Tissue Disease Species symbol ID Platform Type Expression Target Pathway Method Drug Function PMID Title Year brain multiple_sclerosis homo_sapiens GSDMB circ_0141336 circBase circRNA up-regulation NA NA qRT-PCR NA "Both alternative splicing (AS) isoforms and the identified ecircRNA were significantly dysregulated in peripheral blood mononuclear cells of relapsing-remitting multiple sclerosis (MS) patients compared to controls, further supporting the notion that aberrant RNA metabolism is a characteristic feature of the disease." 28272342 The Characterization of GSDMB Splicing and Backsplicing Profiles Identifies Novel Isoforms and a Circular RNA That Are Dysregulated in Multiple Sclerosis 2017 brain multiple_sclerosis homo_sapiens circ_101539 circ_101539 circBase circRNA down-regulation NA NA qRT-PCR; microarray NA "We carried out expression profiling of 13617 circular RNA in peripheral blood leucocytes from multiple sclerosis patients and healthy controls finding 406 differentially expressed and demonstrate after validation that, circ_0005402 and circ_0035560 are underexpressed in multiple sclerosis patients and could be used as biomarkers of the disease." 28651352 Circular RNA profiling reveals that circular RNAs from ANXA2 can be used as new biomarkers for multiple sclerosis. 2017 brain multiple_sclerosis homo_sapiens circ_0035560 circ_0035560 circBase circRNA down-regulation NA NA qRT-PCR; microarray NA "We carried out expression profiling of 13617 circular RNA in peripheral blood leucocytes from multiple sclerosis patients and healthy controls finding 406 differentially expressed and demonstrate after validation that, circ_0005402 and circ_0035560 are underexpressed in multiple sclerosis patients and could be used as biomarkers of the disease." 28651352 Circular RNA profiling reveals that circular RNAs from ANXA2 can be used as new biomarkers for multiple sclerosis. 2017 cell_line atherosclerosis homo_sapiens circANRIL NA NA circRNA up-regulation NA NA qRT-PCR NA "CircANRIL induces nucleolar stress and p53 activation, resulting in the induction of apoptosis and inhibition of proliferation, which are key cell functions in atherosclerosis." 27539542 Circular non-coding RNA ANRIL modulates ribosomal RNA maturation and atherosclerosis in humans 2016 heart myocardial_infarction homo_sapiens circ-LAS1L NA NA circRNA down-regulation SFRP5 NA dual-luciferase reporter assay no Circ_las1l/miR-125b/Sfrp5 pathway can regulate the biological function of cardiac fibroblasts and may play an important role in the process of myocardial fibrosis. 31950540 "Circ_LAS1L regulates cardiac fibroblast activation, growth, and migration through miR-125b/SFRP5 pathway" 2020 heart cardiomegaly homo_sapiens circ-YAP NA NA circRNA down-regulation ACTG TGF-BETA SIGNALING PATHWAY RT-PCR; no "Such bindings led to an increased TPM4 interaction with ACTG, resulting in the inhibition of actin polymerization and the following fibrosis." 33279723 "YAP Circular RNA, circYap, Attenuates Cardiac Fibrosis via Binding with Tropomyosin-4 and Gamma-Actin Decreasing Actin Polymerization" 2021 heart cardiac_senescence homo_sapiens circ-Foxo3 NA NA circRNA up-regulation Foxo3 NA qRT-PCR no We also found that silencing circ-Foxo3 inhibited senescence of mouse embryonic fibroblasts and that ectopic expression of circ-Foxo3 induced senescence. 26873092 Foxo3 circular RNA promotes cardiac senescence by modulating multiple factors associated with stress and senescence responses 2017 intestine colorectal_neoplasms homo_sapiens circ0817 NA NA circRNA down-regulation NA NA qRT-PCR; RNA-seq NA We are the first to report a global reduction of circular RNA abundance in colorectal cancer cell lines and cancer compared to normal tissues and discovered a negative correlation of global circular RNA abundance and proliferation. 