Tissue Disease Species symbol ID Platform Type Expression Target Pathway Method Drug Function PMID Title Year brain neurofibromatosis homo_sapiens CDKN2B-AS1 100048912 Gene lncrna dysregulation NA NA NA NA Genetic variation in lncRNA genes causes disease and influences susceptibility 23791884 Long non-coding RNAs: a new frontier in the study of human diseases https://pubmed.ncbi.nlm.nih.gov/23791884/ 2013 brain stroke homo_sapiens CDKN2B-AS1 100048912 Gene lncrna dysregulation NA NA NA NA "Moreover, genome-wide association studies have demonstrated that the 9p21 genomic locus is a hotspot for the risk of stroke, glioma, plexiform neurofibroma and other disorders" 22814587 "Emerging roles of non-coding RNAs in brain evolution, development, plasticity and disease" https://pubmed.ncbi.nlm.nih.gov/22814587/ 2012 brain glioma homo_sapiens CDKN2B-AS1 100048912 Gene lncrna dysregulation NA NA NA NA "Moreover, genome-wide association studies have demonstrated that the 9p21 genomic locus is a hotspot for the risk of stroke, glioma, plexiform neurofibroma and other disorders" 22814587 "Emerging roles of non-coding RNAs in brain evolution, development, plasticity and disease" https://pubmed.ncbi.nlm.nih.gov/22814587/ 2012 brain neurofibromatosis homo_sapiens CDKN2B-AS1 100048912 Gene lncrna dysregulation NA NA NA NA "Moreover, genome-wide association studies have demonstrated that the 9p21 genomic locus is a hotspot for the risk of stroke, glioma, plexiform neurofibroma and other disorders" 22814587 "Emerging roles of non-coding RNAs in brain evolution, development, plasticity and disease" https://pubmed.ncbi.nlm.nih.gov/22814587/ 2012 brain neurofibromatosis homo_sapiens CDKN2B-AS1 100048912 Gene lncrna up-regulation NA NA q-PCR; microarray NA "Single-nucleotide polymorphism rs2151280 (located in ANRIL) was statistically significantly associated with the number of PNFs in NF1 patients. In addition,allele T of rs2151280 was statistically significantly associated with reduced ANRIL transcript levels,suggesting that modulation of ANRIL expression mediates PNF susceptibility." 22034633 Role of noncoding RNA ANRIL in genesis of plexiform neurofibromas in neurofibromatosis type 1 https://pubmed.ncbi.nlm.nih.gov/22034633/ 2011 cell_line diabetes_mellitus homo_sapiens HYMAI ENSG00000283122 Ensembl lncrna dysregulation NA NA qRT-PCR etc. NA "In TNDM fibroblasts, the monoallelic expression of both ZAC and HYMAI is relaxed, providing strong supportive evidence that the presence of two unmethylated alleles of this locus is indeed associated with the inappropriate gene expression of neighbouring genes." 11935319 Relaxation of imprinted expression of ZAC and HYMAI in a patient with transient neonatal diabetes mellitus https://pubmed.ncbi.nlm.nih.gov/11935319/ 2002 cell_line fibrosarcoma homo_sapiens MALAT1 ENSG00000251562 Ensembl lncrna expression NA NA northern blot analysis; q-PCR NA "We first examined the decay of MALAT-1 in various cancer cells (H1299,H1975,A549,HT1080,and HeLa TO cells) by DRB chase experiments using 7SK RNA as a control. Half-lives of MALAT-1 in H1299,H1975,A549,HT1080,and HeLa TO cells were > 12,12,12,12,and 9 h,respectively. MALAT-1 stabilities varied in various cancer cells." 22491206 "Stability of MALAT-1, a nuclear long non-coding RNA in mammalian cells, varies in various cancer cells" https://pubmed.ncbi.nlm.nih.gov/22491206/ 2010 eye diabetes_mellitus homo_sapiens MALAT1 ENSG00000251562 Ensembl lncrna dysregulation NA NA RT-PCR etc. NA "In addition, MALAT1, a conserved lncRNA, was significantly upregulated in an RF/6A cell model of hyperglycemia, in the aqueous humor samples, and in fibrovascular membranes of diabetic patients." 24436191 Aberrant expression of long noncoding RNAs in early diabetic retinopathy https://pubmed.ncbi.nlm.nih.gov/24436191/ 2014 eye glaucoma homo_sapiens GUCY1B2 2974 Gene lncrna dysregulation NR-003923; IL22RA1? NA immunofluorescence; RT-PCR etc. no Nr_003923 and il22ra1 might contribute to glaucoma progression and be a novel and potential biomarkers and therapeutic targets for glaucoma. 31391457 "LncRNA NR_003923 promotes cell proliferation, migration, fibrosis, and autophagy via the miR-760/miR-215-3p/IL22RA1 axis in human Tenon's capsule fibroblasts" https://pubmed.ncbi.nlm.nih.gov/31391457/ 2019 heart myocardial_infarction homo_sapiens CDKN2B-AS1 100048912 Gene lncrna up-regulation NA NA qRT-PCR; no "Anril overexpression caused myocardial fibrosis and myocardial cell apoptosis, and it increased the expression of the myocardial fibrosis-related proteins TGF-beta1,collagen i and collagen iii in the myocardial infarction (MI) mice." 31469688 Expression and function of lncRNA ANRIL in a mouse model of acute myocardial infarction combined with type 2 diabetes mellitus https://pubmed.ncbi.nlm.nih.gov/31469688/ 2019 heart atrial_fibrillation mus_musculus Miat ENSMUSG00000097767 Ensembl lncrna up-regulation MIR-133A-3P NA qPCR no "Atrial fibrillation(AF)-induced myocardial fibrosis, and the functional regulatory pathway of Miat targeting miR-133a-3p." 32130618 LncRNA MIAT/miR-133a-3p axis regulates atrial fibrillation and atrial fibrillation-induced myocardial fibrosis https://pubmed.ncbi.nlm.nih.gov/32130618/ 2020 heart myocardial_infarction mus_musculus Mirt1 ENSMUSG00000097636 Ensembl lncrna down-regulation NA NF-KAPPA B SIGNALING PATHWAY NA no Down-regulation of miRt1 improves myocardial i/r injury in aged diabetic rats by inhibition of activation of NF-KB signaling pathway. 30611788 Down-regulation of myocardial infarction associated transcript 1 improves myocardial ischemia-reperfusion injury in aged diabetic rats by inhibition of activation of NF-KB signaling pathway https://pubmed.ncbi.nlm.nih.gov/30611788/ 2019 heart endomyocardial_fibrosis mus_musculus Gas5 ENSMUSG00000053332 Ensembl lncrna down-regulation PTEN-MMP2 PI3K-AKT SIGNALING PATHWAY PCR; immunofluorescence etc. no Gas5 plays a suppressive role in cardiac fibrosis via negative regulation of miR-21. Gas5 that upregulated or downregulated the expression of PTEN through miR-21 in cardiac fibroblasts. 28526319 LncRNA GAS5 controls cardiac fibroblast activation and fibrosis by targeting miR-21 via PTEN/MMP-2 signaling pathway https://pubmed.ncbi.nlm.nih.gov/28526319/ 2017 heart endomyocardial_fibrosis mus_musculus H19 ENSMUSG00000000031 Ensembl lncrna up-regulation DUSP5 MAPK SIGNALING PATHWAY PCR; Masson's trichrome staining etc. no "H19 endogenous expression is overexpressed in cardiac fibroblast and fibrosis tissues, and an opposite pattern is observed for Dusp5. H19 ectopic overexpression reduces Dusp5 abundance and increases the proliferation of cardiac fibroblast, whereas h19 silencing causes the opposite effects." 27318893 Long noncoding RNA H19 controls DUSP5/ERK1/2 axis in cardiac fibroblast proliferation and fibrosis https://pubmed.ncbi.nlm.nih.gov/21412773/ 2016 heart endomyocardial_fibrosis mus_musculus H19 ENSMUSG00000000031 Ensembl lncrna up-regulation CTGF NA PCR; dual-luciferase reporter assay etc. no "H19 knockdown could enhance the antifibrotic role of miR-455 and attenuate the CTGF expression and further decrease fibrosis-associated protein synthesis (collagen i, iii, and alfa-SMA)." 28753062 Long Noncoding RNA H19 Acts as a Competing Endogenous RNA to Mediate CTGF Expression by Sponging miR-455 in Cardiac Fibrosis https://pubmed.ncbi.nlm.nih.gov/28753062/ 2017 heart heart_failure mus_musculus Kcnq1ot1 ENSMUSG00000101609 Ensembl lncrna down-regulation FUS NA qRT-PCR; no "Kcnq1ot1 ovexpression improved myocardial histopathological changes, reduced myocardial fibrosis areas, down-regulated FUS expression, and inhibited cell apoptosis of heart failure(HF) mice." 32497620 LncRNA KCNQ1OT1 contributes to cardiomyocyte apoptosis by targeting FUS in heart failure https://pubmed.ncbi.nlm.nih.gov/32497620/ 2020 heart diabetic_cardiomyopathy mus_musculus Kcnq1ot1 ENSMUSG00000101609 Ensembl lncrna up-regulation NA NOD-LIKE RECEPTOR SIGNALING PATHWAY dual-luciferase reporter assay no Kcnq1ot1/miR-214-3p/caspase-1/TGF-beta signal pathway presents a new mechanism of diabetes cardiomyopathy (DCM) progression and could potentially be a novel therapeutic target. 30250027 Silencing long non-coding RNA Kcnq1ot1 alleviates pyroptosis and fibrosis in diabetic cardiomyopathy https://pubmed.ncbi.nlm.nih.gov/30250027/ 2018 heart endomyocardial_fibrosis mus_musculus Miat ENSMUSG00000097767 Ensembl lncrna up-regulation MIR-24;FURIN TGF-BETA SIGNALING PATHWAY PCR; dual-luciferase reporter assay etc. no Knockdown of endogenous miat by its sirna reduced cardiac fibrosis and improved cardiac function and restored the deregulated expression of the fibrosis-related regulators. 28198439 MIAT Is a Pro-fibrotic Long Noncoding RNA Governing Cardiac Fibrosis in Post-infarct Myocardium https://pubmed.ncbi.nlm.nih.gov/28198439/ 2016 heart myocardial_infarction homo_sapiens MIR222HG ENSG00000270069? Ensembl lncrna up-regulation NA TGF-BETA SIGNALING PATHWAY microarray data analysis no "Lnc-ang362 promoted cardiac fibrosis after myocardial infarction (MI) via directly suppressing smad7, which may decrease the inhibitory feedback regulation of TGF-beta1/smad signaling pathway." 32240638 Lnc-Ang362 is a pro-fibrotic long non-coding RNA promoting cardiac fibrosis after myocardial infarction by suppressing Smad7 https://pubmed.ncbi.nlm.nih.gov/32240638/ 2020 heart cardiovascular_diseases mus_musculus Gas5 ENSMUSG00000053332 Ensembl lncrna up-regulation MIRI PI3K-AKT SIGNALING PATHWAY dual-luciferase reporter assay no Lncrna gas5 was able to regulate miRNA through the PI3k/Akt apoptosis pathway by sponging miR-532-5p. 31985016 Long non-coding RNA GAS5 regulates myocardial ischemia-reperfusion injury through the PI3K/AKT apoptosis pathway by sponging miR-532-5p https://pubmed.ncbi.nlm.nih.gov/31985016/ 2020 heart myocardial_infarction mus_musculus Malat1 ENSMUSG00000092341 Ensembl lncrna up-regulation MIR-145 TGF-BETA SIGNALING PATHWAY qRT-PCR; Masson's trichrome staining no Lncrna malat1 promotes cardiac fibrosis and deteriorates cardiac function post-myocardial infarction (MI) by regulating TGF-beta activity via miR-145. 30146700 Long noncoding RNA MALAT1 mediates cardiac fibrosis in experimental postinfarct myocardium mice model https://pubmed.ncbi.nlm.nih.gov/30146700/ 2019 heart endomyocardial_fibrosis homo_sapiens LINC-ROR ENSG00000258609 Ensembl lncrna up-regulation NA NA qRT-PCR; no "Lncrna ror up-regulates the expression of c-myc and increases the level of serum IL-6, thereby facilitating the proliferation and differentiation of cardiac fibroblasts." 31858568 LncRNA ROR facilitates myocardial fibrosis in rats with viral myocarditis through regulating C-Myc expression https://pubmed.ncbi.nlm.nih.gov/31858568/ 2019 heart endomyocardial_fibrosis mus_musculus Snhg7 ENSMUSG00000086775 Ensembl lncrna up-regulation MIR-34-5P NA qRT-PCR; dual-luciferase reporter assay etc. no Lncrna snhg7 could promote cardiac fibrosis via targeting miR-34-5p through acting as a ceRNA in mice aftermyocardial infarction (MI). 32507765 LncRNA SNHG7 promotes cardiac remodeling by upregulating ROCK1 via sponging miR-34-5p https://pubmed.ncbi.nlm.nih.gov/32507765/ 2020 heart heart_failure mus_musculus Fendrr ENSMUSG00000097336 Ensembl lncrna up-regulation TAC NA qRT-PCR yes "Loss-function of fendrr significantly alleviated the cardiac fibrosis phenotypes induced by TAC, indicating that fendrr is required for the pathogenesis of cardiac fibrosis." 31982134 Fendrr involves in the pathogenesis of cardiac fibrosis via regulating miR-106b/SMAD3 axis https://pubmed.ncbi.nlm.nih.gov/31982134/ 2020 heart diabetic_cardiomyopathy homo_sapiens RP11-544D21.2 NA NA lncrna up-regulation NA NA qRT-PCR; northern blot analysis; flow cytometery etc. no "Microarray assays in 14 Dilated cardiomyopathy and 10 control human heart samples identified 313 significantly differentially expressed lncRNAs. SiRNAs were used to explore the potential function of specific lncRNAs (RP11-544D21.2 and XLOC_014288) in human cardiac myocytes, human cardiac fibroblasts and human cardiac microvascular endothelial cells, respectively. RNA-seq and pathway analyses revealed the function of lncRNA RP11-544D21.2 and XLOC_014288 in three heart cells. Furthermore, impaired tube formation and migration were observed in si-RP11-544D21.2 treated endothelial cells. Moreover, TAF10 was predicted and verified to be one of the causes of some up-regulated lncRNAs. Then, we found that the left ventricular ejection fraction correlated with these changed lncRNAs." 