosis in mice 2021 kidney iga_nephropathy homo_sapiens mir-93 MI0000095 miRBase miRNA up-regulation Ccnd1 NA luciferase reporter assay no MiR-93 cluster could upregulate Ccnd1 expression through direct binding with the 3'UTR of Ccnd1. 34197043 Deletion of the miR-25/93/106b cluster induces glomerular deposition of immune complexes and renal fibrosis in mice 2021 kidney iga_nephropathy homo_sapiens mir-106b MI0000734 miRBase miRNA up-regulation Ccnd1 NA luciferase reporter assay no MiR-106b cluster could upregulate Ccnd1 expression through direct binding with the 3'UTR of Ccnd1. 34197043 Deletion of the miR-25/93/106b cluster induces glomerular deposition of immune complexes and renal fibrosis in mice 2021 kidney renal_fibrosis homo_sapiens mir-27b MI0000440 miRBase miRNA up-regulation NA NA qRT-PCR;western blot;luciferase reporter assay etc. yes "PAT altered miR-27b levels and PPAR, with associated changes to NF-KAPPA B activation, downstream IL-6 and CYP1B1 expression." 35217024 miR-27b inhibition contributes to cytotoxicity in patulin-exposed HEK293 cells 2022 kidney renal_fibrosis homo_sapiens mir-4709 MI0017342 miRBase miRNA up-regulation LATS2 HIPPO SIGNALING PATHWAY FISH;RT-qRT-PCR;luciferase assay no "Aberrant miR-4709-3p expression plays an essential function in the renal fibrosis progression, and miR-4709-3p overexpression could advance obstructive renal fibrosis via LATS2 targeting in Hippo signaling pathway." 34931960 MicroRNA miR-4709-3p targets Large Tumor Suppressor Kinase 2 (LATS2) and induces obstructive renal fibrosis through Hippo signaling 2021 kidney diabetic_nephropathy homo_sapiens mir-4709-3p MI0017342 miRBase miRNA up-regulation LATS2 HIPPO SIGNALING PATHWAY FISH;RT-qRT-PCR;luciferase assay no "Aberrant miR-4709-3p expression plays an essential function in the renal fibrosis progression, and miR-4709-3p overexpression could advance obstructive renal fibrosis via LATS2 targeting in Hippo signaling pathway." 34931960 MicroRNA miR-4709-3p targets Large Tumor Suppressor Kinase 2 (LATS2) and induces obstructive renal fibrosis through Hippo signaling 2021 kidney renal_interstitial_fibrosis homo_sapiens mir-4709-3p MI0017342 miRBase miRNA up-regulation LATS2 HIPPO SIGNALING PATHWAY FISH;RT-qRT-PCR;luciferase assay no "Aberrant miR-4709-3p expression plays an essential function in the renal fibrosis progression, and miR-4709-3p overexpression could advance obstructive renal fibrosis via LATS2 targeting in Hippo signaling pathway." 34931960 MicroRNA miR-4709-3p targets Large Tumor Suppressor Kinase 2 (LATS2) and induces obstructive renal fibrosis through Hippo signaling 2021 kidney diabetic_nephropathy homo_sapiens mir-32 MI0000090 miRBase miRNA up-regulation Smad7 NA RT-PCR;dual luciferase reporter assay no "Reintroduction of SMAD7 expression rescued miR-32 autophagy suppression, epithelial-mesenchymal transition and renal fibrosis." 