25624062 "Correlation of circular RNA abundance with proliferation-exemplified with colorectal and ovarian cancer, idiopathic lung fibrosis, and normal human tissues" 2015 intestine colorectal_neoplasms homo_sapiens circ3204 NA NA circRNA down-regulation NA NA qRT-PCR; RNA-seq NA We are the first to report a global reduction of circular RNA abundance in colorectal cancer cell lines and cancer compared to normal tissues and discovered a negative correlation of global circular RNA abundance and proliferation. 25624062 "Correlation of circular RNA abundance with proliferation-exemplified with colorectal and ovarian cancer, idiopathic lung fibrosis, and normal human tissues" 2015 intestine colorectal_neoplasms homo_sapiens circ6229 NA NA circRNA down-regulation NA NA qRT-PCR; RNA-seq NA We are the first to report a global reduction of circular RNA abundance in colorectal cancer cell lines and cancer compared to normal tissues and discovered a negative correlation of global circular RNA abundance and proliferation. 25624062 "Correlation of circular RNA abundance with proliferation-exemplified with colorectal and ovarian cancer, idiopathic lung fibrosis, and normal human tissues" 2015 intestine colorectal_neoplasms homo_sapiens circ7374 NA NA circRNA up-regulation NA NA qRT-PCR; RNA-seq NA We are the first to report a global reduction of circular RNA abundance in colorectal cancer cell lines and cancer compared to normal tissues and discovered a negative correlation of global circular RNA abundance and proliferation. 25624062 "Correlation of circular RNA abundance with proliferation-exemplified with colorectal and ovarian cancer, idiopathic lung fibrosis, and normal human tissues" 2015 intestine colorectal_neoplasms homo_sapiens circ7780 NA NA circRNA down-regulation NA NA qRT-PCR; RNA-seq NA We are the first to report a global reduction of circular RNA abundance in colorectal cancer cell lines and cancer compared to normal tissues and discovered a negative correlation of global circular RNA abundance and proliferation. 25624062 "Correlation of circular RNA abundance with proliferation-exemplified with colorectal and ovarian cancer, idiopathic lung fibrosis, and normal human tissues" 2015 kidney diabetic_nephropathy homo_sapiens circ_0000064 circ_0000064 circBase circRNA up-regulation NA NA NA no Circ_0000064 play a role in diabetic nephropathy via targeting miR-143. 32683074 Circular RNA Circ_0000064 promotes the proliferation and fibrosis of mesangial cells via miR-143 in diabetic nephropathy 2020 kidney diabetic_nephropathy homo_sapiens circ-WBSCR17 NA NA circRNA up-regulation SOX6 NA qRT-PCR; enzyme-linked immunosorbent assay etc. no Circ_WBSCR17 aggravates inflammatory responses and fibrosis by targeting miR-185-5p/SOX6 regulatory axis in high glucose-induced human kidney tubular cells. 32798559 Circ_WBSCR17 aggravates inflammatory responses and fibrosis by targeting miR-185-5p/SOX6 regulatory axis in high glucose-induced human kidney tubular cells 2020 kidney diabetic_nephropathy homo_sapiens CIRCACTR2 NA NA circRNA up-regulation NA NA microarray analysis no "Circactr2 regulates high glucose-induced pyroptosis, inflammation and fibrosis in proximal tubular cells." 32115515 CircACTR2: A Novel Mechanism Regulating High Glucose-Induced Fibrosis in Renal Tubular Cells via Pyroptosis 2020 kidney glomerulosclerosis_focal_segmental homo_sapiens znf609 circ_0000615 circBase circRNA up-regulation COL1 TGF-BETA SIGNALING PATHWAY qPCR; immunohistochemistry no Circznf609 expression increased in glomeruli and tubules of fsgs patient renal biopsies. 32800553 CircZNF609 is involved in the pathogenesis of focal segmental glomerulosclerosis by sponging miR-615-5p 2020 kidney lupus_nephritis homo_sapiens circ_0123190 circ_0123190 circBase circRNA down-regulation APLNR NA qRT-PCR; dual-luciferase reporter assay; Masson's trichrome staining etc. no Hsa_circ_0123190 may function as a cerna to regulate aplnr expression by sponging hsa-miR-483-3p in lupus nephritis. 