29365080 Identification of cardiac long non-coding RNA profile in human dilated cardiomyopathy https://pubmed.ncbi.nlm.nih.gov/29365080/ 2018 heart endomyocardial_fibrosis mus_musculus Rmrp ENSMUSG00000115420 Ensembl lncrna up-regulation NA NA dual-luciferase reporter assay no miR-613 was indicated to mediate the promoting effect of RMRP on cardiac fibroblast activation. 31485650 Upregulation of lncRNA RMRP promotes the activation of cardiac fibroblasts by regulating miR-613 https://pubmed.ncbi.nlm.nih.gov/31485650/ 2019 heart diabetic_cardiomyopathy mus_musculus Crnde ENSMUSG00000031736 Ensembl lncrna down-regulation NA TGF-BETA SIGNALING PATHWAY NA no Overexpression of Crnde attenuated cardiac fibrosis and enhanced cardiac function in mice with diabetes cardiomyopathy (DCM). 30748104 Long noncoding RNA Crnde attenuates cardiac fibrosis via Smad3-Crnde negative feedback in diabetic cardiomyopathy https://pubmed.ncbi.nlm.nih.gov/30748104/ 2019 heart endomyocardial_fibrosis mus_musculus Gas5 ENSMUSG00000053332 Ensembl lncrna down-regulation NA PI3K-AKT SIGNALING PATHWAY RT-PCR; no "Overexpression of gas5 after injection with PCDNA-gas5 could attenuate cardiac fibrosis and improve cardiac function through increasing the expression of PTEN and decreasing the expression of MMP-2, alfa-SMA, and collagen i." 31173316 Overexpression of lncRNA GAS5 attenuates cardiac fibrosis through regulating PTEN/MMP-2 signal pathway in mice https://pubmed.ncbi.nlm.nih.gov/31173316/ 2019 heart endomyocardial_fibrosis mus_musculus Gas5 ENSMUSG00000053332 Ensembl lncrna up-regulation HMGB1 NF-KAPPA B SIGNALING PATHWAY qRT-PCR; cell counting kit-8 analysis etc. yes Palmitic acid (PA) can induce gas5 expression and that the downregulation of gas5 alleviated pa-induced myocardial inflammatory injury through the miR-26a/HMGB1/NF-KB axis. 30365114 Downregulation of growth arrest-specific transcript 5 alleviates palmitic acid-induced myocardial inflammatory injury through the miR-26a/HMGB1/NF-KB axis https://pubmed.ncbi.nlm.nih.gov/30365114/ 2018 heart myocarditis homo_sapiens LINC00654 149837 Gene lncrna up-regulation SOX5 NA qPCR yes Pentoxifylline (PTX) has the potential to alleviate cardiac injury and increase the number of c-kit + cells following ischemia-reperfusion in the rat model via modulation of lncrna-00654 and miR-133a-sox5 mrna expressions. 31972363 Pentoxifylline alleviated cardiac injury via modulating the cardiac expression of lncRNA-00654-miR-133a-SOX5 mRNA in the rat model of ischemia-reperfusion https://pubmed.ncbi.nlm.nih.gov/31972363/ 2020 heart endomyocardial_fibrosis mus_musculus Rassf1 ENSMUSG00000010067 Ensembl lncrna up-regulation NA NA dual-luciferase reporter assay no Rassf1-as1 inhibits the translation of rassf1a to exacerbate cardiac fibrosis in mice. 30571844 "RASSF1-AS1, an antisense lncRNA of RASSF1A, inhibits the translation of RASSF1A to exacerbate cardiac fibrosis in mice" https://pubmed.ncbi.nlm.nih.gov/30571844/ 2019 heart endomyocardial_fibrosis mus_musculus Sail NA NA lncrna down-regulation NA TGF-BETA SIGNALING PATHWAY NA no "SAIL inhibited the fibrotic process by directly binding with SAFB via 23 conserved nucleotide sequences, in turn blocked the access of SAFB to RNA pol II (RNA polymerase II) and reduced the transcription of fibrosis-related genes. Intriguingly,the human conserved fragment of SAIL (hSAIL) significantly suppressed the proliferation and collagen production of human cardiac fibroblasts." 33675440 SAIL: a new conserved anti-fibrotic lncRNA in the heart https://pubmed.ncbi.nlm.nih.gov/33675440/ 2021 heart heart_failure mus_musculus Sox2ot ENSMUSG00000105265 Ensembl lncrna up-regulation NA TGF-BETA SIGNALING PATHWAY qRT-PCR; dual-luciferase reporter assay etc. no Sox2ot/smad3 feedback loop promotes cardiac fibrosis in heart failure(HF). 32959533 LncRNA SOX2OT/Smad3 feedback loop promotes myocardial fibrosis in heart failure https://pubmed.ncbi.nlm.nih.gov/32959533/ 2020 heart endomyocardial_fibrosis mus_musculus AK081284 NA NA lncrna up-regulation NA NA RT-PCR no "The levels of long noncoding RNA-AK081284 were increased in the cardiac fibroblasts (CFs) treated with high glucose or interleukin-17(IL-17). Knockout of IL-17 abrogated high glucose induced upregulation of AK081284. Overexpression of AK081284 in cultured CFs promoted the production of collagen and TGF-beta1. Both high glucose and IL-17 induced collagen and TGF-beta1 production were mitigated by the application of the siRNA for AK081284. In summary, deletion of IL-17 is able to mitigate myocardial fibrosis and improve cardiac function of diabetic mice. The IL-17/AK081284/TGFbeta1 signaling pathway mediates high glucose induced collagen production." 29305939 Ablation of interleukin-17 alleviated cardiac interstitial fibrosis and improved cardiac function via inhibiting long non-coding RNA-AK081284 in diabetic mice https://pubmed.ncbi.nlm.nih.gov/29305939/ 2018 heart myocardial_infarction mus_musculus H19 ENSMUSG00000000031 Ensembl lncrna down-regulation KDM3A NA dual-luciferase reporter assays;qRT-PCR; etc. no NA 31755219 LncRNA H19 ameliorates myocardial infarction-induced myocardial injury and maladaptive cardiac remodelling by regulating KDM3A https://pubmed.ncbi.nlm.nih.gov/31755219/ 2020 heart endomyocardial_fibrosis mus_musculus Miat ENSMUSG00000097767 Ensembl lncrna up-regulation MIR-29 NA dual-luciferase reporter assay no NA 32795172 Mechanism underlying increased cardiac extracellular matrix deposition in perinatal nicotine-exposed offspring https://pubmed.ncbi.nlm.nih.gov/32795172/ 2020 heart ventricular_dysfunction mus_musculus Miat ENSMUSG00000097767 Ensembl lncrna up-regulation MIR-29 NA dual-luciferase reporter assay no NA 32795172 Mechanism underlying increased cardiac extracellular matrix deposition in perinatal nicotine-exposed offspring https://pubmed.ncbi.nlm.nih.gov/32795172/ 2020 intestine colorectal_neoplasms mus_musculus Trp53cor1 100504267 Gene lncrna dysregulation NA NA qRT-PCR etc. NA "One of them, lincRNA-p21, was regulated by p53 and contributed to apoptosis in mouse embryonic fibroblasts." 24012455 Clinical significance of long intergenic noncoding RNA-p21 in colorectal cancer https://pubmed.ncbi.nlm.nih.gov/24012455/ 2013 kidney diabetic_nephropathy mus_musculus Cyp4b1-ps1 ENSMUSG00000081006 Ensembl lncrna down-regulation NA NA Microarray no A novel long non-coding RNA CYP4B1 PS1-001 regulates proliferation and fibrosis in diabetic nephropathy. 26923441 A novel long non-coding RNA CYP4B1-PS1-001 regulates proliferation and fibrosis in diabetic nephropathy https://pubmed.ncbi.nlm.nih.gov/26923441/ 2016 kidney kidney_failure_chronic mus_musculus Gas5 ENSMUSG00000053332 Ensembl lncrna down-regulation NA NA qRT-PCR; no Activation of lncrna-gas5 attenuates kidney fibrosis by modulating miR-21 activity. 32791063 Long noncoding RNA-GAS5 retards renal fibrosis through repressing miR-21 activity https://pubmed.ncbi.nlm.nih.gov/32791063/ 2020 kidney diabetic_nephropathy homo_sapiens CASC2 ENSG00000177640 Ensembl lncrna down-regulation SOCS2 JAK-STAT SIGNALING PATHWAY qPCR; dual-luciferase reporter assay no "Casc2 could alleviate the degree and process of apoptosis, inflammation, and fibrosis in diabetic nephropathic models by regulating the miR-144/socs2 axis." 33227790 LncRNA CASC2 Alleviates the Progression of Diabetic Nephropathy by Regulating the miR-144/SOCS2 Signalling Axis https://pubmed.ncbi.nlm.nih.gov/33227790/ 2020 kidney kidney_diseases homo_sapiens CHCHD4P4 ENSG00000213964 Ensembl lncrna down-regulation NA NA NA no Chchd4p4 inhibited cell proliferation and promoted the epithelial-mesenchymal transition in kidney damage and fibrosis caused by calcium oxalate crystallization and deposition. 29160413 Long non-coding RNA CHCHD4P4 promotes epithelial-mesenchymal transition and inhibits cell proliferation in calcium oxalate-induced kidney damage https://pubmed.ncbi.nlm.nih.gov/29160413/ 2017 kidney diabetic_nephropathy mus_musculus Neat1 ENSMUSG00000092274 Ensembl lncrna up-regulation NA PI3K-AKT SIGNALING PATHWAY cell counting kit-8 analysis; MTT ASSAY no Decrease of neat1 repressed the proliferation and fibrosis in diabetic nephropathies via activating the Akt/mTOR signaling pathway. 30515796 Long noncoding RNA NEAT1 accelerates the proliferation and fibrosis in diabetic nephropathy through activating Akt/mTOR signaling pathway https://pubmed.ncbi.nlm.nih.gov/30515796/ 2019 kidney kidney_failure_chronic homo_sapiens LINC00667 ENSG00000263753 Ensembl lncrna up-regulation CTGF APELIN SIGNALING PATHWAY immunofluorescence no Decreased lncrna linc00667 could promote renal tubular epithelial cell proliferation and ameliorate renal fibrosis in chronic renal failure via the miR-19b-3p/linc00667/CTGF signaling pathway. 30555030 "Effects of long non-coding RNA LINC00667 on renal tubular epithelial cell proliferation, apoptosis and renal fibrosis via the miR-19b-3p/LINC00667/CTGF signaling pathway in chronic renal failure/Corrigendum to 'Effects of long non-coding RNA LINC00667 on renal tubular epithelial cell proliferation, apoptosis and renal fibrosis via the miR-19b-3p/LINC00667/CTGF signaling pathway in chronic renal failure'" https://pubmed.ncbi.nlm.nih.gov/30555030/;https://pubmed.ncbi.nlm.nih.gov/30731325/ 2019 kidney nephritis_interstitia homo_sapiens LINC00963 ENSG00000204054 Ensembl lncrna up-regulation FOXO3 FOXO SIGNALING PATHWAY dual-luciferase reporter assay no Down-regulation of linc00963 suppresses renal interstitial fibrosis and oxidative stress of chronic renal failure by activating the foxo signaling pathway. 29627834 Effects of Long Non-Coding RNA LINC00963 on Renal Interstitial Fibrosis and Oxidative Stress of Rats with Chronic Renal Failure via the Foxo Signaling Pathway https://pubmed.ncbi.nlm.nih.gov/29627834/ 2018 kidney kidney_diseases homo_sapiens H19 ENSG00000288237 Ensembl lncrna up-regulation NA NA NA no H19 up-regulation contributes to renal fibrosis. 27391349 Long non-coding RNA-H19 antagonism protects against renal fibrosis https://pubmed.ncbi.nlm.nih.gov/27391349/ 2016 kidney acute_kidney_injury mus_musculus Malat1 ENSMUSG00000092341 Ensembl lncrna up-regulation NA NA small-RNA sequencing; whole genome expression analysis no Hypoxia-induced long non-coding RNA malat1 (metastasis associated lung adenocarcinoma transcript 1) to be upregulated in renal i/r injury. 29467431 Hypoxia-induced long non-coding RNA Malat1 is dispensable for renal ischemia/reperfusion-injury https://pubmed.ncbi.nlm.nih.gov/29467431/ 2018 kidney nephritis_interstitia mus_musculus Arid2 ENSMUSG00000033237 Ensembl lncrna up-regulation NA TGF-BETA SIGNALING PATHWAY qPCR; no "In vitro knockdown of Arid2-IR from tubular epithelial cells produced no effect on TGF-beta-induced Smad3 signaling and fibrosis but inhibited interleukin-1beta-stimulated NF-KB-dependent inflammatory response. In contrast, overexpression of Arid2-IR promoted interleukin-1beta-induced NF-KB signaling and inflammatory cytokine expression without alteration of TGF-beta-induced fibrotic response. Furthermore, treatment of obstructed kidney with Arid2-IR shRNA blunted NF-KB-driven renal inflammation without effect on TGF-beta/Smad3-mediated renal fibrosis." 25743111 Long Noncoding RNA Arid2-IR Is a Novel Therapeutic Target for Renal Inflammation https://pubmed.ncbi.nlm.nih.gov/25743111/ 2015 kidney diabetic_nephropathy homo_sapiens KCNQ1O1T ENSG00000269821 Ensembl lncrna up-regulation NA NF-KAPPA B SIGNALING PATHWAY qRT-PCR; dual-luciferase reporter assay no "Kcnq1ot1 regulated diabetic nephropathies cells proliferation, apoptosis and fibrosis via kcnq1ot1/miR-18b-5p/sorbs2 axis and NF-KB pathway." 32905431 "LncRNA KCNQ1OT1 affects cell proliferation, apoptosis and fibrosis through regulating miR-18b-5p/SORBS2 axis and NF- B pathway in diabetic nephropathy" https://pubmed.ncbi.nlm.nih.gov/32905431/ 2020 kidney diabetic_nephropathy mus_musculus Gas5 ENSMUSG00000053332 Ensembl lncrna down-regulation FN1 NA NA no "Knockdown of lncrna gas5 leads to antifibrosis by competitively binding miR-96-5p, which inhibits the expression of FN1." 