32959695 MiR-32-5p knockdown inhibits epithelial to mesenchymal transition and renal fibrosis by targeting SMAD7 in diabetic nephropathy 2021 kidney renal_interstitial_fibrosis homo_sapiens mir-101-2 MI0000739 miRBase miRNA up-regulation TbetaR-I TGF-BETA SIGNALING PATHWAY RT-qRT-PCR no MiR-101 is capable of inhibiting TGF-beta1 induced tubular epithelial-to-mesenchymal transition by targeting TbetaR-I. 33955520 MicroRNA-101 inhibits renal tubular epithelial-to-mesenchymal transition by targeting TGF-beta1 type I receptor 2021 kidney renal_interstitial_fibrosis homo_sapiens mir-101-1 MI0000103 miRBase miRNA up-regulation TbetaR-I TGF-BETA SIGNALING PATHWAY RT-qRT-PCR no MiR-101 is capable of inhibiting TGF-beta1 induced tubular epithelial-to-mesenchymal transition by targeting TbetaR-I. 33955520 MicroRNA-101 inhibits renal tubular epithelial-to-mesenchymal transition by targeting TGF-beta1 type I receptor 2021 kidney diabetic_kidney_disease homo_sapiens mir-205 MI0000285 miRBase miRNA down-regulation HDAC NA NA no MiR-205 agonist attenuated extracellular matrix production in HK2 cell. 35084460 The HDAC2/SP1/miR-205 feedback loop contributes to tubular epithelial cell extracellular matrix production in diabetic kidney disease 2022 kidney renal_fibrosis homo_sapiens miR-363-3p MIMAT0000707 miRBase miRNA down-regulation NA TGF-BETA SIGNALING PATHWAY qRT-PCR;western blot;dual-luciferase reporter no MiR-363-3p plays a protective role in renal fibrosis by regulating the TGF-beta2/Smad3 signaling pathway. 33630202 MicroRNA-363-3p Inhibits the Expression of Renal Fibrosis Markers in TGF-beta1-Treated HK-2 Cells by Targeting TGF-beta2 2021 kidney diabetic_nephropathy homo_sapiens miR-17-5p MIMAT0000070 miRBase miRNA up-regulation KIF23 WNT SIGNALING PATHWAY RT-qRT-PCR;flow cytometry;western blot etc. no MiR-17-5p inhibition alleviates the apoptosis and fibrosis in high glucose-treated HMCs by targeting KIF23 activating Wnt/beta-catenin signaling. 34014023 MiR-17-5p downregulation alleviates apoptosis and fibrosis in high glucose-induced human mesangial cells through inactivation of Wnt/beta-catenin signaling by targeting KIF23 2021 kidney diabetic_nephropathy homo_sapiens mir-365b MI0000769 miRBase miRNA up-regulation BDNF NA RT-qRT-PCR;western blot;luciferase reporter assay etc. no MiR-365 could regulate BDNF-TrkB signal axis in streptozotocin induced diabetic nephropathy fibrosis and renal function. 33881703 Mechanism of miR-365 in regulating BDNF-TrkB signal axis of HFD/STZ induced diabetic nephropathy fibrosis and renal function 2021 kidney diabetic_nephropathy homo_sapiens mir-365a MI0000767 miRBase miRNA up-regulation BDNF NA RT-qRT-PCR;western blot;luciferase reporter assay etc. no MiR-365 could regulate BDNF-TrkB signal axis in streptozotocin induced diabetic nephropathy fibrosis and renal function. 33881703 Mechanism of miR-365 in regulating BDNF-TrkB signal axis of HFD/STZ induced diabetic nephropathy fibrosis and renal function 2021 kidney diabetic_nephropathy homo_sapiens miR-199b-3p MIMAT0004563 miRBase miRNA down-regulation KDM6A NA the dual-luciferase assay no MiR-199b-3p improves E-cadherin expression and prevents the progression of diabetic nephropathy through targeting KDM6A. 34257820 hsa-miR-199b-3p Prevents the Epithelial-Mesenchymal Transition and Dysfunction of the Renal Tubule by Regulating E-cadherin through Targeting KDM6A in Diabetic Nephropathy 2021 kidney chronic_kidney_disease homo_sapiens mir-30a MI0000088 miRBase miRNA down-regulation NA NA qRT-PCR;immunoblotting;immunofluorescence staining no CircHIPK3 may contribute to progressive renal fibrosis by sponging miR-30a. 35058790 circHIPK3 Exacerbates Folic Acid-Induced Renal Tubulointerstitial Fibrosis by Sponging miR-30a 2022