33436040 Hsa_circ_0123190 acts as a competitive endogenous RNA to regulate APLNR expression by sponging hsa-miR-483-3p in lupus nephritis 2021 liver liver_cirrhosis homo_sapiens FASN circ_0046367 circBase circRNA dysregulation NA NA bioinformatic analysis; RT-PCR; etc. no "Circrna_0046367, therefore, is suggested to be potential approach to the therapy of lipid peroxidative damage." 29018509 CircRNA_0046367 Prevents Hepatoxicity of Lipid Peroxidation: An Inhibitory Role against Hepatic Steatosis 2017 liver liver_cirrhosis homo_sapiens MTO1 circ_0007874 circBase circRNA down-regulation cMTO1 NA q-PCR; dual-lucimmunofluorescenceerase reporter assay etc. yes "Cmto1 inhibits hsc activation, at least in part, through mir-181b-5p-mediated pten expression. Our results also suggest that cmto1 may be a novel therapeutic target in liver fibrosis." 32850833 Circular RNA cMTO1 Promotes PTEN Expression Through Sponging miR-181b-5p in Liver Fibrosis 2020 liver liver_cirrhosis homo_sapiens PDXK circ_0061893 circBase circRNA down-regulation NA NA qRT-PCR; bioinformatic analysis NA "Compared with the normal HSC, 179 circRNAs were found to be up-regulated and 630 circRNAs were down-regulated in irradiated HSC (fold change >=2.0 and P<0.05). Six dysregulated circRNAs selected randomly were successfully verified by qRT-PCR. Bioinformatic analyses indicated that dysregulated circRNA might be involved in the cell response to irradiation and biological processes of hepatic fibrosis. Furthermore, inhibition of hsa_circ_0071410 increased the expression of miR-9-5p, resulting in the attenuation of irradiation induced HSC activation." 28774651 Microarray profiling of circular RNAs and the potential regulatory role of hsa_circ_0071410 in the activated human hepatic stellate cell induced by irradiation 2017 liver liver_cirrhosis homo_sapiens PALLD circ_0071410 circBase circRNA up-regulation NA NA qRT-PCR; bioinformatic analysis NA "Compared with the normal HSC, 179 circRNAs were found to be up-regulated and 630 circRNAs were down-regulated in irradiated HSC (fold change >=2.0 and P<0.05). Six dysregulated circRNAs selected randomly were successfully verified by qRT-PCR. Bioinformatic analyses indicated that dysregulated circRNA might be involved in the cell response to irradiation and biological processes of hepatic fibrosis. Furthermore, inhibition of hsa_circ_0071410 increased the expression of miR-9-5p, resulting in the attenuation of irradiation induced HSC activation." 28774651 Microarray profiling of circular RNAs and the potential regulatory role of hsa_circ_0071410 in the activated human hepatic stellate cell induced by irradiation 2017 liver liver_cirrhosis homo_sapiens CCNB1 circ_0072765 circBase circRNA up-regulation NA NA qRT-PCR; bioinformatic analysis NA "Compared with the normal HSC, 179 circRNAs were found to be up-regulated and 630 circRNAs were down-regulated in irradiated HSC (fold change >=2.0 and P<0.05). Six dysregulated circRNAs selected randomly were successfully verified by qRT-PCR. Bioinformatic analyses indicated that dysregulated circRNA might be involved in the cell response to irradiation and biological processes of hepatic fibrosis. Furthermore, inhibition of hsa_circ_0071410 increased the expression of miR-9-5p, resulting in the attenuation of irradiation induced HSC activation." 28774651 Microarray profiling of circular RNAs and the potential regulatory role of hsa_circ_0071410 in the activated human hepatic stellate cell induced by irradiation 2017 liver liver_cirrhosis homo_sapiens DPYD circ_0013255 circBase circRNA down-regulation NA NA qRT-PCR; microarray NA "Furthermore, inhibition of hsa_circ_0071410 increased the expression of miR-9-5p, resulting in the attenuation of irradiation induced HSC activation." 