31810140 LncRNA GAS5 exacerbates renal tubular epithelial fibrosis by acting as a competing endogenous RNA of miR-96-5p https://pubmed.ncbi.nlm.nih.gov/31810140/ 2020 kidney kidney_diseases homo_sapiens PVT1 ENSG00000249859 Ensembl lncrna up-regulation NA TGF-BETA SIGNALING PATHWAY qPCR; no Knockdown of pvt1 significantly inhibited the progression of renal fibrosis in vitro and in vivo. 32921988 LncRNA PVT1 Suppresses the Progression of Renal Fibrosis via Inactivation of TGF-beta Signaling Pathway https://pubmed.ncbi.nlm.nih.gov/32921988/ 2020 kidney diabetic_nephropathy mus_musculus Gm4419 ENSMUSG00000097055 Ensembl lncrna up-regulation P50 NF-KAPPA B SIGNALING PATHWAY qRT-PCR no "Lincrna-gm4419 may participate in the inflammation, fibrosis and proliferation in mesangial cells under high-glucose condition through NF-KB/Nlrp3 inflammasome signaling pathway." 28151474 LincRNA-Gm4419 knockdown ameliorates NF-KB/NLRP3 inflammasome-mediated inflammation in diabetic nephropathy https://pubmed.ncbi.nlm.nih.gov/28151474/ 2017 kidney diabetic_nephropathy mus_musculus Hottip ENSMUSG00000055408 Ensembl lncrna up-regulation NA WNT SIGNALING PATHWAY qRT-PCR; MTT assay etc. no "Lncrna hottip/miR-455-3p/wnt2b axis plays an important role in cell proliferation, inflammation, and extracellular matrix (ecm) accumulation in diabetic nephropathy." 31934070 Long non-coding RNA Hottip modulates high-glucose-induced inflammation and ECM accumulation through miR-455-3p/WNT2B in mus musculus mesangial cells https://pubmed.ncbi.nlm.nih.gov/31934070/ 2019 kidney diabetic_nephropathy mus_musculus Tug1 ENSMUSG00000056579 Ensembl lncrna down-regulation TIMP3 NA dual-luciferase reporter assay no Lncrna tug1 inhibited high glucose-stimulated NRK-52e cell fibrosis and renal fibrosis in diabetic nephropathies mice. 31933879 LncRNA TUG1 ameliorates diabetic nephropathy by inhibiting miR-21 to promote TIMP3-expression https://pubmed.ncbi.nlm.nih.gov/31933879/ 2019 kidney kidney_failure_chronic mus_musculus Zfas1 ENSMUSG00000074578 Ensembl lncrna up-regulation NA WNT SIGNALING PATHWAY dual-luciferase reporter assay no LncRNA ZFAS1 from HCM could promote cardiac fibrosis through WNT/beta-catenin signal via exosome pathways. 33640882 Exosome-derived long non-coding RNA ZFAS1 controls cardiac fibrosis in chronic kidney disease https://pubmed.ncbi.nlm.nih.gov/33640882/ 2021 kidney kidney_diseases homo_sapiens LNCRNA-ATB 114004396 Gene lncrna up-regulation NA TGF-BETA SIGNALING PATHWAY qRT-PCR; cell counting kit-8 analysis no "Lncrna-atb overexpression have promoting effects on inflammation, cell apoptosis and senescence in TGF-beta1 induced human kidney 2 (HK-2) cells via activating the TGF-beta/smad2/3 signaling pathway." 32447340 "Long Non-Coding RNA -ATB Promotes Inflammation, Cell Apoptosis and Senescence in Transforming Growth Factor-beta1 (TGF-beta1) Induced Human Kidney 2 (HK-2) Cells via TGFbeta/SMAD2/3 Signaling Pathway" https://pubmed.ncbi.nlm.nih.gov/32447340/ 2020 kidney kidney_diseases homo_sapiens TSIX ENSG00000270641 Ensembl lncrna down-regulation NA TGF-BETA SIGNALING PATHWAY NA no Lnc-tsi reduced renal fibrogenesis through negative regulation of the TGF-beta/smad pathway. 30305452 Long noncoding RNA lnc-TSI inhibits renal fibrogenesis by negatively regulating the TGF-beta/Smad3 pathway https://pubmed.ncbi.nlm.nih.gov/30305452/ 2018 kidney diabetic_nephropathy mus_musculus Tmcc3 ENSMUSG00000020023 Ensembl lncrna down-regulation NA NA qRT-PCR; no Long non-coding RNA ENSMUST00000147869 protects mesangial cells from proliferation and fibrosis induced by diabetic nephropathy. 27083175 Long non-coding RNA ENSMUST00000147869 protects mesangial cells from proliferation and fibrosis induced by diabetic nephropathy https://pubmed.ncbi.nlm.nih.gov/27083175/ 2016 kidney kidney_diseases homo_sapiens LUCAT1 ENSG00000248323 Ensembl lncrna up-regulation ZEB1 NA NA no Lucat1 likely promotes high-glucose (HG)-induced emt through zeb1 by sponging miR-199a-5p. 33426083 Knockdown of the Long Noncoding RNA LUCAT1 Inhibits High-Glucose-Induced Epithelial-Mesenchymal Transition through the miR-199a-5p-ZEB1 Axis in Human Renal Tubular Epithelial Cells https://pubmed.ncbi.nlm.nih.gov/33426083/ 2020 kidney diabetic_nephropathy homo_sapiens MALAT1 ENSG00000251562 Ensembl lncrna up-regulation ZEB2 NA qRT-PCR; dual-luciferase reporter assay no "Malat1 functions as a sponge rna for miR-145 to derepress the expression of target gene zeb2, thereby inducing epithelial-mesenchymal transition (EMT) and fibrosis." 31081103 LncRNA MALAT1 facilities high glucose induced endothelial to mesenchymal transition and fibrosis via targeting miR-145/ZEB2 axis https://pubmed.ncbi.nlm.nih.gov/31081103/ 2019 kidney diabetic_nephropathy mus_musculus Malat1 ENSMUSG00000092341 Ensembl lncrna up-regulation ZEB2 NA qRT-PCR; dual-luciferase reporter assay no "Malat1 functions as a sponge RNA for miR-145 to derepress the expression of target gene zeb3, thereby inducing epithelial-mesenchymal transition (EMT) and fibrosis." 31081103 LncRNA MALAT1 facilities high glucose induced endothelial to mesenchymal transition and fibrosis via targeting miR-145/ZEB2 axis https://pubmed.ncbi.nlm.nih.gov/31081103/ 2019 kidney diabetic_nephropathy homo_sapiens LOC100507156 ENSG00000253837 Ensembl lncrna up-regulation NA MAPK SIGNALING PATHWAY dual-luciferase reporter assay no "miR-218 was upregulated in high glucose (hg) treated podocytes, which are essential components of the glomerular filtration barrier and a major prognostic determinant in diabetic nephropathy." 31430717 LncRNA NR_038323 Suppresses Renal Fibrosis in Diabetic Nephropathy by Targeting the miR-324-3p/DUSP1 Axis https://pubmed.ncbi.nlm.nih.gov/31430717/ 2019 kidney diabetic_nephropathy mus_musculus Oip5os1 ENSMUSG00000085438 Ensembl lncrna down-regulation NA HIF-1 SIGNALING PATHWAY dual-luciferase reporter assay no Overexpression of 1700020i14rik inhibited cell proliferation and expressions of renal fibrosis markers through miR-34a-5p/sirt1/hif-1 alfa pathway in mouse mesangial cells under high glucose condition. 29700282 LincRNA 1700020I14Rik alleviates cell proliferation and fibrosis in diabetic nephropathy via miR-34a-5p/Sirt1/HIF-1alpha signaling https://pubmed.ncbi.nlm.nih.gov/29700282/ 2018 kidney diabetic_nephropathy mus_musculus Xist ENSMUSG00000086503 Ensembl lncrna up-regulation CDKN1A NA dual-luciferase reporter assay no Silenced xist inducing miR-93-5p-dependent cdkn1a inhibition was beneficial for preventing renal interstitial fibrosis in diabetic nephropathies. 31545928 Silencing of long noncoding RNA XIST protects against renal interstitial fibrosis in diabetic nephropathy via microRNA-93-5p-mediated inhibition of CDKN1A https://pubmed.ncbi.nlm.nih.gov/31545928/ 2019 kidney diabetic_nephropathy homo_sapiens XIST ENSG00000229807 Ensembl lncrna up-regulation CDKN1A NA dual-luciferase reporter assay no Silenced xist inducing miR-93-5p-dependent cdkn2a inhibition was beneficial for preventing renal interstitial fibrosis in diabetic nephropathies. 31545928 Silencing of long noncoding RNA XIST protects against renal interstitial fibrosis in diabetic nephropathy via microRNA-93-5p-mediated inhibition of CDKN1A https://pubmed.ncbi.nlm.nih.gov/31545928/ 2019 kidney nephritis_interstitia homo_sapiens HOTAIR ENSG00000228630 Ensembl lncrna up-regulation NOTCH1 NA qRT-PCR; no "Silencing lncrna hotair can up-regulate miR-124 to block notch1 pathway, and thereby alleviating epithelial-mesenchymal transition and renal interstitial fibrosis." 29717517 LncRNA HOTAIR promotes renal interstitial fibrosis by regulating Notch1 pathway via the modulation of miR-124 https://pubmed.ncbi.nlm.nih.gov/29717517/ 2019 kidney nephritis_interstitia mus_musculus Hotair ENSMUSG00000086903 Ensembl lncrna up-regulation NOTCH1 NA qRT-PCR; no "Silencing lncrna hotair can up-regulate miR-124 to block notch2 pathway, and thereby alleviating epithelial-mesenchymal transition and renal interstitial fibrosis." 29717517 LncRNA HOTAIR promotes renal interstitial fibrosis by regulating Notch1 pathway via the modulation of miR-124 https://pubmed.ncbi.nlm.nih.gov/29717517/ 2019 kidney diabetic_nephropathy homo_sapiens NEAT1 ENSG00000245532 Ensembl lncrna up-regulation NA MAPK SIGNALING PATHWAY NA no Silencing neat1 can reverse the activation of epithelial-mesenchymal transition and fibrosis caused by klotho silencing in a manner dependent on the erk1/2 signaling pathway. 32054986 Long noncoding RNA NEAT1 is involved in the protective effect of Klotho on renal tubular epithelial cells in diabetic kidney disease through the ERK1/2 signaling pathway https://pubmed.ncbi.nlm.nih.gov/32054986/ 2020 kidney diabetic_nephropathy mus_musculus Neat1 ENSMUSG00000092274 Ensembl lncrna up-regulation NA MAPK SIGNALING PATHWAY NA no Silencing neat1 can reverse the activation of epithelial-mesenchymal transition and fibrosis caused by klotho silencing in a manner dependent on the erk1/3 signaling pathway. 32054986 Long noncoding RNA NEAT1 is involved in the protective effect of Klotho on renal tubular epithelial cells in diabetic kidney disease through the ERK1/2 signaling pathway https://pubmed.ncbi.nlm.nih.gov/32054986/ 2020 kidney nephritis_interstitia homo_sapiens LOC105375913 105375913 Gene lncrna up-regulation NA MAPK SIGNALING PATHWAY NA no "The activation of C3a/p38/xbp-1s pathway induces the expression of loc105375913 in tubular cells,and loc105375913 increases the level of snail and induces tubulointerstitial fibrosis through competitive binding of miR-27b in tubular cells of focal segmental glomerulosclerosis patients." 30679767 Upregulated long noncoding RNA LOC105375913 induces tubulointerstitial fibrosis in focal segmental glomerulosclerosis https://pubmed.ncbi.nlm.nih.gov/30679767/ 2019 kidney nephritis_interstitia mus_musculus Hotair ENSMUSG00000086903 Ensembl lncrna up-regulation NOTCH1 NOTCH SIGNALING PATHWAY NA yes "The contributory effect of lncrna hotair on renal interstitial fibrosis by activating the notch1/jagged1 signaling pathway via inhibition of miR-124, whereas administration of PAE can alleviate the effects of hotair on renal interstitial fibrosis." 30714138 Paeonol reverses promoting effect of the HOTAIR/miR-124/Notch1 axis on renal interstitial fibrosis in a rat model https://pubmed.ncbi.nlm.nih.gov/30714138/ 2019 kidney nephritis_interstitia homo_sapiens TUG1 ENSG00000253352 Ensembl lncrna up-regulation NA TGF-BETA SIGNALING PATHWAY immunofluorescence etc. no Tug1 promotes epithelial-mesenchymal transition in TGF-beta-induced human renal proximal tubular epithelial cells via upregulation of beta-catenin levels by sponging miR-141-3p. 33135476 Silencing of the lncRNA TUG1 attenuates the epithelial-mesenchymal transition of renal tubular epithelial cells by sponging miR-141-3p via regulating beta-catenin https://pubmed.ncbi.nlm.nih.gov/33135476/ 2020 kidney nephritis_interstitia mus_musculus Tug1 ENSMUSG00000056579 Ensembl lncrna up-regulation NA TGF-BETA SIGNALING PATHWAY immunofluorescence etc. no Tug1 promotes epithelial-mesenchymal transition in TGF-beta-induced human renal proximal tubular epithelial cells via upregulation of beta-catenin levels by sponging miR-141-3p. 33135476 Silencing of the lncRNA TUG1 attenuates the epithelial-mesenchymal transition of renal tubular epithelial cells by sponging miR-141-3p via regulating beta-catenin https://pubmed.ncbi.nlm.nih.gov/33135476/ 2020 kidney diabetic_nephropathy homo_sapiens SNHG18 ENSG00000250786 Ensembl lncrna down-regulation NA NA qRT-PCR no Twelve lncRNAs displayed the same expressional tendencies in both renal tissues and mesangial cells. 28151474 LincRNA-Gm4419 knockdown ameliorates NF-KB/NLRP3 inflammasome-mediated inflammation in diabetic nephropathy https://pubmed.ncbi.nlm.nih.gov/28151474/ 2017 kidney diabetic_nephropathy homo_sapiens SNHG6 ENSG00000245910 Ensembl lncrna down-regulation NA NA qRT-PCR no Twelve lncRNAs displayed the same expressional tendencies in both renal tissues and mesangial cells. 