28774651 Microarray profiling of circular RNAs and the potential regulatory role of hsa_circ_0071410 in the activated human hepatic stellate cell induced by irradiation 2017 liver liver_cirrhosis homo_sapiens LRPPRC circ_0054345 circBase circRNA up-regulation NA NA qRT-PCR; microarray NA "Furthermore, inhibition of hsa_circ_0071410 increased the expression of miR-9-5p, resulting in the attenuation of irradiation induced HSC activation." 28774651 Microarray profiling of circular RNAs and the potential regulatory role of hsa_circ_0071410 in the activated human hepatic stellate cell induced by irradiation 2017 liver liver_cirrhosis homo_sapiens SCLT1 circ_0070963 circBase circRNA down-regulation NA NA qRT-PCR; microarray NA "Furthermore, inhibition of hsa_circ_0071410 increased the expression of miR-9-5p, resulting in the attenuation of irradiation induced HSC activation." 28774651 Microarray profiling of circular RNAs and the potential regulatory role of hsa_circ_0071410 in the activated human hepatic stellate cell induced by irradiation 2017 liver liver_cirrhosis homo_sapiens PALLD circ_0071406 circBase circRNA dysregulation NA NA qRT-PCR; microarray NA "Furthermore, inhibition of hsa_circ_0071410 increased the expression of miR-9-5p, resulting in the attenuation of irradiation induced HSC activation." 28774651 Microarray profiling of circular RNAs and the potential regulatory role of hsa_circ_0071410 in the activated human hepatic stellate cell induced by irradiation 2017 liver liver_cirrhosis homo_sapiens IFT80 circ_0067835 circBase circRNA dysregulation CIRCRNA-0067835 CIRCRNA-0067835; MIR-155; FOXO3 qRT-PCR; dual-lucimmunofluorescenceerase reporter assay; etc. yes "Our experiments showed that circrna-0067835 regulated liver fibrosis progression by acting as a sponge of mir-155 to promote foxo3a expression, indicating that circrna-0067835 may serve as a potential therapeutic target for patients with liver fibrosis." 30481761 Thymosin-beta4 Mediates Hepatic Stellate Cell Activation by Interfering with CircRNA-0067835/miR-155/FoxO3 Signaling Pathway 2018 lung chronic_thromboembolic_pulmonary_hypertension homo_sapiens circ_0022342 circ_0022342 circBase circRNA down-regulation NA hsa_circ_0022342-hsa-miR-940-CRKL-ErbB signaling pathway Screening of differentially expressed circRNAs; Construction of the circRNA-miRNA-mRNA network; miRNA prediction of differentially expressed circRNAs etc. no "Combined with the results of our present study showing that hsa_circ_002234 regulated hsa-miR-940, we suggested that circRNAs play potential roles in CTEPH via the hsa_circ_0022342-hsa-miR-940-CRKL-ErbB signaling pathway." 28682884 Microarray expression profile of circular RNAs in chronic thromboembolic pulmonary hypertension 2017 lung chronic_thromboembolic_pulmonary_hypertension homo_sapiens circ_0002062 circ_0002062 circBase circRNA down-regulation NA hsa_circ_0002062-hsa-miR-942-5p-CDK6 signaling pathway Screening of differentially expressed circRNAs; Construction of the circRNA-miRNA-mRNA network; miRNA prediction of differentially expressed circRNAs etc. no "Combining these findings with the results of our present study showing that hsa_circ_0002062 regulated hsa-miR-942-5p, we suggested that circRNAs function in CTEPH via hsa_circ_0002062-hsa-miR-942-5p-CDK6-pathways involved in cancer." 28682884 Microarray expression profile of circular RNAs in chronic thromboembolic pulmonary hypertension 2017 heart cardiomegaly homo_sapiens CIRCYAP NA NA circRNA down-regulation ACTG TGF-BETA SIGNALING PATHWAY RT-PCR no "Such bindings led to an increased TPM4 interaction with ACTG, resulting in the inhibition of actin polymerization and the following fibrosis." 33279723 "YAP Circular RNA, circYap, Attenuates Cardiac Fibrosis via Binding with Tropomyosin-4 and Gamma-Actin Decreasing Actin Polymerization" 2021 kidney lupus_nephritis homo_sapiens circ-0123190 NA NA circRNA down-regulation APLNR NA qRT-PCR; dual-luciferase reporter assay; Masson's trichrome staining etc. no Hsa_circ_0123190 may function as a cerna to regulate aplnr expression by sponging hsa-miR-483-3p in lupus nephritis. 33436040 Hsa_circ_0123190 acts as a competitive endogenous RNA to regulate APLNR expression by sponging hsa-miR-483-3p in lupus nephritis 2021 intestine colorectal_neoplasms homo_sapiens CDR1as circ-0001946 circBase circRNA dysregulation NA NA NA NA "In this study, we summarize in detail the latest research findings and demonstrate the function and regulatory mechanism of CDR1as in various cancer processes, and its potential as a biomarker for cancer prevention and prognosis." 33665157 The Prognostic and Predictive Significance of circRNA CDR1as in Tumor Progression 2021 liver liver_cirrhosis homo_sapiens RPH3AL circ-0041150 circBase circRNA down-regulation NA NA qRT-PCR etc. no This study therefore identified circRNAs as potential prognostic markers for patients who undergo curative surgery for HCC and highlighted hsa_circ_0036683 as the most useful biomarker. 33727578 Genome-wide identification and characterization of circular RNA in resected hepatocellular carcinoma and background liver tissue 2021 liver liver_cirrhosis homo_sapiens circ-0025624 circ-0025624 circBase circRNA down-regulation NA NA qRT-PCR etc. no This study therefore identified circRNAs as potential prognostic markers for patients who undergo curative surgery for HCC and highlighted hsa_circ_0036683 as the most useful biomarker. 33727578 Genome-wide identification and characterization of circular RNA in resected hepatocellular carcinoma and background liver tissue 2021 liver liver_cirrhosis homo_sapiens circ-0001020 circ-0001020 circBase circRNA down-regulation NA NA qRT-PCR etc. no This study therefore identified circRNAs as potential prognostic markers for patients who undergo curative surgery for HCC and highlighted hsa_circ_0036683 as the most useful biomarker. 33727578 Genome-wide identification and characterization of circular RNA in resected hepatocellular carcinoma and background liver tissue 2021 liver liver_cirrhosis homo_sapiens circ-0028129 circ-0028129 circBase circRNA down-regulation NA NA qRT-PCR etc. no This study therefore identified circRNAs as potential prognostic markers for patients who undergo curative surgery for HCC and highlighted hsa_circ_0036683 as the most useful biomarker. 33727578 Genome-wide identification and characterization of circular RNA in resected hepatocellular carcinoma and background liver tissue 2021 liver liver_cirrhosis homo_sapiens circ-0008558 circ-0008558 circBase circRNA down-regulation NA NA qRT-PCR etc. no This study therefore identified circRNAs as potential prognostic markers for patients who undergo curative surgery for HCC and highlighted hsa_circ_0036683 as the most useful biomarker. 33727578 Genome-wide identification and characterization of circular RNA in resected hepatocellular carcinoma and background liver tissue 2021 liver liver_cirrhosis homo_sapiens circ-0036683 circ-0036683 circBase circRNA down-regulation NA NA qRT-PCR etc. no This study therefore identified circRNAs as potential prognostic markers for patients who undergo curative surgery for HCC and highlighted hsa_circ_0036683 as the most useful biomarker. 33727578 Genome-wide identification and characterization of circular RNA in resected hepatocellular carcinoma and background liver tissue 2021 liver liver_cirrhosis homo_sapiens circ-0058087 circ-0058087 circBase circRNA down-regulation NA NA qRT-PCR etc. no This study therefore identified circRNAs as potential prognostic markers for patients who undergo curative surgery for HCC and highlighted hsa_circ_0036683 as the most useful biomarker. 