28151474 LincRNA-Gm4419 knockdown ameliorates NF-KB/NLRP3 inflammasome-mediated inflammation in diabetic nephropathy https://pubmed.ncbi.nlm.nih.gov/28151474/ 2017 kidney diabetic_nephropathy mus_musculus Snhg18 ENSMUSG00000096956 Ensembl lncrna down-regulation NA NA qRT-PCR no Twelve lncRNAs displayed the same expressional tendencies in both renal tissues and mesangial cells. 28151474 LincRNA-Gm4419 knockdown ameliorates NF-KB/NLRP3 inflammasome-mediated inflammation in diabetic nephropathy https://pubmed.ncbi.nlm.nih.gov/28151474/ 2017 kidney diabetic_nephropathy mus_musculus 1500026H17Rik ENSMUSG00000097383 Ensembl lncrna up-regulation NA NA qRT-PCR no Twelve lncRNAs displayed the same expressional tendencies in both renal tissues and mesangial cells. 28151474 LincRNA-Gm4419 knockdown ameliorates NF-KB/NLRP3 inflammasome-mediated inflammation in diabetic nephropathy https://pubmed.ncbi.nlm.nih.gov/28151474/ 2017 kidney diabetic_nephropathy mus_musculus 2610035D17Rik ENSMUSG00000087259 Ensembl lncrna down-regulation NA NA qRT-PCR no Twelve lncRNAs displayed the same expressional tendencies in both renal tissues and mesangial cells. 28151474 LincRNA-Gm4419 knockdown ameliorates NF-KB/NLRP3 inflammasome-mediated inflammation in diabetic nephropathy https://pubmed.ncbi.nlm.nih.gov/28151474/ 2017 kidney diabetic_nephropathy mus_musculus 4930556M19Rik ENSMUSG00000096971 Ensembl lncrna down-regulation NA NA qRT-PCR no Twelve lncRNAs displayed the same expressional tendencies in both renal tissues and mesangial cells. 28151474 LincRNA-Gm4419 knockdown ameliorates NF-KB/NLRP3 inflammasome-mediated inflammation in diabetic nephropathy https://pubmed.ncbi.nlm.nih.gov/28151474/ 2017 kidney diabetic_nephropathy mus_musculus 6030443J06Rik ENSMUSG00000097207 Ensembl lncrna up-regulation NA NA qRT-PCR no Twelve lncRNAs displayed the same expressional tendencies in both renal tissues and mesangial cells. 28151474 LincRNA-Gm4419 knockdown ameliorates NF-KB/NLRP3 inflammasome-mediated inflammation in diabetic nephropathy https://pubmed.ncbi.nlm.nih.gov/28151474/ 2017 kidney diabetic_nephropathy mus_musculus C330002G04Rik ENSMUSG00000097930 Ensembl lncrna down-regulation NA NA qRT-PCR no Twelve lncRNAs displayed the same expressional tendencies in both renal tissues and mesangial cells. 28151474 LincRNA-Gm4419 knockdown ameliorates NF-KB/NLRP3 inflammasome-mediated inflammation in diabetic nephropathy https://pubmed.ncbi.nlm.nih.gov/28151474/ 2017 kidney diabetic_nephropathy mus_musculus D630029K05Rik ENSMUSG00000031294 Ensembl lncrna down-regulation NA NA qRT-PCR no Twelve lncRNAs displayed the same expressional tendencies in both renal tissues and mesangial cells. 28151474 LincRNA-Gm4419 knockdown ameliorates NF-KB/NLRP3 inflammasome-mediated inflammation in diabetic nephropathy https://pubmed.ncbi.nlm.nih.gov/28151474/ 2017 kidney diabetic_nephropathy mus_musculus Snhg6 ENSMUSG00000098234 Ensembl lncrna down-regulation NA NA qRT-PCR no Twelve lncRNAs displayed the same expressional tendencies in both renal tissues and mesangial cells. 28151474 LincRNA-Gm4419 knockdown ameliorates NF-KB/NLRP3 inflammasome-mediated inflammation in diabetic nephropathy https://pubmed.ncbi.nlm.nih.gov/28151474/ 2017 kidney diabetic_nephropathy mus_musculus 1700020I14Rik ENSMUSG00000085438 Ensembl lncrna down-regulation NA NA qRT-PCR no Twelve lncRNAs displayed the same expressional tendencies in both renal tissues and mesangial cells. 28151474 LincRNA-Gm4419 knockdown ameliorates NF-KB/NLRP3 inflammasome-mediated inflammation in diabetic nephropathy https://pubmed.ncbi.nlm.nih.gov/28151474/ 2017 kidney diabetic_nephropathy mus_musculus AV099323 ENSMUSG00000087377 Ensembl lncrna down-regulation NA NA qRT-PCR no Twelve lncRNAs displayed the same expressional tendencies in both renal tissues and mesangial cells. 28151474 LincRNA-Gm4419 knockdown ameliorates NF-KB/NLRP3 inflammasome-mediated inflammation in diabetic nephropathy https://pubmed.ncbi.nlm.nih.gov/28151474/ 2017 kidney diabetic_nephropathy mus_musculus C920006O11Rik ENSMUSG00000097574 Ensembl lncrna down-regulation NA NA qRT-PCR no Twelve lncRNAs displayed the same expressional tendencies in both renal tissues and mesangial cells. 28151474 LincRNA-Gm4419 knockdown ameliorates NF-KB/NLRP3 inflammasome-mediated inflammation in diabetic nephropathy https://pubmed.ncbi.nlm.nih.gov/28151474/ 2017 kidney renal_fibrosis mus_musculus 3110045C21Rik ENSMUSG00000097503 Ensembl lncrna down-regulation NA NA qPCR no "We identified a long list of differentially expressed lncRNA genes in a statistical significant manner (P<0.05).In particular, we identified 62 lncRNAs that were differentially expressed in SO vs 2D, 110 lncRNAs in SO vs 8D and 24 in 2D vs 10D ." 27189340 Whole-transcriptome analysis of UUO mouse model of renal fibrosis reveals new molecular players in kidney diseases https://pubmed.ncbi.nlm.nih.gov/27189340/ 2016 kidney renal_fibrosis mus_musculus 3110099E03Rik ENSMUSG00000085582 Ensembl lncrna down-regulation NA NA qPCR no "We identified a long list of differentially expressed lncRNA genes in a statistical significant manner (P<0.05).In particular, we identified 62 lncRNAs that were differentially expressed in SO vs 2D, 110 lncRNAs in SO vs 8D and 24 in 2D vs 11D ." 27189340 Whole-transcriptome analysis of UUO mouse model of renal fibrosis reveals new molecular players in kidney diseases https://pubmed.ncbi.nlm.nih.gov/27189340/ 2016 kidney renal_fibrosis mus_musculus 3300005D01Rik ENSMUSG00000096965 Ensembl lncrna up-regulation NA NA qPCR no "We identified a long list of differentially expressed lncRNA genes in a statistical significant manner (P<0.05).In particular, we identified 62 lncRNAs that were differentially expressed in SO vs 2D, 110 lncRNAs in SO vs 8D and 24 in 2D vs 12D ." 27189340 Whole-transcriptome analysis of UUO mouse model of renal fibrosis reveals new molecular players in kidney diseases https://pubmed.ncbi.nlm.nih.gov/27189340/ 2016 kidney renal_fibrosis mus_musculus 4833418N02Rik ENSMUSG00000085287 Ensembl lncrna down-regulation NA NA qPCR no "We identified a long list of differentially expressed lncRNA genes in a statistical significant manner (P<0.05).In particular, we identified 62 lncRNAs that were differentially expressed in SO vs 2D, 110 lncRNAs in SO vs 8D and 24 in 2D vs 13D ." 27189340 Whole-transcriptome analysis of UUO mouse model of renal fibrosis reveals new molecular players in kidney diseases https://pubmed.ncbi.nlm.nih.gov/27189340/ 2016 kidney renal_fibrosis mus_musculus 9130409J20Rik ENSMUSG00000085683 Ensembl lncrna down-regulation NA NA qPCR no "We identified a long list of differentially expressed lncRNA genes in a statistical significant manner (P<0.05).In particular, we identified 62 lncRNAs that were differentially expressed in SO vs 2D, 110 lncRNAs in SO vs 8D and 24 in 2D vs 14D ." 27189340 Whole-transcriptome analysis of UUO mouse model of renal fibrosis reveals new molecular players in kidney diseases https://pubmed.ncbi.nlm.nih.gov/27189340/ 2016 kidney renal_fibrosis mus_musculus 9330175E14Rik ENSMUSG00000097194 Ensembl lncrna up-regulation NA NA qPCR no "We identified a long list of differentially expressed lncRNA genes in a statistical significant manner (P<0.05).In particular, we identified 62 lncRNAs that were differentially expressed in SO vs 2D, 110 lncRNAs in SO vs 8D and 24 in 2D vs 15D ." 27189340 Whole-transcriptome analysis of UUO mouse model of renal fibrosis reveals new molecular players in kidney diseases https://pubmed.ncbi.nlm.nih.gov/27189340/ 2016 kidney renal_fibrosis mus_musculus A730020E08Rik ENSMUSG00000097924 Ensembl lncrna up-regulation NA NA qPCR no "We identified a long list of differentially expressed lncRNA genes in a statistical significant manner (P<0.05).In particular, we identified 62 lncRNAs that were differentially expressed in SO vs 2D, 110 lncRNAs in SO vs 8D and 24 in 2D vs 16D ." 27189340 Whole-transcriptome analysis of UUO mouse model of renal fibrosis reveals new molecular players in kidney diseases https://pubmed.ncbi.nlm.nih.gov/27189340/ 2016 kidney renal_fibrosis mus_musculus AI504432 ENSMUSG00000056145 Ensembl lncrna up-regulation NA NA qPCR no "We identified a long list of differentially expressed lncRNA genes in a statistical significant manner (P<0.05).In particular, we identified 62 lncRNAs that were differentially expressed in SO vs 2D, 110 lncRNAs in SO vs 8D and 24 in 2D vs 17D ." 27189340 Whole-transcriptome analysis of UUO mouse model of renal fibrosis reveals new molecular players in kidney diseases https://pubmed.ncbi.nlm.nih.gov/27189340/ 2016 kidney renal_fibrosis mus_musculus AI662270 ENSMUSG00000087107 Ensembl lncrna up-regulation NA NA qPCR no "We identified a long list of differentially expressed lncRNA genes in a statistical significant manner (P<0.05).In particular, we identified 62 lncRNAs that were differentially expressed in SO vs 2D, 110 lncRNAs in SO vs 8D and 24 in 2D vs 18D ." 27189340 Whole-transcriptome analysis of UUO mouse model of renal fibrosis reveals new molecular players in kidney diseases https://pubmed.ncbi.nlm.nih.gov/27189340/ 2016 kidney renal_fibrosis mus_musculus D630024D03Rik ENSMUSG00000085772 Ensembl lncrna down-regulation NA NA qPCR no "We identified a long list of differentially expressed lncRNA genes in a statistical significant manner (P<0.05).In particular, we identified 62 lncRNAs that were differentially expressed in SO vs 2D, 110 lncRNAs in SO vs 8D and 24 in 2D vs 19D ." 27189340 Whole-transcriptome analysis of UUO mouse model of renal fibrosis reveals new molecular players in kidney diseases https://pubmed.ncbi.nlm.nih.gov/27189340/ 2016 kidney renal_fibrosis mus_musculus D630029K05Rik ENSMUSG00000031294 Ensembl lncrna down-regulation NA NA qPCR no "We identified a long list of differentially expressed lncRNA genes in a statistical significant manner (P<0.05).In particular, we identified 62 lncRNAs that were differentially expressed in SO vs 2D, 110 lncRNAs in SO vs 8D and 24 in 2D vs 20D ." 27189340 Whole-transcriptome analysis of UUO mouse model of renal fibrosis reveals new molecular players in kidney diseases https://pubmed.ncbi.nlm.nih.gov/27189340/ 2016 kidney renal_fibrosis mus_musculus Gdap10 100504486 Gene lncrna up-regulation NA NA qPCR no "We identified a long list of differentially expressed lncRNA genes in a statistical significant manner (P<0.05).In particular, we identified 62 lncRNAs that were differentially expressed in SO vs 2D, 110 lncRNAs in SO vs 8D and 24 in 2D vs 21D ." 27189340 Whole-transcriptome analysis of UUO mouse model of renal fibrosis reveals new molecular players in kidney diseases https://pubmed.ncbi.nlm.nih.gov/27189340/ 2016 kidney renal_fibrosis mus_musculus Gm10069 ENSMUSG00000059659 Ensembl lncrna up-regulation NA NA qPCR no "We identified a long list of differentially expressed lncRNA genes in a statistical significant manner (P<0.05).In particular, we identified 62 lncRNAs that were differentially expressed in SO vs 2D, 110 lncRNAs in SO vs 8D and 24 in 2D vs 22D ." 27189340 Whole-transcriptome analysis of UUO mouse model of renal fibrosis reveals new molecular players in kidney diseases https://pubmed.ncbi.nlm.nih.gov/27189340/ 2016 kidney renal_fibrosis mus_musculus Gm10804 ENSMUSG00000075025 Ensembl lncrna down-regulation NA NA qPCR no "We identified a long list of differentially expressed lncRNA genes in a statistical significant manner (P<0.05).In particular, we identified 62 lncRNAs that were differentially expressed in SO vs 2D, 110 lncRNAs in SO vs 8D and 24 in 2D vs 23D ." 27189340 Whole-transcriptome analysis of UUO mouse model of renal fibrosis reveals new molecular players in kidney diseases https://pubmed.ncbi.nlm.nih.gov/27189340/ 2016 kidney renal_fibrosis mus_musculus Gm11752 ENSMUSG00000087404 Ensembl lncrna down-regulation NA NA qPCR no "We identified a long list of differentially expressed lncRNA genes in a statistical significant manner (P<0.05).In particular, we identified 62 lncRNAs that were differentially expressed in SO vs 2D, 110 lncRNAs in SO vs 8D and 24 in 2D vs 24D ." 27189340 Whole-transcriptome analysis of UUO mouse model of renal fibrosis reveals new molecular players in kidney diseases https://pubmed.ncbi.nlm.nih.gov/27189340/ 2016 kidney renal_fibrosis mus_musculus Gm12678 ENSMUSG00000084854 Ensembl lncrna down-regulation NA NA qPCR no "We identified a long list of differentially expressed lncRNA genes in a statistical significant manner (P<0.05).In particular, we identified 62 lncRNAs that were differentially expressed in SO vs 2D, 110 lncRNAs in SO vs 8D and 24 in 2D vs 25D ." 27189340 Whole-transcriptome analysis of UUO mouse model of renal fibrosis reveals new molecular players in kidney diseases https://pubmed.ncbi.nlm.nih.gov/27189340/ 2016 kidney renal_fibrosis mus_musculus Gm13412 ENSMUSG00000085017 Ensembl lncrna down-regulation NA NA qPCR no "We identified a long list of differentially expressed lncRNA genes in a statistical significant manner (P<0.05).In particular, we identified 62 lncRNAs that were differentially expressed in SO vs 2D, 110 lncRNAs in SO vs 8D and 24 in 2D vs 26D ." 27189340 Whole-transcriptome analysis of UUO mouse model of renal fibrosis reveals new molecular players in kidney diseases https://pubmed.ncbi.nlm.nih.gov/27189340/ 2016 kidney renal_fibrosis mus_musculus Gm16685 ENSMUSG00000097804 Ensembl lncrna up-regulation NA NA qPCR no "We identified a long list of differentially expressed lncRNA genes in a statistical significant manner (P<0.05).In particular, we identified 62 lncRNAs that were differentially expressed in SO vs 2D, 110 lncRNAs in SO vs 8D and 24 in 2D vs 27D ." 27189340 Whole-transcriptome analysis of UUO mouse model of renal fibrosis reveals new molecular players in kidney diseases https://pubmed.ncbi.nlm.nih.gov/27189340/ 2016 kidney renal_fibrosis mus_musculus Gm9951 ENSMUSG00000054618 Ensembl lncrna up-regulation NA NA qPCR no "We identified a long list of differentially expressed lncRNA genes in a statistical significant manner (P<0.05).In particular, we identified 62 lncRNAs that were differentially expressed in SO vs 2D, 110 lncRNAs in SO vs 8D and 24 in 2D vs 28D ." 27189340 Whole-transcriptome analysis of UUO mouse model of renal fibrosis reveals new molecular players in kidney diseases https://pubmed.ncbi.nlm.nih.gov/27189340/ 2016 kidney renal_fibrosis mus_musculus Malat1 ENSMUSG00000092341 Ensembl lncrna up-regulation NA NA qPCR no "We identified a long list of differentially expressed lncRNA genes in a statistical significant manner (P<0.05).In particular, we identified 62 lncRNAs that were differentially expressed in SO vs 2D, 110 lncRNAs in SO vs 8D and 24 in 2D vs 29D ." 27189340 Whole-transcriptome analysis of UUO mouse model of renal fibrosis reveals new molecular players in kidney diseases https://pubmed.ncbi.nlm.nih.gov/27189340/ 2016 kidney renal_fibrosis mus_musculus Neat1 ENSMUSG00000092274 Ensembl lncrna up-regulation NA NA qPCR no "We identified a long list of differentially expressed lncRNA genes in a statistical significant manner (P<0.05).In particular, we identified 62 lncRNAs that were differentially expressed in SO vs 2D, 110 lncRNAs in SO vs 8D and 24 in 2D vs 30D ." 27189340 Whole-transcriptome analysis of UUO mouse model of renal fibrosis reveals new molecular players in kidney diseases https://pubmed.ncbi.nlm.nih.gov/27189340/ 2016 kidney renal_fibrosis mus_musculus Snhg6 ENSMUSG00000098234 Ensembl lncrna up-regulation NA NA qPCR no "We identified a long list of differentially expressed lncRNA genes in a statistical significant manner (P<0.05).In particular, we identified 62 lncRNAs that were differentially expressed in SO vs 2D, 110 lncRNAs in SO vs 8D and 24 in 2D vs 34D ." 27189340 Whole-transcriptome analysis of UUO mouse model of renal fibrosis reveals new molecular players in kidney diseases https://pubmed.ncbi.nlm.nih.gov/27189340/ 2016 kidney renal_fibrosis mus_musculus 1810034E14Rik ENSMUSG00000097101 Ensembl lncrna down-regulation NA NA qPCR no "We identified a long list of differentially expressed lncRNA genes in a statistical significant manner (P<0.05).In particular, we identified 62 lncRNAs that were differentially expressed in SO vs 2D, 110 lncRNAs in SO vs 8D and 24 in 2D vs 8D ." 27189340 Whole-transcriptome analysis of UUO mouse model of renal fibrosis reveals new molecular players in kidney diseases https://pubmed.ncbi.nlm.nih.gov/27189340/ 2016 kidney renal_fibrosis mus_musculus Epb41l4aos ENSMUSG00000087590 Ensembl lncrna up-regulation NA NA qPCR no "We identified a long list of differentially expressed lncRNA genes in a statistical significant manner (P<0.05).In particular, we identified 62 lncRNAs that were differentially expressed in SO vs 2D, 110 lncRNAs in SO vs 8D and 24 in 2D vs 9D ." 27189340 Whole-transcriptome analysis of UUO mouse model of renal fibrosis reveals new molecular players in kidney diseases https://pubmed.ncbi.nlm.nih.gov/27189340/ 2016 kidney kidney_diseases mus_musculus Miat ENSMUSG00000097767 Ensembl lncrna up-regulation NA NA qRT-PCR; pathway analysis; immunohistochemistry no NA 30914951 Long Non-coding RNAs Rian and Miat Mediate Myofibroblast Formation in Kidney Fibrosis https://pubmed.ncbi.nlm.nih.gov/30914951/ 2019 kidney kidney_diseases mus_musculus Meg8 ENSMUSG00000097451 Ensembl lncrna down-regulation NA NA qRT-PCR; pathway analysis; immunohistochemistry no NA 30914951 Long Non-coding RNAs Rian and Miat Mediate Myofibroblast Formation in Kidney Fibrosis https://pubmed.ncbi.nlm.nih.gov/30914951/ 2019 kidney kidney_diseases homo_sapiens NEAT1 ENSG00000245532 Ensembl lncrna up-regulation NA NA NA no NA 32475133 Long noncoding RNA NEAT1 sponges miR-130 to modulate renal fibrosis by regulation of collagen type I https://pubmed.ncbi.nlm.nih.gov/32475134/ 2020 kidney kidney_diseases mus_musculus Neat1 ENSMUSG00000092274 Ensembl lncrna up-regulation NA NA NA no NA 32475133 Long noncoding RNA NEAT1 sponges miR-130 to modulate renal fibrosis by regulation of collagen type I https://pubmed.ncbi.nlm.nih.gov/32475134/ 2020 liver liver_cirrhosis mus_musculus H19 ENSMUSG00000000031 Ensembl lncrna dysregulation LNCRNA H19 NA flow cytometry etc. no Cholangiocyte-derived exosomal h19 plays a critical role in the progression of cholestatic liver fibrosis by promoting hsc differentiation and activation and represents a potential diagnostic biomarker and therapeutic target for cholangiopathies. 30985008 Cholangiocyte-Derived Exosomal Long Noncoding RNA H19 Promotes Hepatic Stellate Cell Activation and Cholestatic Liver Fibrosis https://pubmed.ncbi.nlm.nih.gov/30985008/ 2019 liver liver_cirrhosis mus_musculus LFAR1 NA NA lncrna down-regulation LNC-LFAR1 TGF-BETA SIGNALING PATHWAY; NOTCH SIGNALING PATHWAY qRT-PCR; etc. no "Demonstrate that a liver-enriched lncrna, lnc-lfar1, promotes liver fibrosis and hsc activation by activating tgfbeta and notch signaling." 28747678 The liver-enriched lnc-LFAR1 promotes liver fibrosis by activating TGFbeta and Notch pathways https://pubmed.ncbi.nlm.nih.gov/28747678/ 2017 liver liver_cirrhosis homo_sapiens GAS5 ENSG00000234741 Ensembl lncrna dysregulation NA NA rna extraction; qRT-PCR no Elevated circulating levels of the lncrna gas5 are associated with the progression of liver fibrosis prior to the development of cirrhosis. 32413995 Expression of the Long Noncoding RNA GAS5 Correlates with Liver Fibrosis in Patients with Nonalcoholic Fatty Liver Disease https://pubmed.ncbi.nlm.nih.gov/32413995/ 2020 liver liver_cirrhosis homo_sapiens APTR ENSG00000214293 Ensembl lncrna up-regulation NA NA qRT-PCR; etc. no Evidence is proposed for a new biological role of aptr in hepatofibrogenesis. 26043697 Long non-coding RNA APTR promotes the activation of hepatic stellate cells and the progression of liver fibrosis https://pubmed.ncbi.nlm.nih.gov/26043697/ 2015 liver carcinoma_hepatocellular mus_musculus Malat1 ENSMUSG00000092341 Ensembl lncrna dysregulation NA NA NA NA "HCC and HPBL have clearly different patterns of gene expression, with genes IGF2, Fibronectin, DLK1, TGFb1, MALAT1 and MIG6 being over-expressed in HPBL versus HCC" 17006932 Transcriptomic and genomic analysis of human hepatocellular carcinomas and hepatoblastomas https://pubmed.ncbi.nlm.nih.gov/17006932/ 2006 liver liver_cirrhosis mus_musculus H19 ENSMUSG00000000031 Ensembl lncrna up-regulation NA TGF-BETA SIGNALING PATHWAY qRT-PCR; immunohistochemistry etc. no Histone deacetylase inhibition suppresses the transforming growth factor beta1-induced epithelial-to-mesenchymal transition in hepatocytes. 27350269 MeCP2 silencing of LncRNA H19 controls hepatic stellate cell proliferation by targeting IGF1R https://pubmed.ncbi.nlm.nih.gov/27350269/ 2016 liver liver_cirrhosis homo_sapiens SNHG7 ENSG00000233016 Ensembl lncrna dysregulation DNMT3A NA qRT-PCR; dual-lucimmunofluorescenceerase reporter assay etc. no "Inhibition of lncrna-snhg7 can inhibitliver fibrosis. This is partly due to snhg7 acts as a competitive endogenous rna (cerna) to affect the expression of dnmt3a, a downstream target gene of mir-29b, by binding to mir-29b, thereby affecting the activation, autophagy and proliferation of hscs." 32893175 "LncRNA-SNHG7/miR-29b/DNMT3A axis affects activation, autophagy and proliferation of hepatic stellate cells in liver fibrosis" https://pubmed.ncbi.nlm.nih.gov/32893175/ 2020 liver liver_cirrhosis homo_sapiens SCRG1 ENSG00000164106 Ensembl lncrna dysregulation TNF-alfa; MMP-2 NA q-PCR; H&E staining; etc. no Linc-scrg1 reduced ttp and restricted its degradation of target genes tnf-alfa and mmp-2. 30226813 Linc-SCRG1 accelerates liver fibrosis by decreasing RNA-binding protein tristetraprolin https://pubmed.ncbi.nlm.nih.gov/30226813/ 2019 liver liver_cirrhosis homo_sapiens NEAT1 ENSG00000245532 Ensembl lncrna up-regulation LNCRNA NEAT1 NA RT-PCR; immunofluorescence etc. no "Lncrna neat1 could regulate fibrosis, inflammatory response, and lipid metabolism via the mir-506;Gli3 axis as a cerna, which is a novel mechanistic role in the regulation of nafld. These results provide a new potential treatment target for nafld." 31957704 LncRNA NEAT1 regulates fibrosis and inflammatory response induced by nonalcoholic fatty liver by regulating miR-506/GLI3 https://pubmed.ncbi.nlm.nih.gov/31957704/ 2019 liver liver_cirrhosis mus_musculus LNCRNA-ATB 114004396 Gene lncrna up-regulation LNCRNA-ATB NA qRT-PCR; immunocytocH&E stainingmistry etc. no Lncrna-atb;Mir-200a;beta-Catenin regulatory axis likely contributed to the development of liver fibrosis in hcv patients. Knockdown of lncrna-atb might be a novel therapeutic target for hcv-related liver fibrosis. 28302418 LncRNA-ATB/microRNA-200a/beta-catenin regulatory axis involved in the progression of HCV-related hepatic fibrosis https://pubmed.ncbi.nlm.nih.gov/28302418/ 2017 liver liver_cirrhosis mus_musculus Neat1 ENSMUSG00000092274 Ensembl lncrna dysregulation NA NA NA yes Neat1 was significantly increased in ccl4-induced mice and activated hscs. Loss of neat1 suppressed liver fibrosis in vivo and in vitro. Klf6 and mir-122 were required for the effects of neat1 on hsc activation. Neat1 contributes to hsc activation via competitively binding mir-122. We disclose a novel neat1-mir-122-klf6 signaling cascade. 28864835 NEAT1 accelerates the progression of liver fibrosis via regulation of microRNA-122 and Kruppel-like factor 6 https://pubmed.ncbi.nlm.nih.gov/28864835/ 2017 liver liver_cirrhosis homo_sapiens MEG8 ENSG00000225746 Ensembl lncrna down-regulation LNCRNA MEG8 NOTCH SIGNALING PATHWAY immunofluorescence; qRT-PCR; etc. no Our findings indicate that meg8 may serve as a novel protective molecule and a potential therapeutic target of liver fibrosis. 31711641 LncRNA Meg8 suppresses activation of hepatic stellate cells and epithelial-mesenchymal transition of hepatocytes via the Notch pathway https://pubmed.ncbi.nlm.nih.gov/31711641/ 2020 liver liver_cirrhosis mus_musculus H19 ENSMUSG00000000031 Ensembl lncrna dysregulation LNCRNA-H19 AMPKA RT-PCR; immunofluorescence etc. no "Our results highlighted the role of lncrna-h19 in the metabolism of lipid droplets in hscs, and revealed a new molecular target for alleviating liver fibrosis." 