33727578 Genome-wide identification and characterization of circular RNA in resected hepatocellular carcinoma and background liver tissue 2021 lung pulmonary_fibrosis mus_musculus Hipk3 circ_0001052 circBase circRNA up-regulation miR-30a-3p NA qRT-PCR; Immunofluorescence; Dual-lucimmunofluorescenceerase Reporter Assay etc. no "Next, we detected circHIPK3 and miR-30a-3p expression levels in this model and observed circHIPK3 was up-regulated, while miR-30a-3p was markedly down-regulated in a time-dependent manner. Besides, the lactate levels and the protein expression of Foxk2 and glycolytic enzymes (HK2, PFKM, PKM2, and PDK1) were also upregulated after silica exposure." 34239356 CircHIPK3 regulates pulmonary fibrosis by facilitating glycolysis in miR-30a-3p/FOXK2-dependent manner 2021 lung pulmonary_fibrosis mus_musculus Mllt10 circ_0000981 circBase circRNA up-regulation miR-211-5p NA qRT-PCR; Western Blot; Immunohistochemistry etc. yes The results showed that circRNA-0000981 expression was increased in the TGF-beta1-treated group. 33855682 Atractylon Treatment Attenuates Pulmonary Fibrosis via Regulation of the mmu_circ_0000981/miR-211-5p/TGFBR2 Axis in an Ovalbumin-Induced Asthma Mouse Model 2021 heart acute_myocardial_infarction mus_musculus CircUbe3a NA NA circRNA up-regulation miR-138-5p;RhoC NA qRT-PCR;RNA immunoprecipitation (RIP);dual-luciferase reporter assays no "M2M-derived circUbe3a-containing small extracellular vesicles promote the proliferation, migration, and phenotypic transformation of cardiac fibroblasts by directly targeting the miR-138-5p/RhoC axis." 33995660 CircUbe3a from M2 macrophage-derived small extracellular vesicles mediates myocardial fibrosis after acute myocardial infarction 2021 heart heart_failure mus_musculus circSnx12 NA NA circRNA dysregulation miR-224-5p NA qRT-PCR;western blot;luciferase reporter assay etc. no "CircSnx12 could act as an endogenous sponge to bind with miR-224-5p, and the 3'UTR region of FTH1 also had miRNA binding sites." 33969020 circSnx12 Is Involved in Ferroptosis During Heart Failure by Targeting miR-224-5p 2021 heart atrial_fibrillation mus_musculus circ_0005019 NA NA circRNA down-regulation miR-499-5p NA dual-luciferase reporter assays;RIP no Mmu_circ_0005019 exerted biological functions by acting as a miR-499-5p sponge to regulate the expression of its target gene Kcnn3. 34154526 Circular RNA mmu_circ_0005019 inhibits fibrosis of cardiac fibroblasts and reverses electrical remodeling of cardiomyocytes 2021 heart acute_myocardial_infarction mus_musculus circCELF1 NA NA circRNA down-regulation NA NA RT-qRT-PCR;flow cytometry;western blot etc. no CircCELF1 inhibits myocardial fibrosis by regulating the expression of DKK2 Through FTO/m 6 A and miR-636. 35132536 circCELF1 Inhibits Myocardial Fibrosis by Regulating the Expression of DKK2 Through FTO/m 6 A and miR-636 2022 kidney renal_fibrosis mus_musculus circRNA_30032 NA NA circRNA down-regulation NA NA qRT-PCR;western blot;luciferase reporter assay etc. no "CircRNA_30032 mediated TGF-BETA1-induced and unilateral ureteral obstruction-induced renal fibrosis by sponging miR-96-5p and increasing the expression of profibrotic proteins, including HBEGF, KRAS, collagen I, collagen III and fibronectin." 33973871 CircRNA_30032 promotes renal fibrosis in unilateral ureteral obstruction model mice via miRNA-96-5p/HBEGF/KRAS axis 2021 kidney diabetic_nephropathy mus_musculus circ-RBM4 NA NA circRNA down-regulation NA NA ELISA assay;dual-luciferase reporter;cell counting kit-8 etc. no Circ-RBM4 alleviated the renal inflammation and renal fibrosis in diabetic nephropathy by targeting the miR-153-3p/NFIC axis. 34197715 Overexpression of mm9_circ_013935 alleviates renal inflammation and fibrosis in diabetic nephropathy via the miR-153-3p/NFIC axis 2021 kidney diabetic_nephropathy mus_musculus circ-ITCH NA NA circRNA down-regulation NA NA RT-qRT-PCR;western blot;luciferase reporter assay etc. no Circ-ITCH alleviated renal inflammation and fibrosis in STZ-induced diabetic mice by regulating the miR-33a-5p/SIRT6 axis. 34216220 CircRNA circ-ITCH improves renal inflammation and fibrosis in streptozotocin-induced diabetic mice by