32445757 HIF-1alfa-upregulated lncRNA-H19 regulates lipid droplet metabolism through the AMPKalfa pathway in hepatic stellate cells https://pubmed.ncbi.nlm.nih.gov/32445757/ 2020 liver liver_cirrhosis mus_musculus Scarna10 ENSMUSG00000089617 Ensembl lncrna up-regulation SCARNA10 NA miRNA microarray chip detection etc. no "Our study identified a crucial role of scarna10 in liver fibrosis, providing a proof of this molecule as a potential diagnostic marker and a possible therapeutic target against liver fibrosis." 31281502 "SCARNA10, a nuclear-retained long non-coding RNA, promotes liver fibrosis and serves as a potential biomarker" https://pubmed.ncbi.nlm.nih.gov/31281502/ 2019 liver liver_cirrhosis mus_musculus Mical2 ENSMUSG00000038244 Ensembl lncrna down-regulation P66SHC MICAL2; MIR-230-3P; P66SHC qRT-PCR; dual-lucimmunofluorescenceerase reporter assay etc. no "Our study reveals that p66shc is critical for liver fibrosis and that mical2, journal pre-proof journal pre-proof 4 mir-203a-3p and p66shc compose a novel regulatory pathway in liver fibrosis." 32659284 LncRNA Mical2/miR-203a-3p sponge participates in epithelial-mesenchymal transition by targeting p66Shc in liver fibrosis https://pubmed.ncbi.nlm.nih.gov/32659284/ 2020 liver liver_cirrhosis mus_musculus Pvt1 ENSMUSG00000097039 Ensembl lncrna patched2 demethylation NA HEDGEHOG SIGNALING PATHWAY qRT-PCR; dual-lucimmunofluorescenceerase reporter assay etc. no "Pvt1 epigenetically down-regulates ptch1 expression via competitively binding mir-152, contributing to emt process in liver fibrosis." 27588491 Long non-coding RNA PVT1 activates hepatic stellate cells through competitively binding microRNA-152 https://pubmed.ncbi.nlm.nih.gov/27588491/ 2016 liver liver_cirrhosis mus_musculus Meg3 ENSMUSG00000021268 Ensembl lncrna down-regulation NA NA qRT-PCR; etc. no "Serum level of lncrna-meg3 is lowly expressed in chb patients, which is negatively correlated to the liver fibrotic degree. Lncrna-meg3 may serve as a diagnostic biomarker for chb." 31173310 Diagnostic value of LncRNA-MEG3 as a serum biomarker in patients with hepatitis B complicated with liver fibrosis https://pubmed.ncbi.nlm.nih.gov/31173310/ 2019 liver liver_cirrhosis mus_musculus Mecp2 ENSMUSG00000031393 Ensembl lncrna phosphorylation NA NA sirna transfection; hyaluronic acid quantimmunofluorescenceication yes Strategies to inhibit mecp2 phosphorylation at s80 might be developed for treatment of liver fibrosis. 31352003 Fibrogenic Activity of MECP2 Is Regulated by Phosphorylation in Hepatic Stellate Cells https://pubmed.ncbi.nlm.nih.gov/31352003/ 2019 liver liver_cirrhosis mus_musculus H19 ENSMUSG00000000031 Ensembl lncrna up-regulation NA NA q-PCR; dual-lucimmunofluorescenceerase reporter assay etc. no The activation of hepatic h19rna promoted cholestatic liver fibrosis in mice through the zeb1;Epcam signaling pathway. 28407375 H19 promotes cholestatic liver fibrosis by preventing ZEB1-mediated inhibition of EpCAM https://pubmed.ncbi.nlm.nih.gov/28407375/ 2017 liver liver_cirrhosis mus_musculus Trp53cor1 100504267 Gene lncrna dysregulation LINCRNA-P21 TGF-BETA SIGNALING PATHWAY flow cytometry; H&E staining; etc. no The pleiotropic roles of hepatocyte lincrna-p21 suggest that it may represent an unknown paradigm in liver fibrosis and serve as a potential target for therapy. 28592847 TGF-beta-induced hepatocyte lincRNA-p21 contributes to liver fibrosis in mice https://pubmed.ncbi.nlm.nih.gov/28592847/ 2017 liver liver_cirrhosis mus_musculus Meg3 ENSMUSG00000021268 Ensembl lncrna hypermethylation MEG3 NA qRT-PCR; immunofluorescence etc. yes These findings suggested that meg3 may play an important role in stellate cell activation and liver fibrosis progression and act as a novel potential therapeutic target for liver fibrosis. 25201080 Inhibitory effects of long noncoding RNA MEG3 on hepatic stellate cells activation and liver fibrogenesis https://pubmed.ncbi.nlm.nih.gov/25201080/ 2014 liver liver_cirrhosis mus_musculus HULC 728655 Gene lncrna up-regulation NA NA qRT-PCR; etc. no "We confirmed the effects of hulc on tregs differentiation in hbv-related liver cirrhosis. In addition, it was proved that hulc regulates the function of tregs through down-regulated the level of p18 directly." 25952928 LncRNA HULC affects the differentiation of Treg in HBV-related liver cirrhosis https://pubmed.ncbi.nlm.nih.gov/25952928/ 2015 liver liver_cirrhosis homo_sapiens HOTAIR ENSG00000228630 Ensembl lncrna up-regulation HOTAIR NA qRT-PCR; etc. yes "We demonstrate that hotair downregulates mir-29b expression and attenuates its control on epigenetic regulation, leading to enhanced pten methylation, which contributes to the progression of liver fibrosis." 28129115 HOTAIR Epigenetically Modulates PTEN Expression via MicroRNA-29b: A Novel Mechanism in Regulation of Liver Fibrosis https://pubmed.ncbi.nlm.nih.gov/28129115/ 2017 liver liver_cirrhosis homo_sapiens MEG3 ENSG00000214548 Ensembl lncrna down-regulation MEG3 NA qRT-PCR; immunoblot yes We demonstrate that meg3 inhibits hh-mediated emt process in liver fibrosis via smo protein and mir-212. 30282972 LncRNA-MEG3 inhibits activation of hepatic stellate cells through SMO protein and miR-212 https://pubmed.ncbi.nlm.nih.gov/30282972/ 2018 liver liver_cirrhosis homo_sapiens SNHG7 ENSG00000233016 Ensembl lncrna up-regulation DVL2 WNT SIGNALING PATHWAY; CATENIN BETA 1 q-PCR; dual-lucimmunofluorescenceerase reporter assay etc. yes "We demonstrate that snhg7 reduces mir-378a-3p and attenuates its control on dvl2, leading to aberrant wnt;beta-Catenin activity, which contributes to liver fibrosis progression." 31272073 Loss of lncRNA-SNHG7 Promotes the Suppression of Hepatic Stellate Cell Activation via miR-378a-3p and DVL2 https://pubmed.ncbi.nlm.nih.gov/31272073/ 2019 liver liver_cirrhosis mus_musculus Gpr137b-ps ENSMUSG00000097715 Ensembl lncrna up-regulation LNCRNA GPR137B-PS AND CXCL14 NA NA yes We demonstrated a lncrna gpr137b-ps;Mir-200a-3p;Cxcl14 axis that modulates hsc activation and might exert an effect on the pathogenesis of liver fibrosis. 33069761 A lncRNA Gpr137b-ps/miR-200a-3p/CXCL14 axis modulates hepatic stellate cell (HSC) activation https://pubmed.ncbi.nlm.nih.gov/33069761/ 2021 liver liver_cirrhosis mus_musculus Hottip ENSMUSG00000055408 Ensembl lncrna up-regulation SRF NA q-PCR; dual-lucimmunofluorescenceerase reporter assay etc. no We provide a novel hottip-mir-150-srf signalling cascade in liver fibrosis. 30548190 Long noncoding RNA HOTTIP mediates SRF expression through sponging miR-150 in hepatic stellate cells https://pubmed.ncbi.nlm.nih.gov/30548190/ 2019 liver liver_cirrhosis mus_musculus Xist ENSMUSG00000086503 Ensembl lncrna up-regulation NA NA enzyme-linked immunosorbent assay; qRT-PCR; etc. no Xist enhances ethanol-induced hscs autophagy and activation via mir-29b;Hmgb1 axis. 31418997 Long noncoding RNA XIST enhances ethanol-induced hepatic stellate cells autophagy and activation via miR-29b/HMGB1 axis https://pubmed.ncbi.nlm.nih.gov/31418997/ 2019 lung idiopathic_pulmonary_fibrosis mus_musculus Mir17hg ENSMUSG00000089726 Gene lncrna dysregulation NA NA qRT-PCR; Examination of DNA methylation patterns; Dual-luciferase reporter assay etc. no "Compared with control samples, miR-17~92 expression was reduced in lung biopsies and lung fibroblasts from patients with IPF, whereas DNMT-1 expression and methylation of the miR-17~92 promoter was increased. Several miRNAs from the miR-17~92 cluster targeted DNMT-1 expression resulting in a negative feedback loop. Similarly, miR-17~92 expression was reduced in the lungs of bleomycin-treated mice. Treatment with 5'-aza-2'-deoxycytidine in a murine bleomycin-induced pulmonary fibrosis model reduced fibrotic gene and DNMT-1 expression, enhanced miR-17~92 cluster expression, and attenuated pulmonary fibrosis." 23306545 Epigenetic regulation of miR-17~92 contributes to the pathogenesis of pulmonary fibrosis https://www.atsjournals.org/doi/full/10.1164/rccm.201205-0888OC 2013 lung idiopathic_pulmonary_fibrosis mus_musculus H19 ENSMUSG00000000031 Ensembl lncrna up-regulation Col1a1 NA qRT-PCR; Dual-luciferase reporter assay etc. no "H19 play a promotive role in bleomycin-induced epithelial-mesenchymal transition of alveolar epithelial cell through miR-29b regulation. H19 expression was positively correlated with COL1A1 and Acta2 expression; H19 knockdown inhibited COL1A1 and Acta2 expression. Moreover, H19 interacted with miR-29b through directly binding to the 3'UTR; MiR-29b inhibited COL1A1 expression by directly binding to the 3'UTR. In conclusion, we revealed the promotive effect of H19 on BLM-induced IPF, and demonstrated the mechanism by which H19/miR-29b interaction exerts its effect on regulating pulmonary fibrosis." 27613097 The effect of H19-miR-29b interaction on bleomycin-induced mouse model of idiopathic pulmonary fibrosis https://linkinghub.elsevier.com/retrieve/pii/S0006291X16314772 2016 lung pulmonary_hypertension mus_musculus Mir17hg ENSMUSG00000089726 Gene lncrna down-regulation Pdlim5? NA Isolation of Mouse PASMC; Lentivirus-based miR-17?92 Overexpression in HPASMC; PDLIM5 3'-Untranslated Region Luciferase Reporter Assay no "Human PASMC (HPASMC) from patients with PAH expressed decreased levels of the miR-17 92 cluster, TGF-B, and SMC markers. Knockdown of Smad3 but not Smad2 prevented miR-17 92-induced expression of SMC markers. SMC-specific knockout of miR-17 92 attenuated hypoxia-induced pulmonary hypertension (PH) in mice, whereas reconstitution of miR-17 92 restored hypoxia-induced PH in these mice. PDLIM5 is a direct target of miR-17/20a, and hypertensive HPASMC and mouse PASMC expressed elevated PDLIM5 levels. Suppression of PDLIM5 increased expression of SMC markers and enhanced TGF-B/Smad2/3 activity in vitro and enhanced hypoxia-induced PH in vivo, whereas overexpression of PDLIM5 attenuated hypoxia-induced PH." 25647182 Loss of MicroRNA-17 92 in Smooth Muscle Cells Attenuates Experimental Pulmonary Hypertension via Induction of PDZ and LIM Domain 5 https://www.atsjournals.org/doi/10.1164/rccm.201405-0941OC 2015 lung pulmonary_fibrosis mus_musculus NONMMUT021928.2 URS00009B9A54_10090 RNAcentral lncrna up-regulation miR-18a NA qRT-PCR; Immunohistochemistry etc. no "In the present study, we identified that lncRNA NONMMUT021928, designated as pulmonary fibrosis-associated lncRNA (PFAL), was up-regulated in the lungs of mice with experimental lung fibrosis, and in TGF-beta1-induced fibrotic lung fibroblasts. Further study showed that overexpression of PFAL promoted cell proliferation, migration, and fibroblast-myofibroblast transition. Overexpression further resulted in extracellular matrix deposition and fibrogenesis in lung fibroblasts through regulation of microRNA-18a (miR-18a). Importantly, knockdown of PFAL alleviated lung fibrosis both in vitro and in vivo. Mechanistically, our study showed that PFAL promoted lung-fibroblast activation and fibrogenesis by acting as a competing endogenous RNA for miR-18a: forced expression of PFAL inhibited the expression and activity of miR-18a, whereas silencing of PFAL had the opposite effect. Furthermore, we found that miR-18a was decreased during lung fibrosis in vitro and in vivo, as well as in patients with IPF. Moreover, knockdown of miR-18a led to fibrogenesis in lung fibroblasts, whereas enhanced expression of miR-18a attenuated TGF-beta1-induced lung fibrosis by directly targeting the regulation of connecting tissue growth factor." 29683732 lncRNA PFAL promotes lung fibrosis through CTGF by competitively binding miR-18a https://faseb.onlinelibrary.wiley.com/doi/full/10.1096/fj.201800055R 2018 lung silicosis mus_musculus Chrf 105463121 Gene lncrna up-regulation Myd88; Smad3 NA qRT-PCR; Dual-luciferase reporter assay etc. no "Levels were reduced in both macrophages that were exposed to silica and fibroblasts that were exposed to TGF-B1. MiR-489 inhibited silica-induced pulmonary fibrosis primarily by repressing its target genes MyD88 and Smad3. Moreover, the up-regulated lncRNA cardiac hypertrophy-related factor (CHRF) reversed the inhibitory effect of miR-489 on MyD88 and Smad3 and then triggered the inflammation and fibrotic signaling pathways." 