regulating the miR-33a-5p/SIRT6 axis 2021 kidney diabetic_nephropathy mus_musculus Circ_0000712 NA NA circRNA up-regulation SOX6 NA ELISA;RT-qRT-PCR;luciferase assay etc. no Circ_0000712 knockdown could hinder high glucose-inducted SV40-MES13 cell injury through targeting the miR-879-5p/SOX6 axis. 33980772 "Circular RNA circ_0000712 regulates high glucose-induced apoptosis, inflammation, oxidative stress, and fibrosis in (DN) by targeting the miR-879-5p/SOX6 axis" 2021 kidney renal_fibrosis mus_musculus circRNA_37492 NA NA circRNA up-regulation NA NA GO;KEGG no CircRNA_37492 attenuated renal fibrosis via targeting miR-7682-3p/Fgb axis. 35246505 The mmu_circRNA_37492/hsa_circ_0012138 function as potential ceRNA to attenuate obstructive renal fibrosis 2022 kidney renal_fibrosis homo_sapiens circRNA_0012138 NA NA circRNA up-regulation NA NA GO;KEGG no Hsa_circRNA_0012138 was speculated as a possible ceRNA to regulate multiple gene expressions and involve in human renal fibrosis. 35246505 The mmu_circRNA_37492/hsa_circ_0012138 function as potential ceRNA to attenuate obstructive renal fibrosis 2022 kidney kidney_injury homo_sapiens circ_0045861 NA NA circRNA up-regulation NA NA western blot;bioinformatics analysis;luciferase reporter assays etc. no Circ_0045861 may be a novel candidate circRNA in the pathogenesis of ureteropelvic junction obstruction (UPJO) by acting as a pro-apoptotic factor via the miR-181d-5p/SIRT1 axis. 34790777 Hsa_circRNA_0045861 promotes renal injury in ureteropelvic junction obstruction via the microRNA-181d-5p/sirtuin 1 signaling axis 2021 kidney chronic_kidney_disease homo_sapiens circHIPK3 NA NA circRNA up-regulation NA NA qRT-PCR;immunoblotting;immunofluorescence staining no CircHIPK3 may contribute to progressive renal fibrosis by sponging miR-30a. 35058790 circHIPK3 Exacerbates Folic Acid-Induced Renal Tubulointerstitial Fibrosis by Sponging miR-30a 2022 kidney chronic_kidney_disease mus_musculus circHIPK3 NA NA circRNA up-regulation NA NA qRT-PCR;immunoblotting;immunofluorescence staining no CircHIPK3 may contribute to progressive renal fibrosis by sponging miR-30a. 35058790 circHIPK3 Exacerbates Folic Acid-Induced Renal Tubulointerstitial Fibrosis by Sponging miR-30a 2022 kidney diabetic_nephropathy mus_musculus circEIF4G2 NA NA circRNA up-regulation NA NA NA no CircEIF4G2 promotes renal tubular epithelial cell fibrosis via the miR-218/SERBP1 pathway 33615661 Circular RNA circEIF4G2 aggravates renal fibrosis in diabetic nephropathy by sponging miR-218 2022 kidney diabetic_nephropathy homo_sapiens circ_0125310 NA NA circRNA up-regulation NA NA the dual-luciferase assay no High glucose-induced exo-circ_0125310 promoted cell proliferation and fibrosis in diabetic nephropathy via sponging miR-422a and targeting the IGF1R/p38 axis. 34854210 Exosomal hsa_circ_0125310 promotes cell proliferation and fibrosis in diabetic nephropathy via sponging miR-422a and targeting the IGF1R/p38 axis 2022 kidney diabetic_nephropathy homo_sapiens circTAOK1 NA NA circRNA up-regulation NA NA qRT-PCR;western blot;dual-luciferase reporter etc. no "GEC-circTAOK1-Exo could boost proliferation, fibrosis, and epithelial-mesenchymal transition (EMT) of glomerular mesangial cells (GMCs) through targeting the miR-520h/SMAD3 axis, providing new insights into the pathogenesis of diabetic nephropathy." 35142978 Exosomal circTAOK1 contributes to diabetic kidney disease progression through regulating SMAD3 expression by sponging miR-520h 2022 kidney diabetic_nephropathy homo_sapiens circ_0037128 NA NA circRNA up-regulation NA NA qRT-PCR;CCK-8 assays;western blot etc. no Circ_0037128 downregulation could mitigate HG-stimulated cell damage via regulating the miR-497-5p/NFAT5 axis in HK-2 cells in vitro. 34753398 Circular RNA_0037128 aggravates high glucose-induced damage in HK-2 cells via regulation of microRNA-497-5p/nuclear factor of activated T cells 5 axis 2021