27506999 MiR-489 inhibits silica-induced pulmonary fibrosis by targeting MyD88 and Smad3 and is negatively regulated by lncRNA CHRF https://www.nature.com/articles/srep30921 2016 lung respiratory_distress_syndrome_acute mus_musculus Trp53cor1 100504267 Gene lncrna up-regulation NA NA BAL; qRT-PCR; etc. no LincRNA-p21 expression was time-dependently increased and Thy-1 expression was time-dependently reduced in a mouse model of ARDS and in LPS-treated lung fibroblasts. LincRNA-p21 overexpression dramatically inhibited acetylation of H3 and H4 at the Thy-1 promoter and Thy-1 expression levels in HLF1 cells.LincRNA-p21 interference rescued LPS-induced increase of lung and BAL collagen contents. LincRNA-p21 could lead to pulmonary fibrosis in ARDS by inhibition of the expression of Thy-1. 27392907 Lipopolysaccharide promotes pulmonary fibrosis in acute respiratory distress syndrome (ARDS) via lincRNA-p21 induced inhibition of Thy-1 expression https://link.springer.com/article/10.1007%2Fs11010-016-2745-7 2016 lung respiratory_distress_syndrome_acute mus_musculus Trp53cor1 100504267 Gene lncrna histone deacetylation NA NA BAL; qRT-PCR; etc. no LincRNA-p21 expression was time-dependently increased and Thy-1 expression was time-dependently reduced in a mouse model of ARDS and in LPS-treated lung fibroblasts. LincRNA-p21 overexpression dramatically inhibited acetylation of H3 and H4 at the Thy-1 promoter and Thy-1 expression levels in HLF1 cells.LincRNA-p21 interference rescued LPS-induced increase of lung and BAL collagen contents. LincRNA-p21 could lead to pulmonary fibrosis in ARDS by inhibition of the expression of Thy-1. 27392907 Lipopolysaccharide promotes pulmonary fibrosis in acute respiratory distress syndrome (ARDS) via lincRNA-p21 induced inhibition of Thy-1 expression https://link.springer.com/article/10.1007%2Fs11010-016-2745-7 2016 lung idiopathic_pulmonary_fibrosis mus_musculus H19 ENSMUSG00000000031 Ensembl lncrna interact with miRNA Lsp1; Tnnt3; Mrpl23; Igf2; AC013548.1 NA qPCR; Knockdown etc. no "Moreover, H19 interacted with miR-29b through directly binding to the 3'UTR; miR-29b inhibited COL1A1 expression by directly binding to the 4'UTR." 27613097 The effect of H19-miR-29b interaction on bleomycin-induced mouse model of idiopathic pulmonary fibrosis https://linkinghub.elsevier.com/retrieve/pii/S0006291X16314772 2016 lung idiopathic_pulmonary_fibrosis mus_musculus Hoxaas3 ENSMUSG00000085696 Ensembl lncrna dysregulation NA NA Immunohistochemistry; Immunofluorescence; etc. no Overexpression of uc.77 or 2700086A05Rik in human lung epithelial cells induced EMT as demonstrated by changes in gene and protein expression of various EMT markers and cell morphology. 26824344 Integrated long non-coding RNA analyses identify novel regulators of epithelial-mesenchymal transition in the mouse model of pulmonary fibrosis https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4929291/ 2016 stomach fibroma homo_sapiens MALAT1 ENSG00000251562 Ensembl lncrna up-regulation NA NA microarray NA "We showed that the truncated GLI1 protein is overexpressed and retains its capacity to transcriptionally activate its target genes. A specific FISH assay was developed to detect the novel MALAT1-GLI1 translocation in formalin-fixed,paraffin-embedded (FFPE) material. This resulted in the identification of two additional cases with this fusion and two cases with polysomy of the GLI1 gene. Finally,immunohistochemistry revealed that the GLI1 protein is exclusively overexpressed in those cases that harbour GLI1/12q13 genomic alterations. In conclusion,overexpression of GLI1 through a recurrent MALAT1-GLI1 translocation or GLI1 up-regulation delineates a pathogenically distinct subgroup of plexiform fibromyxomas with activation of the Sonic Hedgehog signalling pathway" 27101025 Recurrent MALAT1-GLI1 oncogenic fusion and GLI1 up-regulation define a subset of plexiform fibromyxoma https://pubmed.ncbi.nlm.nih.gov/27101025/ 2016 liver liver_cirrhosis mus_musculus Gpr137b-ps ENSMUSG00000097715 Ensembl lncrna up-regulation LNCRNA GPR137B-PS AND CXCL14 NA NA yes We demonstrated a lncrna gpr137b-ps;Mir-200a-3p;Cxcl14 axis that modulates hsc activation and might exert an effect on the pathogenesis of liver fibrosis. 33069761 A lncRNA Gpr137b-ps/miR-200a-3p/CXCL14 axis modulates hepatic stellate cell (HSC) activation https://pubmed.ncbi.nlm.nih.gov/33069761/ 2021 heart endomyocardial_fibrosis mus_musculus Sail NA NA lncrna down-regulation NA TGF-BETA SIGNALING PATHWAY NA no "SAIL inhibited the fibrotic process by directly binding with SAFB via 23 conserved nucleotide sequences, in turn blocked the access of SAFB to RNA pol II (RNA polymerase II) and reduced the transcription of fibrosis-related genes. Intriguingly,the human conserved fragment of SAIL (hSAIL) significantly suppressed the proliferation and collagen production of human cardiac fibroblasts." 33675440 SAIL: a new conserved anti-fibrotic lncRNA in the heart https://pubmed.ncbi.nlm.nih.gov/33675440/ 2021 kidney kidney_failure_chronic mus_musculus Zfas1 ENSMUSG00000074578 Ensembl lncrna up-regulation NA WNT SIGNALING PATHWAY dual-luciferase reporter assay no LncRNA ZFAS1 from HCM could promote cardiac fibrosis through WNT/beta-catenin signal via exosome pathways. 33640882 Exosome-derived long non-coding RNA ZFAS1 controls cardiac fibrosis in chronic kidney disease https://pubmed.ncbi.nlm.nih.gov/33640882/ 2021 liver carcinoma_hepatocellular homo_sapiens NBR2 ENSG00000198496 Ensembl lncrna down-regulation NA ERK and JNK pathways NA NA "Taken together, NBR2 suppressed autophagy-induced cell proliferation at least partly through ERK and JNK pathways. These data indicated that NBR2 served as a tumor suppressor gene in hepatocellular carcinoma. The current study provides a novel insight and treatment strategy for hepatocellular carcinoma." 33378941 LncRNA NBR2 inhibits tumorigenesis by regulating autophagy in hepatocellular carcinoma https://pubmed.ncbi.nlm.nih.gov/33378941/ 2021 liver carcinoma_hepatocellular homo_sapiens DLX6-AS1 ENSG00000231764 Ensembl lncrna up-regulation NA miR-513c/Cul4A/ANXA10 qRT-PCR etc. NA "Thus, the silencing of lncRNA DLX6-AS1 impaired miR-513c-dependent Cul4A inhibition and subsequently elevated ubiquitination-mediated degradation of ANXA10, thereby preventing the occurrence and development of HCC." 33277615 Upregulated lncRNA DLX6-AS1 underpins hepatocellular carcinoma progression via the miR-513c/Cul4A/ANXA10 axis https://pubmed.ncbi.nlm.nih.gov/33277615/ 2021 liver carcinoma_hepatocellular homo_sapiens ZEB1-AS1 ENSG00000237036 Ensembl lncrna down-regulation miR-23c NA qRT-PCR etc. yes "As a ceRNA, lncRNA ZEB1-AS1 may play a vital role in inhibiting HCC progression through miR-23c, which will provide new clues and theoretical basis for the HCC diagnosis and treatment." 33865414 LncRNA ZEB1-AS1 regulates hepatocellular carcinoma progression by targeting miR-23c https://pubmed.ncbi.nlm.nih.gov/33865414/ 2021 liver carcinoma_hepatocellular homo_sapiens NIFK-AS1 ENSG00000236859 Ensembl lncrna up-regulation NA NA NA yes "Taken together, these results suggest an essential role for NIFK-AS1 in HCC progression and promote NIFK-AS1 as a new therapeutic target and predictor of sorafenib benefit in HCC patients." 34374933 Upregulation of lncRNA NIFK-AS1 in hepatocellular carcinoma by m?6?A methylation promotes disease progression and sorafenib resistance https://pubmed.ncbi.nlm.nih.gov/34374933/ 2021 lung pulmonary_fibrosis mus_musculus NONMMUT060091 NA NA lncrna down-regulation SRSF1 NA qRT-PCR; Immunofluorescence; Western Blot etc. no "A series of molecular assays to assess the role of the novel lncRNA NONMMUT060091, designated as pulmonary fibrosis inhibitor (PFI), which was significantly downregulated in lung fibrosis. Functionally, knockdown of endogenous PFI by smart silencer promoted proliferation, differentiation, and extracellular matrix (ECM) deposition in primary mouse lung fibroblasts (MLFs)." 33981019 The long non-coding RNA PFI protects against pulmonary fibrosis by interacting with splicing regulator SRSF1 https://pubmed.ncbi.nlm.nih.gov/33981019/ 2021 lung idiopathic_pulmonary_fibrosis homo_sapiens VTRNA1-1 ENSG00000199990 Ensembl lncrna down-regulation NA NA GO and pathway enrichment analysis etc. no "SPP1, MMP1, and BPIFB1 were the three main significant DEGs, while VTRNA1-1, SNORD41, and SNORA3A represented the three most significantly negatively regulated DEGs." 34734011 Bioinformatic analysis of differentially expressed genes and pathways in idiopathic pulmonary fibrosis https://pubmed.ncbi.nlm.nih.gov/34734011/ 2021 heart acute_myocardial_infarction rattus_norvegicus Tug1 100125371 Gene lncrna up-regulation NA TGF-BETA SIGNALING PATHWAY cell counting kit-8;transwell assays;western blot no TUG1 expression was increased in AMI tissue and cardiac fibroblasts treated with TGF-beta1. TUG1 knockdown suppressed the biological process of cardiac fibroblasts treated with TGF-beta1 by sponging miR-590. 34341870 TUG1 knockdown suppresses cardiac fibrosis after myocardial infarction https://pubmed.ncbi.nlm.nih.gov/34341870/ 2021 heart myocardial_infarction mus_musculus Mhrt ENSMUSG00000097652 Ensembl lncrna up-regulation NA NA qRT-PCR;western blot;MTT and EdU assays etc. no "Overexpression of MHRT promoted collagen production and CF proliferation, while silencing of MHRT showed the opposite effect." 34334583 LncRNA MHRT Promotes Cardiac Fibrosis via miR-3185 Pathway Following Myocardial Infarction https://pubmed.ncbi.nlm.nih.gov/34334583/ 2021 heart myocardial_infarction rattus_norvegicus Tug1 100125371 Gene lncrna up-regulation NA NA luciferase activity;RIP experiments no TUG1 knockdown inhibited the Ang-II induced cardiac myofibroblast activation and TUG1 overexpression increased proliferation and collagen generation of cardiac myofibroblasts. 34553456 LncRNA TUG1 acts as a competing endogenous RNA to mediate CTGF expression by sponging miR-133b in myocardial fibrosis after myocardial infarction https://pubmed.ncbi.nlm.nih.gov/34553456/ 2021 heart acute_myocardial_infarction mus_musculus Norad ENSMUSG00000102869 Ensembl lncrna up-regulation NA NA RT-qRT-PCR;flow cytometry;western blot no NORAD aggravates acute myocardial infarction by promoting fibrosis and apoptosis via the miR-577/COBLL1 axis. 34355838 Long non-coding RNA NORAD aggravates acute myocardial infarction by promoting fibrosis and apoptosis via miR-577/COBLL1 axis https://pubmed.ncbi.nlm.nih.gov/34355838/ 2021 heart diabetic_cardiomyopathy mus_musculus Norad ENSMUSG00000102869 Ensembl lncrna down-regulation NA NA NA no NORAD lentivirus shRNA improved cardiac function and fibrosis and reduced inflammatory responses in diabetic cardiomyopathy mice via the ceRNA network of NORAD/miR-125a-3p/Fyn. 34591118 NORAD lentivirus shRNA mitigates fibrosis and inflammatory responses in diabetic cardiomyopathy via the ceRNA network of NORAD/miR-125a-3p/Fyn https://pubmed.ncbi.nlm.nih.gov/34591118/ 2021 heart diabetic_cardiomyopathy mus_musculus Gas5 ENSMUSG00000053332 Ensembl lncrna up-regulation NA NA qRT-PCR;luciferase reporter assay;RNA immunoprecipitation assay no GAS5 promotes diabetic cardiomyopathy progression by regulating miR-26a/b-5p. 34091757 Silencing lncRNA GAS5 alleviates apoptosis and fibrosis in diabetic cardiomyopathy by targeting miR-26a/b-5p https://pubmed.ncbi.nlm.nih.gov/34091757/ 2021 heart heart_failure mus_musculus Snhg20 ENSMUSG00000086859 Ensembl lncrna down-regulation miR-335 NA qRT-PCR; Cell Counting Kit-8 assays;dual-luciferase reporter assay etc. no "Downregulation of SNHG20 effectively enhanced cell viability and decreased cell size of HL-1 cells and the expression levels of fibrosis-related proteins (fibronectin, collagen IaI, and alpha-SMA) and apoptosis-related proteins (cleaved caspase-3 and cleaved PARP), which were induced by angiotensin II treatment." 34228494 Inhibition of Long Noncoding RNA SNHG20 Improves Angiotensin II-Induced Cardiac Fibrosis and Hypertrophy by Regulating the MicroRNA 335/ Galectin-3 Axis https://pubmed.ncbi.nlm.nih.gov/34228494/ 2021 heart myocardial_infarction mus_musculus Malat1 ENSMUSG00000092341 Ensembl lncrna up-regulation miR-25-3p NA NA no "MALAT1 sponged miR-25-3p to upregulate CDC42. miR-25-3p overexpression promoted oxygen-glucose deprivation-treated cell viability, proliferation, and angiogenesis." 34745428 M1 Bone Marrow-Derived Macrophage-Derived Extracellular Vesicles Inhibit Angiogenesis and Myocardial Regeneration Following Myocardial Infarction via the MALAT1/MicroRNA-25-3p/CDC42 Axis https://pubmed.ncbi.nlm.nih.gov/34745428/ 2021 heart atrial_fibrosis mus_musculus Nron ENSMUSG00000086484 Ensembl lncrna down-regulation miR-23a NA NA no NRON promotes M2 macrophage polarization and alleviates atrial fibrosis through suppressing exosomal miR-23a derived from atrial myocytes. 33246743 LncRNA NRON promotes M2 macrophage polarization and alleviates atrial fibrosis through suppressing exosomal miR-23a derived from atrial myocytes https://pubmed.ncbi.nlm.nih.gov/33246743/ 2021 heart atrial_fibrillation homo_sapiens LINC00636 ENSG00000240423 Ensembl lncrna down-regulation NA NA RT-qRT-PCR;GO no "LINC00636, which is present in human pericardial fluid, is an antifibrotic molecule that inhibits MAPK1 through the miR-450a-2-3p overexpression and improves cardiac fibrosis in patients with atrial fibrillation." 34257520 Exosomes Containing LINC00636 Inhibit MAPK1 through the miR-450a-2-3p Overexpression in Human Pericardial Fluid and Improve Cardiac Fibrosis in Patients with Atrial Fibrillation https://pubmed.ncbi.nlm.nih.gov/34257520/ 2021 heart myocardial_infarction mus_musculus Snhg7 72091 Gene lncrna up-regulation miR-455-3p NA qRT-PCR;western blot;flow cytometry etc. no "LncRNA SNHG7 depletion exerted protective roles in apoptosis, fibrosis, and inflammation in Ang-II-induced cardiac fibroblasts by regulating miR-455-3p/PTAFR axis, providing a potential molecular target for myocardial infarction therapy." 33929392 Long Noncoding RNA Small Nuclear RNA Host Gene 7 Knockdown Protects Mouse Cardiac Fibroblasts Against Myocardial Infarction by Regulating miR-455-3p/Platelet-Activating Factor Receptor Axis https://pubmed.ncbi.nlm.nih.gov/33929392/ 2021 heart heart_failure homo_sapiens MIAT ENSG00000225783 Ensembl lncrna up-regulation NA PI3K-AKT SIGNALING PATHWAY RT-PCR;ELISA assay no MIAT promoted the expression of inflammatory factors in myocardial fibrosis by activating the PI3K/Akt signaling pathway. 34275376 The mechanism of myocardial fibrosis is ameliorated by myocardial infarction-associated transcript through the PI3K/Akt signaling pathway to relieve heart failure https://pubmed.ncbi.nlm.nih.gov/34275376/ 2021 heart myocardial_infarction mus_musculus Miat ENSMUSG00000097767 Ensembl lncrna up-regulation NA NA qRT-PCR;western blot no "Ablation of Miat attenuates pathological hypertrophy and heart failure, in part, by enhancing cardiomyocyte contractility." 34335976 Ablation of lncRNA Miat attenuates pathological hypertrophy and heart failure https://pubmed.ncbi.nlm.nih.gov/34335976/ 2021 heart endomyocardial_fibrosis homo_sapiens DNM3OS ENSG00000230630 Ensembl lncrna up-regulation NA TGF-BETA SIGNALING PATHWAY RT-qRT-PCR;western blot no Dnm3os silencing may affect the process of cardiac fibroblast activation by inhibiting TGF-beta1/Smad2/3 signal pathway. 34180204 The potential role of long non-coding RNA Dnm3os in the activation of cardiac fibroblasts https://pubmed.ncbi.nlm.nih.gov/34180204/ 2021 heart myocardial_infarction homo_sapiens MANTIS ENSG00000288869 Ensembl lncrna up-regulation NA NA NA no IncRNA MANTIS silencing prevents Dioscin-induced migration and angiogenesis in hypoxic endothelial cells. 34081836 Dioscin elevates lncRNA MANTIS in therapeutic angiogenesis for heart diseases https://pubmed.ncbi.nlm.nih.gov/34081836/ 2021 heart acute_myocardial_infarction homo_sapiens XIST ENSG00000229807 Ensembl lncrna up-regulation miR-155-5p NA RT-qRT-PCR;western blot;flow cytometry etc. no XIST promoted cell proliferation and the expression level of fibrosis-related proteins by sponging miR-155-5p. 33767772 Long non-coding RNA XIST promotes the proliferation of cardiac fibroblasts and the accumulation of extracellular matrix by sponging microRNA-155-5p https://pubmed.ncbi.nlm.nih.gov/33767772/ 2021 kidney renal_fibrosis mus_musculus Gas5 ENSMUSG00000053332 Ensembl lncrna down-regulation NA NA NA no "Long noncoding RNA growth arrest-specific 5 (GAS5), acting in a renoprotective role via the Smad3/miRNA-142-5p axis, that modulates extracellular matrix formation and cell apoptosis." 34486400 LncRNA GAS5 protects against TGF-beta-induced renal fibrosis via the Smad3/miRNA-142-5p axis https://pubmed.ncbi.nlm.nih.gov/34486400/ 2021 kidney diabetic_nephropathy mus_musculus Isg20 ENSMUSG00000039236 Ensembl lncrna up-regulation NA NA RT-qRT-PCR;western blot;luciferase reporter assay etc. no Lnc-ISG20 promotes the renal fibrosis process in diabetic nephropathy by activating AKT through the miR-486-5p/NFAT5 axis. 33939247 LncRNA lnc-ISG20 promotes renal fibrosis in diabetic nephropathy by inducing AKT phosphorylation through miR-486-5p/NFAT5 https://pubmed.ncbi.nlm.nih.gov/33939247/ 2021 kidney renal_fibrosis homo_sapiens XIST ENSG00000229807 Ensembl lncrna up-regulation miR-19b NA qRT-PCR;western blot;luciferase reporter assay etc. no Knockdown of XIST inhibited apoptosis and inflammation of renal fibrosis via miR-19b-mediated downregulation of SOX6. 34461493 Knockdown of lncRNA XIST inhibited apoptosis and inflammation in renal fibrosis via microRNA-19b-mediated downregulation of SOX6 https://pubmed.ncbi.nlm.nih.gov/34461493/ 2021 kidney renal_fibrosis mus_musculus Xist ENSMUSG00000086503 Ensembl lncrna up-regulation miR-19b NA qRT-PCR;western blot;histology no Knockdown of XIST inhibited apoptosis and inflammation of renal fibrosis via miR-19b-mediated downregulation of SOX6. 34461493 Knockdown of lncRNA XIST inhibited apoptosis and inflammation in renal fibrosis via microRNA-19b-mediated downregulation of SOX6 https://pubmed.ncbi.nlm.nih.gov/34461493/ 2021 kidney chronic_kidney_disease homo_sapiens lnc453774.1 ENST00000453774.1 Ensembl lncrna down-regulation NA NA NA no "FBN1, IGF1R, and KLF7 serve as downstream targets of lnc453774.1, and that lnc453774.1 may protect against renal fibrosis through competing endogenous miRs which target FBN1, IGF1R, and KLF7 mRNAs." 34614499 "Elevation of LncRNA ENST00000453774.1 Prevents Renal Fibrosis by Upregulating FBN1, IGF1R, and KLF7" https://pubmed.ncbi.nlm.nih.gov/34614499/ 2021 kidney renal_fibrosis homo_sapiens GAS5 ENSG00000234741 Ensembl lncrna down-regulation Fn1 NA NA no "The transcription factor Creb5, a target gene of lncRNA Gas5 that might regulate extracellular Fn1 deposition." 33876672 LncRNA Gas5 regulates Fn1 deposition via Creb5 in renal fibrosis https://pubmed.ncbi.nlm.nih.gov/33876672/ 2021 kidney renal_fibrosis homo_sapiens LINC00667 ENSG00000263753 Ensembl lncrna up-regulation miR-34c NA qRT-PCR;western blot;luciferase reporter assay etc. no "LINC00667 could reduce the proliferation and invasion of chronic kidney disease cells, increase the apoptosis rate by regulating miR-34c, and improve renal fibrosis." 32705492 Down-regulation of LINC00667 hinders renal tubular epithelial cell apoptosis and fibrosis through miR-34c https://pubmed.ncbi.nlm.nih.gov/32705492/ 2021 kidney diabetic_nephropathy mus_musculus Rmrp ENSMUSG00000088088 Ensembl lncrna up-regulation NA NA NA no Sp1 induced lncRNA Rmrp could drive the expression of JunD via sponging miR-1a-3p in diabetic nephropathy progression. 34512545 Sp1-Induced lncRNA Rmrp Promotes Mesangial Cell Proliferation and Fibrosis in Diabetic Nephropathy by Modulating the miR-1a-3p/JunD Pathway https://pubmed.ncbi.nlm.nih.gov/34512545/ 2021 kidney renal_fibrosis homo_sapiens LNCRNA-ATB 114004396 Gene lncrna up-regulation NA NA qRT-PCR;CCK-8 assays;western blot etc. no "LncRNA-ATB promoted the calcium oxalate monohydrate induced cell injury, cell apoptosis, proliferation inhibition, and epithelial-mesenchymal transition to participate in the process of CaOx crystal-induced renal injury by sponging miR-200s." 34736391 LncRNA-ATB participates in the regulation of calcium oxalate crystal-induced renal injury by sponging the miR-200 family https://pubmed.ncbi.nlm.nih.gov/34736391/ 2021 kidney diabetic_nephropathy homo_sapiens HMGA2 ENSG00000149948 Ensembl lncrna up-regulation NA NA qRT-PCR; Cell Counting Kit-8 assays;dual-luciferase reporter assay etc. no "HMGA2 was a target of miR-93-5p, and HMGA2 overexpression abolished the effects of miR-93-5p restoration. HCP5 knockdown inhibited the AKT/mTOR signaling pathway." 34187448 "LncRNA HCP5 knockdown inhibits high glucose-induced excessive proliferation, fibrosis and inflammation of human glomerular mesangial cells by regulating the miR-93-5p/HMGA2 axis" https://pubmed.ncbi.nlm.nih.gov/34187448/ 2021 kidney diabetic_nephropathy mus_musculus Sox2ot ENSMUSG00000105265 Ensembl lncrna down-regulation NA PI3K-AKT SIGNALING PATHWAY immunohistochemistry;immunofluorescence;western blot etc. no LncRNA SOX2OT alleviates the pathogenesis of diabetic nephropathy via regulating Akt/mTOR-mediated autophagy. 34238205 LncRNA SOX2OT alleviates mesangial cell proliferation and fibrosis in diabetic nephropathy via Akt/mTOR-mediated autophagy https://pubmed.ncbi.nlm.nih.gov/34238205/ 2021 kidney chronic_kidney_disease mus_musculus H19 ENSMUSG00000000031 Ensembl lncrna up-regulation NA WNT SIGNALING PATHWAY qRT-PCR;western blot;dual-luciferase reporter etc. no LncRNA-H19 overexpression significantly upregulates Wnt1 and beta-catenin expression in kidney tissues and fibroblasts of mice. 34818249 The Long Noncoding RNA-H19 Mediates the Progression of Fibrosis from Acute Kidney Injury to Chronic Kidney Disease by Regulating the miR-196a/Wnt/beta-Catenin Signaling https://pubmed.ncbi.nlm.nih.gov/34818249/ 2022 kidney acute_kidney_injury mus_musculus H19 ENSMUSG00000000031 Ensembl lncrna up-regulation NA WNT SIGNALING PATHWAY qRT-PCR;western blot;dual-luciferase reporter etc. no LncRNA-H19 overexpression significantly upregulates Wnt1 and beta-catenin expression in kidney tissues and fibroblasts of mice. 34818249 The Long Noncoding RNA-H19 Mediates the Progression of Fibrosis from Acute Kidney Injury to Chronic Kidney Disease by Regulating the miR-196a/Wnt/beta-Catenin Signaling https://pubmed.ncbi.nlm.nih.gov/34818249/ 2022 kidney renal_interstitial_fibrosis homo_sapiens Gm26669 MGP_AKRJ_G0005332 NA lncrna up-regulation NA NA bioinformatic analyses yes Norcantharidin alleviated renal interstitial fibrosis by inhibiting Gm26669 and the nuclear translocation of Sp1. 34421354 NCTD Prevents Renal Interstitial Fibrosis via Targeting Sp1/lncRNA Gm26669 Axis https://pubmed.ncbi.nlm.nih.gov/34421354/ 2021 kidney diabetic_nephropathy homo_sapiens MALAT1 ENSG00000251562 Ensembl lncrna up-regulation NA NA the luciferase reporter gene;pull-down assays no MALAT1 overexpression may enhance renal fibrosis in diabetic rats and cell damage in high glucose-induced HK-2 cells via the miR-2355-3p/IL6ST axis. 33995063 lncRNA MALAT1 Promotes Renal Fibrosis in Diabetic Nephropathy by Targeting the miR-2355-3p/IL6ST Axis https://pubmed.ncbi.nlm.nih.gov/33995063/ 2021 kidney diabetic_nephropathy mus_musculus Malat1 ENSMUSG00000092341 Ensembl lncrna up-regulation NA NA the luciferase reporter gene;pull-down assays no MALAT1 overexpression may enhance renal fibrosis in diabetic rats and cell damage in high glucose-induced HK-2 cells via the miR-2355-3p/IL6ST axis. 33995063 lncRNA MALAT1 Promotes Renal Fibrosis in Diabetic Nephropathy by Targeting the miR-2355-3p/IL6ST Axis https://pubmed.ncbi.nlm.nih.gov/33995063/ 2021 kidney diabetic_nephropathy mus_musculus Dlx6os1 ENSMUSG00000090063 Ensembl lncrna up-regulation SOX6 NA ELISA;RT-qRT-PCR;western blot etc. no LncRNA Dlx6os1 accelerates the progression of diabetic nephropathy by epigenetically repressing SOX6 via recruiting EZH2. 35038705 LncRNA Dlx6os1 Accelerates Diabetic Nephropathy Progression by Epigenetically Repressing SOX6 via Recruiting EZH2 https://pubmed.ncbi.nlm.nih.gov/35038705/ 2022 kidney diabetic_nephropathy mus_musculus ANRIL ENSMUSG00000086035 Ensembl lncrna down-regulation NA NA NA no "Lnc-ANRIL knock-down suppresses mouse mesangial cell proliferation, fibrosis, inflammation, Wnt/beta-catenin and MEK/ERK pathways in diabetic nephropathy." 32726814 "Knock-Down of Long Non-Coding RNA ANRIL Suppresses Mouse Mesangial Cell Proliferation, Fibrosis, Inflammation via Regulating Wnt/beta-Catenin and MEK/ERK Pathways in Diabetic Nephropathy" https://pubmed.ncbi.nlm.nih.gov/32726814/ 2022